LOCUS       NM_008149               5956 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus glycerol-3-phosphate acyltransferase, mitochondrial
            (Gpam), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_008149
VERSION     NM_008149.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5956)
  AUTHORS   Zhang,C., Steadman,M., Santos,H.P. Jr., Shaikh,S.R. and Xavier,R.M.
  TITLE     GPAT1 Activity and Abundant Palmitic Acid Impair Insulin
            Suppression of Hepatic Glucose Production in Primary Mouse
            Hepatocytes
  JOURNAL   J Nutr 154 (4), 1109-1118 (2024)
   PUBMED   38354952
  REMARK    GeneRIF: GPAT1 Activity and Abundant Palmitic Acid Impair Insulin
            Suppression of Hepatic Glucose Production in Primary Mouse
            Hepatocytes.
REFERENCE   2  (bases 1 to 5956)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5956)
  AUTHORS   Smith,K.R., Wang,W., Miller,M.R., Boucher,M., Reynold,J.E.,
            Daurio,N.A., Li,D., Hirenallur-Shanthappa,D., Ahn,Y., Beebe,D.A.,
            Kelly,K.L., Ross,T.T., Bence,K.K. and Wan,M.
  TITLE     GPAT1 Deficiency in Mice Modulates NASH Progression in a
            Model-Dependent Manner
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (2), 279-291 (2024)
   PUBMED   37844795
  REMARK    GeneRIF: GPAT1 Deficiency in Mice Modulates NASH Progression in a
            Model-Dependent Manner.
REFERENCE   4  (bases 1 to 5956)
  AUTHORS   Wang,Z., Zhu,S., Jia,Y., Wang,Y., Kubota,N., Fujiwara,N.,
            Gordillo,R., Lewis,C., Zhu,M., Sharma,T., Li,L., Zeng,Q., Lin,Y.H.,
            Hsieh,M.H., Gopal,P., Wang,T., Hoare,M., Campbell,P., Hoshida,Y.
            and Zhu,H.
  TITLE     Positive selection of somatically mutated clones identifies
            adaptive pathways in metabolic liver disease
  JOURNAL   Cell 186 (9), 1968-1984 (2023)
   PUBMED   37040760
REFERENCE   5  (bases 1 to 5956)
  AUTHORS   Song,Z., Xiaoli,A.M., Li,Y., Siqin,G., Wu,T., Strich,R.,
            Pessin,J.E. and Yang,F.
  TITLE     The conserved Mediator subunit cyclin C (CCNC) is required for
            brown adipocyte development and lipid accumulation
  JOURNAL   Mol Metab 64, 101548 (2022)
   PUBMED   35863637
REFERENCE   6  (bases 1 to 5956)
  AUTHORS   Welch,C.L., Xia,Y.R., Edwards,P.A., Lusis,A.J. and Ericsson,J.
  TITLE     Assignment of Gpam to distal mouse chromosome 19 by linkage
            analysis
  JOURNAL   Mamm Genome 9 (1), 93 (1998)
   PUBMED   9434961
REFERENCE   7  (bases 1 to 5956)
  AUTHORS   Kume,K. and Shimizu,T.
  TITLE     cDNA cloning and expression of murine
            1-acyl-sn-glycerol-3-phosphate acyltransferase
  JOURNAL   Biochem Biophys Res Commun 237 (3), 663-666 (1997)
   PUBMED   9299423
REFERENCE   8  (bases 1 to 5956)
  AUTHORS   Neuwald,A.F.
  TITLE     Barth syndrome may be due to an acyltransferase deficiency
  JOURNAL   Curr Biol 7 (8), R465-R466 (1997)
   PUBMED   9259571
REFERENCE   9  (bases 1 to 5956)
  AUTHORS   Jerkins,A.A., Liu,W.R., Lee,S. and Sul,H.S.
  TITLE     Characterization of the murine mitochondrial glycerol-3-phosphate
            acyltransferase promoter
  JOURNAL   J Biol Chem 270 (3), 1416-1421 (1995)
   PUBMED   7836409
REFERENCE   10 (bases 1 to 5956)
  AUTHORS   Shin,D.H., Paulauskis,J.D., Moustaid,N. and Sul,H.S.
  TITLE     Transcriptional regulation of p90 with sequence homology to
            Escherichia coli glycerol-3-phosphate acyltransferase
  JOURNAL   J Biol Chem 266 (35), 23834-23839 (1991)
   PUBMED   1721057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110206.21.
            
            On Sep 28, 2017 this sequence version replaced NM_008149.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019201.1, SRR10223971.18265.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC110206.21        98754-98902         c
            150-280             AC110206.21        96922-97052         c
            281-403             AC110206.21        95546-95668         c
            404-477             AC110206.21        93344-93417         c
            478-591             AC110206.21        90561-90674         c
            592-738             AC110206.21        88223-88369         c
            739-835             AC110206.21        87536-87632         c
            836-972             AC110206.21        86810-86946         c
            973-1072            AC110206.21        83123-83222         c
            1073-1285           AC110206.21        82626-82838         c
            1286-1399           AC110206.21        81027-81140         c
            1400-1485           AC110206.21        80817-80902         c
            1486-1601           AC110206.21        79809-79924         c
            1602-1672           AC110206.21        78641-78711         c
            1673-1937           AC110206.21        77748-78012         c
            1938-2080           AC110206.21        77251-77393         c
            2081-2158           AC110206.21        75716-75793         c
            2159-2296           AC110206.21        74967-75104         c
            2297-2486           AC110206.21        73996-74185         c
            2487-2545           AC110206.21        72137-72195         c
            2546-5956           AC110206.21        67061-70471         c
FEATURES             Location/Qualifiers
     source          1..5956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 50.81 cM"
     gene            1..5956
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="glycerol-3-phosphate acyltransferase,
                     mitochondrial"
                     /db_xref="GeneID:14732"
                     /db_xref="MGI:MGI:109162"
     exon            1..149
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            150..280
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            281..403
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            404..477
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            478..591
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            592..738
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            739..835
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            836..972
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1072
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1285
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1399
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1485
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1601
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1672
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1937
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2080
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2158
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2296
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2486
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2545
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..5956
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2928..2933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="hexamer: ATTAAA"
     polyA_site      2953
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="major polyA site"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="hexamer: AATAAT"
     polyA_site      3040
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="hexamer: GATAAA"
     polyA_site      3850
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
     regulatory      4788..4793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
                     /note="hexamer: AATAAA"
     polyA_site      4810
                     /gene="Gpam"
                     /gene_synonym="GPAT; GPAT-1; GPAT1; P90"
ORIGIN      
        1 ggcgcgccgc tgcagcaggc gcagagccga agcgctggca gctgcgtgcg cccaggcgcg
       61 agctgccggg cgggtggaga ggagcgcggt gcgctgtgcg cggtgcgggc tgcggctgca
      121 gacgccgctg ggccggagcg cggggtcagc acatggtttg ggacttgcac gttctgccat
      181 ggaggagtct tcagtgacag ttggcacaat agacgtttct tatctgccca gttcatcgga
      241 atacagcctt ggccgatgta aacacaccag tgaggactgg gttgactgtg ggttcaaacc
      301 taccttcttc agatctgcaa cactgaaatg gaaggagagc cttatgagcc ggaagaggcc
      361 cttcgtggga aggtgctgct attcctgcac gccacagagc tgggaaaggt ttttcaaccc
      421 cagtatccca tctctgggtt tgcggaatgt tatttatatc aatgaaacgc acacaaggca
      481 cagaggatgg ctggcgagac ggctgtctta catccttttt gttcaagagc gagacgtcca
      541 taagggcatg tttgccacca gtgttactga gaatgtactg agcagcagca gagtccaaga
      601 ggcaattgct gaagtggctg cggagttgaa cccagatgga tctgcccagc agcagtccaa
      661 agccatccag aaggtgaaaa ggaaagccag gaagatcctc caggagatgg tcgccaccgt
      721 ctccccaggg atgatcaggc tgactggctg ggtgttacta aagctcttca acagcttctt
      781 ctggaacatt cagattcaca agggtcaact cgagatggtc aaggctgcaa ctgagacgaa
      841 cctgccgctc ttgtttctgc cggtgcacag atcccacatt gactacctgt tgctcacctt
      901 catcctcttt tgccacaaca tcaaggcgcc gtacatcgcc tcgggcaata atctcaacat
      961 ccccgtcttc agtaccttga ttcacaagct tgggggcttt ttcataagac ggaggctcga
     1021 tgaaacccca gatggacgca aagacattct gtacagagcg ttgctccatg ggcatgtagt
     1081 tgaactcctc cgacagcagc agttcctgga gatcttcctg gaaggcaccc gctcccgcag
     1141 tggcaagacc tcctgtgccc gggcagggct cctctcagtg gtagtggata ctctgtcgtc
     1201 caacaccatc cccgacatcc tcgtcatacc cgtgggcatc tcgtatgatc gcataatcga
     1261 aggtcactac aatggcgaac agttgggaaa gcccaagaag aacgagagcc tctggagtgt
     1321 ggcgagaggc gttatcagaa tgctgcggaa aaactacggc tacgtccgag tggattttgc
     1381 acagccattt tccttgaagg aatatttaga aggccagagt cagaaacctg tatctgcccc
     1441 cctttctctg gagcaagcac tgttaccagc gatccttcct tcaagaccga atgatgttgc
     1501 tgatgaacat caagacctat ccagtaacga gtccagaaac ccagcagacg aagccttccg
     1561 acgaaggctg attgcaaacc tggctgagca cattctcttc accgccagca agtcctgcgc
     1621 tatcatgtcc acccacattg tggcctgtct gctcctctac agacacaggc agggaatcca
     1681 tctctccacg cttgtggaag acttctttgt gatgaaggag gaagtcctag ctcgcgattt
     1741 cgacctaggc ttctccggga attcagaaga tgtcgtcatg catgctattc agcttctggg
     1801 gaactgtgtc acaatcaccc acacgagcag gaaagatgag ttttttatta ctcccagcac
     1861 aactgtcccg tcagtctttg aactcaactt ctacagcaat ggcgtacttc atgtgttcat
     1921 catggaagcc atcatagctt gcagcatcta tgcagtcctg aataagaggt gctctggagg
     1981 gtccgctgga ggcctcggca acctgatcag ccaggagcag ctggtgagga aggccgccag
     2041 cctgtgctac cttctctcta acgaaggtac catttctctg ccctgccaga ctttttacca
     2101 agtttgtcat gagacagttg gcaagttcat ccagtatggc attctcacag tggcagagca
     2161 agatgaccag gaagatgtca gtcctggcct tgcagaacag cagtgggaca agaagcttcc
     2221 ggaactgaac tggagaagtg acgaggaaga tgaagacagt gactttggtg aggagcagcg
     2281 agattgctat ctcaaggtga gccagtccaa ggagcaccag caattcatca cctttcttca
     2341 gaggcttcta ggtcccctgc tagaagccta cagctctgct gccatctttg tccacaactt
     2401 cagcggtcca gttcccgagt ctgagtacct gcagaaactg cacaggtacc ttatcaccag
     2461 gacggaaagg aacgttgccg tgtacgctga gagtgccaca tactgtctcg tgaagaacgc
     2521 tgtgaaaatg tttaaggaca tcggggtttt caaagagacc aagcaaaagc gagtgtctgt
     2581 tctagaactg agcagtactt tcctacctca gtgcaaccgg cagaaactcc tagagtatat
     2641 tctgagtttt gtggtgctgt agcgatctct cagcacctat ctcgagcgag gagctgatga
     2701 gtcccttgca gcctccagtc tgacccagag tggcaggtat cctggcatgg cccagcctgc
     2761 cctaccccga ggagacttcc aggaagacac gtgccttctg cccccgtgga cctgcgctcc
     2821 tcccaacaca gacgcagtgg cctgcgcaga gcactcaggg ccagtgccat ctgtgattca
     2881 tgatcactag gttataggtg aaatctcagt aagttatttt ggagtttatt aaaggttcac
     2941 attttaagta caacttttca ggctagttac tgtgatggac attgaggtgt ttgtagaact
     3001 gactcttata tagtaagtaa taatgtttcc tttaaaataa ttgggccatc cattctctgt
     3061 ctccattatc gctgtcaaca gaagttatgg tttgtatgtg agccctttcc tctcaactgc
     3121 tttactaagg agcaatgttg tcctgcgccg gcacactcaa gatgtatctg agtagctgcc
     3181 tgaaagcaga tgacactgca gtcaggaggt gagaggctga ggaaagagcc agcatcagga
     3241 ggtgactctg gttggcaagg gtgagctgtg cttggccagg aaggtggcat taaaggctgt
     3301 gctcacgtga caagagtgcc tttgagctgt aatgaccagt gtttagagtc cctgttgctg
     3361 atacctttga gtgattgaca cctgctgctt ttgaggagct cggctgcagt gatcactggc
     3421 gtgtggcact ctggctacaa actgctgacc caggggttcc agacactgct cactcactgg
     3481 gtgctgtgct gtggctagtg tatggcttgt acccagatgg cgcactgtgc agcctgtgta
     3541 gcatgcacag tgacccagct gagtggcagg tggttggagg caaggacatt tatgtgggcc
     3601 acatacccaa acttcctgcc atgtaaaggc gagtgattgt gaaagcacct ctgttgtagt
     3661 gggtaggtgc ctttctcatg agcggggagc ataactgtta gttatttgtg gtgattatgg
     3721 cagatttcaa gatcacgtga caatgcagtc tctaattgtt cactgtccat atatatgatt
     3781 ttacggaatt atgaattttt ctgatgagtg ttgtatagat gatttgaatt gataaaagta
     3841 ttagggatga ggtttgtact ttcctgaact tgaatttcaa acactaactg tatcctatga
     3901 gtgacgtgtg tgttggggga gggtgggcct gcctggtgtt acacagagca tggcgtggct
     3961 ggtctggagc gcatagcaat aatactgtgc tgtggtgacc tccgcccttg ccttgtgcat
     4021 gtcacacctc cttttccttt gcttcacttc tgtcaactgt agcgactttg gtgtgcagtg
     4081 agatgctcac ctttagcctc tgctccccta actaggctgg cacttccctt ggctgtactt
     4141 gggggacacc cagagaggct ggtgtactcc cttgggttta tctgtgggga ctcaagcatt
     4201 ttattggtct ctgttttttt ttttttccct ctaaatggaa actgtaggtg gcttcctctg
     4261 atctgtctgc cagtgggtgt tgctgccctg cttgtcagct ctgcaaatga gcgctgctcc
     4321 ccagcttgcg cagagacgtg tgcgtcccac gtcccttgcc gtgctctccc ttttggtagg
     4381 tgttacttta agaactgcag tcagacttgc tgttgcctga caattaactc actgtgagga
     4441 taggcacgca cgcttttcat aattaactgg tgctttgaaa cctttcttat ggaagaaaaa
     4501 tctcaaccaa agttatgctc ttcctgacaa gctgaccctt gagttaattt tagcacaact
     4561 cattcttcag tgcctcatta tgaaagacaa aaagcatcac aataaggctt ccaggtagcc
     4621 ctgttcccta atagaaacat tccccttgtt ttccagcagt gggtggcttc ctcgaacgat
     4681 taaacaaact aggtgcttgt atataattta ttacagttta ctctactgca tttctgtcaa
     4741 gttgaaatgc atgcccttca ggggaagact gtgagtcaag tttaataaat aaaaacctaa
     4801 tactaagcaa tatgaagctg cactctgctt ttaagtgagg ccaagccaag taagccagag
     4861 ggggaggggc atttgctttc caaatcctaa ggaaaaatga aggcaaaaca agtgttatgt
     4921 ccattcagcc aggaacacac tctagccttc ctgactctct taaactgtgg acgtcaggag
     4981 gccgaatgca gaaaagtata tctgggatgg atggcaggga atagaagcta ggactggagt
     5041 tcctgtcctg ccgccttggt tcctgcagta tcgtgatgcc ctgagatggg gatccgtggg
     5101 aacatgcagt gccctgcagt gccctgcggt gcggacagga ctgcatctga tagtacacag
     5161 actgatgcac gtagcatttc ccaaactgtt tggacctcag gaccttttcc cctctgggac
     5221 actgcatgcc gtggaaaacc ttttcagaaa ctacattcat tgttctttaa gcagaccaaa
     5281 agtcacaaca gtggcaggca ggctgcatgc tttttgtatc gctcacgatg cactgtggtg
     5341 tgctcgggta tctttcctca ctggagagag caagcacagg aagctggctg cagtgccttc
     5401 ctcatgaagg atctaccaca accctggcct ttttaaaact gagagtagca gaattaatag
     5461 agaaattaaa aaattaaaat tggggtaaat aataaaggtt ttaattcaga tctagaagaa
     5521 aactgcacag ttgaatgcag atttttatcc atagataact gtagtgtttt gaaatgatag
     5581 gccctacctt tgaagtttct aagacttatt atgggatgta aatctgtttt ttaaaaacac
     5641 tttttagggg cttgagagct gccacctggc atttagttta gtgcggccag tgactgcttc
     5701 aagagacttc tgaccttgct tcccaacagc taaagggcta actgtcttta tggaaggcac
     5761 ttgttacagt atttgcccat tgtacagagc aatgctacat tgttgtaaaa agaattgcta
     5821 ttgtaaaaaa gcactgtgtg actttgtgaa ggacactgcc ttggaaatgt tgactgacgt
     5881 ttatgcctgg tgatagcatg tcccgagaag catggacatg gagttttgtt ttaataaacc
     5941 agaaaaaaaa aacccg
//
