LOCUS       NM_021610               2546 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glycoprotein A33 transmembrane (Gpa33), transcript
            variant 1, mRNA.
ACCESSION   NM_021610
VERSION     NM_021610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Malaterre,J., Pereira,L., Putoczki,T., Millen,R.,
            Paquet-Fifield,S., Germann,M., Liu,J., Cheasley,D., Sampurno,S.,
            Stacker,S.A., Achen,M.G., Ward,R.L., Waring,P., Mantamadiotis,T.,
            Ernst,M. and Ramsay,R.G.
  TITLE     Intestinal-specific activatable Myb initiates colon tumorigenesis
            in mice
  JOURNAL   Oncogene 35 (19), 2475-2484 (2016)
   PUBMED   26300002
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Buchert,M., Rohde,F., Eissmann,M., Tebbutt,N., Williams,B.,
            Tan,C.W., Owen,A., Hirokawa,Y., Gnann,A., Orend,G., Orner,G.,
            Dashwood,R.H., Heath,J.K., Ernst,M. and Janssen,K.P.
  TITLE     A hypermorphic epithelial beta-catenin mutation facilitates
            intestinal tumorigenesis in mice in response to compounding
            WNT-pathway mutations
  JOURNAL   Dis Model Mech 8 (11), 1361-1373 (2015)
   PUBMED   26398937
REFERENCE   4  (bases 1 to 2546)
  AUTHORS   Williams,B.B., Tebbutt,N.C., Buchert,M., Putoczki,T.L., Doggett,K.,
            Bao,S., Johnstone,C.N., Masson,F., Hollande,F., Burgess,A.W.,
            Scott,A.M., Ernst,M. and Heath,J.K.
  TITLE     Glycoprotein A33 deficiency: a new mouse model of impaired
            intestinal epithelial barrier function and inflammatory disease
  JOURNAL   Dis Model Mech 8 (8), 805-815 (2015)
   PUBMED   26035389
  REMARK    GeneRIF: Gpa33(-/-) mice provide a valuable model to study the
            mechanisms linking intestinal permeability and multiple
            inflammatory pathologies.
REFERENCE   5  (bases 1 to 2546)
  AUTHORS   Clemons,N.J., Wang,D.H., Croagh,D., Tikoo,A., Fennell,C.M.,
            Murone,C., Scott,A.M., Watkins,D.N. and Phillips,W.A.
  TITLE     Sox9 drives columnar differentiation of esophageal squamous
            epithelium: a possible role in the pathogenesis of Barrett's
            esophagus
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 303 (12), G1335-G1346
            (2012)
   PUBMED   23064761
REFERENCE   6  (bases 1 to 2546)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2546)
  AUTHORS   Orner,G.A., Dashwood,W.M., Blum,C.A., Diaz,G.D., Li,Q.,
            Al-Fageeh,M., Tebbutt,N., Heath,J.K., Ernst,M. and Dashwood,R.H.
  TITLE     Response of Apc(min) and A33 (delta N beta-cat) mutant mice to
            treatment with tea, sulindac, and
            2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
  JOURNAL   Mutat Res 506-507, 121-127 (2002)
   PUBMED   12351151
REFERENCE   8  (bases 1 to 2546)
  AUTHORS   Johnstone,C.N., White,S.J., Tebbutt,N.C., Clay,F.J., Ernst,M.,
            Biggs,W.H., Viars,C.S., Czekay,S., Arden,K.C. and Heath,J.K.
  TITLE     Analysis of the regulation of the A33 antigen gene reveals
            intestine-specific mechanisms of gene expression
  JOURNAL   J Biol Chem 277 (37), 34531-34539 (2002)
   PUBMED   12114523
  REMARK    GeneRIF: cloning, chromosomal localizations, exon-intron structures
            and transcription start sites - target gene for the
            intestine-specific homeobox transcription factor, CDX1
REFERENCE   9  (bases 1 to 2546)
  AUTHORS   Abud,H.E., Johnstone,C.N., Tebbutt,N.C. and Heath,J.K.
  TITLE     The murine A33 antigen is expressed at two distinct sites during
            development, the ICM of the blastocyst and the intestinal
            epithelium
  JOURNAL   Mech Dev 98 (1-2), 111-114 (2000)
   PUBMED   11044613
REFERENCE   10 (bases 1 to 2546)
  AUTHORS   Johnstone,C.N., Tebbutt,N.C., Abud,H.E., White,S.J., Stenvers,K.L.,
            Hall,N.E., Cody,S.H., Whitehead,R.H., Catimel,B., Nice,E.C.,
            Burgess,A.W. and Heath,J.K.
  TITLE     Characterization of mouse A33 antigen, a definitive marker for
            basolateral surfaces of intestinal epithelial cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (3), G500-G510 (2000)
   PUBMED   10960348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138358.12 and AF247659.1.
            
            On Feb 17, 2018 this sequence version replaced NM_021610.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247659.1, SRR5189685.161951.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC138358.12        35648-35886         c
            240-2546            AF247659.1         1-2307
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.49 cM"
     gene            1..2546
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /note="glycoprotein A33 transmembrane"
                     /db_xref="GeneID:59290"
                     /db_xref="MGI:MGI:1891703"
     exon            1..384
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1301
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell surface A33 antigen"
                     /codon_start=1
                     /product="cell surface A33 antigen isoform 1 precursor"
                     /protein_id="NP_067623.1"
                     /db_xref="CCDS:CCDS15447.1"
                     /db_xref="GeneID:59290"
                     /db_xref="MGI:MGI:1891703"
                     /translation="MLGKAGSVVWMFCAIWVAADALTVETTQDILRAARGRSVTLPCT
                     YNTYVSDREGFIQWDKLLRSQTERVVTWNFVTKKYIYGNRYENRVRVSNDAELSNASI
                     TIDQLTMDDNGTYECSVSLMSDQDVNAKSRVRLLVLVPPSKPDCSIQGEMVIGNNIQL
                     TCHSAEGSPSPQYSWKSYNAQNQQRPLTQPVSGEPLLLKNISTETAGYYICTSSNDVG
                     IESCNITVAPRPPSMNIALYAGIAGSVFVALIIIGVIVYCCCCREKDDKDQDREDARP
                     NRAAYQVPKKEQKEISRGREDEDDHRHEDRWSSGRSTPDQPFQ"
     exon            385..539
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     exon            540..756
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     exon            757..912
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1032
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1168
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..2532
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
     polyA_site      2532
                     /gene="Gpa33"
                     /gene_synonym="2010310L10Rik; 2210401D16Rik; mA33"
                     /note="major polyA site"
ORIGIN      
        1 agttatgaga ggtccacacc ttctgagaag cacaggactt tgcactcctg ctgaagaggg
       61 agaaggcagg aagatggctg gctccaggaa ggaagaagac tcttgttggg gcctttcata
      121 gagtaggtgg agcaggggcc tcaccccata ggtgagctca cctgccagtc cgttgactgg
      181 gtggggcatg tgggcccagt ctggcccagg tgagctggag gagagtcaca gggactacag
      241 gctgaaccag gccagaggcc atagctttaa ccagacagcc cagacctgtc cagtgccctg
      301 ccagttccag actgggcttg tgtcgggaaa ggagccagac catgttgggg aaggcaggat
      361 ctgtggtgtg gatgttctgt gcaatctggg tcgctgctga tgctcttacc gtggaaacta
      421 cacaggacat tcttcgggct gctcgaggaa ggagtgtcac cctcccgtgc acctacaaca
      481 cctatgtttc agaccgagag gggttcattc agtgggataa gcttctccga agtcagacgg
      541 aaagagtggt cacctggaat tttgtgacaa agaaatacat ctatgggaac cgttatgaga
      601 atcgagtgag agtatctaac gatgctgagt tgtcaaatgc ctctatcacc atcgaccagc
      661 tgaccatgga cgacaatggc acctacgagt gctccgtgtc actgatgtcg gaccaggatg
      721 tcaacgccaa gtctcgagtc cgcctcttgg tccttgttcc accctccaag ccagactgca
      781 gcatccaagg ggagatggtg atcgggaaca acatccagct gacatgccac tctgcagagg
      841 gctctccgag cccacaatac agctggaaga gttacaacgc ccagaaccag cagcggcccc
      901 tcacccagcc agtctcaggc gagccattgt tgctgaagaa catctccacg gagacagcgg
      961 gttactacat ctgcacctcc agcaatgacg tggggataga gtcctgcaac atcaccgtgg
     1021 cacccagacc tccctccatg aacattgcgc tgtatgcggg cattgcgggg agtgtctttg
     1081 tggccctcat catcatcggt gtcattgtct actgctgctg ctgccgggaa aaggatgaca
     1141 aagatcaaga cagggaggat gcgcggccga accgagcagc ttaccaagtg cctaaaaagg
     1201 agcagaaaga aatttccaga gggcgggaag acgaagatga ccacagacat gaggatcggt
     1261 ggagctcggg gcgtagcact ccagaccagc ctttccaatg aaggagcctt ctgcccagcg
     1321 gggagagggg ggaggtctag ggcccaggct cctgctctgg ccacccttct ccccagcccc
     1381 atagtcctgc tcctcccccc aggcattggt ggagcacttc tttctgtgta tctgcctcag
     1441 gggcgcatca ctggcctggc tactgacgtc ctacctgatg accactgaaa ggacccttcc
     1501 tcattgctaa atctgactca gggtctggcc ttctccctag accagacagc atcctctgcc
     1561 tctcttacgg ctggcagggc ctcctagaat ctcggcacga tgcagggctg cttctgttcc
     1621 aagctcgcca tacaggcaag cgccagcttc agcaccagtt tcagaaggtg ggagtctgcc
     1681 ctgcctcacc atgcccgaca ctcagaggag aaccagtgat gggcctgcac gcaatatttt
     1741 gttgaatgaa gggaagaaat caacgataag gtgtagtttc tgtgatttac ccagcttaat
     1801 tgcgcccccc ccccccccat gctgaggggc cacggtggcc tccagcgtcc ccctctgctc
     1861 catctcccac catggcgttt ctgttcctgg acacacacct tcttaggact tctccaaaca
     1921 cagttccatc tctgcctgtc aagggcctgc ctgtccttag aactcactag tcttggatcc
     1981 ccaaatcttt cttaatcctg tgactgctaa cacaccagga ggcaatgaag tcactttgtc
     2041 ccacacctag acctgggctg catgcaaggc catcagagct acacttcctg ctgtgttaga
     2101 gtaggtgccc tggagcaagg tctggatctt ggagcctggc agcctcaact ggggacttgc
     2161 tctcatggac agtgctttgc ctcctgggtg tgacttggga cacctggtga ctccacccaa
     2221 gccccgtgtt agtctggcta ggtgggcaga ctgatttaca atgaacacag acaaaagctt
     2281 acttccctcg cacctgccag ctgccctgcc tgccgcagcc tcccctttcc attactatcc
     2341 aggactcagg ccagatgggc tgctccaaat gtgttttact actggataaa cctttctgga
     2401 tcaccagaaa agcaactgta tcaatccctt ccctcctctg attttatgta cacatatatt
     2461 ttatatactt ggctaaattc tttgtttcaa tcaaaatgtt tctttatcaa taaagttact
     2521 ggtggaaatt caaaaaaaaa aaaaaa
//
