LOCUS       NM_008148               2215 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus glycoprotein 5 platelet (Gp5), mRNA.
ACCESSION   NM_008148
VERSION     NM_008148.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Potts,K.S., Sargeant,T.J., Dawson,C.A., Josefsson,E.C.,
            Hilton,D.J., Alexander,W.S. and Taoudi,S.
  TITLE     Mouse prenatal platelet-forming lineages share a core
            transcriptional program but divergent dependence on MPL
  JOURNAL   Blood 126 (6), 807-816 (2015)
   PUBMED   25995324
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Li,R. and Emsley,J.
  TITLE     The organizing principle of the platelet glycoprotein Ib-IX-V
            complex
  JOURNAL   J Thromb Haemost 11 (4), 605-614 (2013)
   PUBMED   23336709
  REMARK    Review article
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Jansen,A.J., Josefsson,E.C., Rumjantseva,V., Liu,Q.P., Falet,H.,
            Bergmeier,W., Cifuni,S.M., Sackstein,R., von Andrian,U.H.,
            Wagner,D.D., Hartwig,J.H. and Hoffmeister,K.M.
  TITLE     Desialylation accelerates platelet clearance after refrigeration
            and initiates GPIbalpha metalloproteinase-mediated cleavage in mice
  JOURNAL   Blood 119 (5), 1263-1273 (2012)
   PUBMED   22101895
  REMARK    GeneRIF: Desialylation of platelet VWFR therefore triggers platelet
            clearance and primes GPIbalpha and GPV for MP-dependent cleavage.
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Cosemans,J.M., Schols,S.E., Stefanini,L., de Witt,S., Feijge,M.A.,
            Hamulyak,K., Deckmyn,H., Bergmeier,W. and Heemskerk,J.W.
  TITLE     Key role of glycoprotein Ib/V/IX and von Willebrand factor in
            platelet activation-dependent fibrin formation at low shear flow
  JOURNAL   Blood 117 (2), 651-660 (2011)
   PUBMED   21037087
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Suva,L.J., Hartman,E., Dilley,J.D., Russell,S., Akel,N.S.,
            Skinner,R.A., Hogue,W.R., Budde,U., Varughese,K.I., Kanaji,T. and
            Ware,J.
  TITLE     Platelet dysfunction and a high bone mass phenotype in a murine
            model of platelet-type von Willebrand disease
  JOURNAL   Am J Pathol 172 (2), 430-439 (2008)
   PUBMED   18187573
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Ni,H., Ramakrishnan,V., Ruggeri,Z.M., Papalia,J.M., Phillips,D.R.
            and Wagner,D.D.
  TITLE     Increased thrombogenesis and embolus formation in mice lacking
            glycoprotein V
  JOURNAL   Blood 98 (2), 368-373 (2001)
   PUBMED   11435305
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Kahn,M.L., Diacovo,T.G., Bainton,D.F., Lanza,F., Trejo,J. and
            Coughlin,S.R.
  TITLE     Glycoprotein V-deficient platelets have undiminished thrombin
            responsiveness and Do not exhibit a Bernard-Soulier phenotype
  JOURNAL   Blood 94 (12), 4112-4121 (1999)
   PUBMED   10590056
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Ramakrishnan,V., Reeves,P.S., DeGuzman,F., Deshpande,U.,
            Ministri-Madrid,K., DuBridge,R.B. and Phillips,D.R.
  TITLE     Increased thrombin responsiveness in platelets from mice lacking
            glycoprotein V
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13336-13341 (1999)
   PUBMED   10557321
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Katsutani,S., Fujimoto,T.T., Noda,M., Shimomura,T., Takafuta,T.,
            Kimura,A. and Fujimura,K.
  TITLE     Cloning and characterization of the gene encoding the murine
            glycoprotein V: the conserved thrombin-cleavable protein on
            platelet surface
  JOURNAL   Thromb Res 92 (1), 43-51 (1998)
   PUBMED   9783673
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   Ravanat,C., Morales,M., Azorsa,D.O., Moog,S., Schuhler,S.,
            Grunert,P., Loew,D., Van Dorsselaer,A., Cazenave,J.P. and Lanza,F.
  TITLE     Gene cloning of rat and mouse platelet glycoprotein V:
            identification of megakaryocyte-specific promoters and
            demonstration of functional thrombin cleavage
  JOURNAL   Blood 89 (9), 3253-3262 (1997)
   PUBMED   9129030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235812.1, AK031272.1 and BE948546.1.
            
            On Nov 2, 2012 this sequence version replaced NM_008148.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY235812.1, AK172059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY235812.1         1-2
            3-2191              AK031272.1         2-2190
            2192-2215           BE948546.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.26 cM"
     gene            1..2215
                     /gene="Gp5"
                     /gene_synonym="GPV"
                     /note="glycoprotein 5 platelet"
                     /db_xref="GeneID:14729"
                     /db_xref="MGI:MGI:1096363"
     exon            1..27
                     /gene="Gp5"
                     /gene_synonym="GPV"
                     /inference="alignment:Splign:2.1.0"
     exon            28..2199
                     /gene="Gp5"
                     /gene_synonym="GPV"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1733
                     /gene="Gp5"
                     /gene_synonym="GPV"
                     /note="platelet glycoprotein V"
                     /codon_start=1
                     /product="platelet glycoprotein V precursor"
                     /protein_id="NP_032174.2"
                     /db_xref="CCDS:CCDS28100.1"
                     /db_xref="GeneID:14729"
                     /db_xref="MGI:MGI:1096363"
                     /translation="MLRSALLSAVLALLRAQPFPCPKTCKCVVRDAAQCSGGSVAHIA
                     ELGLPTNLTHILLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKT
                     LRLTRNKISRLPRAILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSF
                     LPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLG
                     ALTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFEN
                     PLEELPDVLFGEMAGLRELWLNGTHLSTLPAAAFRNLSGLQTLGLTRNPRLSALPRGV
                     FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESV
                     QLEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRHHPDILGRDEPPQ
                     CRGPEPRASLSFWELLQGDPWCPDPRSLPLDPPTENALEAPVPSWLPNSWQSQTWAQL
                     VARGESPNNRLYWGLYILLLVAQAIIAAFIVFAMIKIGQLFRTLIREKLLLEAMGKSC
                     N"
ORIGIN      
        1 tcagtccagg gtgcagaact gcttcagaca tgctaagaag cgccctgctg tccgcggtgc
       61 tcgcactctt gcgtgcccaa ccttttccct gccccaaaac ctgcaagtgt gtggtccgcg
      121 atgccgcgca gtgctcgggc ggcagcgtgg ctcacatcgc tgagctaggt ctgcctacga
      181 acctcacaca catcctgctc ttccgaatgg accagggcat attgcggaac cacagcttca
      241 gcggcatgac agtccttcag cgcctgatgc tctcagatag ccacatttcc gccatcgacc
      301 ccggcacctt caatgacctg gtaaaactga aaaccctcag gttgacgcgc aacaaaatct
      361 ctcgtcttcc acgtgcgatc ctggataaga tggtactctt ggaacagctg ttcttggacc
      421 acaatgcact aagggacctt gatcaaaacc tgtttcagca actgcgtaac cttcaggagc
      481 tcggtttgaa ccagaatcag ctctcttttc ttcctgctaa ccttttctcg agcctgagag
      541 aactgaagtt gttggattta tcgcgaaaca acctgaccca cctgcccaag ggactgcttg
      601 gggctcaagt taagcttgag aaactgctgc tctattcaaa ccagctcacg tctgtggatt
      661 cggggctgct gagcaacctg ggcgccctga ctgagctgcg gctggagcgg aatcacctcc
      721 gctccgtagc cccgggtgcc ttcgaccgcc tcggaaacct gagctccttg actctatccg
      781 gaaacctcct ggagtctctg ccgcccgcgc tcttccttca cgtgagcagc gtgtctcggc
      841 tgactctgtt cgagaacccc ctggaggagc tcccggacgt gttgttcggg gagatggccg
      901 gcctgcggga gctgtggctg aacggcaccc acctgagcac gctgcccgcc gctgccttcc
      961 gcaacctgag cggcttgcag acgctggggc tgacgcggaa cccgcgcctg agcgcgctcc
     1021 cgcgcggcgt gttccagggc ctacgggagc tgcgcgtgct cgcgctgcac accaacgccc
     1081 tggcggagct gcgggacgac gcgctgcgcg gcctcgggca cctgcgccag gtgtcgctgc
     1141 gccacaaccg gctgcgggcc ctgccccgca cgctcttccg caacctcagc agcctcgaga
     1201 gcgtgcagct agagcacaac cagctggaga cgctgccagg agacgtgttc gcggctctgc
     1261 cccagctgac ccaggtcctg ctgggtcaca acccctggct ctgcgactgt ggcctgtggc
     1321 ccttcctcca gtggctgcgg catcacccgg acatcctggg ccgagacgag cccccgcagt
     1381 gccgtggccc ggagccacgc gccagcctgt cgttctggga gctgctgcag ggtgacccgt
     1441 ggtgcccgga tcctcgcagc ctgcctctcg accctccaac cgaaaatgct ctggaagccc
     1501 cggttccgtc ctggctgcct aacagctggc agtcccagac gtgggcccag ctggtggcca
     1561 ggggtgaaag tcccaataac aggctctact ggggtcttta tattctgctt ctagtagccc
     1621 aggccatcat agccgcgttc atcgtgtttg ccatgattaa aatcggccag ctgtttcgaa
     1681 cattaatcag agagaagctc ttgttagagg caatgggaaa atcgtgtaac taatgaaact
     1741 gaccagagca ttgtggacgg ggccccaagg agaatgcagt caggatgctg gcgtgccatt
     1801 acactatttc ccaggccttt tctcctctcc cgtgctctta gtgtctcttc ttctcccctc
     1861 tcttcagaag tagcttttgt aaatcgctac tgctttctag cctggcctgg gttacctcct
     1921 ctgctgttag tttcaagggg gctgagggtg ggggttcgac gggacttggc tcatcaggtc
     1981 caactgtgca gcgctgggtg cctagtggag agaggagccc tttcttggtt tctgaatttg
     2041 aggacacatc ctgccagtgg gcaagacctc tccgggaccc agcaagggtt gagtaacatt
     2101 tgctgaagga acaccggctt aaaacgaacc ctaggtccaa gagatgaagg ctcttcccaa
     2161 aataaaggtg gagtgttctt gtccctttac ctgaaaggaa aaaaaaaaaa aaaaa
//
