LOCUS       NM_172412               2561 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glypican 2 cerebroglycan (Gpc2), transcript variant 1,
            mRNA.
ACCESSION   NM_172412 XM_979560
VERSION     NM_172412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Wu,J., Li,H., Han,L., Sun,T., Tian,Y. and Wang,X.
  TITLE     The spatiotemporal expression pattern of Syndecans in murine
            embryonic teeth
  JOURNAL   Gene Expr Patterns 36, 119109 (2020)
   PUBMED   32220631
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Ahrens,M.J., Li,Y., Jiang,H. and Dudley,A.T.
  TITLE     Convergent extension movements in growth plate chondrocytes require
            gpi-anchored cell surface proteins
  JOURNAL   Development 136 (20), 3463-3474 (2009)
   PUBMED   19762422
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Jen,Y.H., Musacchio,M. and Lander,A.D.
  TITLE     Glypican-1 controls brain size through regulation of fibroblast
            growth factor signaling in early neurogenesis
  JOURNAL   Neural Dev 4, 33 (2009)
   PUBMED   19732411
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Luxardi,G., Galli,A., Forlani,S., Lawson,K., Maina,F. and Dono,R.
  TITLE     Glypicans are differentially expressed during patterning and
            neurogenesis of early mouse brain
  JOURNAL   Biochem Biophys Res Commun 352 (1), 55-60 (2007)
   PUBMED   17107664
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Ford-Perriss,M., Turner,K., Guimond,S., Apedaile,A., Haubeck,H.D.,
            Turnbull,J. and Murphy,M.
  TITLE     Localisation of specific heparan sulfate proteoglycans during the
            proliferative phase of brain development
  JOURNAL   Dev Dyn 227 (2), 170-184 (2003)
   PUBMED   12761845
REFERENCE   10 (bases 1 to 2561)
  AUTHORS   Hikake,T., Mori,T., Iseki,K., Hagino,S., Zhang,Y., Takagi,H.,
            Yokoya,S. and Wanaka,A.
  TITLE     Comparison of expression patterns between CREB family transcription
            factor OASIS and proteoglycan core protein genes during murine
            tooth development
  JOURNAL   Anat Embryol (Berl) 206 (5), 373-380 (2003)
   PUBMED   12684764
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159257.2.
            
            On Mar 9, 2023 this sequence version replaced NM_172412.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083180.1, AK049639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC159257.2         186235-186568       c
            335-493             AC159257.2         185425-185583       c
            494-816             AC159257.2         184801-185123       c
            817-897             AC159257.2         183993-184073       c
            898-1060            AC159257.2         183170-183332       c
            1061-1191           AC159257.2         182794-182924       c
            1192-1338           AC159257.2         182515-182661       c
            1339-1478           AC159257.2         182293-182432       c
            1479-1648           AC159257.2         182041-182210       c
            1649-2561           AC159257.2         180243-181155       c
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.0 cM"
     gene            1..2561
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /note="glypican 2 cerebroglycan"
                     /db_xref="GeneID:71951"
                     /db_xref="MGI:MGI:1919201"
     exon            1..334
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1908
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glypican-2"
                     /codon_start=1
                     /product="glypican-2 isoform 1 precursor"
                     /protein_id="NP_766000.1"
                     /db_xref="CCDS:CCDS19799.1"
                     /db_xref="GeneID:71951"
                     /db_xref="MGI:MGI:1919201"
                     /translation="MSALRPLLLLLLHLCPGLGPGHGSEAKVVRSCAETRQVLGARGY
                     SLNLIPPSLISGEHLQVCPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLAA
                     RHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLD
                     DTLADFWAQLLERAFPLLHPQYSFPPDFLLCLTRLTSTADGSLQPFGDSPRRLRLQIS
                     RALVAARALVQGLETGRNVVSEALKVPVLEGCRQALMRLIGCPLCRGVPSLMPCRGFC
                     LNVAHGCLSSRGLEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQEN
                     SVKVSAKVFQECGTPHPVQSRSRRAPAPREEASRSWRASAEEERPTTAAGTNLHRLVW
                     ELRERLSRVRGFWAGLPVTVCGDSRMAADLSQETAPCWTGVGRGRYMSPVVVGSLNEQ
                     LHNPELDTSSPDVPTRRRRLHLRAATARMKAAALGQDLDMHDADEDASGSGGGQQYAD
                     DWKAGAVPVVPPARPPRPPRPPRRDGLGVRGGSGSARYNQGRSRNLGSSVGLHTPLVL
                     LLLPSALTLLVLR"
     exon            335..493
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..816
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..897
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1060
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1191
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1338
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1478
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1648
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2561
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2539..2544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2561
                     /gene="Gpc2"
                     /gene_synonym="2410016G05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agatgcctcc tggtcctgct acggtgctgg ggttgttcag ttttagggga cacgctccta
       61 ttcttttctt cgagacgtcc cgcggccgag aacggggttc tagagttccg cggactcttc
      121 tttcctcctt aggacccact ttgccccgtc ccagggagga gagcacctat gtctgcgctg
      181 cgacctctcc tgcttttgct gctccatctg tgtccgggtc tagggccggg acatgggagt
      241 gaggcaaagg tcgtccggag ttgtgcagag actcggcagg tgctgggggc ccggggatat
      301 agcttaaacc taatccctcc ctccctcatc tcaggtgagc accttcaagt ctgtcctcag
      361 gagtacacct gctgttccag tgagacagag cagaagttga tcagggatgc tgaagtcaca
      421 ttccgtggcc tggtagagga cagtggctct ttcctgattc acacactggc tgcccggcat
      481 agaaagttta atgagttttt tcgggagatg ctgtctatat cccagcattc tttggctcag
      541 ctcttctcgc attcctatgg tcgcctgtat tcccagcacg ccgtcatctt caatagcctg
      601 ttttccggcc tgcgggacta ctatgagaag tctggcgagg ggttagatga caccttggcg
      661 gatttctggg cacagctcct ggagagagcc ttccctttgc tgcacccaca atacagtttc
      721 cctcctgact tcctgctctg tcttactcgg cttacttcaa ctgctgatgg ctctctgcag
      781 cccttcggag actcaccccg ccgcctccgc ctacagatat ccagggcact ggtggcagcc
      841 cgggccttgg tccagggtct ggagactgga agaaatgtgg tcagcgaagc acttaaggta
      901 ccagtgttgg aaggctgcag acaggccctg atgcgtctga ttggctgccc tctttgtcgg
      961 ggagttcctt cacttatgcc ctgccggggc ttctgcctca atgtagccca tggctgcctc
     1021 agcagtaggg gactggagcc tgaatggggc ggatatctgg atggtctcct gctgctggct
     1081 gagaaactcc aaggaccctt ttcctttgaa ctggctgctg agtccattgg ggtgaagatc
     1141 tcagaaggtt tgatgcactt acaggaaaac agtgtaaagg tgtcagcgaa ggtgtttcag
     1201 gaatgtggga ccccccatcc cgtgcagtcc cgcagccggc gagcaccagc accccgagaa
     1261 gaggctagcc ggtcgtggag ggcttcagcg gaggaagaac ggcccacaac agcggcaggc
     1321 actaatctgc accgcttggt ttgggagctc cgggagagac ttagccgagt acggggcttc
     1381 tgggctggac tgcctgtaac cgtatgtggg gactcccgca tggcggcaga tctctcacag
     1441 gagacggcac cctgctggac tggagttggg agaggccggt atatgtcgcc tgtggtcgtg
     1501 ggctccttga atgagcagct ccacaacccg gagttggata cttcgagtcc cgatgtcccg
     1561 acgcggaggc ggaggctaca tctccgagca gctactgctc gaatgaaggc ggctgcgctg
     1621 ggtcaggatc ttgacatgca tgatgcggat gaagatgcca gtggctctgg agggggacag
     1681 cagtatgcag acgactggaa agctggggca gtgcctgtgg ttcccccagc caggcctcca
     1741 aggccacctc gtcctcctcg aagggacggt cttggagtga gaggaggaag tggcagtgcc
     1801 agatacaacc agggccgaag caggaatctg gggtcatctg ttggcctcca taccccactt
     1861 gtcctcctcc tccttccctc agccctgacc ctgcttgtac ttcgataacg agggaggggc
     1921 gccctagcat caaaaggctt agtggctctt tttcttccac ctccctcagc caggcatgag
     1981 gaggagtgga agggggctac agagagggca gaaagggact ttgtgggtga atggctgggg
     2041 ccccaaatcc aggagtttcc aattaatggg gtgggaggta gatgggtttc ataatattta
     2101 ttttttcatt tgggaactgg ggatatttat ttaggaagga tggttcagct cttttaaatc
     2161 tttgggctca ctgatggggt ggggggtggg acacggggtt gaaggaactt gaaagtgggg
     2221 aggaatggta ctattggcat gggggtacct ggtattgaaa atggacacat aaactagctg
     2281 agagtgatgt cacttgcctg taaacccatt attctttggg atgctgaggc aggaggattg
     2341 agagttaggg actaataaag ctaggtgctg acagtagaac aggaaggagg gtagaacctg
     2401 agttttgttg cctcttttaa aatcatctgc ttcttaagta tggggcgggg ggagggaccc
     2461 atctagcgac ctttgccatc cacatccatc acaaacttcc acttcatatt tcagtgttca
     2521 tatcagtgtc tattggtaaa taaagaattt attggaccac g
//
