LOCUS       NM_028802               3716 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glycerophosphocholine phosphodiesterase 1 (Gpcpd1),
            transcript variant 2, mRNA.
ACCESSION   NM_028802
VERSION     NM_028802.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3716)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3716)
  AUTHORS   Cikes,D., Leutner,M., Cronin,S.J.F., Novatchkova,M., Pfleger,L.,
            Klepochova,R., Lair,B., Lac,M., Bergoglio,C., Viguerie,N.,
            Durnberger,G., Roitinger,E., Grivej,M., Rullman,E., Gustafsson,T.,
            Hagelkruys,A., Tavernier,G., Bourlier,V., Knauf,C., Krebs,M.,
            Kautzky-Willer,A., Moro,C., Krssak,M., Orthofer,M. and
            Penninger,J.M.
  TITLE     Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its
            deficiency severely perturbs glucose metabolism
  JOURNAL   Nat Aging 4 (1), 80-94 (2024)
   PUBMED   38238601
  REMARK    GeneRIF: Gpcpd1-GPC metabolic pathway is dysfunctional in aging and
            its deficiency severely perturbs glucose metabolism.
REFERENCE   3  (bases 1 to 3716)
  AUTHORS   Okazaki,Y., Nakamura,K., Takeda,S., Yoshizawa,I., Yoshida,F.,
            Ohshima,N., Izumi,T., Klein,J.D., Kumrungsee,T., Sands,J.M. and
            Yanaka,N.
  TITLE     GDE5 inhibition accumulates intracellular glycerophosphocholine and
            suppresses adipogenesis at a mitotic clonal expansion stage
  JOURNAL   Am J Physiol Cell Physiol 316 (2), C162-C174 (2019)
   PUBMED   30462540
  REMARK    GeneRIF: Decreased GDE5 expression suppresses adipocyte
            differentiation by intracellular glycerophosphocholine
            accumulation.
REFERENCE   4  (bases 1 to 3716)
  AUTHORS   Corda,D., Mosca,M.G., Ohshima,N., Grauso,L., Yanaka,N. and
            Mariggio,S.
  TITLE     The emerging physiological roles of the glycerophosphodiesterase
            family
  JOURNAL   FEBS J 281 (4), 998-1016 (2014)
   PUBMED   24373430
  REMARK    Review article
REFERENCE   5  (bases 1 to 3716)
  AUTHORS   Okazaki,Y., Ohshima,N., Yoshizawa,I., Kamei,Y., Mariggio,S.,
            Okamoto,K., Maeda,M., Nogusa,Y., Fujioka,Y., Izumi,T., Ogawa,Y.,
            Shiro,Y., Wada,M., Kato,N., Corda,D. and Yanaka,N.
  TITLE     A novel glycerophosphodiester phosphodiesterase, GDE5, controls
            skeletal muscle development via a non-enzymatic mechanism
  JOURNAL   J Biol Chem 285 (36), 27652-27663 (2010)
   PUBMED   20576599
  REMARK    GeneRIF: GDE5 negatively regulates skeletal muscle development.
REFERENCE   6  (bases 1 to 3716)
  AUTHORS   Pawlowski,T.L., Heringer-Walther,S., Cheng,C.H., Archie,J.G.,
            Chen,C.F., Walther,T. and Srivastava,A.K.
  TITLE     Candidate Agtr2 influenced genes and pathways identified by
            expression profiling in the developing brain of Agtr2(-/y) mice
  JOURNAL   Genomics 94 (3), 188-195 (2009)
   PUBMED   19501643
REFERENCE   7  (bases 1 to 3716)
  AUTHORS   Temeles,G.L. and Schultz,R.M.
  TITLE     Transient polyadenylation of a maternal mRNA following
            fertilization of mouse eggs
  JOURNAL   J Reprod Fertil 109 (2), 223-228 (1997)
   PUBMED   9155731
REFERENCE   8  (bases 1 to 3716)
  AUTHORS   Temeles,G.L., Ram,P.T., Rothstein,J.L. and Schultz,R.M.
  TITLE     Expression patterns of novel genes during mouse preimplantation
            embryogenesis
  JOURNAL   Mol Reprod Dev 37 (2), 121-129 (1994)
   PUBMED   7545925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031658.1, AK030645.1, AK050318.1 and AW125284.1.
            
            On Mar 21, 2014 this sequence version replaced NM_028802.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 8. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 4. Variants 2 and 10 both encode the same
            isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050318.1, AK165952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AK031658.1         3-49
            48-3188             AK030645.1         2-3142
            3189-3510           AK050318.1         3104-3425
            3511-3716           AW125284.1         1-206               c
FEATURES             Location/Qualifiers
     source          1..3716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.57 cM"
     gene            1..3716
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /note="glycerophosphocholine phosphodiesterase 1"
                     /db_xref="GeneID:74182"
                     /db_xref="MGI:MGI:104898"
     exon            1..181
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            182..251
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2230
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /EC_number="3.1.4.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     preimplantation protein 4; putative glycerophosphodiester
                     phosphodiesterase 5; putative glycerophosphocholine
                     phosphodiesterase GPCPD1; glycerophosphocholine
                     phosphodiesterase GDE1 homolog"
                     /codon_start=1
                     /product="glycerophosphocholine phosphodiesterase GPCPD1
                     isoform 2"
                     /protein_id="NP_083078.3"
                     /db_xref="CCDS:CCDS38246.1"
                     /db_xref="GeneID:74182"
                     /db_xref="MGI:MGI:104898"
                     /translation="MTPSQVTFEIRGTLLPGEVFAICGSCDALGNWNPQNAVALINEN
                     ETGDSVLWKAVIALNRGVSVKYRYFRGCFLEPKTIGGPCQVIVHKWETHLQPRSITPL
                     ESEIIIDDGQFGIHNGVETLDSGWLTCQTEIRLRLHFSEKPPVSISKKKFKKSRFRVK
                     LTLEGLEEDEDDDDDKVSPTVLHKMSNSLEISLISDNEFKCRHSQPECGYGLQPDRWT
                     EYSIQTMEPDNLELIFDFFEEDLSEHVVQGDVLPGHVGTACLLSSTIAESGRSAGILT
                     LPIMSRNSRKTIGKVRVDFIIIKPLPGYSCSMQSSFSKYWKPRIPLDVGHRGAGNSTT
                     TAKLAKVQENTIASLRNAASHGAAFVEFDVHLSKDFVPVVYHDLTCCLTMKRKYEADP
                     VELFEIPVKELTFDQLQLLKLSHVTALKTKDRKQSLYEEENFFSENQPFPSLKMVLES
                     LPENVGFNIEIKWICQHRDGVWDGNLSTYFDMNVFLDIILKTVLENSGKRRIVFSSFD
                     ADICTMVRQKQNKYPILFLTQGKSDIYPELMDLRSRTTPIAMSFAQFENILGINAHTE
                     DLLRNPSYVQEAKAKGLVIFCWGDDTNDPENRRKLKEFGVNGLIYDRIYDWMPEQPNI
                     FQVEQLERLKQELPELKNCLCPTVSHFIPSSFCVEPDIHVDANGIDSVENA"
     exon            252..348
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            349..433
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..509
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..551
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            552..675
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..916
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1079
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1212
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1267
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1360
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1438
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1478
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1540
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1606
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1743
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1879
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2040
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..3701
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3681..3686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /note="hexamer: ATTAAA"
     polyA_site      3700
                     /gene="Gpcpd1"
                     /gene_synonym="2310004G06Rik; 2310032D16Rik; Gde5;
                     mKIAA1434; Prei4"
                     /note="major polyA site"
ORIGIN      
        1 ccttcgaccc cgccccgcgg ggtgggctgg cagtttagtc tagggcagct gaaaccggtt
       61 tgagaggcgg ctgtaactgg gctccttgct tcctcgggcc acctaaggga gcgctggcga
      121 ggcgctgacg ctcggctccg tcggccgcgg cccaggctct cggcgcggcc cggagcggca
      181 gaaatcctaa aattccatca gaatgacacc ttctcaggtc acttttgaaa taagaggaac
      241 tcttttacca ggagaggtct ttgcaatatg tggaagctgt gatgccctgg gaaactggaa
      301 tcctcaaaat gctgtggctc ttattaatga aaacgagaca ggagacagtg tgttgtggaa
      361 agcagtgatt gctctcaata gaggagtgtc agtgaagtac cgctacttca gaggctgctt
      421 tttagaacca aagactatcg gtggtccatg tcaagtcata gttcacaagt gggagactca
      481 tctacaacca cgatcaataa cccctttaga aagtgaaatc attattgacg atggacagtt
      541 tggcatccac aatggtgttg aaacactgga ttctggatgg cttacatgtc agactgaaat
      601 aagattgcgt ctgcattttt ctgagaaacc tcctgtttca attagcaaga aaaagttcaa
      661 aaaatcgaga tttagggtaa agctcacact cgagggtctg gaggaagatg aagatgatga
      721 tgacgataag gtctctccca ctgttcttca caaaatgtcc aacagcctgg agatatcctt
      781 aataagtgac aatgagttca agtgcaggca ctcacagcca gaatgtgggt atggcttaca
      841 gcccgatcgt tggacagagt acagcataca gacaatggaa ccagataatc tggagctcat
      901 ctttgacttt tttgaggaag atctcagtga gcatgtagtt cagggtgatg ttcttcctgg
      961 acacgtgggc acagcatgcc tcctgtcttc taccattgct gagagtggaa gaagcgctgg
     1021 aatccttact cttcccatca tgagcagaaa ttccagaaaa actataggca aagtcagagt
     1081 tgattttatc atcatcaagc cattacctgg atatagttgt tctatgcagt cttcattttc
     1141 caagtattgg aaaccaagaa taccattgga cgttggacat cgtggtgcag ggaactcaac
     1201 aacgactgcc aagctagcta aagtacagga aaatactatc gcttctttaa gaaatgctgc
     1261 cagtcatggc gcagcatttg tagaatttga tgtccacctt tcaaaggact ttgtgcccgt
     1321 ggtgtatcat gacctcacct gctgtctgac catgaagagg aaatatgaag ctgatccagt
     1381 tgaattgttt gaaatcccag taaaagaatt aacatttgac caactccagt tattgaagct
     1441 ttctcatgtg actgcattaa aaaccaaaga ccggaaacaa tctttgtatg aggaggaaaa
     1501 tttcttttct gaaaatcagc catttccttc tcttaagatg gttttagaat cattgccaga
     1561 aaatgtagga tttaatatag aaataaaatg gatttgccaa cacagggatg gagtatggga
     1621 tggcaactta tcaacatatt ttgatatgaa tgtgtttttg gatataattt taaaaactgt
     1681 tttagaaaat tctgggaaga ggagaatagt gttttcttct tttgatgcag atatttgtac
     1741 aatggttcgg cagaagcaga acaaatatcc catattattt ttgacccaag gaaagtctga
     1801 tatttacccc gaactcatgg acctcagatc tcggacaaca cccattgcaa tgagttttgc
     1861 acagtttgaa aatattttgg ggataaatgc ccatactgaa gacctcctta gaaacccatc
     1921 ctatgtccaa gaggcaaaag ctaagggatt ggtcatattc tgctggggtg atgataccaa
     1981 cgatcctgaa aacagaagga aactgaagga atttggagta aatggtctaa tatatgatag
     2041 gatatatgat tggatgcctg aacagccaaa tatattccaa gtggagcagt tggagcgcct
     2101 gaagcaagaa ttgccagagc ttaagaactg tttgtgtccc actgttagcc acttcatccc
     2161 ttcttctttc tgtgtggagc ctgatatcca cgtggatgcc aacggcattg atagtgtgga
     2221 gaacgcttag ttcacagtgc acagaggaca tttaggggca caccgctgcc ctcatgttta
     2281 gttttcacca tcgagcactg ctgttgcctc ttaggttttt cagtccaatg aagcaataat
     2341 gaagtatttt actatttcat tacaggtccc gcaagaatat caagtatgct atttgtcact
     2401 tgtccaggta taattaccaa tcagtctctg tacaataaga aaatatactg ttaaacattt
     2461 cagtgagata tctaagccta taatggtgaa tcttcattaa aagttggaaa ttaacgatat
     2521 aaatatctca tacttaaagt tcaggctttt catttgatta agtcttaaat cttcagtgct
     2581 tgagaaaaat gattgcataa ttatacctga ccatggaaaa actaagtacc tcaatgcatg
     2641 catttgcact ggtggctcca gctgcacagg tctgtgtcat ccatgtacat aggtatcttt
     2701 acatggttga taggaacacg caccattttc ctttagtata aacctcagat tgctgccatt
     2761 tctcacctga cccaagccag cctgcagatg aacctcaaaa cttgtctcat aaaccattca
     2821 aagatattaa agttccagaa tgctgcaggg taacttaatg tataaagtat ttgtaagaag
     2881 tatatattgc atatatagta gtgtagatca gaaggtatca atttgactca atgcatgctt
     2941 taggttttaa gcatgagatt gtacatgttt actgttaagt ccttgcatct ggtgctaggt
     3001 gagggagatg ttaaggacat aaaatatttt gtcgcctaaa aaacaaagtc tgttttagac
     3061 actttgagta tgcttattta gtgtctcact acctagtaaa cataagtgtc tcactaccta
     3121 gtaaacataa ttgctgtgtg ttgcatagta gttaaattcc catgcagaaa aataaatgtc
     3181 ctgaattctc aaattggtat tctttattgt ttaatatata tcatgtatgt aatttattta
     3241 ggaatgtaga tcttactgta tataaatgca tgcttttagg attatactaa gatttcttta
     3301 gaagcagatt gtactgataa aactgtaact tcagaatgaa tgttaaataa aatgacagat
     3361 ttattttttt cctcatctta aaatgaaatt tcaagaaggt attttgtaga atggttttat
     3421 aatggtattc tgtcttacaa atagaaattt tattctgctt gtatgggccg actcaccaca
     3481 ctttctcagt gctcctgctg aggcagtttg tgcatgtatt gacagaagtt aaaaacataa
     3541 gacttgagat gacaagttgt actttttttt ttctttcaat ttttgacaca acctgtgtag
     3601 ccttggctgt cctggaactc actgtgtaag ccagctggct ttgaactctc agatacatct
     3661 gcctctgcct cctaagtggt attaaagtca tgcgccacca caaaaaaaaa aaaaaa
//
