LOCUS       NP_032176                557 aa            linear   ROD 03-APR-2025
DEFINITION  glypican-4 precursor [Mus musculus].
ACCESSION   NP_032176 XP_919156
VERSION     NP_032176.2
DBSOURCE    REFSEQ: accession NM_008150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 557)
  AUTHORS   Puliatti,G., Li Puma,D.D., Aceto,G., Lazzarino,G., Acquarone,E.,
            Mangione,R., D'Adamio,L., Ripoli,C., Arancio,O., Piacentini,R. and
            Grassi,C.
  TITLE     Intracellular accumulation of tau oligomers in astrocytes and their
            synaptotoxic action rely on Amyloid Precursor Protein Intracellular
            Domain-dependent expression of Glypican-4
  JOURNAL   Prog Neurobiol 227, 102482 (2023)
   PUBMED   37321444
  REMARK    GeneRIF: Intracellular accumulation of tau oligomers in astrocytes
            and their synaptotoxic action rely on Amyloid Precursor Protein
            Intracellular Domain-dependent expression of Glypican-4.
REFERENCE   3  (residues 1 to 557)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 557)
  AUTHORS   Shi,W. and Filmus,J.
  TITLE     Glypican-6 and Glypican-4 stimulate embryonic stomach growth by
            regulating Hedgehog and noncanonical Wnt signaling
  JOURNAL   Dev Dyn 251 (12), 2015-2028 (2022)
   PUBMED   36057966
  REMARK    GeneRIF: Glypican-6 and Glypican-4 stimulate embryonic stomach
            growth by regulating Hedgehog and noncanonical Wnt signaling.
REFERENCE   5  (residues 1 to 557)
  AUTHORS   Wu,X., Sosunov,A.A., Lado,W., Teoh,J.J., Ham,A., Li,H.,
            Al-Dalahmah,O., Gill,B.J.A., Arancio,O., Schevon,C.A.,
            Frankel,W.N., McKhann,G.M. 2nd, Sulzer,D., Goldman,J.E. and Tang,G.
  TITLE     Synaptic hyperexcitability of cytomegalic pyramidal neurons
            contributes to epileptogenesis in tuberous sclerosis complex
  JOURNAL   Cell Rep 40 (3), 111085 (2022)
   PUBMED   35858542
REFERENCE   6  (residues 1 to 557)
  AUTHORS   Hagihara,K., Watanabe,K., Chun,J. and Yamaguchi,Y.
  TITLE     Glypican-4 is an FGF2-binding heparan sulfate proteoglycan
            expressed in neural precursor cells
  JOURNAL   Dev Dyn 219 (3), 353-367 (2000)
   PUBMED   11066092
REFERENCE   7  (residues 1 to 557)
  AUTHORS   Siebertz,B., Stocker,G., Drzeniek,Z., Handt,S., Just,U. and
            Haubeck,H.D.
  TITLE     Expression of glypican-4 in haematopoietic-progenitor and
            bone-marrow-stromal cells
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 937-943 (1999)
   PUBMED   10585884
REFERENCE   8  (residues 1 to 557)
  AUTHORS   Matsuki,Y., Kaname,T., Suematsu,S., Yamaguchi,Y., Abe,K. and
            Yamamura,K.
  TITLE     Mouse K-glypican gene, gpc4, maps to chromosome X
  JOURNAL   Genomics 54 (2), 358-359 (1998)
   PUBMED   9828145
REFERENCE   9  (residues 1 to 557)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   10 (residues 1 to 557)
  AUTHORS   Williams,B.O., Schmitt,E.M., Remington,L., Bronson,R.T.,
            Albert,D.M., Weinberg,R.A. and Jacks,T.
  TITLE     Extensive contribution of Rb-deficient cells to adult chimeric mice
            with limited histopathological consequences
  JOURNAL   EMBO J 13 (18), 4251-4259 (1994)
   PUBMED   7925270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672019.7, CJ187434.1, BQ559580.1, CN710713.1, CF168390.1,
            AI892739.1 and BX088698.22.
            
            On May 29, 2009 this sequence version replaced NP_032176.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006622.1, X83577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 28.33 cM"
     Protein         1..557
                     /product="glypican-4 precursor"
                     /calculated_mol_wt=60803
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
                     /calculated_mol_wt=1801
     mat_peptide     19..529
                     /product="Glypican-4. /id=PRO_0000012317"
                     /note="propagated from UniProtKB/Swiss-Prot (P51655.2)"
                     /calculated_mol_wt=57852
     Region          26..550
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75487; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
     Site            494
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
     Site            498
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
     Site            500
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
     Site            514
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51655.2)"
     CDS             1..557
                     /gene="Gpc4"
                     /gene_synonym="9530073D23Rik; K-glypican"
                     /coded_by="NM_008150.2:149..1822"
                     /db_xref="CCDS:CCDS30124.1"
                     /db_xref="GeneID:14735"
                     /db_xref="MGI:MGI:104902"
ORIGIN      
        1 marlgllall ctlaalsasl laaelksksc sevrrlyvsk gfnkndaply eingdhlkic
       61 pqdytccsqe meekyslqsk ddfktvvseq cnhlqaifas rykkfdeffk ellenaeksl
      121 ndmfvktygh lymqnselfk dlfvelkryy vagnvnleem lndfwarlle rmfrlvnsqy
      181 hftdeylecv skyteqlkpf gdvprklklq vtrafvaart faqglavard vvskvsvvnp
      241 taqcthallk miycshcrgl vtvkpcynyc snimrgclan qgdldfewnn fidamlmvae
      301 rlegpfnies vmdpidvkis daimnmqdns vqvsqkvfqg cgppkplpag risrsisesa
      361 fsarfrpyhp eqrpttaagt sldrlvtdvk eklkqakkfw sslpstvcnd ermaagnene
      421 ddcwngkgks rylfavtgng lanqgnnpev qvdtskpdil ilrqimalrv mtskmknayn
      481 gndvdffdis dessgegsgs gceyqqcpse feynatdhsg ksanekadsa ggahaeakpy
      541 llaalcilfl avqgewr
//
