LOCUS       NM_001205369            4215 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus golgi membrane protein 2 (Golm2), transcript variant
            3, mRNA.
ACCESSION   NM_001205369
VERSION     NM_001205369.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4215)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4215)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4215)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064446.1 and AL845286.8.
            
            Transcript Variant: This variant (3) contains an alternate in-frame
            exon in the coding region, compared to variant 1. The encoded
            isoform (3) is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064446.1, SRR9219382.73535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2752              BC064446.1         1-2752
            2753-4215           AL845286.8         174077-175539
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.43 cM"
     gene            1..4215
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="golgi membrane protein 2"
                     /db_xref="GeneID:319996"
                     /db_xref="MGI:MGI:2443129"
     exon            1..562
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1543
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein CASC4; cancer susceptibility candidate gene 4
                     protein homolog; cancer susceptibility candidate 4;
                     protein GOLM2"
                     /codon_start=1
                     /product="protein GOLM2 isoform 3"
                     /protein_id="NP_001192298.1"
                     /db_xref="CCDS:CCDS57183.1"
                     /db_xref="GeneID:319996"
                     /db_xref="MGI:MGI:2443129"
                     /translation="MVGFGANRRAGRLPSFVLVVLLVVIVVLAFNYWSISSRHVLLQE
                     EVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAKEGLG
                     KRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEY
                     ESFQCGQQIKELRAQHEENIKKLADQFLQEQKETHKIQSNDGKELGRNDHGAPKNIPN
                     VPENDANKNEDPSSNHLPHGKEQLKRVGDAGMPGVEENDLAKVDELPAALKKPPVLAS
                     QHESHQTISHLPTGQPLSPNMAPGSHLNQNENPSTSKQNPSNPLQHIIPGPNLDREPR
                     IQTDTLKQATRDRANDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADK
                     QAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQRFSDVL"
     exon            563..617
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            618..720
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            721..811
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            812..953
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1034
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1133
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1304
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1472
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..4215
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3881..3886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="hexamer: AATAAA"
     polyA_site      3903
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="major polyA site"
     regulatory      3940..3945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="hexamer: TATAAA"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="hexamer: ATTAAA"
     polyA_site      3967
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
     regulatory      3972..3977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
                     /note="hexamer: AATAAA"
     polyA_site      3982
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
     polyA_site      4001
                     /gene="Golm2"
                     /gene_synonym="Casc4; D130060C09Rik; VGFG2573"
ORIGIN      
        1 cgcgagtacc agcgccggct tctcccgctt ccctgcggcg ggagcccgct ggccttcgac
       61 tctcggaggg ggcgcggcgg gggcgcagag ggggcgggga ggacccgcga cgccccgccc
      121 ccctccgcgc tctggcggct cggcccgtcc cttggggtcc gggtcccgag gccgctgaga
      181 cagcaggccg gcgctgcccg caggtgtcgg cggcagcggc ggagccaccg gcctcatggt
      241 gggtttcggg gccaaccggc gggccggccg cctgccgtcc ttcgtgctgg tggtgctact
      301 ggtagtcatc gtcgtccttg ccttcaacta ctggagcatc tcctcccgcc acgttctgct
      361 tcaggaggag gtggccgagc tgcagggcca ggtccagcgc accgaggtgg cccgcgggcg
      421 cttggagaag cgcaattcgg acctcttgct cttggtggac acgcataaga agcagatcga
      481 ccagaaggag gccgattacg gtcgcctcag cagccggctg caggccaagg aaggcctggg
      541 gaagagatgc gaggatgaca aggttaagct acaaaacaac atatcatatc agatggcaga
      601 catacatcat ttaaaggagc aactggctga gcttcgtcag gagtttcttc gacaggaaga
      661 tcagcttcaa gactacagga aaaataatac ctaccttgtc aagcggctag aatacgagag
      721 ttttcagtgt ggacagcaga tcaaggagtt aagagcacaa catgaagaaa atattaaaaa
      781 attagcagat cagtttttgc aggaacaaaa ggagactcat aagattcaat caaatgatgg
      841 aaaagaattg ggtagaaacg atcatggagc acctaaaaat attccaaatg tgcctgaaaa
      901 tgatgcaaat aagaatgaag acccctcaag caatcatctt ccccatggga aagaacaact
      961 caaacgagtt ggtgatgcag ggatgcctgg agtagaagag aatgacctag caaaagtaga
     1021 cgagcttcct gctgctttaa agaagccccc tgtgttagct tctcaacatg aaagtcatca
     1081 gacaatctcc catcttccaa ctggacagcc tctctcacca aacatggctc caggttcaca
     1141 tctaaaccag aatgaaaatc ccagtacttc aaaacagaac ccttcaaatc ctcttcagca
     1201 cataattcca ggcccaaact tggatcggga acccagaatt caaacagaca cgttaaagca
     1261 ggccaccagg gacagagcca atgatttcca caagttgaag caaagccggt tctttgatga
     1321 gaatgaatcc cctgttgatc cgcagcatgg ctctaaactg gcggattata atggggatga
     1381 tggtaacgta ggtgagtatg aggcagacaa gcaggctgag ctggcttaca atgaggaaga
     1441 agatggtgat ggtggagagg aagacgtcca agatgatgaa gaacgagagc ttcagatgga
     1501 tcctgcagac tatggcaaac agcgcttcag tgatgtcctt taagtctaag ggattcccga
     1561 aacccaaagt gctgtgcaac agatcatctc tacttgtcaa ttttgacttt tgctgtaaag
     1621 atcagttgta tcagttgtaa agatacattg agatagattt aaggaaattt taatgaagga
     1681 atgtaccaat gtacatatgt gaactttttc atattatatt atcaaagcag atactttttt
     1741 tggttactac acagctgggc caaaaacagt taatctttgc attttaaagc aaactaatgt
     1801 aaatttcaca ttttattgag cctaattttt ttttcacaaa gagacaaaca ggaacaaatg
     1861 gttgtacagg ttatatgctg cacatagtat aaccacaatg agaacttatt cggctgaaaa
     1921 gtccacatta ctacattttt gttcccccat aggtgtcctc tactacccct cagttaacac
     1981 tcttgaagaa gttctgaata gttacacaga agtggggagg ctggatgcca gacagtgggc
     2041 aaatgtacag aatggccttc tactccttta tcttacatgg gccctgatgt gagtgtgctg
     2101 aggcctgatg aaaagcctag gtcaccgtta catccttacc atatctatca gtagttcctt
     2161 acttggttct tgaagttgtg gaatgcatgg ttgacagtgt atttttattt ttcaagtaat
     2221 accagaactg tttaactctg gtcagcactg gctaaaattc tttctatttt cagagctcaa
     2281 gctggtgaat acattcacca gttaagagtc agaccctgag agagactgaa tccactttga
     2341 aatgagtctg caatcagtac agcaaagctt tgctggtagt tttaatgatc gtatttgatt
     2401 agacttttcc agaactacta agtaagggat tttaacaggt ttttattaat gaacagatga
     2461 gtagaagtac cgtgaagtct gcagctattt tattgaaata gctgaaaact ttgtaataaa
     2521 aaatgagtat ttgtaattaa tgttagttaa gaacccacca agctcatttg ctagacttac
     2581 agaattattt tcagtgcatt gtgtcttttg gcattattca ttaggatata taagctagct
     2641 aatccttgtt tactgatttc aagcactttt aatttttttg tgttccctaa aaattaaagg
     2701 tgttgatcat aaggctgtta atcccaaggc tattattcct tttttttttt ttaagaaggg
     2761 ctgctattaa ttacacataa gcatgaacta ctagagagtg actgtagctc agatgtgcag
     2821 aggcctgggt ttgattcaaa cactaaaaac agcagacaag taagtagaca tgaaaagtcc
     2881 ccacactaag gctctaatcc aaatactaac agaagtattg ttcacctgct gacatctgaa
     2941 gtccttatag ttcagtccaa agttatttaa tggccaggaa aagatggaat aatttattaa
     3001 aatttgtttt ttctgctatc tcagattata taccactggg catgtatcac aactgcaatc
     3061 ctagtgttga ggaaacagaa acaggtgtgt ccctgaggct cactgaatag ccatcctggc
     3121 ctaattagca agttccaggt ccctgtaagg gacagttgtt cctgaggaac atctacacac
     3181 acacacacac acacacacac acacacacac acacacacgc atatataaac aagttgaccc
     3241 tctggcttcc acatacactc ataaacacct gtacctacat gtgcacacat gtaactgcac
     3301 acgcacatac ccacacacca agaaactaaa cagttcatga ttttgttatc agtaaagcta
     3361 ggcctctgta gtaaaaagta tggttcacat taaaatacag tcaaagggga gtgacataca
     3421 accatgggca ttagaaaggg gagctgaacc tacaaatgcc tagtgatact ccatacttga
     3481 tactgtagaa ctgtacagac aaaatcataa agatgcctgt tggttcctct gttataaaag
     3541 cagtcacttg attttatggt acctatctat ctttatatgg aaaaaaactt caattagcag
     3601 cctagacatt ttataaactg aggaatcttg gaccaattga taatatttct gactgtatta
     3661 acattttagt gctataaaat actatgtgaa tctctttaaa ttgtgacatt ctacagtctg
     3721 tattagacat gctattttgt tctgtttaca gtgttttact tctgccttaa gatttagggt
     3781 ttttttttta ttttgttata ttttaatata ttttgccctg aattaagtgt taatttgatg
     3841 ggaactctgc ttttaaaaaa atcatcactt tctgggttct aataaattaa aagttaaact
     3901 tgtttcacag ttttgattat atatatataa ttacatgaat ataaacattt acatcttgac
     3961 attaaaactt gaataaatgt tatcatttat tttaaggtaa attggactaa aagactaggg
     4021 ttgggctggt gagatggctc agtgggtaag agcacccgac tgctcttcca aaggtccaga
     4081 gttcaaatcc cagcaaccac atggtggctc acaaccatcc gtaatgagat ctgatgccct
     4141 cttctggtgt gtctgaagac agctacagtg tacttacata taataaataa ataaatcttt
     4201 aaaaaaaaaa aaaaa
//
