LOCUS       NM_178883               2559 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus golgin, RAB6-interacting (Gorab), transcript variant
            1, mRNA.
ACCESSION   NM_178883
VERSION     NM_178883.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Liu,Y., Chen,X., Choi,Y.J., Yang,N., Song,Z., Snedecor,E.R.,
            Liang,W., Leung,E.L., Zhang,L., Qin,C. and Chen,J.
  TITLE     GORAB promotes embryonic lung maturation through antagonizing AKT
            phosphorylation, versican expression, and mesenchymal cell
            migration
  JOURNAL   FASEB J 34 (4), 4918-4933 (2020)
   PUBMED   32067289
  REMARK    GeneRIF: GORAB promotes embryonic lung maturation through
            antagonizing AKT phosphorylation, versican expression, and
            mesenchymal cell migration.
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Chan,W.L., Steiner,M., Witkos,T., Egerer,J., Busse,B., Mizumoto,S.,
            Pestka,J.M., Zhang,H., Hausser,I., Khayal,L.A., Ott,C.E.,
            Kolanczyk,M., Willie,B., Schinke,T., Paganini,C., Rossi,A.,
            Sugahara,K., Amling,M., Knaus,P., Chan,D., Lowe,M., Mundlos,S. and
            Kornak,U.
  TITLE     Impaired proteoglycan glycosylation, elevated TGF-beta signaling,
            and abnormal osteoblast differentiation as the basis for bone
            fragility in a mouse model for gerodermia osteodysplastica
  JOURNAL   PLoS Genet 14 (3), e1007242 (2018)
   PUBMED   29561836
  REMARK    GeneRIF: Gorab role in the abnormal osteoblast differentiation in
            the gerodermia osteodysplastica
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Yang,H., Albiol,L., Chan,W.L., Wulsten,D., Seliger,A., Thelen,M.,
            Thiele,T., Spevak,L., Boskey,A., Kornak,U., Checa,S. and
            Willie,B.M.
  TITLE     Examining tissue composition, whole-bone morphology and mechanical
            behavior of GorabPrx1 mice tibiae: A mouse model of premature aging
  JOURNAL   J Biomech 65, 145-153 (2017)
   PUBMED   29108851
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Liu,Y., Snedecor,E.R., Choi,Y.J., Yang,N., Zhang,X., Xu,Y., Han,Y.,
            Jones,E.C., Shroyer,K.R., Clark,R.A., Zhang,L., Qin,C. and Chen,J.
  TITLE     Gorab Is Required for Dermal Condensate Cells to Respond to
            Hedgehog Signals during Hair Follicle Morphogenesis
  JOURNAL   J Invest Dermatol 136 (2), 378-386 (2016)
   PUBMED   26967474
  REMARK    Review article
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Lai,C., Lin,X., Chandran,J., Shim,H., Yang,W.J. and Cai,H.
  TITLE     The G59S mutation in p150(glued) causes dysfunction of dynactin in
            mice
  JOURNAL   J Neurosci 27 (51), 13982-13990 (2007)
   PUBMED   18094236
  REMARK    GeneRIF: The G59S mutation in p150(glued) protein abrogates the
            normal function of the protein and accelerates motor neuron
            degeneration.
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Gauthier,L.R., Charrin,B.C., Borrell-Pages,M., Dompierre,J.P.,
            Rangone,H., Cordelieres,F.P., De Mey,J., MacDonald,M.E.,
            Lessmann,V., Humbert,S. and Saudou,F.
  TITLE     Huntingtin controls neurotrophic support and survival of neurons by
            enhancing BDNF vesicular transport along microtubules
  JOURNAL   Cell 118 (1), 127-138 (2004)
   PUBMED   15242649
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Di,Y., Li,J., Fang,J., Xu,Z., He,X., Zhang,F., Ling,J., Li,X.,
            Xu,D., Li,L., Li,Y.Y. and Huo,K.
  TITLE     Cloning and characterization of a novel gene which encodes a
            protein interacting with the mitosis-associated kinase-like protein
            NTKL
  JOURNAL   J Hum Genet 48 (6), 315-321 (2003)
   PUBMED   12783284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848512.1, AK169151.1 and CK626643.1.
            
            On Sep 1, 2015 this sequence version replaced NM_178883.5.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043953.1, AK169151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BB848512.1         2-37
            37-2539             AK169151.1         2-2504
            2540-2559           CK626643.1         585-604
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.67 cM"
     gene            1..2559
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="golgin, RAB6-interacting"
                     /db_xref="GeneID:98376"
                     /db_xref="MGI:MGI:2138271"
     exon            1..147
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1193
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SCY1-like 1 binding protein 1; RAB6-interacting golgin;
                     NTKL-binding protein 1; SCYL1-binding protein 1;
                     N-terminal kinase-like-binding protein 1"
                     /codon_start=1
                     /product="RAB6-interacting golgin isoform 1"
                     /protein_id="NP_849214.2"
                     /db_xref="CCDS:CCDS15429.1"
                     /db_xref="GeneID:98376"
                     /db_xref="MGI:MGI:2138271"
                     /translation="MAQDWAGFSEEELRRLKQNKDPFEPQRRIPVKKTRQQLQREKAL
                     LEQSQKLGLQDGSASLLPEQLLSAPKQRANSQKPRSPSPVAPSPLTPTSSSGDGKLPG
                     VGSQPQEPGLENSHHGHKSAEVRAPKPDCKVEKKKMELQEKSRWEVLQQEQRLMEEKN
                     KRKKALLAQAIAERSKKTQAETIKLKRIQKELQALDDMVSADIGILRNRIDQASLEYS
                     YARKRFDRAEAEYITAKLDLQRKTETKEQLTEHLCTIIQQNELRKAKKLEELMQQLDV
                     QADEEALQLEVEVEQLLREQEAEAAKQMASVERLCPPDGESVSSELAEENNEPQKQAP
                     SPETDKPGKCCSSSPHRLDCPDPGAKNFSAAVAT"
     exon            148..505
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..607
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..748
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..2543
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="hexamer: AATAAA"
     polyA_site      2538
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaaccc ggatgtgcct gtggagctgt gttggcagtc tgcgcgcgga gatttgggca
       61 ctctttgggt gcccagggct aggcggatgg ctcaggattg ggcgggcttc tctgaggaag
      121 agctgaggag actaaagcag aataaagatc catttgaacc tcagcgtcga attcctgtga
      181 agaaaactcg acaacagctt cagcgtgaaa aagcccttct agagcagagc caaaagcttg
      241 gcctccaaga tgggtcagcc tcattgcttc cagagcagct gctctctgca cccaaacaga
      301 gagctaacag tcaaaagcca cgctctcctt cccctgtggc ccccagtccc ctcacaccca
      361 cctcttcctc tggcgatgga aagctacctg gtgttggaag tcagccccaa gaaccaggac
      421 ttgagaattc ccaccatggt cacaaaagtg ccgaggttcg agctccaaag ccagattgca
      481 aagtggagaa aaagaaaatg gaattgcaag agaaatctcg ttgggaagtc ctccaacaag
      541 aacagcgact aatggaagag aaaaataaac gtaagaaagc ccttttggct caagccattg
      601 cggaaagatc taagaagacc caagcagaga ccataaaact aaagaggatc cagaaggagt
      661 tgcaggcctt agacgacatg gtgtcagctg acattggcat cctcaggaac agaatcgacc
      721 aggccagcct ggagtattcc tacgcacgga agcgctttga tagagctgaa gctgagtaca
      781 ttacagcaaa gctggattta cagcgcaaaa ccgagacgaa agagcagctc accgaacacc
      841 tctgcaccat catccagcag aacgagctcc gaaaggccaa gaagctggag gagctgatgc
      901 agcagctgga cgtgcaggct gatgaggagg ctttgcaact cgaggtggag gttgaacagt
      961 tgcttcggga acaggaagca gaggcagcca aacaaatggc ttctgtagag aggctgtgtc
     1021 cgcctgatgg cgagagtgtg tcttcagaac tggctgaaga gaacaatgag cctcaaaagc
     1081 aagctccttc cccagagaca gacaagccag gcaaatgttg cagtagctct ccccatagac
     1141 tagactgccc agatccagga gccaagaact tttcagctgc tgtggccaca tgagcggcca
     1201 gtgttttttc agttaatatc tctgcggtaa attatagctt gtctctgatc aaacttcttt
     1261 caactcattt gtgtttgaat caatgcttag tgatagtatg ttagcatgtc agatcattcc
     1321 aaagtcagaa gtagtgactg tttcctatcc agggagtgtt gacccctcga agttggggtt
     1381 ccttcaagcc ttgtcactga gttagaatag gtgactcaca gggtgggagt gctcggggcc
     1441 ctgggtttga ccttcaacac tacaagcaca gtggtagaag aaaaactaca tggcttctta
     1501 gcccttggcc aaacttaact tgtgagagaa ctgggtttga ccttaaacac tacaaaccaa
     1561 gcacagtggt agaagaaaaa ctacatgact tcttagtcct tggccaaact taacttgtga
     1621 gagaacactg agactttgtg gccttctatg tagtcattaa aaagacaaca attcttatat
     1681 acagagagaa ggagagaaaa aacgggttaa cttacctacc cggatgctac tagagtgagt
     1741 agacacaagt tggaagacaa cctaagccaa cattattttc cctttacttt gtcagtaaat
     1801 ggtttctcgt tcccacctga attgtggcta gttgatccac atccatagat aagctgtgaa
     1861 tgtgtggctt tacctttact ttcttctgtt ttccttaatg agtggacagg gaaactttag
     1921 acaatgaaaa tgtttctaaa gtgactctga gagtggcaag tctcattgat tatccaacaa
     1981 tgatgtattc tctcgctgaa gctctgtaat gtggatattt atatgtcagg tattgcttct
     2041 tctgtcatga agcattgaaa tcgttaaagc actcattttc taattgcttt catagtttgt
     2101 caatcacctg ttcccaaaaa cttgactggt gcattgtgct agatttgaat gtgtataaat
     2161 gtcttagttt tgccacaaat attaccttaa attatcgatt tctcagaaat cacaaaaaat
     2221 gaaaaatgtg tttcattcat aaaaaaggag ctgtatttta aaggagataa agacagctgt
     2281 ttccataata cattgtagaa acgttaggga tgtcctattt ttagactatt gtctaagaca
     2341 tcttctgata gtaaggatgc tttgtatttt tttctatgat ctgagccaca agtataattg
     2401 tccattactg atttctaaac acaagcattt atttccatag tgttgttttt atttatgaat
     2461 gagacgcata caaatttaaa acttcattgc ccaatacagt cttatttttc taaggaataa
     2521 acaagtctga taagtttaca gtaaaaaaaa aaaaaaaaa
//
