LOCUS       NM_001163014            1152 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus glycoprotein 6 platelet (Gp6), mRNA.
ACCESSION   NM_001163014 XM_145298 XM_911566
VERSION     NM_001163014.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1152)
  AUTHORS   Benson,T.W., Pike,M.M., Spuzzillo,A., Hicks,S.M., Ali,S., Pham,M.,
            Mix,D.S., Brunner,S.I., Wadding-Lee,C., Conrad,K.A., Russell,H.M.,
            Jennings,C., Coughlin,T.M., Aggarwal,A., Lyden,S., Mani,K.,
            Bjorck,M., Wanhainen,A., Bhandari,R., Lipworth-Elliot,L.,
            Robinson-Cohen,C., Caputo,F.J., Shim,S., Quesada,O., Tourdot,B.,
            Edwards,T.L., Tranter,M., Gardiner,E.E., Mackman,N., Cameron,S.J.
            and Owens,A.P. 3rd.
  TITLE     Soluble glycoprotein VI predicts abdominal aortic aneurysm growth
            rate and is a novel therapeutic target
  JOURNAL   Blood 144 (16), 1663-1678 (2024)
   PUBMED   38900973
  REMARK    GeneRIF: Soluble glycoprotein VI predicts abdominal aortic aneurysm
            growth rate and is a novel therapeutic target.
REFERENCE   2  (bases 1 to 1152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1152)
  AUTHORS   Reusswig,F., Dille,M., Kruger,E., Ortscheid,J., Feige,T.,
            Gorressen,S., Fischer,J.W. and Elvers,M.
  TITLE     Platelets modulate cardiac remodeling via the collagen receptor
            GPVI after acute myocardial infarction
  JOURNAL   Front Immunol 14, 1275788 (2024)
   PUBMED   38274818
  REMARK    GeneRIF: Platelets modulate cardiac remodeling via the collagen
            receptor GPVI after acute myocardial infarction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1152)
  AUTHORS   Burkard,P., Schonhart,C., Vogtle,T., Kohler,D., Tang,L.,
            Johnson,D., Hemmen,K., Heinze,K.G., Zarbock,A., Hermanns,H.M.,
            Rosenberger,P. and Nieswandt,B.
  TITLE     A key role for platelet GPVI in neutrophil recruitment, migration,
            and NETosis in the early stages of acute lung injury
  JOURNAL   Blood 142 (17), 1463-1477 (2023)
   PUBMED   37441848
  REMARK    GeneRIF: A key role for platelet GPVI in neutrophil recruitment,
            migration, and NETosis in the early stages of acute lung injury.
REFERENCE   5  (bases 1 to 1152)
  AUTHORS   Rudran,T., Antoniak,S., Flick,M.J., Ginsberg,M.H., Wolberg,A.S.,
            Bergmeier,W. and Lee,R.H.
  TITLE     Protease-activated receptors and glycoprotein VI cooperatively
            drive the platelet component in thromboelastography
  JOURNAL   J Thromb Haemost 21 (8), 2236-2247 (2023)
   PUBMED   37068592
  REMARK    GeneRIF: Protease-activated receptors and glycoprotein VI
            cooperatively drive the platelet component in thromboelastography.
REFERENCE   6  (bases 1 to 1152)
  AUTHORS   Massberg,S., Gawaz,M., Gruner,S., Schulte,V., Konrad,I.,
            Zohlnhofer,D., Heinzmann,U. and Nieswandt,B.
  TITLE     A crucial role of glycoprotein VI for platelet recruitment to the
            injured arterial wall in vivo
  JOURNAL   J Exp Med 197 (1), 41-49 (2003)
   PUBMED   12515812
REFERENCE   7  (bases 1 to 1152)
  AUTHORS   Leo,L., Di Paola,J., Judd,B.A., Koretzky,G.A. and Lentz,S.R.
  TITLE     Role of the adapter protein SLP-76 in GPVI-dependent platelet
            procoagulant responses to collagen
  JOURNAL   Blood 100 (8), 2839-2844 (2002)
   PUBMED   12351393
REFERENCE   8  (bases 1 to 1152)
  AUTHORS   Locke,D., Chen,H., Liu,Y., Liu,C. and Kahn,M.L.
  TITLE     Lipid rafts orchestrate signaling by the platelet receptor
            glycoprotein VI
  JOURNAL   J Biol Chem 277 (21), 18801-18809 (2002)
   PUBMED   11844795
REFERENCE   9  (bases 1 to 1152)
  AUTHORS   Jandrot-Perrus,M., Busfield,S., Lagrue,A.H., Xiong,X., Debili,N.,
            Chickering,T., Le Couedic,J.P., Goodearl,A., Dussault,B.,
            Fraser,C., Vainchenker,W. and Villeval,J.L.
  TITLE     Cloning, characterization, and functional studies of human and
            mouse glycoprotein VI: a platelet-specific collagen receptor from
            the immunoglobulin superfamily
  JOURNAL   Blood 96 (5), 1798-1807 (2000)
   PUBMED   10961879
REFERENCE   10 (bases 1 to 1152)
  AUTHORS   Nieswandt,B., Bergmeier,W., Schulte,V., Rackebrandt,K.,
            Gessner,J.E. and Zirngibl,H.
  TITLE     Expression and function of the mouse collagen receptor glycoprotein
            VI is strictly dependent on its association with the FcRgamma chain
  JOURNAL   J Biol Chem 275 (31), 23998-24002 (2000)
   PUBMED   10825177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137969.9.
            
            On or before Jul 8, 2009 this sequence version replaced
            XM_911566.2, XM_145298.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138170.1, AK079424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC137969.9         10856-10949
            95-130              AC137969.9         14072-14107
            131-388             AC137969.9         14236-14493
            389-673             AC137969.9         23460-23744
            674-727             AC137969.9         35337-35390
            728-778             AC137969.9         36947-36997
            779-829             AC137969.9         38396-38446
            830-1152            AC137969.9         39565-39887
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.52 cM"
     gene            1..1152
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /note="glycoprotein 6 platelet"
                     /db_xref="GeneID:243816"
                     /db_xref="MGI:MGI:1889810"
     exon            1..94
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1002
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /note="platelet glycoprotein VI; glycoprotein 5"
                     /codon_start=1
                     /product="platelet glycoprotein VI precursor"
                     /protein_id="NP_001156486.1"
                     /db_xref="CCDS:CCDS51972.1"
                     /db_xref="GeneID:243816"
                     /db_xref="MGI:MGI:1889810"
                     /translation="MSPASPTFFCIGLCVLQVIQTQSGPLPKPSLQAQPSSLVPLGQS
                     VILRCQGPPDVDLYRLEKLKPEKYEDQDFLFIPTMERSNAGRYRCSYQNGSHWSLPSD
                     QLELIATGVYAKPSLSAHPSSAVPQGRDVTLKCQSPYSFDEFVLYKEGDTGSYKRPEK
                     WYRANFPIITVTAAHSGTYRCYSFSSSSPYLWSAPSDPLVLVVTGLSATPSQVPTEES
                     FPVTESSRRPSILPTNKISTTEKPMNITASPEGLSPPFGFAHQHYAKGNLVRICLGAT
                     IIIILLGLLAEDWHSRKKCLQHRMRALQRPLPPLPLA"
     exon            95..130
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            131..388
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            389..673
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            674..727
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            728..778
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            779..829
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1152
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1129..1134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /note="hexamer: AATAAA"
     polyA_site      1152
                     /gene="Gp6"
                     /gene_synonym="9830166G18Rik; Gm469; Gpvi"
                     /note="major polyA site"
ORIGIN      
        1 gttccaggca tctacaactt ccctgcttgg ccacatagct caggactggg ttgcagaacc
       61 atgtctccag cctcacccac tttcttctgt attgggctgt gtgtactgca agtgatccaa
      121 acacagagtg gcccactccc caagccttcc ctccaggctc agcccagttc cctggtaccc
      181 ctgggtcagt cagttattct gaggtgccag ggacctccag atgtggattt atatcgcctg
      241 gagaaactga aaccggagaa gtatgaagat caagactttc tcttcattcc aaccatggaa
      301 agaagtaatg ctggacggta tcgatgctct tatcagaatg ggagtcactg gtctctccca
      361 agtgaccagc ttgagctaat tgctacaggt gtgtatgcta aaccctcact ctcagctcat
      421 cccagctcag cagtccctca aggcagggat gtgactctga agtgccagag cccatacagt
      481 tttgatgaat tcgttctata caaagaaggg gatactgggt cttataagag acctgagaaa
      541 tggtaccggg ccaatttccc catcatcaca gtgactgctg ctcacagtgg gacgtaccgg
      601 tgttacagct tctccagctc atctccatac ctgtggtcag ccccgagtga ccctctagtg
      661 cttgtggtta ctggactctc tgccactccc agccaggtac ccacggaaga atcatttcct
      721 gtgacagaat cctccaggag accttccatc ttacccacaa acaaaatatc tacaactgaa
      781 aagcctatga atatcactgc ctctccagag gggctgagcc ctccatttgg ttttgctcat
      841 cagcactatg ccaaggggaa tctggtccgg atatgccttg gtgccacgat tataataatt
      901 ttgttggggc ttctagcaga ggattggcac agtcggaaga aatgcctgca acacaggatg
      961 agagctttgc aaaggccact accacccctc ccactggcct agaaataact tggctttcag
     1021 cagagggatt gaccagacat ccatgcacaa ccatggacat caccactaga gccacagaca
     1081 tggacatact caagagtggg gaggttatat aaaaaaatga gtgtggagaa taaatgcaga
     1141 gccaacaagg ta
//
