LOCUS       NM_016696               3608 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus glypican 1 (Gpc1), mRNA.
ACCESSION   NM_016696
VERSION     NM_016696.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Souza,D.S., Chignalia,A.Z. and Carvalho-de-Souza,J.L.
  TITLE     Modulation of cardiac voltage-activated K+ currents by glypican 1
            heparan sulfate proteoglycan
  JOURNAL   Life Sci 308, 120916 (2022)
   PUBMED   36049528
  REMARK    GeneRIF: Modulation of cardiac voltage-activated K(+) currents by
            glypican 1 heparan sulfate proteoglycan.
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Bartosch,A.M.W., Mathews,R., Mahmoud,M.M., Cancel,L.M., Haq,Z.S.
            and Tarbell,J.M.
  TITLE     Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in
            shear-induced endothelial nitric oxide production
  JOURNAL   Sci Rep 11 (1), 11386 (2021)
   PUBMED   34059731
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Dull,R.O., Patel,M., Isbatan,A. and Hahn,R.G.
  TITLE     Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and
            Urine Response to Fluid Challenge in Mice
  JOURNAL   J Vasc Res 58 (1), 58-64 (2021)
   PUBMED   33105135
  REMARK    GeneRIF: Syndecan-1 and Glypican-1 Knockout Alters Body Water
            Balance and Urine Response to Fluid Challenge in Mice.
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Szpirer,C., Szpirer,J., Riviere,M., Van Vooren,P., Veugelers,M. and
            David,G.
  TITLE     Mapping of the rat glypican genes
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 83-86 (2001)
   PUBMED   11474185
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Litwack,E.D., Ivins,J.K., Kumbasar,A., Paine-Saunders,S.,
            Stipp,C.S. and Lander,A.D.
  TITLE     Expression of the heparan sulfate proteoglycan glypican-1 in the
            developing rodent
  JOURNAL   Dev Dyn 211 (1), 72-87 (1998)
   PUBMED   9438425
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Acton,R.T., Blankenhorn,E.P., Douglas,T.C., Owen,R.D., Hilgers,J.,
            Hoffman,H.A. and Boyse,E.A.
  TITLE     Variations among sublines of inbred AKR mice
  JOURNAL   Nat New Biol 245 (140), 8-10 (1973)
   PUBMED   4353891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131059.6.
            
            On Sep 19, 2017 this sequence version replaced NM_016696.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154899.1, BC062902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               AC131059.6         118087-118539
            454-612             AC131059.6         139789-139947
            613-1001            AC131059.6         141300-141688
            1002-1167           AC131059.6         142349-142514
            1168-1298           AC131059.6         143429-143559
            1299-1418           AC131059.6         143690-143809
            1419-1552           AC131059.6         143914-144047
            1553-1728           AC131059.6         144297-144472
            1729-3608           AC131059.6         144774-146653
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.6 cM"
     gene            1..3608
                     /gene="Gpc1"
                     /note="glypican 1"
                     /db_xref="GeneID:14733"
                     /db_xref="MGI:MGI:1194891"
     exon            1..453
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1961
                     /gene="Gpc1"
                     /codon_start=1
                     /product="glypican-1 precursor"
                     /protein_id="NP_057905.1"
                     /db_xref="CCDS:CCDS15177.1"
                     /db_xref="GeneID:14733"
                     /db_xref="MGI:MGI:1194891"
                     /translation="MELRTRGWWLLCAAAALVVCARGDPASKSRSCSEVRQIYGAKGF
                     SLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMELESALHDSSRALQATLAT
                     QLHGIDDHFQRLLNDSERTLQEAFPGAFGDLYTQNTRAFRDLYAELRLYYRGANLHLE
                     ETLAEFWARLLERLFKQLHPQLLPDDYLDCLGKQAEALRPFGDAPRELRLRATRAFVA
                     ARSFVQGLGVASDVVRKVAQVPLAPECSRAIMKLVYCAHCRGVPGARPCPDYCRNVLK
                     GCLANQADLDAEWRNLLDSMVLITDKFWGPSGAESVIGGVHVWLAEAINALQDNKDTL
                     TAKVIQACGNPKVNPHGSGPEEKRRRGKLALQEKPSTGTLEKLVSEAKAQLRDIQDFW
                     ISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQINNPEVEVDITKPDM
                     TIRQQIMQLKIMTNRLRGAYGGNDVDFQDASDDGSGSGSGGGCPDDTCGRRVSKKSSS
                     SRTPLTHALPGLSEQEGQKTSAATCPEPHSFFLLFLVTLVLAAARPRWR"
     exon            454..612
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1001
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1167
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1298
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1418
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1552
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1728
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..3608
                     /gene="Gpc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3593
                     /gene="Gpc1"
                     /note="major polyA site"
ORIGIN      
        1 tggggccggg cgggcggcgg gggaggcgcc gagccggggc tgcgcgttcg cccgccgcgc
       61 tctaggcggc ccgactgagc ggccggacct cgcgcctcgc gcctagctcc ccgcgccgca
      121 gccgcagccg gcttttgttg tctccgcctc ctcgactgcc accgcctctg gaccacgagc
      181 gtcgcgcgct gggaccttgg ctctgccctt cgcgcacact gggctgagcg ggccggccgg
      241 gaccgaggga ggcgcgcacc ggcggccagg gagcctcggg ccccgccatg gaactccgga
      301 cccgaggctg gtggctgctg tgcgcggccg ccgcgctggt cgtctgcgcc cgcggggacc
      361 ccgccagcaa gagccggagc tgcagcgaag tccgccagat ctacggggct aagggcttta
      421 gcctgagcga tgtgcctcag gcagagatct cgggtgagca cctgcggatc tgcccccagg
      481 gctacacttg ctgtactagt gagatggagg agaatttggc caaccacagc cgaatggagc
      541 tggagagcgc actccatgac agcagccgcg ccctgcaggc cacactggcc acccagctgc
      601 atggcatcga tgaccacttc cagcgcctgc tgaatgactc ggagcgcaca ctgcaggagg
      661 ctttccctgg ggcctttggg gacctgtata cgcagaacac tcgtgccttc cgggacctat
      721 atgctgagct gcgcctctac taccgtgggg ccaacctgca ccttgaggag acgctggccg
      781 agttctgggc acggctgctg gagcgcctct tcaagcagct gcacccccag ctgctgcctg
      841 atgactacct ggactgcctg ggcaagcagg cggaggcact gcggccgttt ggagatgccc
      901 ctcgagaact gcgcctgcgg gccacccgtg cctttgtggc tgcacgttcc tttgtgcagg
      961 gcctgggtgt ggccagtgat gtagtccgga aggtggccca ggtacctctg gccccagaat
     1021 gttctcgggc catcatgaag ttggtctact gtgctcattg ccggggagtc ccgggcgccc
     1081 ggccctgccc cgactattgc cgaaatgtgc tcaaaggctg ccttgccaac caggccgacc
     1141 tggatgccga gtggaggaac ctcctggact ccatggtgct catcactgac aagttctggg
     1201 gcccgtcggg tgcggagagt gtcattggcg gtgtgcacgt gtggctggcg gaggccatca
     1261 acgccctcca ggacaacaag gacacactca cagctaaggt catccaggcc tgtggaaacc
     1321 ccaaggtcaa tccccacggc tctgggcccg aggagaagcg tcgccgtggc aaattggcac
     1381 tgcaggagaa gccctccaca ggtactctgg aaaaactggt ctctgaggcc aaggcccagc
     1441 tccgagacat tcaggacttc tggatcagcc tcccagggac actgtgcagt gagaagatgg
     1501 ccatgagtcc tgccagtgac gaccgctgct ggaatggaat ttccaagggc cggtacctac
     1561 cagaggtgat gggtgacggg ctggccaacc agatcaacaa ccctgaggtg gaagtggaca
     1621 tcaccaagcc agacatgacc atccgccagc agattatgca gctcaagatc atgaccaacc
     1681 gtttacgtgg cgcctatggc ggcaacgacg tggacttcca ggatgctagt gatgacggca
     1741 gtggctccgg cagcggtggc ggatgcccag atgacacctg tggccggagg gtcagcaaga
     1801 agagttccag ctcccggacc cccttgaccc atgccctccc cggcctgtca gaacaggagg
     1861 gacagaagac ctcagctgcc acctgcccag agccccacag cttcttcctg ctcttcctcg
     1921 tcaccttggt ccttgcggca gccaggccca ggtggcggta actgccccct atccccaagg
     1981 actgtcttgg ccaaaacatg caacagacca tatttaattc ccttggcctt ttgaggtcca
     2041 gggcaggata aggagacagt agctctgagt gctggggcag ggtgcatggg ggggtcctgg
     2101 cctcctgggt ctggccacgc ctgtcaccct agcttttaat tttgtatcag gtcagctgcg
     2161 agccagtgtc cccaaaagcc atgtatttca gggacctcag gggcacctct ggctgcacac
     2221 tcctccccta ccctcctgca ccacccccag aagctcatga ggccaaccag aagggcggct
     2281 gttagctaca acccaacgga gacctcaagt gagcctgtgc cttcctctcc tgcctcttcc
     2341 cgctggggac tccctaccag accccatggg ccacagatgt cagaaattga ggcccatcct
     2401 gcagctcccc aggaagcctg caagggatgc cagtatgttg ctgtccaggc tctggcaggg
     2461 ccttcaagtt tatgcatgat accttctact cagaagaagc tctgcagcca ggatccccac
     2521 acacagcaga ccaggaccct gtaccactgt ggagctcagt gaatctggtt ctcaaaaaaa
     2581 gacccactgt gggattctct agtatgacgt aggtgaggtg ggaggtggca gctggcacag
     2641 ccatactacg ctcaactctg ccacactgtt tgagggtatg ttccgtcccc tcagatgggc
     2701 tcacaaagac tggccttggt ggtccacatg aggagcctca cttcagggga acagccagct
     2761 acatctagcc cctaccccac ttagaaaggt cacctggcca tggggatgct gggtggctgg
     2821 tgaaacttta gctcagggtc aatgagacct ggcactgcag gtcaagagga tgcctgggcc
     2881 ccttcctgac ccaggcagct ctgcaggagc tggggcagca ttgacagtca agggctttta
     2941 cagacatgca cattcagacc ctcagtgtcc ttgtccactg agcgctacat ctccatcttc
     3001 cttgacagca ctggagaggc tcagggcacc acttggaatc tggtttcctc ctatggcctc
     3061 gagacctggg ggcacctggc ttaccaaggc tgtcaaggct ccatcttccc ttccagggcc
     3121 taggggatgc tgagttgcta tatccaggaa ggcagtggtc ctgacatgca gaaggcctgg
     3181 aaaaaaggct gcttaccgct tttttttttt tttaatttta attttttttt tttaactttc
     3241 ttttagtcac tgggttagag aggctattgc cagcacagca ccaaggcctg cccagtagtc
     3301 aggtcccctg gtccaggatg ggtattctcc ataattggtc tgtgggtttg ttgggcccat
     3361 gccctgagca cactcaaccc agccacagcc ctgctagtgc cactcaagca ggggcactgg
     3421 gagctagacc tgggctctga gatgagtgcc taggtgtcag gacagcagca cccatgctgt
     3481 acagggcagc cgggacagtg gccagggtac tgggtccttt ctctgtcact cggtgtcagt
     3541 ggataatgtg tgttctttga gtccttgtat gaattaaagg ctggggacct acagtggaca
     3601 tgacctca
//
