LOCUS       NM_010271               2798 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus glycerol-3-phosphate dehydrogenase 1 (soluble) (Gpd1),
            mRNA.
ACCESSION   NM_010271
VERSION     NM_010271.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 2798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2798)
  AUTHORS   Oh,S., Jo,S., Bajzikova,M., Kim,H.S., Dao,T.T.P., Rohlena,J.,
            Kim,J.M., Neuzil,J. and Park,S.
  TITLE     Non-bioenergetic roles of mitochondrial GPD2 promote tumor
            progression
  JOURNAL   Theranostics 13 (2), 438-457 (2023)
   PUBMED   36632231
  REMARK    GeneRIF: Non-bioenergetic roles of mitochondrial GPD2 promote tumor
            progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2798)
  AUTHORS   Sato,T., Sayama,N., Inoue,M., Morita,A. and Miura,S.
  TITLE     The enhancement of fat oxidation during the active phase and
            suppression of body weight gain in glycerol-3-phosphate
            dehydrogenase 1 deficient mice
  JOURNAL   Biosci Biotechnol Biochem 84 (11), 2367-2373 (2020)
   PUBMED   32662756
  REMARK    GeneRIF: The enhancement of fat oxidation during the active phase
            and suppression of body weight gain in glycerol-3-phosphate
            dehydrogenase 1 deficient mice.
REFERENCE   5  (bases 1 to 2798)
  AUTHORS   Gonzalez Malagon,S.G., Melidoni,A.N., Hernandez,D., Omar,B.A.,
            Houseman,L., Veeravalli,S., Scott,F., Varshavi,D., Everett,J.,
            Tsuchiya,Y., Timms,J.F., Phillips,I.R. and Shephard,E.A.
  TITLE     The phenotype of a knockout mouse identifies flavin-containing
            monooxygenase 5 (FMO5) as a regulator of metabolic ageing
  JOURNAL   Biochem Pharmacol 96 (3), 267-277 (2015)
   PUBMED   26049045
REFERENCE   6  (bases 1 to 2798)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   7  (bases 1 to 2798)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   8  (bases 1 to 2798)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   9  (bases 1 to 2798)
  AUTHORS   Kozak,L.P. and Murphy,E.D.
  TITLE     The reversible expression of an adult isozyme locus, Gdc-1, in
            tumors of the mouse
  JOURNAL   Cancer Res 36 (10), 3711-3717 (1976)
   PUBMED   953997
REFERENCE   10 (bases 1 to 2798)
  AUTHORS   Kozak,L.P. and Erdelsky,K.J.
  TITLE     The genetics and developmental regulation of L-glycerol 3-phosphate
            dehydrogenase
  JOURNAL   J Cell Physiol 85 (2 Pt 2 Suppl 1), 437-447 (1975)
   PUBMED   1123411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018733.1 and AK137134.1.
            
            On Jul 6, 2018 this sequence version replaced NM_010271.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018733.1, AK137134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               AK018733.1         1-974
            975-2798            AK137134.1         976-2799
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..2798
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /note="glycerol-3-phosphate dehydrogenase 1 (soluble)"
                     /db_xref="GeneID:14555"
                     /db_xref="MGI:MGI:95679"
     exon            1..62
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1071
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /EC_number="1.1.1.8"
                     /note="glycerolphosphate dehydrogenase 1, cytoplasmic
                     adult"
                     /codon_start=1
                     /product="glycerol-3-phosphate dehydrogenase [NAD(+)],
                     cytoplasmic"
                     /protein_id="NP_034401.1"
                     /db_xref="CCDS:CCDS27828.1"
                     /db_xref="GeneID:14555"
                     /db_xref="MGI:MGI:95679"
                     /translation="MAGKKVCIVGSGNWGSAIAKIVGSNAGRLAHFDPRVTMWVFEED
                     IGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAATGADILVFVVPHQFIGKIC
                     DQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEK
                     FCETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLG
                     FGDNTKAAVIRLGLMEMIAFAKLFCSGTVSSATFLESCGVADLITTCYGGRNRKVAEA
                     FARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQP
                     VGEFIRCLQNHPEHM"
     exon            63..240
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            241..381
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            382..520
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            521..633
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            634..867
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            868..974
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     exon            975..2798
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /note="hexamer: AATAAA"
     polyA_site      2792
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /note="major polyA site"
ORIGIN      
        1 agagaagcag caagcagcac catggctggc aagaaagtct gcattgtcgg ctctggcaac
       61 tggggctcag ccattgccaa gatcgtgggt agcaatgcag gccggctggc acactttgac
      121 ccacgggtga ccatgtgggt gtttgaggaa gacatcgggg gcagaaagct aactgagatc
      181 atcaacactc agcacgagaa tgttaaatac ctgccagggc acaagctgcc ccccaatgtg
      241 gtggccatcc cagacgtggt ccaggctgca acaggcgctg acatcctggt ttttgtggta
      301 ccccatcagt tcattggcaa gatctgtgac cagctcaagg gccacttgaa ggccaatact
      361 attggcatat ctcttattaa gggggtagac gagggcccca acgggctgaa gctcatttct
      421 gaagtgattg gggagcgcct tggcattccc atgagcgtgc tgatgggggc caacattgcc
      481 agcgaggtgg ctgaggagaa gttctgtgag acgaccatcg gctgcaagga cccggcccag
      541 ggacagctcc tgaaggacct gatgcagaca cccaactttc gcatcactgt ggtacaagag
      601 gtggacacag tggagatctg tggggccttg aagaatatag tggccgttgg ggctggcttc
      661 tgtgatgggc ttggcttcgg tgacaacacc aaggcggcgg tgatccggtt ggggctcatg
      721 gagatgatcg ccttcgccaa gctcttctgc agtggcactg tgtcctcggc caccttcctg
      781 gagagctgcg gggtcgcaga cctcatcacg acctgctatg gggggcggaa ccgcaaggtg
      841 gcagaggcct ttgctcgaac tggaaagtcc attgagcagc tggagaagga gatgctaaat
      901 gggcagaagc tacaggggcc ccagacagcc cgggagctgc acagcattct ccaacacaag
      961 ggccttgtgg acaagttccc cttgttcact gcggtgtaca aagtgtgcta tgagggccag
     1021 ccagtgggcg aattcatccg ctgtctgcag aaccacccgg aacacatgtg aatggggcca
     1081 gggcccagga caggcagccc ctttgcccca acggagacaa gcggaaggaa gcacgtgaca
     1141 cccgtcatca ggactgtctc caggactccc catctagcag agtcctctct gaaggaccct
     1201 gaggacagga ggctgcgggg ctcagctaca cacctagaga tgctcgccac agaatccaca
     1261 cttccttgct gtcctctggg aagtgtagaa ctaagcccca gtggtgcctg ctccaggggt
     1321 ggggttgggg gaagggaagg cgccaagtca agggctgccg gttgctgcct cacacacact
     1381 gggaaccggt cccaagtccc attaagtgac tgaagaagca cttcagccac aggaaagatg
     1441 gggcaaaggc tgccaaggga agggtctgga tgcctgagct gacacagacc ccagagaccc
     1501 tttggccgac ctctgccagg ccccacacaa catcaacgat ctcactgttt gctaacaaaa
     1561 tacaaagctc tcaaacaacc ccactctaac ttctcctagc aacacttgct tcctcagaag
     1621 cctctacttc cccctccccc aggctactct ggcacaagag ttgctctcca caggcatctc
     1681 tggccctggg gcgctccatt cttcccagag acttcctggt tcctggagct ttgtcagggc
     1741 ctccccaccc tgtgtgacct ttcccagctt tcccttgcct gcacccagct gccagcaccc
     1801 tctttgggga gcaggaatct aatctgctga cagagctaca ctcttttcac agcaggctca
     1861 gatggctcag gctcccctga ccttcctatt tgtccacctc cccagtcagg agctccggcc
     1921 ccggccagcc cctcctactg ctgacctttc ttctcagggt cctccccaca aggccgcttc
     1981 tctctgcagt caccaccaac ttcacgtcta acagaatgta ggatttatag tttatcgtcc
     2041 tcagggctgt cagcccatat tcttgactct gccctttcct tttgcccaag tcgttctcac
     2101 ccagcctgga aggccacccg gcatctgtag gcttagaact aaggagcagc tcaaaggttc
     2161 agtaggtttc cacaagggtt ggtgggtcct agtccaaggc cagctgtcct cggaacagaa
     2221 caaggtcctc gcgagatcgg acccacacac ctcaggagct ggggaactcg agggaaggac
     2281 aattgaaaac tgcctgccct ggggtgaggg agatcagagg gggatgggag actgctttgc
     2341 actggccctg ttccaaagtt gggtggcagc aagagaatgt cacagatcag cagcctggag
     2401 cgctagctat aaatagctgg aggtttctct ctccaccagg ggtctccatt tcctgtgtgg
     2461 cagcaactgg gacaccgtgg ctctggccag cttgatatta aactaacaca ttaaggtgcc
     2521 aggtccctct ctgctcctag cctttaagaa ttccgtctta gtgaaggtca gagctgtcgg
     2581 gtaaggggaa gagggggggc cctgtcatcg atcccgactg ggctggaacc ctcccacgca
     2641 tgactcaatt cagagctgtt ccccgggaga ctggggcggg atgcagacag attccaacac
     2701 cttaacctat gtttgctcag tcagtcaact gtgaatctga ggtcttctgt caggccactt
     2761 gtctacccaa taaagtgtgg tttttccaga aactggaa
//
