LOCUS       NM_016697               2272 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus glypican 3 (Gpc3), mRNA.
ACCESSION   NM_016697
VERSION     NM_016697.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2272)
  AUTHORS   Morrison,J.A., Pushel,I., McLennan,R., McKinney,M.C., Gogol,M.M.,
            Scott,A., Krumlauf,R. and Kulesa,P.M.
  TITLE     Comparative analysis of neural crest development in the chick and
            mouse
  JOURNAL   Dev Biol 519, 142-149 (2025)
   PUBMED   39716593
REFERENCE   2  (bases 1 to 2272)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2272)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2272)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (bases 1 to 2272)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2272)
  AUTHORS   Piscione,T.D. and Rosenblum,N.D.
  TITLE     The malformed kidney: disruption of glomerular and tubular
            development
  JOURNAL   Clin Genet 56 (5), 341-356 (1999)
   PUBMED   10668924
  REMARK    Review article
REFERENCE   7  (bases 1 to 2272)
  AUTHORS   Cano-Gauci,D.F., Song,H.H., Yang,H., McKerlie,C., Choo,B., Shi,W.,
            Pullano,R., Piscione,T.D., Grisaru,S., Soon,S., Sedlackova,L.,
            Tanswell,A.K., Mak,T.W., Yeger,H., Lockwood,G.A., Rosenblum,N.D.
            and Filmus,J.
  TITLE     Glypican-3-deficient mice exhibit developmental overgrowth and some
            of the abnormalities typical of Simpson-Golabi-Behmel syndrome
  JOURNAL   J Cell Biol 146 (1), 255-264 (1999)
   PUBMED   10402475
REFERENCE   8  (bases 1 to 2272)
  AUTHORS   Pellegrini,M., Pilia,G., Pantano,S., Lucchini,F., Uda,M., Fumi,M.,
            Cao,A., Schlessinger,D. and Forabosco,A.
  TITLE     Gpc3 expression correlates with the phenotype of the
            Simpson-Golabi-Behmel syndrome
  JOURNAL   Dev Dyn 213 (4), 431-439 (1998)
   PUBMED   9853964
REFERENCE   9  (bases 1 to 2272)
  AUTHORS   Lage,H. and Dietel,M.
  TITLE     Cloning and characterization of human cDNAs encoding a protein with
            high homology to rat intestinal development protein OCI-5
  JOURNAL   Gene 188 (2), 151-156 (1997)
   PUBMED   9133586
REFERENCE   10 (bases 1 to 2272)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166243.1, AK168402.1, AK146702.1 and CJ321827.1.
            
            On Oct 30, 2009 this sequence version replaced NM_016697.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036126.1, AK146702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CJ166243.1         2-24
            24-2006             AK168402.1         2-1984
            2007-2262           AK146702.1         1984-2239
            2263-2272           CJ321827.1         440-449
FEATURES             Location/Qualifiers
     source          1..2272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 28.74 cM"
     gene            1..2272
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /note="glypican 3"
                     /db_xref="GeneID:14734"
                     /db_xref="MGI:MGI:104903"
     exon            1..342
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1910
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /codon_start=1
                     /product="glypican-3 precursor"
                     /protein_id="NP_057906.2"
                     /db_xref="CCDS:CCDS30125.1"
                     /db_xref="GeneID:14734"
                     /db_xref="MGI:MGI:104903"
                     /translation="MAGTVRTACLLVAMLLGLGCLGQAQPPPPPDATCHQVRSFFQRL
                     QPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFL
                     IIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDI
                     NVDDMVNELFDSLFPVIYTQMMNPGLPESVLDINECLRGARRDLKVFGSFPKLIMTQV
                     SKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGY
                     CNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQ
                     KNGGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKILKVAHVEHEETLSSRRRELIQ
                     KLKSFINFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELK
                     MKGPEPVVSQIIDKLKHINQLLRTMSVPKGKVLDKSLDEEGLESGDCGDDEDECIGSS
                     GDGMVKVKNQLRFLAELAYDLDVDDAPGNKQHGNQKDNEITTSHSVGNMPSPLKILIS
                     VAIYVACFFFLVH"
     exon            343..504
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1199
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1333
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1459
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1580
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1740
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..2269
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2252..2257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="Gpc3"
                     /gene_synonym="OCI-5"
                     /note="major polyA site"
ORIGIN      
        1 tgttcccgcc ctcgcccagc gcccaggtag ctgcgaggaa acttttgcgg cggctgggta
       61 gcggctcctc tcttgctctg tcgggctact gccagacttg ctgagtctcg ggaccgctcc
      121 ggctcttatt gccactctct cgtgctctcc tcgctccccc aagaagcagg atggccggga
      181 ccgtgcgcac cgcgtgcttg ctggtggcga tgctgctagg cttgggctgc ctgggacagg
      241 cgcagccccc gccgcctcca gacgccacct gtcaccaggt ccgttctttc ttccagagac
      301 tgcagcccgg actcaaatgg gttccagaaa cccctgtacc aggatcagat ttgcaagtat
      361 gtctccccaa gggcccaaca tgctgctcaa gaaagatgga agaaaaatac caactaacag
      421 cacggctgaa catggaacaa ctgctccagt ctgcgagtat ggaactcaag ttcttaatta
      481 ttcagaatgc tgcggttttc caagaggcct ttgaaattgt tgttcgccat gccaagaact
      541 acaccaacgc catgttcaag aataactacc ccagcctgac tccacaagct tttgagtttg
      601 tcggtgaatt tttcacagat gtgtctctct acatcttggg ttctgatatc aacgtggatg
      661 atatggtcaa tgaattgttc gacagcctct ttccagtcat ctacacccag atgatgaacc
      721 caggcctgcc tgagtcagtc ttagacatca acgagtgcct ccgaggagca agacgtgacc
      781 tgaaagtatt tggcagtttc cccaagctta ttatgaccca ggtttccaag tcactgcaag
      841 tcactcgaat cttccttcaa gccctgaatc tcggaattga agtcatcaac actaccgacc
      901 acctcaagtt tagtaaggac tgtggccgta tgctcacccg aatgtggtat tgctcttact
      961 gccagggact gatgatggtt aagccttgcg gtggttattg caatgtggtc atgcaaggct
     1021 gtatggctgg tgtggtggag atcgacaagt actggagaga atacattctg tctcttgaag
     1081 agctcgtgaa tggcatgtac agaatctacg acatggagaa tgtgctgctc ggcctctttt
     1141 ctaccatcca tgattccatc cagtatgtgc agaagaacgg aggcaagctg accaccacca
     1201 ttggcaagtt gtgtgcccac tcccagcaac gccaatatag atctgcttat taccctgaag
     1261 atctgtttat tgacaagaag atattaaaag tcgctcatgt cgaacatgaa gaaaccttat
     1321 ccagccgaag aagggaactg attcagaaac tgaagtcttt catcaacttc tatagcgctt
     1381 tgccgggcta catctgcagc catagccccg tggccgaaaa tgataccctg tgctggaacg
     1441 gacaagaact tgtggagaga tacagccaga aggcggcaag gaacgggatg aagaatcagt
     1501 ttaacctcca tgagctgaaa atgaagggcc ctgagccggt ggttagccag atcattgaca
     1561 aactgaagca cattaaccag ctcctgagaa ccatgtctgt gcccaagggt aaagttctgg
     1621 ataaaagcct ggatgaagaa ggacttgaaa gtggagactg cggtgatgat gaagatgaat
     1681 gcattggaag ctctggtgac gggatggtga aagtgaagaa tcaactgcgc ttccttgcag
     1741 aactggccta tgatctggat gtggacgatg ctccggggaa caagcagcat ggaaatcaga
     1801 aggacaacga gatcaccacc tctcacagcg tggggaacat gccgtcccca ctgaagatcc
     1861 tcatcagtgt ggccatctat gtggcgtgct tttttttcct ggtgcactga cttgccagcg
     1921 tccagtgcct gtgctgccct gcagcacctg tggtccctac agaaagggag ccaccttctt
     1981 ttttttttct tttttttttt ttttttatct tttatgcctc ctcccaccac cattaagtag
     2041 gagactaacc gcgtgttatg ttttcgaaaa tcaaatggta tctttatgag gatggtaaat
     2101 tttagtggta ggatagattg tctttttgca aagaaaaaaa aaaccttcaa gttgtgccaa
     2161 attattttct tacatttgac tgttggaaca tggttgtcat gtttccctct tttctctttc
     2221 tctgcatgga tttctttgac aaaaaaaaat aaataaacat tcaaataaaa aa
//
