LOCUS       NM_001199272            4319 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus golgi associated PDZ and coiled-coil motif containing
            (Gopc), transcript variant 1, mRNA.
ACCESSION   NM_001199272
VERSION     NM_001199272.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4319)
  AUTHORS   Bizkarguenaga,M., Gomez-Santos,L., Madrid,J.F., Saez,F.J. and
            Alonso,E.
  TITLE     Zona Pellucida sperm-binding protein 3 receptor distribution during
            Gopc-/- globozoospermic spermatogenesis
  JOURNAL   Microsc Res Tech 85 (4), 1454-1464 (2022)
   PUBMED   34870349
REFERENCE   3  (bases 1 to 4319)
  AUTHORS   Klussendorf,M., Song,I., Schau,L., Morellini,F., Dityatev,A.,
            Koliwer,J. and Kreienkamp,H.J.
  TITLE     The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for
            Synaptic Targeting of mGluR5
  JOURNAL   Mol Neurobiol 58 (11), 5618-5634 (2021)
   PUBMED   34383253
  REMARK    GeneRIF: The Golgi-Associated PDZ Domain Protein Gopc/PIST Is
            Required for Synaptic Targeting of mGluR5.
REFERENCE   4  (bases 1 to 4319)
  AUTHORS   Wilhelmi,I., Grunwald,S., Gimber,N., Popp,O., Dittmar,G.,
            Arumughan,A., Wanker,E.E., Laeger,T., Schmoranzer,J., Daumke,O. and
            Schurmann,A.
  TITLE     The ARFRP1-dependent Golgi scaffolding protein GOPC is required for
            insulin secretion from pancreatic beta-cells
  JOURNAL   Mol Metab 45, 101151 (2021)
   PUBMED   33359402
  REMARK    GeneRIF: The ARFRP1-dependent Golgi scaffolding protein GOPC is
            required for insulin secretion from pancreatic beta-cells.
REFERENCE   5  (bases 1 to 4319)
  AUTHORS   Bizkarguenaga,M., Gomez-Santos,L., Madrid,J.F., Saez,F.J. and
            Alonso,E.
  TITLE     Increase of germ cell nuclear factor expression in globozoospermic
            Gopc-/- knockout mice
  JOURNAL   Andrology 7 (3), 319-328 (2019)
   PUBMED   30786176
REFERENCE   6  (bases 1 to 4319)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
REFERENCE   7  (bases 1 to 4319)
  AUTHORS   Yao,R., Ito,C., Natsume,Y., Sugitani,Y., Yamanaka,H., Kuretake,S.,
            Yanagida,K., Sato,A., Toshimori,K. and Noda,T.
  TITLE     Lack of acrosome formation in mice lacking a Golgi protein, GOPC
  JOURNAL   Proc Natl Acad Sci U S A 99 (17), 11211-11216 (2002)
   PUBMED   12149515
  REMARK    GeneRIF: predominantly localized at the trans-Golgi region in round
            spermatids; male mice in which GOPC has been disrupted are
            infertile with globozoospermia
REFERENCE   8  (bases 1 to 4319)
  AUTHORS   Yao,R., Maeda,T., Takada,S. and Noda,T.
  TITLE     Identification of a PDZ domain containing Golgi protein, GOPC, as
            an interaction partner of frizzled
  JOURNAL   Biochem Biophys Res Commun 286 (4), 771-778 (2001)
   PUBMED   11520064
REFERENCE   9  (bases 1 to 4319)
  AUTHORS   Charest,A., Lane,K., McMahon,K. and Housman,D.E.
  TITLE     Association of a novel PDZ domain-containing peripheral Golgi
            protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive
            fusion protein (NSF) attachment protein receptor) protein syntaxin
            6
  JOURNAL   J Biol Chem 276 (31), 29456-29465 (2001)
   PUBMED   11384996
REFERENCE   10 (bases 1 to 4319)
  AUTHORS   Neudauer,C.L., Joberty,G. and Macara,I.G.
  TITLE     PIST: a novel PDZ/coiled-coil domain binding partner for the
            rho-family GTPase TC10
  JOURNAL   Biochem Biophys Res Commun 280 (2), 541-547 (2001)
   PUBMED   11162552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY016379.1, CJ174667.1, BC051171.1, AK032613.1 and CF755307.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030427.1, AK030637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY016379.1         2-25
            25-49               CJ174667.1         24-48
            50-194              BC051171.1         1-145
            195-2492            AK032613.1         1-2298
            2493-4260           BC051171.1         2420-4187
            4261-4319           CF755307.1         187-245
FEATURES             Location/Qualifiers
     source          1..4319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 26.54 cM"
     gene            1..4319
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /note="golgi associated PDZ and coiled-coil motif
                     containing"
                     /db_xref="GeneID:94221"
                     /db_xref="MGI:MGI:2149946"
     exon            1..514
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1618
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /note="isoform a is encoded by transcript variant 1;
                     golgi-associated PDZ and coiled-coil motif-containing
                     protein; PDZ protein interacting specifically with TC10;
                     PDZ domain-containing protein PIST; CFTR-associated
                     ligand"
                     /codon_start=1
                     /product="Golgi-associated PDZ and coiled-coil
                     motif-containing protein isoform a"
                     /protein_id="NP_001186201.1"
                     /db_xref="GeneID:94221"
                     /db_xref="MGI:MGI:2149946"
                     /translation="MSAGGPCPAGAGGGPGGSSCPVGVSPGGVSMFRWLEVLEKEFDK
                     AFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDL
                     RSELTETQAEKVVLEKEVHEQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSVEDLE
                     RELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGR
                     VQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQD
                     SLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVG
                     DAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRY
                     RLYLDELEGSGNSGASCKDSSGEMKMLQGYNKKAVRDAHENGDVGAAGESPLDDTAAR
                     AAHLHSLHQKKAY"
     exon            515..679
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            680..703
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            704..879
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1045
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1141
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1306
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1487
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..4317
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4284..4289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /note="hexamer: ATTAAA"
     polyA_site      4317
                     /gene="Gopc"
                     /gene_synonym="2210402P09Rik; CAL; FIG; GOPC1; PIST"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcgctgt cgctgcttca gccccgcttc ctttgctgct ctggagctgc gctgccggcg
       61 ttggcggcgc gagggaaggg aggggaccgg cgggtgtgtg tctgtgtgtg tgtgcgtgtg
      121 tgtctgtgtg tgcgcgcgcg cggggggcgc cgcggtgcta gcagttcccc tcgcgcgggg
      181 cgggcggcca gagtgagcag cagtcggcga ggccctggac ggcgccatgt cggcgggtgg
      241 cccatgcccg gcgggagccg gcggcggccc agggggctcc tcctgccctg tgggggtctc
      301 ccctggcggg gtgtccatgt tccgatggct tgaggtgctg gagaaggagt tcgacaaggc
      361 cttcgtggat gtggatctgc ttttgggcga gatcgatccg gaccaggcgg acatcactta
      421 tgaggggcgt cagaagatga ccagccttag ctcctgcttt gcgcagctat gccacaaagc
      481 ccagactgtg tcccagatca accacaagct tgaggcacag ttggtggatc tgcgatcgga
      541 attgacagag actcaagcag agaaagttgt tctggagaaa gaagtccacg agcagctttt
      601 acagctgcac tccactcagc ttcagcttca tgccaagact ggtcaaagtg ttgactctgg
      661 ggccatcaag gcaaaattgt ctgtccactc tgtggaggat ctggaaagag aacttgaagc
      721 aaataaaaca gaaaaggtaa aagaagctcg acttgaagct gaagtgaagc tactaaggaa
      781 ggagaacgag gctcttcgaa ggcacatagc tgttctccag gctgaagttt atggggcgag
      841 gttggctgcc aagtacttgg ataaggagct ggccggcagg gtgcaacaga tacaattact
      901 gggacgggat atgaagggac ctgctcacga taagctctgg aaccagttag aagctgaaat
      961 acatttgcat cgccacaaaa ctgtcatcag agcctgcaga gggcgcaacg acttgaagcg
     1021 gcccatgcaa gcacccccag gccacgatca agactctttg aagaaaagcc agggagtcgg
     1081 tccaattaga aaagttctcc tccttaagga agaccatgaa ggcctgggca tttctatcac
     1141 aggtgggaaa gagcacggtg ttcccatcct catctctgag atccacccgg gacagcctgc
     1201 ggatagatgt ggagggctgc atgttggaga tgctattctg gcagtcaatg gagtcaacct
     1261 aagagacaca aagcataaag aagctgtaac tatactctcc cagcagagag gagagattga
     1321 gtttgaagta gtctacgtgg cacctgaagt ggattctgac gatgaaaatg tagagtatga
     1381 agacgagagt ggacaccgct atcgtctgta tcttgacgag ttagaaggca gtgggaattc
     1441 tggtgctagt tgcaaagaca gcagtggcga gatgaaaatg ttacaagggt ataacaagaa
     1501 ggcagtgagg gatgcgcatg agaatgggga cgtgggggct gcaggtgaga gccctctgga
     1561 tgacactgct gcgagagcgg ctcatctgca cagcctgcat cagaagaagg cctactaacc
     1621 cagacacgct gcttgtcaga ctcgtggagt gtggggcact agagaagacg gtgacaaaga
     1681 ctgcacaaga tcagggaggc tgtgtgttgc ctagagaaag gcgggaacct cagggcttca
     1741 tgtgaacaat tctaagtgca taaacccctg ttttctgtgg tataccttaa ttagctattg
     1801 catggaaggc agttttgatt ttcctggaat ctaagcacca aagcatgtgt ttcccaaagg
     1861 ggttttacta ggctcttaca ggccaagtgg atgctatttc atttggctcc ttttcatgta
     1921 taacaggaca gtgctaactg gaattctcta agtacccttt aaatacagca gagtaaatga
     1981 taccatatat tccctaagga taactgcgga atttcagatg acagaacttt actcagtgaa
     2041 ttgcaaaaat ctaggttgac atttttgctt aattgaaaat tttgtttcag gtttttttta
     2101 aaaagtatct tgtacattcc tgatatctaa attaattact atcttaaatc attatgatga
     2161 gttcactctc caggtaactc aactgcagta caaaacggtt ttctttaggc aatcctgtat
     2221 caatcaatgc tgctctagga atagtttggg aaaagttact gtgcatttga ctttggactt
     2281 ttaaaggaaa cgcagacaag tggaaaatgg cctgttttca attatgttga tctgtgtgca
     2341 tggtattgga gcattacact gttaatgttt agtcccaaat gttaattgtc tggaatccac
     2401 gaaaaacagc tttatacatt tttgagctgt tcccaagctt tgtcttgtga tagtcaggaa
     2461 cattactatg tcatgaaata cattgtgttc aaacagcagt tggctttaag tacctgactt
     2521 gccagtcatt taaaaagccg ggggccaagg taggcaagat gaggtaaaga cattttggta
     2581 cagtgagcat attggttttt atatcagtat atgtttgact aaagcaatac tcgtgtgcaa
     2641 actctgtaaa tgtattagtt ctattgtatc agaactaagt acagagtgcc tgctcccttc
     2701 tttcctgacc tacagacaat tgcaccctgc ctgccgggca aactgaaaat actgtactta
     2761 aagaggtgtg atttttgcta agtcactgtt ttaaaggatt tacacctaag ggaatcttat
     2821 gtgggagaag cctacatata tcgggctttt acaatatcag tatcttcttt cttggtatgc
     2881 ttgtttttcc cagatgcatt atatatttgt tcaaagttaa aatctataaa atgtatatac
     2941 tttattttgt gattttgcta tttataaatt ttctttttaa ctgttgctca tttatggtct
     3001 ctgggtggtt tcgttcttca tagtatcacc atgttaactg gtaactgaaa gtgcacttcg
     3061 tatgtatatt gttagtgatg ctgagatacc ttgtagtgta acattgcctg taaacaaggt
     3121 tagtatttta actgtacaaa tgaataaaca cgttacatat tactgtttgc tcctgatagg
     3181 ctagacctct taaaagaaag attgtttttt cctcaagtat tcctcccaca ccaaacacat
     3241 accccagtgc atgacttgag accttcaaag taggtggtag ccattgtatt catttaagga
     3301 aaaaatgttc atggtaacag atctgaaata tttttgcttt gacctgaaac catgctgctc
     3361 ctatatcctt tcagcattgc ctgggaagga ccagggccat tttattttcc tttttattca
     3421 tagattatat gccttatata ctatgattga atcgctagga aatgtaagct atataaccct
     3481 ttgaattttt tcaagaactt cacagcagat gtgaaagcaa aacttggatg agcattttca
     3541 tgtgctgcct aggagggatt gtgtgagatg ggtacagaat atatttagaa agagtagttt
     3601 atggttctac aggtccgtct ttccatctct gctttctggt ttggaagcat aggagagtgc
     3661 tgtggcgtga aacctgctct gagagcatcc tggtactctc ccaggcccac tggagagttc
     3721 acttcagagt gtgtggtccc aaagcactaa gtgaaaagta gtctttatag ttcatgttca
     3781 taggaaagat gcccatataa cactgactct tcttgaacaa agccaaaaaa tggggggaaa
     3841 gctgttgcaa agccattaca atgaaaacgt gtagagcatg agaggtgtgt gcgtggacat
     3901 actcacactt attgtgtgaa attgtcttct gcagttttct gttctgaaca tgatgaaagt
     3961 gacgtattcg ggttagggat tattgttaaa ttaaatttga gagagatgaa gagcttgcaa
     4021 gtctgttgat tagaattaaa caattacaaa taacataacc tgtccatggt gctggaatag
     4081 accccacagc aaggggctta tgttgttttc atattttaaa acaaaaaata tattaattta
     4141 catataaggg gatttatgat aattgtatta tatctagttg agtttcatat tcttaattag
     4201 cctgtaaata aaaatgacat attctacatt aaagcagtat tgatcagatt tgaaggaaaa
     4261 taaatgtttt ctctttcatt cacattaaat attttggttt attatgggtt ctgagtaaa
//
