LOCUS       NM_008150               2325 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glypican 4 (Gpc4), mRNA.
ACCESSION   NM_008150 XM_914063
VERSION     NM_008150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2325)
  AUTHORS   Puliatti,G., Li Puma,D.D., Aceto,G., Lazzarino,G., Acquarone,E.,
            Mangione,R., D'Adamio,L., Ripoli,C., Arancio,O., Piacentini,R. and
            Grassi,C.
  TITLE     Intracellular accumulation of tau oligomers in astrocytes and their
            synaptotoxic action rely on Amyloid Precursor Protein Intracellular
            Domain-dependent expression of Glypican-4
  JOURNAL   Prog Neurobiol 227, 102482 (2023)
   PUBMED   37321444
  REMARK    GeneRIF: Intracellular accumulation of tau oligomers in astrocytes
            and their synaptotoxic action rely on Amyloid Precursor Protein
            Intracellular Domain-dependent expression of Glypican-4.
REFERENCE   3  (bases 1 to 2325)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2325)
  AUTHORS   Shi,W. and Filmus,J.
  TITLE     Glypican-6 and Glypican-4 stimulate embryonic stomach growth by
            regulating Hedgehog and noncanonical Wnt signaling
  JOURNAL   Dev Dyn 251 (12), 2015-2028 (2022)
   PUBMED   36057966
  REMARK    GeneRIF: Glypican-6 and Glypican-4 stimulate embryonic stomach
            growth by regulating Hedgehog and noncanonical Wnt signaling.
REFERENCE   5  (bases 1 to 2325)
  AUTHORS   Wu,X., Sosunov,A.A., Lado,W., Teoh,J.J., Ham,A., Li,H.,
            Al-Dalahmah,O., Gill,B.J.A., Arancio,O., Schevon,C.A.,
            Frankel,W.N., McKhann,G.M. 2nd, Sulzer,D., Goldman,J.E. and Tang,G.
  TITLE     Synaptic hyperexcitability of cytomegalic pyramidal neurons
            contributes to epileptogenesis in tuberous sclerosis complex
  JOURNAL   Cell Rep 40 (3), 111085 (2022)
   PUBMED   35858542
REFERENCE   6  (bases 1 to 2325)
  AUTHORS   Hagihara,K., Watanabe,K., Chun,J. and Yamaguchi,Y.
  TITLE     Glypican-4 is an FGF2-binding heparan sulfate proteoglycan
            expressed in neural precursor cells
  JOURNAL   Dev Dyn 219 (3), 353-367 (2000)
   PUBMED   11066092
REFERENCE   7  (bases 1 to 2325)
  AUTHORS   Siebertz,B., Stocker,G., Drzeniek,Z., Handt,S., Just,U. and
            Haubeck,H.D.
  TITLE     Expression of glypican-4 in haematopoietic-progenitor and
            bone-marrow-stromal cells
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 937-943 (1999)
   PUBMED   10585884
REFERENCE   8  (bases 1 to 2325)
  AUTHORS   Matsuki,Y., Kaname,T., Suematsu,S., Yamaguchi,Y., Abe,K. and
            Yamamura,K.
  TITLE     Mouse K-glypican gene, gpc4, maps to chromosome X
  JOURNAL   Genomics 54 (2), 358-359 (1998)
   PUBMED   9828145
REFERENCE   9  (bases 1 to 2325)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   10 (bases 1 to 2325)
  AUTHORS   Williams,B.O., Schmitt,E.M., Remington,L., Bronson,R.T.,
            Albert,D.M., Weinberg,R.A. and Jacks,T.
  TITLE     Extensive contribution of Rb-deficient cells to adult chimeric mice
            with limited histopathological consequences
  JOURNAL   EMBO J 13 (18), 4251-4259 (1994)
   PUBMED   7925270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672019.7, CJ187434.1, BQ559580.1, CN710713.1, CF168390.1,
            AI892739.1 and BX088698.22.
            
            On May 29, 2009 this sequence version replaced NM_008150.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006622.1, X83577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL672019.7         39384-39429         c
            47-514              CJ187434.1         1-468
            515-891             BQ559580.1         37-413
            892-1151            CN710713.1         370-629
            1152-1581           CF168390.1         175-604
            1582-1780           AI892739.1         281-479
            1781-2325           BX088698.22        144903-145447       c
FEATURES             Location/Qualifiers
     source          1..2325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 28.33 cM"
     gene            1..2325
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="glypican 4"
                     /db_xref="GeneID:14735"
                     /db_xref="MGI:MGI:104902"
     exon            1..308
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1822
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /codon_start=1
                     /product="glypican-4 precursor"
                     /protein_id="NP_032176.2"
                     /db_xref="CCDS:CCDS30124.1"
                     /db_xref="GeneID:14735"
                     /db_xref="MGI:MGI:104902"
                     /translation="MARLGLLALLCTLAALSASLLAAELKSKSCSEVRRLYVSKGFNK
                     NDAPLYEINGDHLKICPQDYTCCSQEMEEKYSLQSKDDFKTVVSEQCNHLQAIFASRY
                     KKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGNVNLEEM
                     LNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAA
                     RTFAQGLAVARDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRG
                     CLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVS
                     QKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGTSLDRLVTDVKEK
                     LKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKGKSRYLFAVTGNGLANQGNNPEV
                     QVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCP
                     SEFEYNATDHSGKSANEKADSAGGAHAEAKPYLLAALCILFLAVQGEWR"
     exon            309..467
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            468..859
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1025
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1156
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1303
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1440
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1616
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2325
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="hexamer: AGTAAA"
     polyA_site      1870
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="major polyA site"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="hexamer: ATTAAA"
     polyA_site      2280
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="major polyA site"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="hexamer: ATTAAA"
     polyA_site      2322
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /note="major polyA site"
ORIGIN      
        1 cctccttcac taccaacttc aactccccgg ttctcgctcc gctcgtgagt gttcactccg
       61 cgcctctccg cccgctccgc agcgctgctt tccatcgggt ctcattctgt cccctaaagg
      121 tgggagcgcg tccgtcaggg tccgcaccat ggcacgctta ggcttgctcg cgctcctctg
      181 caccctggcc gcgctcagcg cctcgctgct ggctgcggag ctcaagtcga aaagttgctc
      241 ggaagtgcga cgtctctacg tgtccaaagg cttcaacaag aatgatgccc ccctctatga
      301 gatcaacggt gaccatttga agatctgtcc ccaggattat acatgctgtt ctcaagagat
      361 ggaagagaag tacagcctgc aaagtaaaga tgatttcaaa accgtggtca gcgaacagtg
      421 caaccatttg caagccatct ttgcatcccg ttacaagaag tttgatgaat tcttcaaaga
      481 acttcttgaa aatgcagaga aatccctgaa tgatatgttc gtgaagacat atggccactt
      541 atacatgcaa aattcagagc tatttaaaga tctcttcgtt gagttgaagc gctactatgt
      601 ggcgggaaat gtgaacctgg aagaaatgtt aaatgacttc tgggctcgcc ttctggagcg
      661 catgtttcgc ctggtgaact cccagtacca ttttacagat gagtacttgg aatgtgtgag
      721 caaatataca gagcagctga agccttttgg agatgtccct cggaaactga agctccaggt
      781 tacccgcgca tttgttgcag ccaggacctt cgctcaaggc ttagcagttg caagggatgt
      841 agtaagcaaa gtgtccgtgg tgaaccccac agctcagtgc acccatgcac tgctgaagat
      901 gatctactgc tcccactgcc ggggcctggt gactgtgaag ccctgttaca actattgctc
      961 aaacatcatg cgaggctgtt tggccaacca aggagacctt gattttgagt ggaacaattt
     1021 catagatgct atgctgatgg tggcagagag gctggagggt cctttcaaca ttgagtccgt
     1081 tatggatccc atcgatgtga agatttctga tgctatcatg aatatgcagg ataatagtgt
     1141 tcaagtgtct cagaaggttt tccaaggctg tggccctccg aagcctctcc cagctggacg
     1201 aatttctcgc tccatctctg aaagtgcctt cagtgctcga ttcagacctt atcatccaga
     1261 gcaacgccca accacggcag ctggcactag tttggaccga ctggttactg atgtcaagga
     1321 gaaactgaaa caagctaaga agttctggtc ctctctccca agcaccgttt gcaatgatga
     1381 gaggatggca gcaggaaatg aaaatgagga tgactgctgg aatggcaaag gcaaaagcag
     1441 gtacctgttt gcagtgacag gaaatggatt ggccaaccag ggcaacaacc cagaagtcca
     1501 ggttgacacc agcaagccag acatactgat ccttcgtcag atcatggccc ttcgggttat
     1561 gaccagtaaa atgaagaatg cttacaatgg aaatgacgtg gacttctttg acatcagtga
     1621 tgagagtagt ggagagggaa gtggaagcgg atgtgaatat cagcagtgcc cttcggagtt
     1681 cgagtacaac gccactgacc attctgggaa gagtgccaac gagaaagctg acagtgccgg
     1741 tggtgcccat gcagaggcaa agccctacct cctcgctgct ctctgcatcc tgtttctcgc
     1801 tgtgcaggga gagtggagat aattgtcaaa ctctgagtaa aagcgttcat catcagaaag
     1861 ttcaaaggca ccaagttctc actttttttt tttttaacca tcctagtgac tttgcttttt
     1921 aaatgaatgg acaacaatgt acagttttta ctgtgtggcc actggtttaa gcaatgttga
     1981 ctttgttttg ctcattcagt ttgaggggac agcggggcct cctgccttta agtttgttcc
     2041 tccccctcac ctcccccctc ctttgagact cgtgttctgc gtggctagca gtgtaggtac
     2101 agaactgtag ttagttgtgc attggtgatc ttgttttctt tgttggcttc tctcatttta
     2161 tttgtggggt ttttcttttc caattatggt ctcaccttgt ttctcacaag aaaaccaggg
     2221 tcctttcttg gcatgtaaca tgtacgtatt tctgaaatat taaatagctg tacagaagca
     2281 ggtttattta tcatgttatc ttattaaaag aaaaagccca aacaa
//
