LOCUS       NM_010327               1847 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glycoprotein Ib, beta polypeptide (Gp1bb), transcript
            variant 2, mRNA.
ACCESSION   NM_010327
VERSION     NM_010327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1847)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1847)
  AUTHORS   Bertovic,I., Kurelic,R., Mahmutefendic Lucin,H. and Jurak
            Begonja,A.
  TITLE     Early Endosomal GTPase Rab5 (Ras-Related Protein in Brain 5)
            Regulates GPIbbeta (Glycoprotein Ib Subunit beta) Trafficking and
            Platelet Production In Vitro
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (1), e10-e26 (2022)
   PUBMED   34732055
  REMARK    GeneRIF: Early Endosomal GTPase Rab5 (Ras-Related Protein in Brain
            5) Regulates GPIbbeta (Glycoprotein Ib Subunit beta) Trafficking
            and Platelet Production In Vitro.
REFERENCE   3  (bases 1 to 1847)
  AUTHORS   Gowert,N.S., Kruger,I., Klier,M., Donner,L., Kipkeew,F., Gliem,M.,
            Bradshaw,N.J., Lutz,D., Kober,S., Langer,H., Jander,S., Jurk,K.,
            Frotscher,M., Korth,C., Bock,H.H. and Elvers,M.
  TITLE     Loss of Reelin protects mice against arterial thrombosis by
            impairing integrin activation and thrombus formation under high
            shear conditions
  JOURNAL   Cell Signal 40, 210-221 (2017)
   PUBMED   28943410
  REMARK    GeneRIF: These results indicate that Reelin is an important
            regulator of GPIb-mediated platelet activation and may represent a
            new therapeutic target for the prevention and treatment of cardio-
            and cerebrovascular diseases
REFERENCE   4  (bases 1 to 1847)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1847)
  AUTHORS   Strassel,C., Bull,A., Moog,S., Receveur,N., Mallo,L., Mangin,P.,
            Eckly,A., Freund,M., Dubart-Kupperschmitt,A., Gachet,C. and
            Lanza,F.
  TITLE     Lentiviral gene rescue of a Bernard-Soulier mouse model to study
            platelet glycoprotein Ibbeta function
  JOURNAL   J Thromb Haemost 14 (7), 1470-1479 (2016)
   PUBMED   27148783
  REMARK    GeneRIF: GPIbbeta has a repressor function in thrombus formation
            Erratum:[J Thromb Haemost. 2017 Jan;15(1):208. doi:
            10.1111/jth.13522.. PMID: 28133955]
REFERENCE   6  (bases 1 to 1847)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   7  (bases 1 to 1847)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   8  (bases 1 to 1847)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1847)
  AUTHORS   Kitaguchi,T., Murata,M., Anbo,H., Moriki,T. and Ikeda,Y.
  TITLE     Characterization of the gene encoding mouse platelet glycoprotien
            Ib beta
  JOURNAL   Thromb Res 87 (2), 235-244 (1997)
   PUBMED   9259114
REFERENCE   10 (bases 1 to 1847)
  AUTHORS   Rhim,H., Savagner,P., Thibaudeau,G., Thiery,J.P. and Pavan,W.J.
  TITLE     Localization of a neural crest transcription factor, Slug, to mouse
            chromosome 16 and human chromosome 8
  JOURNAL   Mamm Genome 8 (11), 872-873 (1997)
   PUBMED   9337409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053108.1, AA024279.1, AA222119.1 and BX631606.1.
            
            On Jul 16, 2004 this sequence version replaced NM_010327.1.
            
            Transcript Variant: This variant (2) lacks an internal segment, as
            compared to variant 1. It encodes isoform 2 which has an alternate
            N-terminus, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, C57BL/6J and C57BL/6, because no single
            transcript from the same strain was available for the full length
            of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ043921.1, AI324189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               BC053108.1         1-766
            767-844             AA024279.1         1-78
            845-1700            BC053108.1         1083-1938
            1701-1776           AA222119.1         388-463
            1777-1847           BX631606.1         6-76                c
FEATURES             Location/Qualifiers
     source          1..1847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.53 cM"
     gene            1..1847
                     /gene="Gp1bb"
                     /note="glycoprotein Ib, beta polypeptide"
                     /db_xref="GeneID:14724"
                     /db_xref="MGI:MGI:107852"
     exon            1..833
                     /gene="Gp1bb"
                     /inference="alignment:Splign:2.1.0"
     CDS             824..1444
                     /gene="Gp1bb"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; platelet glycoprotein Ib beta chain; GPIbB;
                     GPIb-beta; GP-Ib beta"
                     /codon_start=1
                     /product="platelet glycoprotein Ib beta chain isoform 2
                     precursor"
                     /protein_id="NP_034457.1"
                     /db_xref="CCDS:CCDS49787.1"
                     /db_xref="GeneID:14724"
                     /db_xref="MGI:MGI:107852"
                     /translation="MGSRPRGALSLLLLLLALLSRPASGCPAPCSCAGTLVDCGRRGL
                     TWASLPAAFPPDTTELVLTGNNLTALPPGLLDALPALRAAHLGANPWRCDCRLLPLRA
                     WLAGRPERAPYRDLRCVAPPALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVL
                     GLLHALLLALLLGRLRRLRARARARSIQEFSLTAPLVAESARGGAS"
     exon            834..1847
                     /gene="Gp1bb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gp1bb"
                     /note="hexamer: AATAAA"
     polyA_site      1701
                     /gene="Gp1bb"
                     /note="major polyA site"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gp1bb"
                     /note="hexamer: GATAAA"
     polyA_site      1847
                     /gene="Gp1bb"
ORIGIN      
        1 gcacaacctc caagatctcc cttcctagaa gatcactgcc ccccagcggg ccaataaacc
       61 agggtagagg agggacgtgg atgcaggatc ttgggcctat tacccaagct agtgctgcag
      121 agtggagttg ggaggccccc ctctgccgat tccagtgggc tacgaagcat ttgctaatgg
      181 cctactgagc gcggaagtag gccggttcct cccttactcc ctaatcatgc tctgttcagg
      241 atcggaggcg gcggggtttg gaggctaagg cctttaggaa gaccccagat ctagaggctt
      301 ctgggaggaa ggcggggccg cgatgctcta gaccgctcgc gccccttcct gagtctacct
      361 gaaggactcc aagggcggta gagacggggt gtccctatgc ctagactact ttcgtccacc
      421 cataggtcaa ggtcttttct tcccagcaac tctgttgcac aaggattcca gcccttggcc
      481 tcctccatat ctccacccgc atgattcctc cccacacacc ccatgctccg ttttgttcag
      541 ttgtgaatgc cgcgtcctgt cctggtgaca ggagaacaaa gttggtgaac gtcgcaccga
      601 gtgtccgagt gttccatgag cccctgggag cgggcggggg gacggaagcc cgggctgcct
      661 gcggccccag gcgatagtac cctatctgcc ttcgcaacgc ccttgcgcgc cggctcggag
      721 ttatttctgg ccaggcggca gaattgtggt ctgttgctgt agactcaggc aggctctcgg
      781 gccaacgcct ctccagaacg aagtaggcca ccatcctctc gccatgggct cccggccccg
      841 tggggcgctg agcctgctgc ttctgttgct agcgctgctc agccgcccag cctctggctg
      901 ccccgcgcca tgcagctgcg cagggacgct cgtggactgt gggcgccgcg ggctgacctg
      961 ggcgtcgctg ccggctgcct tccctcccga caccaccgaa ttggtgctga ccggcaacaa
     1021 cctgacggcg ctgccgcccg ggcttctgga cgcgttgcct gctctgcgcg cagcacacct
     1081 gggcgccaac ccctggcgct gcgactgccg cctattgccg ctgcgcgcct ggctggccgg
     1141 ccgcccggag cgcgcgccct accgcgacct gcgctgtgtc gcgcccccag cgctgcgcgg
     1201 ccgcttgctg ccctacgtgg cggaggatga gctgcgggcc gcgtgcgcac ccggtctact
     1261 ctgctgggga gcactggtgg cccagctagc actgctggtc ctcgggctgc tacacgcgct
     1321 gctattggca cttctactag gtcgcctgcg gaggctgcgc gcgcgtgcgc gcgcacgctc
     1381 catccaagag ttctctctca cagccccgct ggtggccgag tcggccagag gtggtgcatc
     1441 ctaagaaagg acaggcactg agcaacaagg acctgcaaac tttacaggtc cctgcaggag
     1501 gaccctcacc ttcacctgga tccgccttgg cctctaccct tgcccaacct cccagacccg
     1561 agctctgcaa gcctgaatca acatggtgcc aaactgattc cagtactacc agagtgaagc
     1621 aaccttgagt cttcagagcc tagagtgatg gaacagccca gtctcctgcc agactcctca
     1681 ctgaataaac cgttctcctc atttggcggt ttctgtacca cccgactttg ccaaattcta
     1741 gaaagggcct gagggaatgt tgttaaaagg gacataatca cttcttcaca cgctgccaaa
     1801 ctggcctagg gcaagcagga gtcgatggat aaaactccct gtaccca
//
