LOCUS       NM_019650               3091 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus golgi SNAP receptor complex member 2 (Gosr2),
            transcript variant 1, mRNA.
ACCESSION   NM_019650
VERSION     NM_019650.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Praschberger,R., Lowe,S.A., Malintan,N.T., Giachello,C.N.G.,
            Patel,N., Houlden,H., Kullmann,D.M., Baines,R.A., Usowicz,M.M.,
            Krishnakumar,S.S., Hodge,J.J.L., Rothman,J.E. and Jepson,J.E.C.
  TITLE     Mutations in Membrin/GOSR2 Reveal Stringent Secretory Pathway
            Demands of Dendritic Growth and Synaptic Integrity
  JOURNAL   Cell Rep 21 (1), 97-109 (2017)
   PUBMED   28978487
  REMARK    GeneRIF: Mutations in GOSR2 reveal stringent secretory pathway
            demands of dendritic growth and synaptic integrity.
REFERENCE   3  (bases 1 to 3091)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3091)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3091)
  AUTHORS   Juriloff,D.M., Harris,M.J., Dewell,S.L., Brown,C.J., Mager,D.L.,
            Gagnier,L. and Mah,D.G.
  TITLE     Investigations of the genomic region that contains the clf1
            mutation, a causal gene in multifactorial cleft lip and palate in
            mice
  JOURNAL   Birth Defects Res A Clin Mol Teratol 73 (2), 103-113 (2005)
   PUBMED   15690355
REFERENCE   6  (bases 1 to 3091)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Dewell,S.L.
  TITLE     A digenic cause of cleft lip in A-strain mice and definition of
            candidate genes for the two loci
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (8), 509-518 (2004)
   PUBMED   15329828
REFERENCE   7  (bases 1 to 3091)
  AUTHORS   Xu,Y., Wong,S.H., Tang,B.L., Subramaniam,V.N., Zhang,T. and Hong,W.
  TITLE     A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor
            attachment protein receptor (Vti1-rp2) implicated in protein
            trafficking in the secretory pathway
  JOURNAL   J Biol Chem 273 (34), 21783-21789 (1998)
   PUBMED   9705316
REFERENCE   8  (bases 1 to 3091)
  AUTHORS   Lowe,S.L., Peter,F., Subramaniam,V.N., Wong,S.H. and Hong,W.
  TITLE     A SNARE involved in protein transport through the Golgi apparatus
  JOURNAL   Nature 389 (6653), 881-884 (1997)
   PUBMED   9349823
REFERENCE   9  (bases 1 to 3091)
  AUTHORS   Hay,J.C., Chao,D.S., Kuo,C.S. and Scheller,R.H.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627252.16 and AK005697.1.
            
            On May 1, 2018 this sequence version replaced NM_019650.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051253.1, AK150004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL627252.16        107607-107642       c
            37-843              AK005697.1         2-808
            844-3091            AL627252.16        86768-89015         c
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.43 cM"
     gene            1..3091
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /note="golgi SNAP receptor complex member 2"
                     /db_xref="GeneID:56494"
                     /db_xref="MGI:MGI:1927204"
     exon            1..94
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..704
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /note="isoform 1 is encoded by transcript variant 1; golgi
                     SNARE; 27 kDa Golgi SNARE protein"
                     /codon_start=1
                     /product="Golgi SNAP receptor complex member 2 isoform 1"
                     /protein_id="NP_062624.2"
                     /db_xref="CCDS:CCDS25521.1"
                     /db_xref="GeneID:56494"
                     /db_xref="MGI:MGI:1927204"
                     /translation="MEPLYQQTNKQVQEIQSHMGRLERADKQSVHLVENEIQASIEQI
                     FSHLERLEILSSKEPLNRRQNAKLRVDQLKYDVQHLQTALRNFQHRRQVREQQERQRD
                     ELLSRTFTTNDSDTTIPMDESLQFNSSLHNIHHGMDDLIGGGHSILEGLRAQRLTLKG
                     TQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCAVMFLVVQYLT"
     exon            95..159
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            160..268
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            269..401
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            402..542
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            543..3091
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3056..3061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="Gosr2"
                     /gene_synonym="2310032N09Rik; Gs27; membrin; SNARE"
                     /note="major polyA site"
ORIGIN      
        1 ggaagccgga agtggggttg tgaggacgtg ttccgaggaa gccgcaggcc ggctaggccg
       61 gcgtcatgga gcccctatac caacaaacga acaagcaggt tcaggagatc cagtctcaca
      121 tgggacgcct ggagagggca gacaagcagt ctgtgcactt agtagaaaat gagatccaag
      181 caagcataga gcaaatattc agccatctgg agcgcctgga gattttgtca agcaaggagc
      241 ccttgaatag aagacagaat gccaaactcc gtgtcgacca gctaaagtat gatgtccagc
      301 acttgcagac tgccctcagg aactttcagc accggcgcca agtcagggag cagcaggaga
      361 gacagcgaga cgagcttctg tctcgcacct tcaccactaa cgactctgac accaccattc
      421 ccatggatga atcactgcag tttaactcct ccctccacaa cattcaccac ggcatggatg
      481 acctcattgg aggcgggcac agtattctgg agggactgag ggcccagaga ctgaccttga
      541 aggggactca gaagaagatc cttgacattg ctaacatgct cggcttgtcc aacacagtga
      601 tgaggctgat tgagaagcgg gccttccagg acaagtactt catgatcggt gggatgctgc
      661 tcacttgtgc agtcatgttc ctcgtggtac agtacctgac atgagccagc tgtacccagc
      721 actggacagc cttcccattg tgtgcgcatg tgcaagcaag aagtgggctg ggaggccctt
      781 ttgaaatgta tgccttaact gtgaagacac ctctcccctc aggactaatc gtggcttagt
      841 atcaaacctg ctttgttttc tgtgacatct ggggagtagg accttgggtc accaagacgt
      901 gtggtgctta ggaagtgggt caagaccctg ttctctggct ttcattgggg gagggatggc
      961 tgggttttgt ggtttgtcca catagctgat gcttgccctg gaaagcgtgc atggtgaggc
     1021 ttttacacag gactgtccac actattcact cctgatggag tgggctggag cacaagtgag
     1081 aagatgagga gagaggtctt tccctgtgcc ctctgggata gatcagttct cacatccttg
     1141 cttctagcca ctggctggcc ccagccccta agaaaacatg acatgtaggt gactaactgc
     1201 taacaccagc accctttcct ggaagcagct actccaggga agcagagaca tcagtgctgc
     1261 tgctgataat gcaagtgttt ccatgccatg gttgctgggt gtttgtcagt gtcccaggga
     1321 gtgttcagtc tggacacgga agccctgagt caccaatgtt ttccagttaa tacggcagtg
     1381 gctcttacag ttcagagacg gtagcttggc acctgcaccc aggctttgac agatgggcct
     1441 ttgccacttt gaaagtagcc atgagcaatg ggcgacttgt cagctgcaga ttcatctagt
     1501 tctgccctct caagttcttt gactatctac cccttgaaac atattagcaa tatatcaatc
     1561 agctaagcct ccattttccc cagccctttc aggccaccct ggggatgtcc ctgggaagtg
     1621 tgtttttgtg agactttcag ggaccagagc atttttactt tttgattgag gctgtgtcag
     1681 tacctggtgc aatgcagaat ttgtgtgagg gttaatgtat cttgagcaca cattgtatta
     1741 atctctgcaa gtactagaac gatctagtga gtttatttgt tcatcagtca caggccctgt
     1801 ccacccaaac agttctaaat ttagtagcct cctagtagga aaaacatgcc agaactccta
     1861 agaactggaa actggtcagt attaatccat cctttgattg ccctacctac ttcctatgtt
     1921 tgcttaagcg tcctctgctg tctccctctt cacagtaggt gttacgtctc acccttcccc
     1981 ttgtgtagcc gtattggtct ctcgggtaca tctgtggcat ccttttgggg aactttatca
     2041 actatacaca ctttaaactt gagtttcctg ggtattagct cagttctggt cagatgcaat
     2101 gtctgttgct ctttccctgt aggttaaatg tgccatagct ggtcagaaag ggggaatgtg
     2161 ccccctctag tcctgcagag tggaaacagt ggccctagag acaggagacc tgcagcatct
     2221 ccacacctcg atctcacttt ggggaggcag atgggcatgg gcttttggct ggccatagag
     2281 tttgtactgc acagacctga ctcctgtgcc ccctggcacc tgaagatccc accagacagc
     2341 atgctttgga agatgtacaa gctgtaattg agccatttga actcaaaatg tgggcagcaa
     2401 aggccctagc ccctgccctt cattggctgt tggagcagtg ttttgtagta cataatgggt
     2461 ttccaccttt gtagcagtcc ttggctttag tgaacttgat gttccacctt cacagccagg
     2521 tctccctttg gaatgaattt gtggtgaggt cagcactact gcctgggggc agggaatgga
     2581 cgcagaggat ctggactcaa ggggcattga gctggttgcc caggctgccc tccctcaaat
     2641 ttccattcag tgccttgtga gatgactctg acctgattgg gcaaactgtc cttacaggct
     2701 ccagcaggga agggccccta gcctgagtgg gatgccctct agtggaggag gcctgcatcc
     2761 ttatcagagc ttgtcagaag ctgcagctag cagatgatgt gtgcaccttg gtacagtcgt
     2821 ctaagtgaca gggtttgaag ctagtagggt gccagaagga atctaagact aagaaaatag
     2881 atgtattctc catgtatggc cacttgaagg aatgctaaat ccaaggacca agtaaatagt
     2941 aggttttaca ggtttcattt caagcttttt ctcaaaagcc agcttgcctt gttgaattta
     3001 aatagctttg attggcaatt tatttacacc ccttgttttc agaacatgtc agctgaataa
     3061 agttgaggtt tatttagaaa actttaaaga a
//
