LOCUS       NM_025989               1985 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus glycoprotein 2 zymogen granule membrane (Gp2), mRNA.
ACCESSION   NM_025989
VERSION     NM_025989.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Prados,A., Onder,L., Cheng,H.W., Morbe,U., Lutge,M., Gil-Cruz,C.,
            Perez-Shibayama,C., Koliaraki,V., Ludewig,B. and Kollias,G.
  TITLE     Fibroblastic reticular cell lineage convergence in Peyer's patches
            governs intestinal immunity
  JOURNAL   Nat Immunol 22 (4), 510-519 (2021)
   PUBMED   33707780
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Kurashima,Y., Kigoshi,T., Murasaki,S., Arai,F., Shimada,K.,
            Seki,N., Kim,Y.G., Hase,K., Ohno,H., Kawano,K., Ashida,H.,
            Suzuki,T., Morimoto,M., Saito,Y., Sasou,A., Goda,Y., Yuki,Y.,
            Inagaki,Y., Iijima,H., Suda,W., Hattori,M. and Kiyono,H.
  TITLE     Pancreatic glycoprotein 2 is a first line of defense for mucosal
            protection in intestinal inflammation
  JOURNAL   Nat Commun 12 (1), 1067 (2021)
   PUBMED   33594081
  REMARK    GeneRIF: Pancreatic glycoprotein 2 is a first line of defense for
            mucosal protection in intestinal inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   He,M., Wu,B., Ye,W., Le,D.D., Sinclair,A.W., Padovano,V., Chen,Y.,
            Li,K.X., Sit,R., Tan,M., Caplan,M.J., Neff,N., Jan,Y.N.,
            Darmanis,S. and Jan,L.Y.
  TITLE     Chloride channels regulate differentiation and barrier functions of
            the mammalian airway
  JOURNAL   Elife 9, e53085 (2020)
   PUBMED   32286221
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   de Lau,W., Kujala,P., Schneeberger,K., Middendorp,S., Li,V.S.,
            Barker,N., Martens,A., Hofhuis,F., DeKoter,R.P., Peters,P.J.,
            Nieuwenhuis,E. and Clevers,H.
  TITLE     Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB
            and are induced by RankL in cultured 'miniguts'
  JOURNAL   Mol Cell Biol 32 (18), 3639-3647 (2012)
   PUBMED   22778137
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Kanaya,T., Hase,K., Takahashi,D., Fukuda,S., Hoshino,K., Sasaki,I.,
            Hemmi,H., Knoop,K.A., Kumar,N., Sato,M., Katsuno,T., Yokosuka,O.,
            Toyooka,K., Nakai,K., Sakamoto,A., Kitahara,Y., Jinnohara,T.,
            McSorley,S.J., Kaisho,T., Williams,I.R. and Ohno,H.
  TITLE     The Ets transcription factor Spi-B is essential for the
            differentiation of intestinal microfold cells
  JOURNAL   Nat Immunol 13 (8), 729-736 (2012)
   PUBMED   22706340
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Hase,K., Kawano,K., Nochi,T., Pontes,G.S., Fukuda,S., Ebisawa,M.,
            Kadokura,K., Tobe,T., Fujimura,Y., Kawano,S., Yabashi,A.,
            Waguri,S., Nakato,G., Kimura,S., Murakami,T., Iimura,M., Hamura,K.,
            Fukuoka,S., Lowe,A.W., Itoh,K., Kiyono,H. and Ohno,H.
  TITLE     Uptake through glycoprotein 2 of FimH(+) bacteria by M cells
            initiates mucosal immune response
  JOURNAL   Nature 462 (7270), 226-230 (2009)
   PUBMED   19907495
  REMARK    GeneRIF: glycoprotein 2 (GP2), specifically expressed on the apical
            plasma membrane of M cells among enterocytes, serves as a
            transcytotic receptor for mucosal antigens
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Yu,S., Michie,S.A. and Lowe,A.W.
  TITLE     Absence of the major zymogen granule membrane protein, GP2, does
            not affect pancreatic morphology or secretion
  JOURNAL   J Biol Chem 279 (48), 50274-50279 (2004)
   PUBMED   15385539
  REMARK    GeneRIF: unlikely that GP2 serves a major intracellular role within
            the acinar cell, may be active after it is secreted
REFERENCE   10 (bases 1 to 1985)
  AUTHORS   Kobayashi,K., Yanagihara,K., Ishiguro,K. and Fukuoka,S.
  TITLE     GP2/THP gene family of self-binding, GPI-anchored proteins forms a
            cluster at chromosome 7F1 region in mouse genome
  JOURNAL   Biochem Biophys Res Commun 322 (2), 659-664 (2004)
   PUBMED   15325280
  REMARK    GeneRIF: Tightly linked to homologue THP.  A Gp2 knockout mouse was
            established which does express THP.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125147.4.
            
            On Feb 9, 2019 this sequence version replaced NM_025989.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009661.1, BC119573.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC125147.4         70239-70326         c
            89-224              AC125147.4         68215-68350         c
            225-671             AC125147.4         65256-65702         c
            672-782             AC125147.4         63898-64008         c
            783-994             AC125147.4         63187-63398         c
            995-1143            AC125147.4         62554-62702         c
            1144-1389           AC125147.4         61114-61359         c
            1390-1552           AC125147.4         60032-60194         c
            1553-1637           AC125147.4         58171-58255         c
            1638-1682           AC125147.4         56534-56578         c
            1683-1985           AC125147.4         53591-53893         c
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.88 cM"
     gene            1..1985
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /note="glycoprotein 2 zymogen granule membrane"
                     /db_xref="GeneID:67133"
                     /db_xref="MGI:MGI:1914383"
     exon            1..88
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            89..224
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..671
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            672..782
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..994
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1143
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1389
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1552
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1637
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1682
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1985
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /note="hexamer: AATACA"
     polyA_site      1985
                     /gene="Gp2"
                     /gene_synonym="2310037I18Rik"
                     /note="major polyA site"
ORIGIN      
        1 acactgggca gggaggaagg atactttggg ttcttctctt atggtaagtc ctgctccaaa
       61 gcccaggaag atttagtctc ccttgcagat ttatgaagaa tctgcaggct gcagagtaac
      121 ctgcaagctt cactttatga aaaggatggt gggttgtgac ctgctgtggc tggctgcagc
      181 ctcctgcgtt ctgacactgg tatctccatc tacaatacat caaggttatg ggaggcccag
      241 gaacagctcc aatctggact tggactgtgg atcccctgac tctccaagtt ctggaatctg
      301 ctttgatccc tgccagaatc acacggtcct gaatgatcct accagaagca cagagaacaa
      361 cgattcatca gttgcatggt gtgatgataa cctgcacggc tggtaccgct ttgtgggtga
      421 tggaggagtg aagatgccag agacctgtgt gagtgtgttc cggtgccaca cctctgcccc
      481 catgtggctg agtggatctc accccatcct tggagatggc attgtcagcc acacagcctg
      541 tgccaactgg aatgaaaatt gttgcttctg gcgttctgag gtccaggtga aggcctgttc
      601 tgaagaacta ggagaatatc acgtgtacaa gttacagggt acccctgaat gcagtctgag
      661 atactgcaca gacccctcca ctgcacccaa gaattgtgag attacttgtc gtcctgagga
      721 ggaatgtgta ttccaaaata acaactggtc ctgtgtctgt aggcaggacc tccatgtttc
      781 tgactctcag agtttgcagc ctcttctgga ctgtggagat aatgagatca aggtgaagtt
      841 ggacaagtgt ttgctgggag gtatgggttt caaggaggag atcattgcct acctcaatga
      901 ccggaactgc aatggtacca tgcaagatga gcccaacaac tgggtgtcca tgaccagccc
      961 tgttgtggct aattactgtg ggaacatcct ggagaaaaat gggacccatg ccatctacag
     1021 aaacaccctt tccttggcca ctgactttat tatcagggac tttcgtgtca atgtcaactt
     1081 ccagtgtgcc tacccactgg acatgagcgt cagcctcgaa actgctctcc agcccattgt
     1141 aagctccctg actgttgatg tggacggagc aggagagttc aatgtcaaga tggccctctt
     1201 ccaagaccag agctacacaa acccttatga aggagccgaa gtgttgcttc cagtggagtc
     1261 tatactctat gtgggtgtcc tcttaaatag aggggatacc tccaggttca aactgttgct
     1321 gaccaactgc tatgccaccc cttcagaaga caggcatgac cctgtgaagt acttcatcat
     1381 caagaacaga tgcccaaacc aacgtgattc caccatcaat gtgcgggaga atggtgtgtc
     1441 ctcagaaagc cgattttcag tgcagatgtt catgtttgct ggaaattatg acttagtttt
     1501 cctgcattgt gaggtttacc tgtgtgactc cactactgaa cagtgtcaac catcttgctc
     1561 tacaaatcga cttcgcagta gtagaccagc cattgactat aatcgggttc tggatttagg
     1621 acccatcact aaaagaagtg ctcagagttc tgctacctcg aaggggactc cccacactac
     1681 agggttcttg ttggcctggc ccatgttctt cctgcctgtc ttcctggctc tactgttctg
     1741 agaggccagc tgagcacctg gccttaaagt tcttccctct ggcaatggct cacacccatc
     1801 cttcagtaga actggattcc tctgtgaatc atttcgattg ccctggaaat gcaatgtata
     1861 ttgataactc ctgggtagag ttgtcctgtt agtggatggg aaagggcaaa tcccatgatc
     1921 ctttcaaaat gcctcttgtt ctgacagcta atgacttgaa tacatcaacc cttgcattta
     1981 ttcta
//
