LOCUS       NM_001313738            2563 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus golgin, RAB6-interacting (Gorab), transcript variant
            2, mRNA.
ACCESSION   NM_001313738 XM_006497069
VERSION     NM_001313738.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Liu,Y., Chen,X., Choi,Y.J., Yang,N., Song,Z., Snedecor,E.R.,
            Liang,W., Leung,E.L., Zhang,L., Qin,C. and Chen,J.
  TITLE     GORAB promotes embryonic lung maturation through antagonizing AKT
            phosphorylation, versican expression, and mesenchymal cell
            migration
  JOURNAL   FASEB J 34 (4), 4918-4933 (2020)
   PUBMED   32067289
  REMARK    GeneRIF: GORAB promotes embryonic lung maturation through
            antagonizing AKT phosphorylation, versican expression, and
            mesenchymal cell migration.
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Chan,W.L., Steiner,M., Witkos,T., Egerer,J., Busse,B., Mizumoto,S.,
            Pestka,J.M., Zhang,H., Hausser,I., Khayal,L.A., Ott,C.E.,
            Kolanczyk,M., Willie,B., Schinke,T., Paganini,C., Rossi,A.,
            Sugahara,K., Amling,M., Knaus,P., Chan,D., Lowe,M., Mundlos,S. and
            Kornak,U.
  TITLE     Impaired proteoglycan glycosylation, elevated TGF-beta signaling,
            and abnormal osteoblast differentiation as the basis for bone
            fragility in a mouse model for gerodermia osteodysplastica
  JOURNAL   PLoS Genet 14 (3), e1007242 (2018)
   PUBMED   29561836
  REMARK    GeneRIF: Gorab role in the abnormal osteoblast differentiation in
            the gerodermia osteodysplastica
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Yang,H., Albiol,L., Chan,W.L., Wulsten,D., Seliger,A., Thelen,M.,
            Thiele,T., Spevak,L., Boskey,A., Kornak,U., Checa,S. and
            Willie,B.M.
  TITLE     Examining tissue composition, whole-bone morphology and mechanical
            behavior of GorabPrx1 mice tibiae: A mouse model of premature aging
  JOURNAL   J Biomech 65, 145-153 (2017)
   PUBMED   29108851
REFERENCE   4  (bases 1 to 2563)
  AUTHORS   Liu,Y., Snedecor,E.R., Choi,Y.J., Yang,N., Zhang,X., Xu,Y., Han,Y.,
            Jones,E.C., Shroyer,K.R., Clark,R.A., Zhang,L., Qin,C. and Chen,J.
  TITLE     Gorab Is Required for Dermal Condensate Cells to Respond to
            Hedgehog Signals during Hair Follicle Morphogenesis
  JOURNAL   J Invest Dermatol 136 (2), 378-386 (2016)
   PUBMED   26967474
  REMARK    Review article
REFERENCE   5  (bases 1 to 2563)
  AUTHORS   Lai,C., Lin,X., Chandran,J., Shim,H., Yang,W.J. and Cai,H.
  TITLE     The G59S mutation in p150(glued) causes dysfunction of dynactin in
            mice
  JOURNAL   J Neurosci 27 (51), 13982-13990 (2007)
   PUBMED   18094236
  REMARK    GeneRIF: The G59S mutation in p150(glued) protein abrogates the
            normal function of the protein and accelerates motor neuron
            degeneration.
REFERENCE   6  (bases 1 to 2563)
  AUTHORS   Gauthier,L.R., Charrin,B.C., Borrell-Pages,M., Dompierre,J.P.,
            Rangone,H., Cordelieres,F.P., De Mey,J., MacDonald,M.E.,
            Lessmann,V., Humbert,S. and Saudou,F.
  TITLE     Huntingtin controls neurotrophic support and survival of neurons by
            enhancing BDNF vesicular transport along microtubules
  JOURNAL   Cell 118 (1), 127-138 (2004)
   PUBMED   15242649
REFERENCE   7  (bases 1 to 2563)
  AUTHORS   Di,Y., Li,J., Fang,J., Xu,Z., He,X., Zhang,F., Ling,J., Li,X.,
            Xu,D., Li,L., Li,Y.Y. and Huo,K.
  TITLE     Cloning and characterization of a novel gene which encodes a
            protein interacting with the mitosis-associated kinase-like protein
            NTKL
  JOURNAL   J Hum Genet 48 (6), 315-321 (2003)
   PUBMED   12783284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848512.1, AK039170.1, AK169151.1 and CK626643.1.
            
            On Sep 1, 2015 this sequence version replaced XM_006497069.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' region and initiates translation at a downstream start
            codon compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.133927.1, AK039170.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BB848512.1         2-23
            23-1574             AK039170.1         2-1553
            1575-1959           AK169151.1         1536-1920
            1960-2563           CK626643.1         1-604
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.67 cM"
     gene            1..2563
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="golgin, RAB6-interacting"
                     /db_xref="GeneID:98376"
                     /db_xref="MGI:MGI:2138271"
     exon            1..147
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..509
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..611
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..1197
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SCY1-like 1 binding protein 1; RAB6-interacting golgin;
                     NTKL-binding protein 1; SCYL1-binding protein 1;
                     N-terminal kinase-like-binding protein 1"
                     /codon_start=1
                     /product="RAB6-interacting golgin isoform 2"
                     /protein_id="NP_001300667.1"
                     /db_xref="GeneID:98376"
                     /db_xref="MGI:MGI:2138271"
                     /translation="MEEKNKRKKALLAQAIAERSKKTQAETIKLKRIQKELQALDDMV
                     SADIGILRNRIDQASLEYSYARKRFDRAEAEYITAKLDLQRKTETKEQLTEHLCTIIQ
                     QNELRKAKKLEELMQQLDVQADEEALQLEVEVEQLLREQEAEAAKQMASVERLCPPDG
                     ESVSSELAEENNEPQKQAPSPETDKPGKCCSSSPHRLDCPDPGAKNFSAAVAT"
     exon            612..752
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..2547
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="hexamer: AATAAA"
     polyA_site      2542
                     /gene="Gorab"
                     /gene_synonym="NTKL-BP1; SCYL1-BP1; Scyl1bp1"
                     /note="major polyA site"
ORIGIN      
        1 gaaggaaccc ggatgtgcct gtggagctgt gttggcagtc tgcgcgcgga gatttgggca
       61 ctctttgggt gcccagggct aggcggatgg ctcaggattg ggcgggcttc tctgaggaag
      121 agctgaggag actaaagcag aataaagatc catttgaacc tcagcgtcga attcctgtga
      181 agaaaactcg acaacagctt cagcgtgaaa aagcccttct agagcagagc caaaagcttg
      241 gcctccaaga tgggtcagcc tcattgcttc cagagcagct gctctctgca cccaaacaga
      301 gagctaacag tcaaaagcca cgctctcctt cccctgtggc ccccagtccc ctcacaccca
      361 cctcttcctc tggcgatgga aagctacctg gtgttggaag tcagccccaa gaaccaggac
      421 ttgagaattc ccaccatggt cacaaaagtg ccgaggttcg agctccaaag ccagattgca
      481 aagtggagaa aaagaaaatg gaattgttag caagagaaat ctcgttggga agtcctccaa
      541 caagaacagc gactaatgga agagaaaaat aaacgtaaga aagccctttt ggctcaagcc
      601 attgcggaaa gatctaagaa gacccaagca gagaccataa aactaaagag gatccagaag
      661 gagttgcagg ccttagacga catggtgtca gctgacattg gcatcctcag gaacagaatc
      721 gaccaggcca gcctggagta ttcctacgca cggaagcgct ttgatagagc tgaagctgag
      781 tacattacag caaagctgga tttacagcgc aaaaccgaga cgaaagagca gctcaccgaa
      841 cacctctgca ccatcatcca gcagaacgag ctccgaaagg ccaagaagct ggaggagctg
      901 atgcagcagc tggacgtgca ggctgatgag gaggctttgc aactcgaggt ggaggttgaa
      961 cagttgcttc gggaacagga agcagaggca gccaaacaaa tggcttctgt agagaggctg
     1021 tgtccgcctg atggcgagag tgtgtcttca gaactggctg aagagaacaa tgagcctcaa
     1081 aagcaagctc cttccccaga gacagacaag ccaggcaaat gttgcagtag ctctccccat
     1141 agactagact gcccagatcc aggagccaag aacttttcag ctgctgtggc cacatgagcg
     1201 gccagtgttt tttcagttaa tatctctgcg gtaaattata gcttgtctct gatcaaactt
     1261 ctttcaactc atttgtgttt gaatcaatgc ttagtgatag tatgttagca tgtcagatca
     1321 ttccaaagtc agaagtagtg actgtttcct atccagggag tgttgacccc tcgaagttgg
     1381 ggttccttca agccttgtca ctgagttaga ataggtgact cacagggtgg gagtgctcgg
     1441 ggccctgggt ttgaccttca acactacaag cacagtggta gaagaaaaac tacatggctt
     1501 cttagccctt ggccaaactt aacttgtgag agaactgggt ttgaccttaa acactacaaa
     1561 ccaagcacag tggtagaaga aaaactacat gacttcttag tccttggcca aacttaactt
     1621 gtgagagaac actgagactt tgtggccttc tatgtagtca ttaaaaagac aacaattctt
     1681 atatacagag agaaggagag aaaaaacggg ttaacttacc tacccggatg ctactagagt
     1741 gagtagacac aagttggaag acaacctaag ccaacattat tttcccttta ctttgtcagt
     1801 aaatggtttc tcgttcccac ctgaattgtg gctagttgat ccacatccat agataagctg
     1861 tgaatgtgtg gctttacctt tactttcttc tgttttcctt aatgagtgga cagggaaact
     1921 ttagacaatg aaaatgtttc taaagtgact ctgagagtgg caagtctcat tgattatcca
     1981 acaatgatgt attctctcgc tgaagctctg taatgtggat atttatatgt caggtattgc
     2041 ttcttctgtc atgaagcatt gaaatcgtta aagcactcat tttctaattg ctttcatagt
     2101 ttgtcaatca cctgttccca aaaacttgac tggtgcattg tgctagattt gaatgtgtat
     2161 aaatgtctta gttttgccac aaatattacc ttaaattatc gatttctcag aaatcacaaa
     2221 aaatgaaaaa tgtgtttcat tcataaaaaa ggagctgtat tttaaaggag ataaagacag
     2281 ctgtttccat aatacattgt agaaacgtta gggatgtcct atttttagac tattgtctaa
     2341 gacatcttct gatagtaagg atgctttgta tttttttcta tgatctgagc cacaagtata
     2401 attgtccatt actgatttct aaacacaagc atttatttcc atagtgttgt ttttatttat
     2461 gaatgagacg catacaaatt taaaacttca ttgcccaata cagtcttatt tttctaagga
     2521 ataaacaagt ctgataagtt tacagtaaaa aaaaaaaaaa aaa
//
