LOCUS       NM_001035122            3557 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus golgi membrane protein 1 (Golm1), transcript variant
            2, mRNA.
ACCESSION   NM_001035122
VERSION     NM_001035122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Lin,Y.F., Liao,L.Z., Wang,S.Y., Zhang,S.Z., Zhong,X.B., Zhou,H.M.,
            Xu,X.F., Xiong,Z.Y., Huang,Y.Q., Liu,M.H., Guo,Y., Liao,X.X. and
            Zhuang,X.D.
  TITLE     Causal Association of Golgi Protein 73 With Coronary Artery
            Disease: Evidence from Proteomics and Mendelian Randomization
  JOURNAL   Int J Med Sci 21 (11), 2127-2138 (2024)
   PUBMED   39239555
  REMARK    GeneRIF: Causal Association of Golgi Protein 73 With Coronary
            Artery Disease: Evidence from Proteomics and Mendelian
            Randomization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Huang,F., Guo,J., Zhao,N., Hou,M., Gai,X., Yang,S., Cai,P.,
            Wang,Y., Ma,Q., Zhao,Q., Li,L., Yang,H., Jing,Y., Jin,D., Hu,Z.,
            Zha,X., Wang,H., Mao,Y., Liu,F. and Zhang,H.
  TITLE     PTEN deficiency potentiates HBV-associated liver cancer development
            through augmented GP73/GOLM1
  JOURNAL   J Transl Med 22 (1), 254 (2024)
   PUBMED   38459588
  REMARK    GeneRIF: PTEN deficiency potentiates HBV-associated liver cancer
            development through augmented GP73/GOLM1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Zhang,Z., Leng,X.K., Zhai,Y.Y., Zhang,X., Sun,Z.W., Xiao,J.Y.,
            Lu,J.F., Liu,K., Xia,B., Gao,Q., Jia,M., Xu,C.Q., Jiang,Y.N.,
            Zhang,X.G., Tao,K.S. and Wu,J.W.
  TITLE     Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress
  JOURNAL   Nat Commun 15 (1), 1908 (2024)
   PUBMED   38459023
  REMARK    GeneRIF: Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Wang,Y., Hu,D., Wan,L., Yang,S., Liu,S., Wang,Z., Li,J., Li,J.,
            Zheng,Z., Cheng,C., Wang,Y., Wang,H., Tian,X., Chen,W., Li,S.,
            Zhang,J., Zha,X., Chen,J., Zhang,H. and Xu,K.F.
  TITLE     GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
  JOURNAL   Am J Respir Cell Mol Biol 70 (3), 178-192 (2024)
   PUBMED   38029327
  REMARK    GeneRIF: GOLM1 Promotes Pulmonary Fibrosis through Upregulation of
            NEAT1.
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Wright,L.M., Huster,D., Lutsenko,S., Wrba,F., Ferenci,P. and
            Fimmel,C.J.
  TITLE     Hepatocyte GP73 expression in Wilson disease
  JOURNAL   J Hepatol 51 (3), 557-564 (2009)
   PUBMED   19596473
  REMARK    GeneRIF: In Atp7b(-/-) mice, GP73 mRNA was significantly elevated
            at 20-46 weeks of age, coincident with extensive hepatic
            inflammation and fibrosis.
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Wright,L.M., Yong,S., Picken,M.M., Rockey,D. and Fimmel,C.J.
  TITLE     Decreased survival and hepato-renal pathology in mice with
            C-terminally truncated GP73 (GOLPH2)
  JOURNAL   Int J Clin Exp Pathol 2 (1), 34-47 (2009)
   PUBMED   18830387
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK391733.1, AK167646.1, CN529028.1, DV645181.1 and AK051066.1.
            
            On Apr 21, 2006 this sequence version replaced NM_001035122.1.
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the 5' UTR, compared to variant 1. Both variants encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011152.1, AK133865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CK391733.1         1-27
            28-1064             AK167646.1         5-1041
            1065-1707           CN529028.1         3-645
            1708-2367           DV645181.1         30-689
            2368-3557           AK051066.1         450-1639
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.87 cM"
     gene            1..3557
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /note="golgi membrane protein 1"
                     /db_xref="GeneID:105348"
                     /db_xref="MGI:MGI:1917329"
     exon            1..58
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            59..208
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1261
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /note="golgi phosphoprotein 2; golgi membrane protein
                     GP73"
                     /codon_start=1
                     /product="Golgi membrane protein 1"
                     /protein_id="NP_001030294.1"
                     /db_xref="CCDS:CCDS26576.1"
                     /db_xref="GeneID:105348"
                     /db_xref="MGI:MGI:1917329"
                     /translation="MMGLGNGRRSMKSPPLILAALVACVIVLGFNYWIASSRSVELQT
                     RIVELEGRVRRAAAERGAVELKKNEFQGELQKQREQLDRIQSSHSFQLENVNKLHQDE
                     KAVLVNNITTGEKLIRDLQDQLKALQRSYSSLQQDIFQFQKNQTSLEKKFSYDLNQCI
                     SQMTEVKEQCDERIEEVIRKRNEAPGSRDLAETNNQHQQALKPQPKLQEEVPSEEQMP
                     QEKGDVPRNKSQIPAPNSESLGLKPQVQNEETNEIQAVGEEHQQASIQGQAVADGTRV
                     GAEKLDQHTQLPAGLLARPEEDSQYPEREQLVIRDRQEQQRASEEGGGQKNPGDEYDM
                     DENEAESEREKQAALAGNDRNINVLNADAQKRGIINVPVGSERQSHILNQVGIHIPQQ
                     A"
     exon            209..388
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            389..443
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            444..546
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            547..676
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            677..821
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1043
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1151
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..3557
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /note="hexamer: AATAAA"
     polyA_site      3557
                     /gene="Golm1"
                     /gene_synonym="2310001L02Rik; D030064E01Rik; Golph2; GP73;
                     PSEC0257"
                     /note="major polyA site"
ORIGIN      
        1 agacgtcctc ggcagagacc gcgcggacga gcggacggag cgcctcgctg ccccgcaggt
       61 tctcggccct ggttctaaga tgatgggatt ggggaatggg cgtcgcagca tgaagtctcc
      121 gccccttatc ctggctgccc tggtggcctg tgttattgtg ctaggcttca actactggat
      181 tgctagctcg agaagcgtgg aactccagac gcgcattgta gagctggaag gccgggtccg
      241 cagggcggct gcagagagag gtgctgtaga gctcaagaag aatgagttcc agggcgagct
      301 gcagaagcag agagagcaac ttgacaggat ccagtctagc cacagcttcc agctggagaa
      361 tgtcaacaag ctacaccagg atgagaaggc ggttttagtg aataacatca ccacaggcga
      421 gaagctcatt cgagacctgc aagaccagtt gaaggcactg cagaggagtt acagcagcct
      481 gcagcaggat atcttccaat tccagaagaa ccagaccagc ctggagaaga agttctccta
      541 tgacctgaac cagtgtatca gccagatgac cgaggtgaag gaacagtgtg acgagcggat
      601 agaggaggtc atcagaaagc gaaacgaagc accgggttcc agagacctgg ctgaaaccaa
      661 caaccaacat cagcaggccc tcaagcctca gcccaagctt caggaagaag tcccatcaga
      721 ggaacagatg ccacaagaga aaggggatgt gcccagaaac aagtcccaga ttccagcccc
      781 caattcagag agcttgggtt tgaagccaca ggtgcagaat gaggaaacca atgagattca
      841 ggctgtcggt gaggagcacc aacaggcatc catccaaggg caggcggtgg cggatggcac
      901 tcgggtagga gctgagaaac tcgatcagca cacacagcta ccagctggcc tgttggccag
      961 gcctgaggag gactctcagt accctgagcg ggagcagctt gtcatccggg ataggcagga
     1021 gcagcagcgt gcatcagagg aagggggagg ccagaagaac ccaggagatg aatacgacat
     1081 ggatgaaaac gaagcagaat ctgagaggga gaagcaggca gcccttgcag ggaatgacag
     1141 aaatataaat gttcttaatg ctgacgctca gaagagaggc ataataaatg tgcccgtcgg
     1201 gagtgaaagg cagagccaca ttctaaatca agtaggcatt catattcctc aacaagcctg
     1261 aagagatcct acgggggttc actgtgactc aactgtgaaa tggacagcga aatgaacgtc
     1321 ggcccattat tgtggggttt aatcagtaca ttttgcaaag aaaaaaaaat gggaccatct
     1381 cagacagttt gggggtactt ttaaagtgtc tacaagagat gtcaaaattg atcaagcttt
     1441 gattaacagg tatttcttaa gcaggtcaac accaaaaaga gaaatgaggc tgtcctgtct
     1501 aggcagcagc acctcctcac cctgcagtgt aagacagagt agactgaggg cagctgctgg
     1561 ccacagcggc tccctccttg tgctgccgct tgccagtttc tgtccacaga tattaagtag
     1621 ctcatcactc ctgcacacac ttgattccac catcaatggc ctagagctct taccgtcagc
     1681 ataaacacca ctagtcagtt ctatacaaaa gctgttctgt gcaaaaactg cattaattaa
     1741 aagacagcca ccatatctgg cttacttcag gattcggaag gctgaggcag gagattgctg
     1801 caagttctga gccagcctaa agcaacatag tgagtgccaa gctaagatga gcaagaatga
     1861 aagcccctgt ctcaaatatc agtgagagtt gttactttaa aaaagactgg tttaaataac
     1921 cttcattatt cttttgatgt acagaacact atgaagttac tgacaatgcg agcacctatg
     1981 gtctgtgttt gtttgattgg gcagagtttc tagtaagtca ctcatctcac taagaaaggc
     2041 agtgcctgca ctgcgctctg gacaaaggct gcatgggcag aggtgtccaa gaggaagggt
     2101 tggctgctgg aggatactca ggtttcaagc tggattccta cgaaggcaag agcaacacga
     2161 gctgtttttc ccaagtttat atactgtttg aaaaacacac aaggtgaatg ttagttttga
     2221 aagatttgta gttcattgat ggtaatgcat cgtaagtctt gattccgatc agcagcttct
     2281 gattgcagac tgactgcagt cacactgacg actcgttcca gaaacgatct ctctgaagag
     2341 tggctgatct gactctgaag tgctggctaa ataggaagca gcagcactag aggcacaggg
     2401 gctgaagatc cctgcagtga agtggatgcc gggtggtcca gctgtctgtg cctctttaaa
     2461 gcacacattt aaacccctat ggcagacgtg ggttgtttct cactgcagaa ctacccagtt
     2521 ctaccccatg tttagatgag tactgtttaa tgtcacaagc cattttcctt tacactttaa
     2581 cttgccagag cctcagatgg actgttctta caccttttct gctcctaggt cccaaactca
     2641 aggggacttt gtatttctag tgcttgtttt ctaccttaat ctggtttggg tttaaagtgt
     2701 agatattgct gacaggctgt gctgatttcc tttttaacaa gtacaatagg taagggccac
     2761 attctaccct ttgggttcta agattccagg gtaccaatag ccatgcatga cagctgagcc
     2821 ataccacctc cgtactgacc aggaagtaac caacatcctg tcttcgctag catcttgatc
     2881 aagtccagtc aggcatgctt cagtgtttct aggaaatgga aggtgccaca gggttgggct
     2941 ggcatagctc cgtgagaact tctacctagc cagtatgtgt gagtccctgg gtcgcatcct
     3001 cagcaccaac gaacactgtc acattagagt taggccactg aaatcttaga gtcatttttg
     3061 ctgtaagcca aatgaactag caatagtcag gccaaaccac aaagccagat tgaatttcag
     3121 ggtggctcac tctgctaaaa gcactgcccc ttcagagtac aaatgggaaa ccccacgggc
     3181 ttagacagtt gtcacagcac accagtgaca agaccagcag aggaatgagc agcaaatcaa
     3241 ggatggggtc tcttgctggt ggccaagaac aaaacctaca cctcagggca cttgggactt
     3301 cagctggaac aaagggatgc accactttcc aacaagacct gaaactcagc ggcctacaaa
     3361 ctcctacctg ataccagcag cagacactgc agtgtgatgt ggttttcctt caactgcatg
     3421 actaaagacc cttagaaatc tgtgtcacaa cacagtcaca atcctcatgt actttagcga
     3481 tcctcttacc tcaaaatcaa tttgtaattt gaccagaatc ttaaatcctt aataaatctt
     3541 gtgttttgaa acttcaa
//
