LOCUS       NP_057905                557 aa            linear   ROD 31-MAY-2024
DEFINITION  glypican-1 precursor [Mus musculus].
ACCESSION   NP_057905
VERSION     NP_057905.1
DBSOURCE    REFSEQ: accession NM_016696.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 557)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 557)
  AUTHORS   Souza,D.S., Chignalia,A.Z. and Carvalho-de-Souza,J.L.
  TITLE     Modulation of cardiac voltage-activated K+ currents by glypican 1
            heparan sulfate proteoglycan
  JOURNAL   Life Sci 308, 120916 (2022)
   PUBMED   36049528
  REMARK    GeneRIF: Modulation of cardiac voltage-activated K(+) currents by
            glypican 1 heparan sulfate proteoglycan.
REFERENCE   4  (residues 1 to 557)
  AUTHORS   Bartosch,A.M.W., Mathews,R., Mahmoud,M.M., Cancel,L.M., Haq,Z.S.
            and Tarbell,J.M.
  TITLE     Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in
            shear-induced endothelial nitric oxide production
  JOURNAL   Sci Rep 11 (1), 11386 (2021)
   PUBMED   34059731
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 557)
  AUTHORS   Dull,R.O., Patel,M., Isbatan,A. and Hahn,R.G.
  TITLE     Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and
            Urine Response to Fluid Challenge in Mice
  JOURNAL   J Vasc Res 58 (1), 58-64 (2021)
   PUBMED   33105135
  REMARK    GeneRIF: Syndecan-1 and Glypican-1 Knockout Alters Body Water
            Balance and Urine Response to Fluid Challenge in Mice.
REFERENCE   6  (residues 1 to 557)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 557)
  AUTHORS   Szpirer,C., Szpirer,J., Riviere,M., Van Vooren,P., Veugelers,M. and
            David,G.
  TITLE     Mapping of the rat glypican genes
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 83-86 (2001)
   PUBMED   11474185
REFERENCE   8  (residues 1 to 557)
  AUTHORS   Litwack,E.D., Ivins,J.K., Kumbasar,A., Paine-Saunders,S.,
            Stipp,C.S. and Lander,A.D.
  TITLE     Expression of the heparan sulfate proteoglycan glypican-1 in the
            developing rodent
  JOURNAL   Dev Dyn 211 (1), 72-87 (1998)
   PUBMED   9438425
REFERENCE   9  (residues 1 to 557)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   10 (residues 1 to 557)
  AUTHORS   Acton,R.T., Blankenhorn,E.P., Douglas,T.C., Owen,R.D., Hilgers,J.,
            Hoffman,H.A. and Boyse,E.A.
  TITLE     Variations among sublines of inbred AKR mice
  JOURNAL   Nat New Biol 245 (140), 8-10 (1973)
   PUBMED   4353891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131059.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154899.1, BC062902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.6 cM"
     Protein         1..557
                     /product="glypican-1 precursor"
                     /calculated_mol_wt=58831
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2547
     Region          22..538
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     mat_peptide     24..529
                     /product="Glypican-1. /id=PRO_0000012297"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZF2.1)"
                     /calculated_mol_wt=55665
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q9QZF2.1)"
     Site            116
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q9QZF2.1)"
     Region          477..531
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZF2.1)"
     Site            485
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZF2.1)"
     Site            487
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZF2.1)"
     Site            489
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QZF2.1)"
     CDS             1..557
                     /gene="Gpc1"
                     /coded_by="NM_016696.5:288..1961"
                     /db_xref="CCDS:CCDS15177.1"
                     /db_xref="GeneID:14733"
                     /db_xref="MGI:MGI:1194891"
ORIGIN      
        1 melrtrgwwl lcaaaalvvc argdpasksr scsevrqiyg akgfslsdvp qaeisgehlr
       61 icpqgytcct semeenlanh srmelesalh dssralqatl atqlhgiddh fqrllndser
      121 tlqeafpgaf gdlytqntra frdlyaelrl yyrganlhle etlaefwarl lerlfkqlhp
      181 qllpddyldc lgkqaealrp fgdaprelrl ratrafvaar sfvqglgvas dvvrkvaqvp
      241 lapecsraim klvycahcrg vpgarpcpdy crnvlkgcla nqadldaewr nlldsmvlit
      301 dkfwgpsgae sviggvhvwl aeainalqdn kdtltakviq acgnpkvnph gsgpeekrrr
      361 gklalqekps tgtleklvse akaqlrdiqd fwislpgtlc sekmamspas ddrcwngisk
      421 grylpevmgd glanqinnpe vevditkpdm tirqqimqlk imtnrlrgay ggndvdfqda
      481 sddgsgsgsg ggcpddtcgr rvskkssssr tplthalpgl seqegqktsa atcpephsff
      541 llflvtlvla aarprwr
//
