LOCUS       NM_025673               2657 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus golgi phosphoprotein 3 (Golph3), mRNA.
ACCESSION   NM_025673
VERSION     NM_025673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Xie,Z., Hur,S.K., Zhao,L., Abrams,C.S. and Bankaitis,V.A.
  TITLE     A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution
            and Cell Polarity during Neurogenesis
  JOURNAL   Dev Cell 44 (6), 725-740 (2018)
   PUBMED   29587143
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Zhang,Q., Zhuang,J., Deng,Y., Yang,L., Cao,W., Chen,W., Lin,T.,
            Lv,X., Yu,H., Xue,Y. and Guo,H.
  TITLE     miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer
            Chemoresistance via Reduced Cancer Stemness
  JOURNAL   Theranostics 7 (19), 4777-4790 (2017)
   PUBMED   29187903
  REMARK    GeneRIF: Golph3 is a target gene of miR34a.  miR34a/GOLPH3 axis
            abrogates cancer cell stemness involved in urothelial bladder
            cancer chemoresistance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Li,T., You,H., Mo,X., He,W., Tang,X., Jiang,Z., Chen,S., Chen,Y.,
            Zhang,J. and Hu,Z.
  TITLE     GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death
            upon Oxygen-Glucose Deprivation and Reoxygenation Injury
  JOURNAL   Mol Neurobiol 53 (2), 1377-1385 (2016)
   PUBMED   25633094
  REMARK    GeneRIF: The current study found that GOLPH3, an outer membrane
            protein of the Golgi complex, was significantly upregulated in N2A
            cells upon oxygen-glucose deprivation and reoxygenation.
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Cinque,L., Forrester,A., Bartolomeo,R., Svelto,M., Venditti,R.,
            Montefusco,S., Polishchuk,E., Nusco,E., Rossi,A., Medina,D.L.,
            Polishchuk,R., De Matteis,M.A. and Settembre,C.
  TITLE     FGF signalling regulates bone growth through autophagy
  JOURNAL   Nature 528 (7581), 272-275 (2015)
   PUBMED   26595272
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Nagano-Ito,M., Yoshikawa,S., Tamura,M., Tsurumaki,M. and
            Ichikawa,S.
  TITLE     Identification and characterization of a novel alternative splice
            variant of mouse GMx33alpha/GPP34
  JOURNAL   Gene 400 (1-2), 82-88 (2007)
   PUBMED   17629635
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC051035.1.
            
            On Jun 9, 2003 this sequence version replaced NM_025673.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051035.1, BC039909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N-3"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 5.9 cM"
     gene            1..2657
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /note="golgi phosphoprotein 3"
                     /db_xref="GeneID:66629"
                     /db_xref="MGI:MGI:1913879"
     exon            1..461
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1133
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /note="coat protein GPP34"
                     /codon_start=1
                     /product="Golgi phosphoprotein 3"
                     /protein_id="NP_079949.1"
                     /db_xref="CCDS:CCDS27389.1"
                     /db_xref="GeneID:66629"
                     /db_xref="MGI:MGI:1913879"
                     /translation="MTSLTQRSSGLVQRRTEASRNAADKERAAGGGGGSGEDEAQSRR
                     DEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGR
                     LQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGET
                     WNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQ
                     EAVLDKWVNDPHRMDKRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDP
                     EVECLKANTNEVLWAVVAAFTK"
     exon            462..593
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..708
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..2608
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2608
                     /gene="Golph3"
                     /gene_synonym="4733401N08Rik; 5730410D03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctgggctgtg tggggggcca cagccgcggg ctgaaggctc ccttgtgtac cccatcgacg
       61 cccggcccgc cggcttcgcc cagctccggc tcctcatgac cgccttcggc cccgcagccc
      121 acggacatcg ccccagctcc aagaattaac acggaagctc ccggggccgg ggccgtgagg
      181 gagagccggc cggtcccgcg tccctgtcgg tccggcgcgg ctcttgtgcg ggagccatga
      241 cctcgctgac ccagcggagc tcgggcctgg tgcagcggcg caccgaggcc tcccggaacg
      301 ctgccgacaa ggagcgggcg gcgggaggcg gcggcggcag cggcgaggac gaggcgcaga
      361 gccgccgcga cgagcaggac gacgacgaca agggcgactc caaggaaacg cggctgaccc
      421 tgatggagga ggtgctcctg ctgggcctca aggaccgaga gggttacaca tcattttgga
      481 atgactgtat atcatctgga ttacgtggct gtatgttaat tgaattagct ttgagaggaa
      541 ggttacagtt agaggcttgt ggaatgagaa gaaaaagtct tttaaccaga aaggtgatct
      601 gtaaatcgga tgctccaaca ggggatgttc ttcttgatga agctctaaag catgttaagg
      661 agactcagcc tccagagaca gtccagaact ggattgagtt acttagtggt gagacgtgga
      721 atccattaaa attgcattat caattaagaa acgtacggga acgattagct aaaaacctgg
      781 tagaaaaggg tgtactgacg acagagaaac agaacttcct cctgtttgac atgacgacac
      841 atcctctcac caataacaac attaagcagc gtctcatcaa gaaggtacaa gaagctgttc
      901 ttgacaaatg ggtaaatgac cctcaccgaa tggacaagcg cttgctggcc ctcatttacc
      961 tagcccatgc ctcggatgtt ttggaaaatg cgtttgctcc tcttctggac gagcagtatg
     1021 atctagccac caagagagta cggcagctcc ttgacttaga cccagaagtg gagtgtctga
     1081 aggccaacac caacgaagtt ctctgggctg tggtagctgc gtttaccaag taactgtcag
     1141 aattcaatgt ttcctttttc tcatgtgaac cagtagtttt tcttctattg actctggttt
     1201 tctgcagttt gtactttccc acactaataa ttggcttttg ttctacaaaa tggtgggtgg
     1261 atatttcttt ttgtatgtac gcaggattct gctggtacga gaggccttcc tctttctgtt
     1321 tgtaaccaac cttctcgcca tattggcacc ctaccccctg ttgccactct cactgttcct
     1381 gttttgggtt tctggtgtac tgtgaccttc agagtacctc cagcccccac ctcatgcaca
     1441 gcgttctatt acctcagctt gagtctccca catgtgctta ttcacctggc cttctgcctg
     1501 cagttcagac aagtcacagc caggccttca actcaccaaa ggcaaacatc tgtatctatt
     1561 aggacgtttt atacacaaac ctcagttgag atgtatactt agcaaaatta tttttcaatt
     1621 gaaacagcac agtaaataca taatataaaa tgccccttga atttttgctt cctttgtaaa
     1681 tctgttgtgt gattacagtt gttataattt tagctgttca atcataatgg tccaattgtt
     1741 tcacaaagcc agtttgggat gggctgcatt ccactaatgc tgtatatagt ttgaattata
     1801 tatgaatcgc cccttcttct ggccacctct gcctcatttt agtattgaat tgtgcatctg
     1861 gtgcccctca cttgcttcat tcattgttat ctgatggcaa aatagagctc tcattattga
     1921 aggagagaga tgtgtgaccc tttcagggct ctttatgagc tatgcccctc atgatagtct
     1981 acctgtgcat cccttttggg actttttttt cctcaacttt tcctgttttt tatgatttgt
     2041 gtaggaaaga ggcttgtgac cagtactaat cttgagtaca gtttttttgt tttgtttttc
     2101 cacttttctg tccttaagta aattaatgtc tgctctgata tatcgttcat ctactcatct
     2161 tctcttgaga aaagaaaatc agatatcagt cctagcagat gttgcatgta aattggtagc
     2221 aagtaacgac tacaactcaa gacgattaag aattttgtaa cagaaagctc tgctatgttt
     2281 taatttttat atacaattat gatattagca taccataaga ctacaaacat ctgcttttta
     2341 atgttgattt tattcattat cattgtttat ttactattcg tttcataatg taaatactat
     2401 acattgaaca aattaaatgt caaattttta ttattatagt tcatgttaat agtggggctt
     2461 tcaggtgtct agaaactttt ggttaacatt tgatgcaaaa atactagatg cgtataactt
     2521 tagagttgaa ttttaaggga ctccctaata tgtatactat ctttttatct ggagtaataa
     2581 ataaactatg atcttgaaag tgcctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaaa aaaaaaa
//
