LOCUS       NM_174985               1340 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus G protein-coupled bile acid receptor 1 (Gpbar1), mRNA.
ACCESSION   NM_174985
VERSION     NM_174985.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Reusswig,F., Reich,M., Wienands,L., Herebian,D.,
            Keitel-Anselmino,V. and Elvers,M.
  TITLE     The bile acid receptor TGR5 inhibits platelet activation and
            thrombus formation
  JOURNAL   Platelets 35 (1), 2322733 (2024)
   PUBMED   38968449
  REMARK    GeneRIF: The bile acid receptor TGR5 inhibits platelet activation
            and thrombus formation.
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Sun,L., Shao,Y., Zhuang,Z., Liu,Z., Liu,M., Qu,C. and Yang,H.
  TITLE     Targeting TGR5 to mitigate liver fibrosis: Inhibition of hepatic
            stellate cell activation through modulation of mitochondrial
            fission
  JOURNAL   Int Immunopharmacol 140, 112831 (2024)
   PUBMED   39111149
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Peiper,A.M., Morales Aparicio,J., Hu,Z., Phophi,L., Helm,E.W.,
            Rubinstein,R.J., Phillips,M., Williams,C.G., Subramanian,S.,
            Cross,M., Iyer,N., Nguyen,Q., Newsome,R., Jobin,C., Langel,S.N.,
            Bucardo,F., Becker-Dreps,S., Tan,X.D., Dawson,P.A. and Karst,S.M.
  TITLE     Metabolic immaturity and breastmilk bile acid metabolites are
            central determinants of heightened newborn vulnerability to
            norovirus diarrhea
  JOURNAL   Cell Host Microbe 32 (9), 1488-1501 (2024)
   PUBMED   39214086
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Zhuang,L., Jia,N., Zhang,L., Zhang,Q., Antwi,S.O., Sartorius,K.,
            Wu,K., Sun,D., Xi,D. and Lu,Y.
  TITLE     Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute
            cholestatic liver injury via antagonizing NLRP3-ASC inflammasome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167266 (2024)
   PUBMED   38806072
  REMARK    GeneRIF: Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated
            acute cholestatic liver injury via antagonizing NLRP3-ASC
            inflammasome.
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Li,C., Wang,L., Xie,W., Chen,E., Chen,Y., Li,H., Can,D., Lei,A.,
            Wang,Y. and Zhang,J.
  TITLE     TGR5 deficiency in excitatory neurons ameliorates Alzheimer's
            pathology by regulating APP processing
  JOURNAL   Sci Adv 10 (26), eado1855 (2024)
   PUBMED   38941459
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Vassileva,G., Golovko,A., Markowitz,L., Abbondanzo,S.J., Zeng,M.,
            Yang,S., Hoos,L., Tetzloff,G., Levitan,D., Murgolo,N.J., Keane,K.,
            Davis,H.R. Jr., Hedrick,J. and Gustafson,E.L.
  TITLE     Targeted deletion of Gpbar1 protects mice from cholesterol
            gallstone formation
  JOURNAL   Biochem J 398 (3), 423-430 (2006)
   PUBMED   16724960
  REMARK    GeneRIF: Gpbar1 plays a critical role in the formation of
            gallstones, possibly via a regulatory mechanism involving the
            cholesterol 7alpha-hydroxylase pathway.
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Moepps,B., Nuesseler,E., Braun,M. and Gierschik,P.
  TITLE     A homolog of the human chemokine receptor CXCR1 is expressed in the
            mouse
  JOURNAL   Mol Immunol 43 (7), 897-914 (2006)
   PUBMED   16084593
REFERENCE   8  (bases 1 to 1340)
  AUTHORS   Katsuma,S., Hirasawa,A. and Tsujimoto,G.
  TITLE     Bile acids promote glucagon-like peptide-1 secretion through TGR5
            in a murine enteroendocrine cell line STC-1
  JOURNAL   Biochem Biophys Res Commun 329 (1), 386-390 (2005)
   PUBMED   15721318
  REMARK    GeneRIF: bile acids induce GLP-1 secretion through TGR5 and
            intracellular cAMP production in STC-1 cells
REFERENCE   9  (bases 1 to 1340)
  AUTHORS   Kawamata,Y., Fujii,R., Hosoya,M., Harada,M., Yoshida,H., Miwa,M.,
            Fukusumi,S., Habata,Y., Itoh,T., Shintani,Y., Hinuma,S.,
            Fujisawa,Y. and Fujino,M.
  TITLE     A G protein-coupled receptor responsive to bile acids
  JOURNAL   J Biol Chem 278 (11), 9435-9440 (2003)
   PUBMED   12524422
  REMARK    GeneRIF: TGR5 is implicated in the suppression of macrophage
            functions by bile acids
REFERENCE   10 (bases 1 to 1340)
  AUTHORS   Maruyama,T., Miyamoto,Y., Nakamura,T., Tamai,Y., Okada,H.,
            Sugiyama,E., Nakamura,T., Itadani,H. and Tanaka,K.
  TITLE     Identification of membrane-type receptor for bile acids (M-BAR)
  JOURNAL   Biochem Biophys Res Commun 298 (5), 714-719 (2002)
   PUBMED   12419312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113473.20.
            
            On Oct 18, 2022 this sequence version replaced NM_174985.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.2000515.1,
                                           SRR17253011.8445626.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC113473.20        186328-186515
            189-1340            AC113473.20        187776-188927
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.53 cM"
     gene            1..1340
                     /gene="Gpbar1"
                     /gene_synonym="BG37; GPCR; GPR131; M-BAR; TGR5"
                     /note="G protein-coupled bile acid receptor 1"
                     /db_xref="GeneID:227289"
                     /db_xref="MGI:MGI:2653863"
     exon            1..188
                     /gene="Gpbar1"
                     /gene_synonym="BG37; GPCR; GPR131; M-BAR; TGR5"
                     /inference="alignment:Splign:2.1.0"
     exon            189..1340
                     /gene="Gpbar1"
                     /gene_synonym="BG37; GPCR; GPR131; M-BAR; TGR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpbar1"
                     /gene_synonym="BG37; GPCR; GPR131; M-BAR; TGR5"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="Gpbar1"
                     /gene_synonym="BG37; GPCR; GPR131; M-BAR; TGR5"
                     /note="major polyA site"
ORIGIN      
        1 aggagtccag gccaggccag agtctgagca ggcaagcctg gttcctgctg tctccaccat
       61 agaaggcagc accatgcgct cactgaccag gacaccaggc atggcccgaa gacctgcaag
      121 agtggctgat gtgactcttt gatccgcaga ggaagagcta gcaagcacca cctgctccta
      181 acagccatgc atgctttctg cagctccgga ccctccatgt gccaagaccc atgatgacac
      241 ccaacagcac tgagctgtcg gccattccca tgggggttct ggggctttcc ttggccctgg
      301 caagcctcat cgtcatcgcc aacctgctcc tggccctagg catcgccctg gaccgccact
      361 tgcgcagccc acctgctggc tgcttcttcc taagcctact actagccggg ctgctcacag
      421 ggctggcact gcccatgctg cctgggctat ggagccggaa ccatcagggc tactggtcct
      481 gcctccttct ccacttgacc cccaactttt gtttcctttc cctgcttgcc aatctgctgc
      541 tggtgcatgg ggaacgctac atggcagtgt tgcagccact ccggccccat ggaagtgtgc
      601 ggctagccct gttcctcacc tgggtcagct ccctgttctt tgccagcctg cctgctctgg
      661 gctggaacca ttggagccct gatgccaact gcagctccca agctgtcttc ccagccccct
      721 acctctacct ggaagtttat ggcctcctgt tgcctgccgt gggggccact gcccttctct
      781 ctgtccgcgt gttggccact gcccaccgcc agctgtgtga gatccgccga ctggagcggg
      841 cagtgtgccg cgatgtaccc tcaaccctgg ctagggctct cacctggagg caggctaggg
      901 cacaggcagg agccacactg ctcttcttgc tgtgttgggg gccctatgtg gccacattgc
      961 tcctgtcagt cttggcctat gagcgtcgcc caccactagg gcctggaact ctgttatcgc
     1021 tcatctcatt gggcagcacc agtgctgccg ctgtgcctgt ggccatgggg ctgggtgatc
     1081 agcgctacac agccccctgg aggacagctg cccaaaggtg tctacgagtg cttcgaggaa
     1141 gagccaagag ggacaatcca ggccccagca ctgcctacca caccagtagc caatgcagca
     1201 ttgacctgga cttgaattag ggaagcagca gctactgctg cctcccagaa cactcttcta
     1261 tctcacagtg ccccacttct ttggattgga accctcactc catgagacct cacccagacc
     1321 aaataaatct ctggccatca
//
