LOCUS       NP_035951                555 aa            linear   ROD 27-APR-2025
DEFINITION  glypican-6 isoform 2 precursor [Mus musculus].
ACCESSION   NP_035951
VERSION     NP_035951.1
DBSOURCE    REFSEQ: accession NM_011821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 555)
  AUTHORS   Mead,T.J., Bhutada,S., Foulcer,S.J., Peruzzi,N., Nelson,C.M.,
            Seifert,D.E., Larkin,J., Tran-Lundmark,K., Filmus,J. and Apte,S.S.
  TITLE     Combined genetic-pharmacologic inactivation of tightly linked
            ADAMTS proteases in temporally specific windows uncovers distinct
            roles for versican proteolysis and glypican-6 in cardiac
            development
  JOURNAL   Matrix Biol 131, 1-16 (2024)
   PUBMED   38750698
REFERENCE   2  (residues 1 to 555)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 555)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 555)
  AUTHORS   Shi,W. and Filmus,J.
  TITLE     Glypican-6 and Glypican-4 stimulate embryonic stomach growth by
            regulating Hedgehog and noncanonical Wnt signaling
  JOURNAL   Dev Dyn 251 (12), 2015-2028 (2022)
   PUBMED   36057966
  REMARK    GeneRIF: Glypican-6 and Glypican-4 stimulate embryonic stomach
            growth by regulating Hedgehog and noncanonical Wnt signaling.
REFERENCE   5  (residues 1 to 555)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 555)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (residues 1 to 555)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   8  (residues 1 to 555)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (residues 1 to 555)
  AUTHORS   Ford-Perriss,M., Turner,K., Guimond,S., Apedaile,A., Haubeck,H.D.,
            Turnbull,J. and Murphy,M.
  TITLE     Localisation of specific heparan sulfate proteoglycans during the
            proliferative phase of brain development
  JOURNAL   Dev Dyn 227 (2), 170-184 (2003)
   PUBMED   12761845
REFERENCE   10 (residues 1 to 555)
  AUTHORS   Veugelers,M., De Cat,B., Ceulemans,H., Bruystens,A.M., Coomans,C.,
            Durr,J., Vermeesch,J., Marynen,P. and David,G.
  TITLE     Glypican-6, a new member of the glypican family of cell surface
            heparan sulfate proteoglycans
  JOURNAL   J Biol Chem 274 (38), 26968-26977 (1999)
   PUBMED   10480909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164668.1, AK135442.1, AK132531.1 and AC132136.3.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The encoded isoform
            (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164668.1, AK132531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 60.34 cM"
     Protein         1..555
                     /product="glypican-6 isoform 2 precursor"
                     /calculated_mol_wt=60671
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2404
     Region          23..522
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     mat_peptide     24..530
                     /product="Glypican-6. /id=PRO_0000012325"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R087.1)"
                     /calculated_mol_wt=57830
     Region          348..376
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R087.1)"
     Region          480..501
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R087.1)"
     CDS             1..555
                     /gene="Gpc6"
                     /coded_by="NM_011821.3:640..2307"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS27330.1"
                     /db_xref="GeneID:23888"
                     /db_xref="MGI:MGI:1346322"
ORIGIN      
        1 mpswiravil plsgllltlp aaadvkarsc sevrqaygak gfsladipyq eiagehlric
       61 pqeytcctte medklsqqsk lefenlveet shfvrttfvs rhkkfdeffr ellenaeksl
      121 ndmfvrtygm lymqnsevfq dlftelkryy tggnvnleem lndfwarlle rmfqlinpqy
      181 hfsedylecv skytdqlkpf gdvprklkiq vtrafiaart fvqgltvgre vanrvskvsp
      241 tpgciralmk mlycpycrgl ptvrpcnnyc lnvmkgclan qadldtewnl fidamllvae
      301 rlegpfnies vmdpidvkis eaimnmqens mqvsakvfqg cgqpkpapal rsarsapenf
      361 ntrfrpynpe erpttaagts ldrlvtdike klklskkvws alpytickde rvtagtsnee
      421 ecwnghskar ylpeimndgl tnqinnpeve vditrpdtfi rqqimalrvm tnklknayng
      481 ndvnfqdtsd essgsgsgsg cmddvcptef efvtteapav dpdrreeess askfssslis
      541 wslvcmvlal qrlyr
//
