LOCUS       NM_001159492            6844 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus G patch domain containing 8 (Gpatch8), mRNA.
ACCESSION   NM_001159492
VERSION     NM_001159492.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6844)
  AUTHORS   Benbarche,S., Pineda,J.M.B., Galvis,L.B., Biswas,J., Liu,B.,
            Wang,E., Zhang,Q., Hogg,S.J., Lyttle,K., Dahi,A., Lewis,A.M.,
            Sarchi,M., Rahman,J., Fox,N., Ai,Y., Mehta,S., Garippa,R.,
            Ortiz-Pacheco,J., Li,Z., Monetti,M., Stanley,R.F., Doulatov,S.,
            Bradley,R.K. and Abdel-Wahab,O.
  TITLE     GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in
            hematologic malignancies
  JOURNAL   Mol Cell 84 (10), 1886-1903 (2024)
   PUBMED   38688280
  REMARK    GeneRIF: GPATCH8 modulates mutant SF3B1 mis-splicing and
            pathogenicity in hematologic malignancies.
REFERENCE   2  (bases 1 to 6844)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6844)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   4  (bases 1 to 6844)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 6844)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 6844)
  AUTHORS   Kai,N., Mishina,M. and Yagi,T.
  TITLE     Molecular cloning of Fyn-associated molecules in the mouse central
            nervous system
  JOURNAL   J Neurosci Res 48 (5), 407-424 (1997)
   PUBMED   9185665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ057626.1, BY136728.1, CV555545.1, BC035255.1, AK142570.1 and
            BE980248.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ057626.1         2-23
            23-325              BY136728.1         2-304
            326-614             CV555545.1         163-451
            615-5528            BC035255.1         674-5587
            5529-6159           AK142570.1         2773-3403
            6160-6687           AK142570.1         3405-3932
            6688-6844           BE980248.1         1-157               c
FEATURES             Location/Qualifiers
     source          1..6844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.31 cM"
     gene            1..6844
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /note="G patch domain containing 8"
                     /db_xref="GeneID:237943"
                     /db_xref="MGI:MGI:1918667"
     exon            1..79
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..4552
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /note="Fyn-binding molecule 1"
                     /codon_start=1
                     /product="G patch domain-containing protein 8"
                     /protein_id="NP_001152964.1"
                     /db_xref="CCDS:CCDS48944.1"
                     /db_xref="GeneID:237943"
                     /db_xref="MGI:MGI:1918667"
                     /translation="MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIG
                     HRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLE
                     VEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDH
                     AHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRP
                     TTVAVDEDGGEEDKDESSTNSGASAVSSCGFGADFSTDKGGSFTSVQITNTTGLSQAP
                     GLASQGISFGIKNNLGPPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGSSEDGTKA
                     DEKSSDQGVQKVGDTDGTGNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGTGATEPE
                     YYHYIPPAHCKVKPNFPFLLFMRASEQMEGDHSAHSKSAPENRKSSSPKPQGCSKTAA
                     SPGAERTVSEASELQKEAAVAGPSEPGGKTETKKGSGGGEDEQSVESRETSESPMCES
                     NPKDISQATPATKAGQGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCN
                     PLYFDFKLSRNKDAKAKGTEKPKDVAGSSKDHLQSLDPREPNKSQEEEQDVVLSSEGR
                     VDEPASGAACSSLNKQEPGGSHMSETEDTGRSHPSKKEPSGKSHRHKKKKKHKKSSKH
                     KRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAAADSERGPKSEPPGSGSPAPPR
                     RRRRAQDDSQRRSLPAEEGNSGKKDDGGGGSSCQDHSGRKHKGEPPTSSCQRRANTKH
                     SSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEEEEEEEEDEDSGSEHSRS
                     RSRSGHRHSSHRSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHD
                     SDDSDYTSSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRS
                     RSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFI
                     RSKIYRSQSPHYFQSGRGEGPGKKEDGRGDDSKGAGLPSQNSNTGTGRGSESDCSPED
                     KNSVTARLLLEKIQSRKVERKPNVCEEVLATPNKAGLKYKNPPQGYFGPKLPPSLGNK
                     PVLPMIGKLPATRKSNKKCEESGLERGEEQEHSEPEEGSPRSSDAPFGHQFSEEAAGP
                     LSDPPPEEPKSEEATADHSVAPLGTPAHTDCYPGDPAISHNYLPDPSDGDTLESLDSG
                     SQPGPVESSLLPIAPDLEHFPNYAPPSGEPSIESTDGTEDASLAPLESQPITFTPEEM
                     EKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATPALQPIHIQQPATASATSITTV
                     QHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATF
                     LASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSG
                     QDLQHPPSHGT"
     exon            80..154
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            155..227
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            228..295
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            296..382
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            383..526
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            527..657
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            658..6830
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5537..5542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /note="hexamer: AATAAA"
     polyA_site      5569
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
     regulatory      5624..5629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /note="hexamer: TATAAA"
     polyA_site      5642
                     /gene="Gpatch8"
                     /gene_synonym="5430405G24Rik; Fbm1; Gpatc8; mKIAA0553"
                     /note="major polyA site"
ORIGIN      
        1 gagcgtcgtc ctgaggagga gtgagagcgg caaaatggcg gaccgcttct cccgcttcaa
       61 cgaggaccga gactttcagg gtaatcactt tgatcagtat gaagaaggac acttggagat
      121 tgaacaagca tcccttgaca agcccataga atcggataat attggacacc gcttactcca
      181 gaaacatggg tggaagctgg gccagggatt gggaaaatct cttcagggga gaacagaccc
      241 tattccaatc gttgtcaagt atgatgtcat gggcatgggt cgaatggaaa tggagctgga
      301 ttatgccgag gatgctaccg aacggcgtcg tgtcctagaa gtagagaaag aagacacaga
      361 agagctgagg cagaagtaca aggattatgt tgacaaagaa aaggcaattg caaaagcctt
      421 ggaagatctc agagccaact tttactgtga actttgtgat aaacagtatc agaaacatca
      481 ggaatttgac aaccacatca attcttatga tcatgcacac aagcagagat taaaagatct
      541 caagcagaga gagtttgccc gaaatgtctc ttcaagatcc cgcaaagacg agaagaaaca
      601 agaaaaagcc cttcggcggc tccatgagtt ggcagagcaa agaaaacaag ctgaatgtgc
      661 accgggaagc gggcccatgt tccgaccaac cacggtggct gtagacgagg atggtggaga
      721 agaggataaa gatgagtcat caaccaacag tggtgcaagt gctgtttctt cttgtggctt
      781 tggagccgac ttctccacag ataaaggggg ctccttcacg tcagtacaga tcactaatac
      841 cactggactg tcacaggctc ctggcttagc ctcccaaggt attagctttg gcattaagaa
      901 taatctggga cccccactgc agaaattggg agtatcattt tcctttgcca agaaagctcc
      961 cgtcaaactt gaatcaatag catccgtttt caaggaccat gcagaggaag ggagctcaga
     1021 agatggaacg aaggctgatg agaagagctc tgaccaaggg gtgcagaagg tgggagatac
     1081 tgatggcact ggtaatcttg atggaaagaa agaagatgaa gaccctcagg atggagggtc
     1141 ccttgcctca acactgtcca agttgaaaag gatgaaacgg gaagaaggaa caggggctac
     1201 agagccagaa tattaccact acatcccccc agcacactgc aaggtcaaac ctaatttccc
     1261 cttcttactc tttatgagag ccagtgaaca gatggaaggg gatcatagtg cacactcaaa
     1321 gagtgccccc gagaacagaa aaagcagctc tcccaagccg caaggctgta gtaagacagc
     1381 agcaagccca ggggcagaaa gaacagtgag tgaagcttct gagctgcaaa aggaagccgc
     1441 tgtggctggg ccttcagagc ctggaggtaa aactgaaaca aagaaaggct ccggaggagg
     1501 ggaagatgag cagagtgtag agagtaggga gacgtcagag agcccgatgt gtgagtccaa
     1561 tcctaaagac atttctcagg ccaccccagc aacaaaagca ggccagggac ccaagcatcc
     1621 tactggtcca ttctttccag ttttaagcaa ggatgaaagc actgccctcc agtggccatc
     1681 agaactactc attttcacca aagcagagcc ttccatctcc tacagttgta atcctttata
     1741 ctttgacttt aaactttcaa gaaacaaaga tgctaaagct aaagggacag aaaagccaaa
     1801 agatgtcgca ggctcctcaa aggatcatct ccagagcctt gatcctagag aaccgaataa
     1861 aagccaggaa gaggagcagg atgtagtgct ctcttcagaa ggcagagtgg atgaacctgc
     1921 atcaggggct gcctgtagca gcctgaacaa gcaggagcct gggggtagcc atatgtcaga
     1981 aactgaagac actgggagaa gccatcctag caagaaagaa ccatcaggca agtctcacag
     2041 acacaagaag aaaaagaaac acaaaaaatc cagcaagcac aaacgtaaac acaaggctga
     2101 cacggaagag aagagttcta aggcagagtc tggggagaaa tctaagaagc gcaagaaacg
     2161 aaaacggaag aagaacaaat catcagccgc agctgattct gaacgcggac ccaaatcaga
     2221 acctcctgga agcggcagcc cggcaccacc gagaaggcgg cgccgagctc aagatgattc
     2281 ccagcggaga tcccttcctg ctgaagaagg aaacagtggc aagaaggatg atggtggggg
     2341 tggtagcagt tgccaagatc acagtgggag gaaacacaaa ggtgaaccac caacttcctc
     2401 ctgccagcgg agagctaaca ccaaacatag cagccggtcc agccatcgga gccaacccag
     2461 tagtggtgat gaggatagtg atgatgcttc ctcacaccga ctgcaccaga agtctccatc
     2521 ccagtacagt gaggaggagg aagaggagga ggaggaagaa gaggaggaag atgaagactc
     2581 cggtagtgag cattctcgta gccgctctcg gtctggccat cgccattcct cacatcgttc
     2641 ctcccggcgc tcttattcta gcagctctga tgcctcttca gaccagagct gctatagtag
     2701 acagcacagt tactctgatg atagctatag tgactatagc gaccgatcac gaaggcactc
     2761 taagcgctct cacgattcag atgattcaga ctataccagc tccaaacaca ggtctaaacg
     2821 acacaaatac tcatcatctg atgatgacta tagcctcagt tgcagccagt cccgaagccg
     2881 atctcggagt catacaaggg agcgatcaag atcccggggt cgaagccgca gtagcagctg
     2941 tagtcgcagt cgaagcaaga ggagaagtcg cagcaccaca gcccacagct ggcagcgaag
     3001 ccgaagctat agccgggacc ggagccgcag caccaggagc ccttctcaga gatcaggctc
     3061 cagaaagggc tcatggggtc atgagagccc agaggaaagg cgctctggcc gccgggattt
     3121 cattcgttca aagatctacc gctctcaatc cccccactat ttccaatcag gtcggggaga
     3181 aggtcctgga aagaaagaag atggcagagg agatgacagt aaaggagcag gcctgccctc
     3241 ccagaatagc aatactggca caggaagggg gtcagaaagt gactgcagtc ctgaagataa
     3301 gaattctgtt actgccagac tgctgctaga gaagatccag tccaggaaag tggagaggaa
     3361 acccaatgtg tgcgaggagg tgctggccac ccctaataag gctgggctca agtacaagaa
     3421 ccccccacaa ggttactttg ggcctaagct ccccccgtct cttggtaata agcctgttct
     3481 tccaatgata gggaagcttc cagctacccg gaagtccaat aagaaatgtg aagagtctgg
     3541 cttagaaagg ggagaagagc aggaacattc agagccagaa gaagggtccc caaggagtag
     3601 tgatgctcca tttgggcatc agttctcaga ggaagcagct ggtcccttat cagaccctcc
     3661 cccagaagag ccaaagtctg aagaagctac tgctgatcac tctgtggctc cgctaggcac
     3721 cccagcccac actgactgct accctgggga tccagccatc tcccataact acctcccgga
     3781 ccccagtgat ggggatactc tggagtctct ggatagtggc agtcaaccag gccctgtgga
     3841 atccagcttg ctgcctatag ccccagacct tgagcacttc cccaattatg cacctcccag
     3901 tggggaacct agtattgaat caacagatgg gactgaggat gcctccttgg ctcctctcga
     3961 gagccagccc atcaccttca cccctgagga gatggagaag tacagcaagc tccagcaggc
     4021 tgcacagcag cacatccagc agcagcttct ggccaaacaa gtgaaggcct ttccagcctc
     4081 caccgcccta gctccagcca caccagccct gcagcccatc cacattcagc agccagccac
     4141 agcctctgcc acctccatca ccactgttca gcatgccatc ctacagcatc atgctgcagc
     4201 cgctgctgcc gccattggca ttcaccctca cccccaccct cagccgcttg ctcaagtaca
     4261 tcatattccc cagccccatc taacccctat ttctttgtcc catctcactc actcaattat
     4321 ccctggccac cctgccacct ttcttgctag ccaccctatc catataattc ctgcctcagc
     4381 catccatcct gggcccttca cctttcatcc cgtcccacac gctgccctct accccaccct
     4441 gcttgcccca cggcctgctg cagcagctgc cacagccctc catcttcacc cactgcttca
     4501 ccccatcttc tcaggtcagg acctgcagca ccctcccagc catgggactt gagttgggag
     4561 tcggaagcct gtgttgagcc agggaaggtg gcctgttctt cccttggggg tgttgagcca
     4621 tttataccag caggtaaaag ctggaacggg cagtgtcttg acagccaaag aaatgagttt
     4681 tggcttgcag ggatggattt agatttgagg tttgctttgg gtttactatc agggatattt
     4741 accccctttc tattagtccc tccctcctgt gtttctaagc tagggaacac cagtaagtgc
     4801 tacccacact cctctgcagc aacatctcca gactgtcaag taagcctcct tcctccctct
     4861 actttctgat cctctgcact tcccctctgt aagttcaaaa cattttcctc ctctaatggg
     4921 ttgtcaccaa agcacttgcc atgggcccat ctggtcctgc cttctcagtg ccacgagaaa
     4981 ggccaggctg tctcttcagt ggtgaaaact ccacttttcg gcagtgtctt tgactatccg
     5041 tttgtgacac gttatcccag gtgaggtgga agagggagtc taacctagaa ccaaaagcaa
     5101 ctcaggctgc aatttgatcc actttcctta caaacagagc catgcatttg gcactactgt
     5161 cctcatgccc ctcatcccag aagaggcatc tacatatccc agaaaagaag atcctatcgt
     5221 gagtagaagc tacactgaac atagggtcac ccatgtgctt cccagaaagg agctcgtgtc
     5281 tgaagggtat atttccttct gttatgttga tgttttcttc ttaatttata ggatttttta
     5341 atgtaaaatt gcactgaact ctataaacat aaatgctgct ttttgtagct catattaaaa
     5401 aggttccgta tttgtagtat actgcaataa tattttttac atccagctct ttaagtgatc
     5461 cttgttctgg tggctttctg taaatatgtt tgccctagtt gaattaagaa actttaaagg
     5521 ttataaaaga aaaaaaaata aaatatttgt tttctgctag atgcaaaaat gactaagcat
     5581 gtatatttta tcaacctcct gtattttttg aagttatgaa ctatataaaa atgttgacac
     5641 ttttttttgt tttgttttgt ttgctgggac agtgttaaat aatttgcagt agttggttca
     5701 tcctgcactg ggactctcgg gttgatgagc agcaggcggc tgctgctgtc aggaggatgc
     5761 acagttgcag tggtctccct gacgtgcttt gttatacaga gaaaccgtgg actccatgga
     5821 ggaggggagg attggttcaa cagctttatt ctctggaagc agtgacactc ggtgattgtc
     5881 tgggaaaagg ggtcctttgg tttccctggg taccttgttc cagacagtct tatttgcctt
     5941 cctagtattt agccccctct gacaattttt taaatgtgcc ttgtgggttg gctagacact
     6001 aaaatagaag tagaccagag gatactagag ttgggacagt tctctctttg ttgggaggtg
     6061 agcacgttta taggtagaga gatttttggc ttcaaagttc tgtgccgtct gcccagctcg
     6121 attgctattt cagcagtaga ggttcctttt tttttttttc tccagtgaca ctgaccagaa
     6181 gtctgtccat ccctctcccc tttgcccttc ccccaggctc tcagccctcc ttaacactga
     6241 cccaaaggtg cttgtaatgc aggtctcatc tcctttgtta gtgctcttcc tatgactaga
     6301 actggttaag cagtcaactg actgttaacc ctgcttgcct aggccaaggt tctctgttcc
     6361 tgccttctca aattcccagc agagtgggct gtgttaggga agtgagtgct gggcacttga
     6421 ggcccgtccc tgcctgagct tctcctacct tctgctcatt gtccccttac aagtatcact
     6481 tttaggataa ctagccctgg aaaaacggta tctgtttgaa gtgaagggac tggttcttct
     6541 tgctttcagc ccgtgtaaat atttaaataa aacagtatta acatttttgt gctgcttctc
     6601 gttaggttgt agatctagcc atgctctggc cgcctctgcc atcctggagg tagttttcct
     6661 taacttccag aatagtgatt ttaaaacttt aaaaaaaaaa aggggggggg ataacctatc
     6721 cttacataca agcataacag attgtatcta actttatcac atatgataga gatgtatatg
     6781 ctgtaaagtg aggggaagga gctttctaat aaaccagtgc tttgtgcaaa aaaaaaaaaa
     6841 aaaa
//
