LOCUS       NP_034401                349 aa            linear   ROD 15-APR-2025
DEFINITION  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [Mus
            musculus].
ACCESSION   NP_034401
VERSION     NP_034401.1
DBSOURCE    REFSEQ: accession NM_010271.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Chen,H., Ferguson,C.J., Mitchell,D.C., Risch,I., Titus,A.,
            Paulo,J.A., Hwang,A., Beck,L.K., Lin,T.H., Gu,W., Song,S.K.,
            Yuede,C.M., Yano,H., Griffith,O.L., Griffith,M., Gygi,S.P.,
            Bonni,A. and Kim,A.H.
  TITLE     The Hao-Fountain syndrome protein USP7 regulates neuronal
            connectivity in the brain via a novel p53-independent ubiquitin
            signaling pathway
  JOURNAL   Cell Rep 44 (2), 115231 (2025)
   PUBMED   39862434
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Oh,S., Jo,S., Bajzikova,M., Kim,H.S., Dao,T.T.P., Rohlena,J.,
            Kim,J.M., Neuzil,J. and Park,S.
  TITLE     Non-bioenergetic roles of mitochondrial GPD2 promote tumor
            progression
  JOURNAL   Theranostics 13 (2), 438-457 (2023)
   PUBMED   36632231
  REMARK    GeneRIF: Non-bioenergetic roles of mitochondrial GPD2 promote tumor
            progression.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 349)
  AUTHORS   Sato,T., Sayama,N., Inoue,M., Morita,A. and Miura,S.
  TITLE     The enhancement of fat oxidation during the active phase and
            suppression of body weight gain in glycerol-3-phosphate
            dehydrogenase 1 deficient mice
  JOURNAL   Biosci Biotechnol Biochem 84 (11), 2367-2373 (2020)
   PUBMED   32662756
  REMARK    GeneRIF: The enhancement of fat oxidation during the active phase
            and suppression of body weight gain in glycerol-3-phosphate
            dehydrogenase 1 deficient mice.
REFERENCE   6  (residues 1 to 349)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   7  (residues 1 to 349)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   8  (residues 1 to 349)
  AUTHORS   King,T.R., Lee,B.K., Behringer,R.R. and Eicher,E.M.
  TITLE     Mapping anti-mullerian hormone (Amh) and related sequences in the
            mouse: identification of a new region of homology between MMU10 and
            HSA19p
  JOURNAL   Genomics 11 (2), 273-283 (1991)
   PUBMED   1685136
REFERENCE   9  (residues 1 to 349)
  AUTHORS   Kozak,L.P. and Murphy,E.D.
  TITLE     The reversible expression of an adult isozyme locus, Gdc-1, in
            tumors of the mouse
  JOURNAL   Cancer Res 36 (10), 3711-3717 (1976)
   PUBMED   953997
REFERENCE   10 (residues 1 to 349)
  AUTHORS   Kozak,L.P. and Erdelsky,K.J.
  TITLE     The genetics and developmental regulation of L-glycerol 3-phosphate
            dehydrogenase
  JOURNAL   J Cell Physiol 85 (2 Pt 2 Suppl 1), 437-447 (1975)
   PUBMED   1123411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018733.1 and AK137134.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018733.1, AK137134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     Protein         1..349
                     /product="glycerol-3-phosphate dehydrogenase [NAD(+)],
                     cytoplasmic"
                     /EC_number="1.1.1.8"
                     /note="glycerolphosphate dehydrogenase 1, cytoplasmic
                     adult"
                     /calculated_mol_wt=37442
     Region          5..342
                     /region_name="glycerol3P_DH"
                     /note="glycerol-3-phosphate dehydrogenase (NAD(+));
                     TIGR03376"
                     /db_xref="CDD:274551"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21695; propagated from
                     UniProtKB/Swiss-Prot (P13707.3)"
     Site            326
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O35077; propagated from
                     UniProtKB/Swiss-Prot (P13707.3)"
     CDS             1..349
                     /gene="Gpd1"
                     /gene_synonym="Gdc-1; Gdc1; GPD-C; GPDH-C"
                     /coded_by="NM_010271.3:22..1071"
                     /db_xref="CCDS:CCDS27828.1"
                     /db_xref="GeneID:14555"
                     /db_xref="MGI:MGI:95679"
ORIGIN      
        1 magkkvcivg sgnwgsaiak ivgsnagrla hfdprvtmwv feediggrkl teiintqhen
       61 vkylpghklp pnvvaipdvv qaatgadilv fvvphqfigk icdqlkghlk antigislik
      121 gvdegpnglk lisevigerl gipmsvlmga niasevaeek fcettigckd paqgqllkdl
      181 mqtpnfritv vqevdtveic galknivavg agfcdglgfg dntkaavirl glmemiafak
      241 lfcsgtvssa tflescgvad littcyggrn rkvaeafart gksieqleke mlngqklqgp
      301 qtarelhsil qhkglvdkfp lftavykvcy egqpvgefir clqnhpehm
//
