LOCUS       NM_010325               2385 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus glutamatic-oxaloacetic transaminase 2, mitochondrial
            (Got2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_010325
VERSION     NM_010325.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Som,R., Fink,B.D., Yu,L. and Sivitz,W.I.
  TITLE     Effect of the mitochondrial transaminase (GOT2) on membrane
            potential-sensitive respiration in mitochondria of differentiated
            C2C12 muscle cells
  JOURNAL   Am J Physiol Cell Physiol 326 (6), C1669-C1682 (2024)
   PUBMED   38646781
  REMARK    GeneRIF: Effect of the mitochondrial transaminase (GOT2) on
            membrane potential-sensitive respiration in mitochondria of
            differentiated C2C12 muscle cells.
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Kerk,S.A., Lin,L., Myers,A.L., Sutton,D.J., Andren,A.,
            Sajjakulnukit,P., Zhang,L., Zhang,Y., Jimenez,J.A., Nelson,B.S.,
            Chen,B., Robinson,A., Thurston,G., Kemp,S.B., Steele,N.G.,
            Hoffman,M.T., Wen,H.J., Long,D., Ackenhusen,S.E., Ramos,J., Gao,X.,
            Nwosu,Z.C., Galban,S., Halbrook,C.J., Lombard,D.B.,
            Piwnica-Worms,D.R., Ying,H., Pasca di Magliano,M., Crawford,H.C.,
            Shah,Y.M. and Lyssiotis,C.A.
  TITLE     Metabolic requirement for GOT2 in pancreatic cancer depends on
            environmental context
  JOURNAL   Elife 11, e73245 (2022)
   PUBMED   35815941
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Qi,L., Martin-Sandoval,M.S., Merchant,S., Gu,W., Eckhardt,M.,
            Mathews,T.P., Zhao,Z., Agathocleous,M. and Morrison,S.J.
  TITLE     Aspartate availability limits hematopoietic stem cell function
            during hematopoietic regeneration
  JOURNAL   Cell Stem Cell 28 (11), 1982-1999 (2021)
   PUBMED   34450065
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   von Deimling,O.H., Groning,J. and Gaa,A.
  TITLE     Genetic and biochemical characterization of a new chymotrypsin
            isozyme of the house mouse, CTRA-1
  JOURNAL   Biochem Genet 29 (11-12), 545-557 (1991)
   PUBMED   1820020
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   White,R.A., Birkenmeier,C.S., Lux,S.E. and Barker,J.E.
  TITLE     Ankyrin and the hemolytic anemia mutation, nb, map to mouse
            chromosome 8: presence of the nb allele is associated with a
            truncated erythrocyte ankyrin
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3117-3121 (1990)
   PUBMED   2139228
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Peters,J. and Nash,H.R.
  TITLE     Polymorphism of esterase 11 in Mus musculus, a further esterase
            locus on chromosome 8
  JOURNAL   Biochem Genet 15 (3-4), 217-226 (1977)
   PUBMED   869894
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Nichols,E.A. and Ruddle,F.H.
  TITLE     Polymorphism and linkage of glutathione reductase in Mus musculus
  JOURNAL   Biochem Genet 13 (5-6), 323-329 (1975)
   PUBMED   1180875
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   Womack,J.E.
  TITLE     Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression
            and linkage relationship to oligosyndactylism (Os), esterase-1
            (Es-1), and esterase-2 (Es-2) in chromosome 8
  JOURNAL   Biochem Genet 13 (5-6), 311-322 (1975)
   PUBMED   170908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127300.3.
            
            On Feb 5, 2019 this sequence version replaced NM_010325.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152921.1, AK136556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC127300.3         10254-10438
            186-342             AC127300.3         20786-20942
            343-471             AC127300.3         22781-22909
            472-531             AC127300.3         24192-24251
            532-693             AC127300.3         26318-26479
            694-798             AC127300.3         26660-26764
            799-949             AC127300.3         27730-27880
            950-1115            AC127300.3         29018-29183
            1116-1266           AC127300.3         31684-31834
            1267-2385           AC127300.3         33404-34522
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.79 cM"
     gene            1..2385
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /note="glutamatic-oxaloacetic transaminase 2,
                     mitochondrial"
                     /db_xref="GeneID:14719"
                     /db_xref="MGI:MGI:95792"
     exon            1..185
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            186..342
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            343..471
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            472..531
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            532..693
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            694..798
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            799..949
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1115
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1266
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..2385
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /note="hexamer: AATAAA"
     polyA_site      2383
                     /gene="Got2"
                     /gene_synonym="FABP-pm; Got-2; Kyat4; mAspAT"
                     /note="major polyA site"
ORIGIN      
        1 actgtcctca ccttttagga gcccgcgcct cggttccagc ggacgcttcc ccagatctcg
       61 gctctaccac catccactgc cgtcttaccg cccaccatgg ccctcctgca ctccagccgc
      121 atcctctccg ggatggctgc tgcctttcac ccaggcctag ctgctgcagc ctctgccaga
      181 gccagctcct ggtggaccca tgttgaaatg ggacctccag atcccatcct gggcgttacc
      241 gaagccttca agagagatac caacagcaag aagatgaacc tgggagttgg tgcctaccgg
      301 gatgataacg gaaaacctta cgtgctcccc agtgtccgga aggcagaggc ccagattgct
      361 gcaaaaaatt tggacaaaga atacctgccc attgggggac tggctgaatt ctgtaaggct
      421 tctgcagaac tggccctggg cgagaacaat gaagtgttga aaagcggccg gttcgtcact
      481 gtgcagacca tttccgggac tggagcctta agggtcgggg ccagttttct gcaaaggttt
      541 tttaagttca gccgagatgt ctttctgccc aaaccatcct ggggaaatca cacgcccatc
      601 ttcagggatg ccggcatgca gctccaaggt tatcgctact atgaccccaa gacttgcggt
      661 tttgacttct ctggagccct agaagacata tcaaaaatcc cagagcagag tgtcctcctc
      721 ctgcatgcct gcgctcacaa ccccaccggc gtggacccgc gtcccgagca gtggaaggag
      781 atagcgtccg tggtgaagaa aaagaatctc ttcgcattct ttgacatggc ctaccaaggc
      841 tttgccagcg gtgatggtga taaggatgcc tgggccgtgc ggcacttcat cgagcagggc
      901 atcaatgtct gcctctgcca atcgtatgcc aagaacatgg gcctgtacgg tgagcgtgtg
      961 ggagccttca cggtggtctg caaagatgca gaagaagcca aaagggtgga gtcacagctg
     1021 aagatcttga tccgtcccct gtattccaac ccacctctca atggggcccg gatcgcagca
     1081 accatcctga cttctccaga cttgcggaag caatggttgc aagaggtgaa aggcatggct
     1141 gaccgcatca tcagcatgag gacccagctg gtctccaacc tgaagaaaga gggctcttcc
     1201 cacaactggc agcacatcac cgaccagatc ggcatgttct gtttcaccgg cctaaagcca
     1261 gagcaggtag agcggctgac caaggagttc tcggtctaca tgacaaagga tggccgaatc
     1321 tccgtggcag gggtcacctc tggcaatgtg ggctaccttg cccatgccat tcaccaggtc
     1381 accaagtaat tcccaggtgc aaaggaacag agaccacttt cccgacagcc tttgcgctcg
     1441 tgagcgtcac gtgcagggtg agggagggtg ggtggtggtg aatagatccg gtttccaacc
     1501 acggtgcata actcagcgac tgaactcgct cctcggaaga gaggtagggc agaggcttcc
     1561 tcggctggta tctggaactt cgtcggctct aaaccaaact ccctcatcct tttgtctcca
     1621 gcttttctga aagtttacac acgcaagaaa aatcacagca ccaaacacct gtcagccatg
     1681 gcactggaat aggtcagacg ctttacctaa agcctcaggt ggtatcaggg gctcccccgt
     1741 ggaccccagt agagcctccc ctaatagagg ctataagaga aaaataacta gttctgtcat
     1801 taacagttgt cctcaagttc gtcctcttgg tgtggagcaa actgtgtcag cagaccacat
     1861 tacagaaatt atgctttaca aaaaccaaca ggtctgttgc cacttcaaca gggacagtag
     1921 aagatgtagt gtcgtgtccg cctgcccctt gtcattgctg ttctagagcc tagagtctca
     1981 tcccgttcta ctgcaaacat ccgcctcagc ctatgggggg agttacataa gaatggagag
     2041 cataggtttt ctgctcctgc atagcctcct ctctcatcaa agagccgtgg agagagagag
     2101 accctgccct tgatttcaga gtcctcttca gtcattgatt gattggctcc tactgggatg
     2161 gggcctctgc ccagctggac ctcttcatcc atcctggctg cacagcctgt ctcttcacat
     2221 gagtcagacg tgcagggtag gatcagaagg agatactctg gggtttgtgt gctgccagcc
     2281 cggctcagac tccgcccttg ggaaagataa ccaccatctg ctctaatcat gtagacgtac
     2341 tgccgcctgg tttctctgtt acaataaaat tactatagac ccagc
//
