LOCUS       NM_010326               4660 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus glycoprotein 1b, alpha polypeptide (Gp1ba), mRNA.
ACCESSION   NM_010326
VERSION     NM_010326.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4660)
  AUTHORS   Bourne,J.H., Campos,J., Hopkin,S.J., Whitworth,K., Palis,J.,
            Senis,Y.A., Rayes,J., Iqbal,A.J. and Brill,A.
  TITLE     Megakaryocyte NLRP3 hyperactivation induces mild anemia and
            potentiates inflammatory response in mice
  JOURNAL   Front Immunol 14, 1226196 (2023)
   PUBMED   37622117
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4660)
  AUTHORS   Nording,H., Sauter,M., Lin,C., Steubing,R., Geisler,S., Sun,Y.,
            Niethammer,J., Emschermann,F., Wang,Y., Zieger,B., Nieswandt,B.,
            Kleinschnitz,C., Simon,D.I. and Langer,H.F.
  TITLE     Activated Platelets Upregulate beta2 Integrin Mac-1 (CD11b/CD18) on
            Dendritic Cells, Which Mediates Heterotypic Cell-Cell Interaction
  JOURNAL   J Immunol 208 (7), 1729-1741 (2022)
   PUBMED   35277420
REFERENCE   3  (bases 1 to 4660)
  AUTHORS   Corken,A., Ghosh,S.P., Du,R., Boerma,M., Ware,J. and Pathak,R.
  TITLE     Platelet glycoprotein Ibalpha provides radiation protection
  JOURNAL   Radiother Oncol 167, 143-148 (2022)
   PUBMED   34971661
REFERENCE   4  (bases 1 to 4660)
  AUTHORS   Xiang,B., Zhang,G., Zhang,Y., Wu,C., Joshi,S., Morris,A.J.,
            Ware,J., Smyth,S.S., Whiteheart,S.W. and Li,Z.
  TITLE     Calcium Ion Chelation Preserves Platelet Function During Cold
            Storage
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (1), 234-249 (2021)
   PUBMED   33176450
REFERENCE   5  (bases 1 to 4660)
  AUTHORS   Lohmeier,H.K., Slobodianuk,T.L., Kanaji,S., Haberichter,S.L.,
            Montgomery,R.R. and Flood,V.H.
  TITLE     von Willebrand factor variant D1472H has no effect in mice with
            humanized VWF-platelet interactions
  JOURNAL   Blood Adv 4 (17), 4065-4068 (2020)
   PUBMED   32870970
REFERENCE   6  (bases 1 to 4660)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
REFERENCE   7  (bases 1 to 4660)
  AUTHORS   Andre,P., Denis,C.V., Ware,J., Saffaripour,S., Hynes,R.O.,
            Ruggeri,Z.M. and Wagner,D.D.
  TITLE     Platelets adhere to and translocate on von Willebrand factor
            presented by endothelium in stimulated veins
  JOURNAL   Blood 96 (10), 3322-3328 (2000)
   PUBMED   11071623
REFERENCE   8  (bases 1 to 4660)
  AUTHORS   Ware,J., Russell,S. and Ruggeri,Z.M.
  TITLE     Generation and rescue of a murine model of platelet dysfunction:
            the Bernard-Soulier syndrome
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2803-2808 (2000)
   PUBMED   10706630
REFERENCE   9  (bases 1 to 4660)
  AUTHORS   Fujita,H., Hashimoto,Y., Russell,S., Zieger,B. and Ware,J.
  TITLE     In vivo expression of murine platelet glycoprotein Ibalpha
  JOURNAL   Blood 92 (2), 488-495 (1998)
   PUBMED   9657748
REFERENCE   10 (bases 1 to 4660)
  AUTHORS   Ware,J., Russell,S. and Ruggeri,Z.M.
  TITLE     Cloning of the murine platelet glycoprotein Ibalpha gene
            highlighting species-specific platelet adhesion
  JOURNAL   Blood Cells Mol Dis 23 (2), 292-301 (1997)
   PUBMED   9410473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596117.19.
            
            On Apr 25, 2018 this sequence version replaced NM_010326.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL596117.19        6486-6562
            78-4660             AL596117.19        6768-11350
FEATURES             Location/Qualifiers
     source          1..4660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.2 cM"
     gene            1..4660
                     /gene="Gp1ba"
                     /gene_synonym="GP-Ib alpha; GPIba; GPIbalpha"
                     /note="glycoprotein 1b, alpha polypeptide"
                     /db_xref="GeneID:14723"
                     /db_xref="MGI:MGI:1333744"
     exon            1..77
                     /gene="Gp1ba"
                     /gene_synonym="GP-Ib alpha; GPIba; GPIbalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            78..4660
                     /gene="Gp1ba"
                     /gene_synonym="GP-Ib alpha; GPIba; GPIbalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2288
                     /gene="Gp1ba"
                     /gene_synonym="GP-Ib alpha; GPIba; GPIbalpha"
                     /note="platelet glycoprotein Ib alpha chain; glycoprotein
                     Ibalpha"
                     /codon_start=1
                     /product="platelet glycoprotein Ib alpha chain precursor"
                     /protein_id="NP_034456.2"
                     /db_xref="CCDS:CCDS24957.1"
                     /db_xref="GeneID:14723"
                     /db_xref="MGI:MGI:1333744"
                     /translation="MALLILLFLLPSPLHSQHTCSISKVTSLLEVNCENKKLTALPAD
                     LPADTGILHLGENQLGTFSTASLVHFTHLTYLYLDRCELTSLQTNGKLIKLENLDLSH
                     NNLKSLPSLGWALPALTTLDVSFNKLGSLSPGVLDGLSQLQELYLQNNDLKSLPPGLL
                     LPTTKLKKLNLANNKLRELPSGLLDGLEDLDTLYLQRNWLRTIPKGFFGTLLLPFVFL
                     HANSWYCDCEILYFRHWLQENANNVYLWKQGVDVKDTTPNVASVRCANLDNAPVYSYP
                     GKGCPTSSGDTDYDDYDDIPDVPATRTEVKFSTNTKVHTTHWSLLAAAPSTSQDSQMI
                     SLPPTHKPTKKQSTFIHTQSPGFTTLPETMESNPTFYSLKLNTVLIPSPTTLEPTSTQ
                     ATPEPNIQPMLTTSTLTTPEHSTTPVPTTTILTTPEHSTIPVPTTAILTTPKPSTIPV
                     PTTATLTTLEPSTTPVPTTATLTTPEPSTTLVPTTATLTTPEHSTTPVPTTATLTTPE
                     HSTTPVPTTATLTTPEPSTTLTNLVSTISPVLTTTLTTPESTPIETILEQFFTTELTL
                     LPTLESTTTIIPEQNSFLNLPEVALVSSDTSESSPFLNSDFCCFLPLGFYVLGLLWLL
                     FASVVLILLLTWTWHVTPHSLDMEQSAALATSTHTTSLEVQRARQVTMPRAWLLFLQG
                     SLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLGTVGIRYSGHSL"
ORIGIN      
        1 tggctctcct tgcagctagt agagagaagg accgagtcat agcctggaag aagctctgtt
       61 cctccaaagg actgtctgtt catatggctc tcctcatctt gctcttcctg ctgccaagtc
      121 ccttgcattc ccagcacact tgtagtatct ccaaagtgac cagcctgctg gaagtaaact
      181 gtgagaacaa gaagctgaca gcactgcctg cagacctgcc agcagacaca ggcatcctcc
      241 acctgggcga gaaccaactg ggtaccttct ccacagcatc actggtgcat ttcactcacc
      301 tcacttatct gtacctggat agatgtgagc tgacgagcct gcagaccaat ggtaaactga
      361 taaagctgga aaacctggac ttatcccata ataacctgaa aagcctgccc tccctaggat
      421 gggcattgcc tgcactcact actctagacg tctccttcaa caagttgggc tcactgtctc
      481 ctggtgtcct ggatggccta agccaactcc aagagctcta cttgcagaac aatgatctta
      541 agagtctgcc ccccgggctc ttgttgccaa cgaccaagct gaagaaactc aatctggcca
      601 acaacaaatt gcgtgagctg ccctctgggc tcctagatgg gctggaggat cttgataccc
      661 tctaccttca aaggaactgg cttcgcacaa taccaaaggg cttctttggg accctcctct
      721 tgccttttgt ttttctccac gccaacagct ggtactgtga ttgtgaaatc ctctacttcc
      781 gtcactggct ccaggaaaat gccaacaatg tctacttatg gaagcagggt gtggatgtca
      841 aggacacaac tcctaacgtg gccagtgtac gatgtgccaa cttggacaat gcgcctgtct
      901 actcctaccc agggaagggc tgccctacta gtagtggtga cacagactat gatgactatg
      961 atgatatccc tgacgtccct gccacaagaa ctgaggtcaa gttctctact aacactaaag
     1021 ttcatactac ccactggagc ctactcgccg cagcaccttc tacttctcaa gacagccaaa
     1081 tgatttcttt gcctccaact cataaaccca ctaagaaaca atctacattc atccacacac
     1141 agagcccagg tttcaccaca ctcccagaga ccatggaatc taacccaacc ttctacagtc
     1201 taaaactcaa tactgtactc atcccctccc caaccaccct agagcccacc tccacccagg
     1261 ctaccccaga gcccaacatc caaccaatgc ttaccacctc caccctgact accccagagc
     1321 acagcaccac cccagtgccc actactacca tcctgacaac cccagagcac agcaccatcc
     1381 cagtgcccac tactgccatc ctgactaccc caaagcccag caccatccca gtgcccacta
     1441 ctgccaccct gactacccta gagcccagca ccaccccagt gcccactact gccaccttaa
     1501 ctaccccaga gcccagcacc accctggtac ccactactgc caccctgact accccagagc
     1561 acagcaccac cccagtgccc actactgcca ctctgactac cccagagcac agcaccaccc
     1621 cagtgcccac tactgccacc ctgactaccc cagagcccag caccacttta actaatctag
     1681 tgtccactat ctccccagtg ctcactacca ccctgaccac tccagagtct accccaattg
     1741 agacaatttt agaacaattt tttaccacag agctcacttt actccctacc ttagaatcca
     1801 ccaccacaat aatcccagag cagaacagct ttctcaatct cccagaggta gctctagtaa
     1861 gctctgatac ttctgaaagc agtccttttc tcaattctga cttttgctgc ttcctccccc
     1921 tgggcttcta tgtccttggt ctcctctggc tcctatttgc ctctgtggtc ctcatcttgt
     1981 tgctgacctg gacctggcat gtgacaccac atagtctgga catggaacaa tctgctgcat
     2041 tggccacaag cactcacacc acaagcctgg aggtgcagag ggcaaggcaa gtaactatgc
     2101 cccgggcctg gctgctcttc cttcaaggat cactccctac tttccggtct agccttttcc
     2161 tgtgggtaag gcctaatggg cgagtggggc ctctggtagc aggacggcga ccctcagctc
     2221 tgagtcaggg tcgtggtcag gacctattgg gcacagtggg cattaggtac tcaggccata
     2281 gtctgtgaca gtgagtggag atcctacgac ttcactggac tctactagga tctaactggg
     2341 atgggaggct gagacaatta caggacatcc tagccatttc tcctttatct gaagccccct
     2401 ctacatctag gcacccagat ccagacctca caaatcaaga ggtagaggtg atggaactgg
     2461 gtggtcacag gatcagcctc ccacattgag cctccactca gaacattgtc aggctacatg
     2521 gtcactacta ccactttgtg agggaaaaag ctagaaaaag caaacagaaa tggagcatgg
     2581 ctcccgctca ttcatacttg gaagaaaact tggaaagcca ttagccagga tgggagcact
     2641 atccctaaat atcatgagta ttttttccct gtttaacact ttctggtttt ctaccaatgt
     2701 tatcatttgt ataataaaaa tatttttaaa aataaaatgt agcttttggg gggaaatgag
     2761 agcggctgaa gcacctgtta caagaattcc caaagtccca actgctacca tcctgatccc
     2821 aaatacccaa caaacttgta gctgtagctg agggtggcag gtaggacacc tccaccttag
     2881 tgattcatct cctgcagagc ttggcttccc gtcaggctac ctcagtatca agtctagaat
     2941 agaaaaggct ctagagctaa agctgcctgg ctgcaggaga ggcggctatg ctcctcacat
     3001 gtgtagtctt tagaacacaa ctctccttgc tggccacgtc agtgggactg gcaaagggtg
     3061 tggcagcctg ttgggtttga gtctcctgtt ttcaaagctg gatgtaatgg catctttctc
     3121 tctcccaaaa tttcatcgat tctcccagtg aggctttctt ccacacctca ttttagttta
     3181 attcggggat tgggggccag ataagggaag gaaggttgca ctttccgggg tctatggaat
     3241 gcccttctcc agatggttct agatcttccg gtgaacctga ctcaatctct ttcctgccat
     3301 taactcttcc aagtagaaga caaatcttag aggttagcca tcagactttt cttcatggac
     3361 ttcaccttct gaaagcagtc cttttctcaa ttctgactgc tgttttctcc ccctgggctt
     3421 ctatgtcctt ggtctcctct ggctcttatt tgcctctgtg gtcctcatct tgttgctgac
     3481 ctggacctgg catgtgacac tagtgtccag cttcatctct catggtgttc accttcatct
     3541 ctcatggtac ctcatacctg aaatgtctca tgggtcacct gtgccagcag tagtcttctt
     3601 ctgagcccat cctcacttta gctaagagtt ctgcctcctt ctcagtctac ctcactacta
     3661 ccatgaacaa atctttctcc taagttgggc aagatgcagt ccactgctat agccatttcc
     3721 aaatgttctt gcatcttctt gctggacttt aaactcctta agtaaaggtg caggctccaa
     3781 atgtctccag gtggctacct agggtggcct agggcatgct gcgcatggaa ggattaagga
     3841 aagtagcggc agaggcacca ggatgttgca ctaccatctt ttttgttaag gctttgccaa
     3901 agggacagct cgcacctgct gcctgcctgt tgtctgacct ggcatacagc cctcaggctg
     3961 cctagcacgt ctcctggttt gacctttcca tagcccttta tatgccaaca agtctgtagg
     4021 atccttgaga gcctgggaat catacttctt aaaaaaatgg atgaaaagcc gggcagtggt
     4081 gcacgccttt aatcccagca cttgggaagc aaaggcaggt ggatttctta gttcgaggcg
     4141 agcctggtct acagagtgag ttccaggaca gctagggcta cacagagaaa ctctgtctca
     4201 aaaaacaaac aaaatggatg aaaaaaataa tcactttctc tagccaaccc agtttctgat
     4261 caatattctt tttgcctcaa tccttgggtt tgactccgtt atatccccca agagctctga
     4321 acctctcact caaccactgt ggctctagcc catagaagtc cagggggttt ttgttgttgc
     4381 tttggtcttt caagacaggg tttctctctg tgaccctggc tgtcctggaa ttcactttgt
     4441 agactaggct ggtcttgaac tcagaaatct gcctcctggg tgctgggata aacagcaagc
     4501 accactatgc cctgcttcaa tttagacttg ttgtcccttc cctcttgatg ctgaaaaggc
     4561 agatcccaga ggcttttcct gacaactgtg atataatttg tgagtcagcc acattttggg
     4621 acaaatggct tgcaagtatg cacaaggccc agttttttct
//
