LOCUS       NM_010324               2065 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus glutamic-oxaloacetic transaminase 1, soluble (Got1),
            mRNA.
ACCESSION   NM_010324 XM_915726
VERSION     NM_010324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Zhang,L., Wu,Z., Qiu,X., Zhang,J. and Cheng,S.C.
  TITLE     Glutamate oxaloacetate transaminase 1 is dispensable in macrophage
            differentiation and anti-pathogen response
  JOURNAL   Commun Biol 7 (1), 817 (2024)
   PUBMED   38965342
  REMARK    GeneRIF: Glutamate oxaloacetate transaminase 1 is dispensable in
            macrophage differentiation and anti-pathogen response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Weisshaar,N., Ma,S., Ming,Y., Madi,A., Mieg,A., Hering,M.,
            Zettl,F., Mohr,K., Ten Bosch,N., Stichling,D., Buettner,M.,
            Poschet,G., Klinke,G., Schulz,M., Kunze-Rohrbach,N., Kerber,C.,
            Klein,I.M., Wu,J., Wang,X. and Cui,G.
  TITLE     The malate shuttle detoxifies ammonia in exhausted T cells by
            producing 2-ketoglutarate
  JOURNAL   Nat Immunol 24 (11), 1921-1932 (2023)
   PUBMED   37813964
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Xu,W., Patel,C.H., Zhao,L., Sun,I.H., Oh,M.H., Sun,I.M.,
            Helms,R.S., Wen,J. and Powell,J.D.
  TITLE     GOT1 regulates CD8+ effector and memory T cell generation
  JOURNAL   Cell Rep 42 (1), 111987 (2023)
   PUBMED   36640309
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Mehrazad Saber,Z., Takeuchi,Y., Sawada,Y., Aita,Y., Ho,M.H.,
            Karkoutly,S., Tao,D., Katabami,K., Ye,C., Murayama,Y., Shikama,A.,
            Masuda,Y., Izumida,Y., Miyamoto,T., Matsuzaka,T., Sugasawa,T.,
            Takekoshi,K., Kawakami,Y., Shimano,H. and Yahagi,N.
  TITLE     High protein diet-induced metabolic changes are transcriptionally
            regulated via KLF15-dependent and independent pathways
  JOURNAL   Biochem Biophys Res Commun 582, 35-42 (2021)
   PUBMED   34688045
  REMARK    GeneRIF: High protein diet-induced metabolic changes are
            transcriptionally regulated via KLF15-dependent and independent
            pathways.
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Youngblood,G.L., Sartorius,C., Taylor,B.A. and Payne,A.H.
  TITLE     Isolation, characterization, and chromosomal mapping of mouse P450
            17 alpha-hydroxylase/C17-20 lyase
  JOURNAL   Genomics 10 (1), 270-275 (1991)
   PUBMED   1840559
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Taylor,B.A. and Rowe,L.
  TITLE     A mouse linkage testing stock possessing multiple copies of the
            endogenous ecotropic murine leukemia virus genome
  JOURNAL   Genomics 5 (2), 221-232 (1989)
   PUBMED   2571572
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Sekine,M., Sakaizumi,M., Moriwaki,K., Yamakawa,T. and Suzuki,A.
  TITLE     Two genes controlling the expression of extended globoglycolipids
            in mouse kidney are closely linked to each other on chromosome 19
  JOURNAL   J Biochem 105 (5), 680-683 (1989)
   PUBMED   2787792
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Horio,Y., Tanaka,T., Taketoshi,M., Uno,T. and Wada,H.
  TITLE     Rat cytosolic aspartate aminotransferase: regulation of its mRNA
            and contribution to gluconeogenesis
  JOURNAL   J Biochem 103 (5), 805-808 (1988)
   PUBMED   3182750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK334037.1, AK147807.1, AK146445.1, BY441762.1 and AV574373.1.
            
            On Nov 14, 2007 this sequence version replaced NM_010324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002057.1, J02623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                CK334037.1         1-80
            81-102              AK147807.1         2-23
            103-2050            AK146445.1         5-1952
            2051-2055           BY441762.1         381-385
            2056-2065           AV574373.1         213-222
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..2065
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /note="glutamic-oxaloacetic transaminase 1, soluble"
                     /db_xref="GeneID:14718"
                     /db_xref="MGI:MGI:95791"
     exon            1..268
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..450
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..574
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..687
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..792
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..943
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1109
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1252
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..2058
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /note="hexamer: AATAAA"
     polyA_site      2058
                     /gene="Got1"
                     /gene_synonym="cAspAT; cCAT; Got-1"
                     /note="major polyA site"
ORIGIN      
        1 cgttgccaag ctccggacgc ggctcgacca ttggaagccg cgggctgccc cgcccgccgg
       61 cgaaggtgag agtctcctcc agtcaccgga ccccgcaccg cacagagctg ctcccggctc
      121 gttctcgagg tctcggcaca ttctgtcgcg atggcgcctc catcagtctt tgcccaggtt
      181 ccgcaagctc ctccggttct ggtctttaag ctcactgcgg acttccggga tgatccagat
      241 ccccgcaagg ttaacctcgg cgtgggagcg taccgcacag atgaatctca gccctgggtt
      301 ttgccagtag tgaggaaggt cgaacagaag attgctaacg acaacagcct caaccacgag
      361 tacctgccca tcctgggcct ggcagagttc cggagctgtg cttctcgcct agttcttggg
      421 gacaacagcc tggctatcag ggagaatcgg gttggagggg tgcagtcttt gggagggaca
      481 ggcgctcttc ggattggagc tgacttctta gggcgatggt acaatggtac agataacaag
      541 aacacaccaa tctacgtatc atcaccaacc tgggagaacc ataatgctgt gttttctgcc
      601 gccggtttta aggacattcg gccctattgc tactgggatg cggagaagag aggactggac
      661 ctccagggtt tcctgaatga tctggagaat gcccccgagt tctccatctt tgtcctccat
      721 gcctgtgcgc acaacccaac agggaccgac ccgactccag agcagtggaa gcagatcgct
      781 gctgtcatgc agcgccgttt tctgttcccc ttctttgact cagcctatca gggctttgca
      841 tctggagacc tagagaaaga tgcgtgggct attcgctatt ttgtgtctga aggcttcgag
      901 ctcttctgtg cccagtcctt ctccaagaac ttcgggctct acaatgagag agtggggaat
      961 ctgaccgtgg tcggaaaaga gtctgacagc gtcctgcggg tcctttccca gatggagaag
     1021 attgtacgaa tcacctggtc caatccccca gcccaaggag ctcggattgt ggccgccacc
     1081 ctctctgacc cggagctctt taaggagtgg aaaggtaacg tgaagacaat ggctgaccgg
     1141 attctgacca tgagatccga actcagggca agactagaag ctctcaagac ccccgggact
     1201 tggtctcaca tcactgagca gattggaatg ttcagtttca ccggcttgaa ccccaagcag
     1261 gtcgagtatt tggtcaacga gaagcatatc tatctcctgc cgagtggtcg gatcaacatg
     1321 tgcggcttga ccaccaagaa cctagattac gtcgctacct ccatccatga agccgtcacc
     1381 aaaatccagt gaagaaacac ctcgtagttc acgccaccaa agcagttctt gtcacacctt
     1441 tcctgcctgc gcaaacctag ctgtacctag ctgtacacgt cctttattag agatgaccga
     1501 ggggaagcag ctgctgttta gctgaccccc cacatgagaa gacgtttctt gaaatgagcc
     1561 ccgggggctc tggggttaga gcctgttgga aaccagagta gattaaagtt atttaagaat
     1621 aaaaagaact ttggctatga gatgtaatca ccttgccttc ctctctagca ttctgcagga
     1681 gtgatgccca cggagccttg ggcttctgcg tgttgcctga ctgtacaaaa gtctagtctc
     1741 aaagatcaag ttggtctgag gagccggatg tgactgtggg tgttggctgg ggcattaaaa
     1801 ctcatcatcg ccacccatct ctgtctctcg tcaccctgat ctccccgcac ggttgtgtcc
     1861 ctggtctgga acattagttt ttttaaggca actgtggcca atatttatat catgacatac
     1921 aaatggattt acgtatttga ctgaaatgaa agttccacta aacggtattt gctcttgtga
     1981 tatgtggcac attgtgatat tttcttagtc tgttctgttt tatttaaaaa ataaaactgc
     2041 tgatcaagac aagtgaaaaa aaaaa
//
