LOCUS       NM_001291069            4551 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus golgi integral membrane protein 4 (Golim4), transcript
            variant 1, mRNA.
ACCESSION   NM_001291069 XM_006502144
VERSION     NM_001291069.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4551)
  AUTHORS   Chau,T.C.Y., Baek,S., Coxam,B., Skoczylas,R., Rondon-Galeano,M.,
            Bower,N.I., Wainwright,E.N., Stacker,S.A., Cooper,H.M.,
            Koopman,P.A., Lagendijk,A.K., Harvey,N.L., Francois,M. and
            Hogan,B.M.
  TITLE     Pkd1 and Wnt5a genetically interact to control lymphatic vascular
            morphogenesis in mice
  JOURNAL   Dev Dyn 251 (2), 336-349 (2022)
   PUBMED   34174014
REFERENCE   2  (bases 1 to 4551)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4551)
  AUTHORS   Betterman,K.L., Sutton,D.L., Secker,G.A., Kazenwadel,J.,
            Oszmiana,A., Lim,L., Miura,N., Sorokin,L., Hogan,B.M., Kahn,M.L.,
            McNeill,H. and Harvey,N.L.
  TITLE     Atypical cadherin FAT4 orchestrates lymphatic endothelial cell
            polarity in response to flow
  JOURNAL   J Clin Invest 130 (6), 3315-3328 (2020)
   PUBMED   32182215
REFERENCE   4  (bases 1 to 4551)
  AUTHORS   Chang,A.H., Raftrey,B.C., D'Amato,G., Surya,V.N., Poduri,A.,
            Chen,H.I., Goldstone,A.B., Woo,J., Fuller,G.G., Dunn,A.R. and
            Red-Horse,K.
  TITLE     DACH1 stimulates shear stress-guided endothelial cell migration and
            coronary artery growth through the CXCL12-CXCR4 signaling axis
  JOURNAL   Genes Dev 31 (13), 1308-1324 (2017)
   PUBMED   28779009
REFERENCE   5  (bases 1 to 4551)
  AUTHORS   Coxam,B., Sabine,A., Bower,N.I., Smith,K.A., Pichol-Thievend,C.,
            Skoczylas,R., Astin,J.W., Frampton,E., Jaquet,M., Crosier,P.S.,
            Parton,R.G., Harvey,N.L., Petrova,T.V., Schulte-Merker,S.,
            Francois,M. and Hogan,B.M.
  TITLE     Pkd1 regulates lymphatic vascular morphogenesis during development
  JOURNAL   Cell Rep 7 (3), 623-633 (2014)
   PUBMED   24767999
REFERENCE   6  (bases 1 to 4551)
  AUTHORS   Lutter,S., Xie,S., Tatin,F. and Makinen,T.
  TITLE     Smooth muscle-endothelial cell communication activates Reelin
            signaling and regulates lymphatic vessel formation
  JOURNAL   J Cell Biol 197 (6), 837-849 (2012)
   PUBMED   22665518
REFERENCE   7  (bases 1 to 4551)
  AUTHORS   Iha,H., Kibler,K.V., Yedavalli,V.R., Peloponese,J.M., Haller,K.,
            Miyazato,A., Kasai,T. and Jeang,K.T.
  TITLE     Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax
            and TNFalpha: implications for stimulus-specific interruption of
            oncogenic signaling
  JOURNAL   Oncogene 22 (55), 8912-8923 (2003)
   PUBMED   14654787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078928.1 and AC161369.3.
            
            On Mar 22, 2014 this sequence version replaced XM_006502144.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078928.1, SRR10223969.3768.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2457              AK078928.1         1-2457
            2458-2458           AC161369.3         201891-201891       c
            2459-3474           AK078928.1         2459-3474
            3475-4551           AC161369.3         191773-192849       c
FEATURES             Location/Qualifiers
     source          1..4551
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.76 cM"
     gene            1..4551
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="golgi integral membrane protein 4"
                     /db_xref="GeneID:73124"
                     /db_xref="MGI:MGI:1920374"
     exon            1..838
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     CDS             652..2703
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="isoform 1 is encoded by transcript variant 1; golgi
                     phosphoprotein 4; decapacitation factor 10"
                     /codon_start=1
                     /product="Golgi integral membrane protein 4 isoform 1"
                     /protein_id="NP_001277998.1"
                     /db_xref="CCDS:CCDS71251.1"
                     /db_xref="GeneID:73124"
                     /db_xref="MGI:MGI:1920374"
                     /translation="MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYLELQTQLRKAE
                     AVALKYQQHQDSLSAQLQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNK
                     GRQDSNSRYSALNVQHQMLKSQHEELRKQHSDLEEEHRKQGEDFSRTFNDHKQRYLQL
                     QQEKEQELSKLKETVYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLE
                     DHKSALAAAQTQVAEYKQLKDTLNRIPSFRNPDPVEQQNVTFPHGTHPPQGYNGREKL
                     TGELQEVQPNHEAGPRRMEEKPLSSMQKDAGFQALEEQNQVEPREPEERQVEEEHRKA
                     LEEEEMEQVGQAEHLEEEHDPSPEEQDRDWRDQQGQNAAHLLDGHPQAEVEHSTKAAT
                     NFQSPYEEQLEQQRLAARRDEEAQRLREHQEALHQQRLHGQLLRQQQQQQFLAREMAQ
                     QKQVAHEDGQQQHQEQLRQQAHYNAVENDIAQGVEDQGIPEEEGGAYDRDNQRQDEAE
                     GDPGNRQELREPGHQEGDPEVEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPE
                     ESEEQKQSEAKQGNVEMDEHLVMAGNPDQQEDNVDEQYQDEGEEEVQEDLTEEKKREM
                     EHNVEETYGEHPDDKNNDGEEQGVHNRAHPKGRQEHYEEEEDEEDGAAVAEKSHRRAE
                     M"
     exon            839..913
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            914..963
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1017
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1168
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1251
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1335
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1497
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1800
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2054
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2137
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2247
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2415
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2484
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2556
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..4551
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="hexamer: AATAAA"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="hexamer: TATAAA"
     polyA_site      4249
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="major polyA site"
     polyA_site      4255
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
     regulatory      4333..4338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="hexamer: ATTAAA"
     polyA_site      4351
                     /gene="Golim4"
                     /gene_synonym="3110027H23Rik; GIMPC; Golph4; GPP130; P138"
                     /note="major polyA site"
ORIGIN      
        1 ggacttcctc ccggaatccc gttggccatg atagcggggc cgtgggtgac acgtaagttg
       61 ggtgggaggt ggcgggcggc tggagcttcc agatcagtga caccagccca ccacccccct
      121 taacctgacc agaccaacca gtccccatct cttcatcaat accgagggac cgttcaaggg
      181 gacgccgcct ggagccaggt ccctttgttg ggcgcgcgtc ccctaccagt ggtagcgaca
      241 aagtccagca gcgggagccg gcgcgagggg cggggactga cggtggggac agcgaggcca
      301 aaaagtgggg agtagggaaa accaagccgg ctgcgcgcgg ggaccagtag caagggcagc
      361 gggctctgaa gtatgcaaag agactccacg cgggcccagc cactcgcgga aatccgacat
      421 cgcagaagtt tggtggctgc tggccgggtg gcgtcgatga cctggcgccc agccggccgc
      481 gggggctgag cggccgcctc ttcctctctg gtccggcttt tgtgtctcgc gtcttctgct
      541 catgccgtgt ccagctactt ctcgcggtgg ccgttgctga gctgtccgac gcagccgagg
      601 accgaggaca cgacggctcc cgccgccgca gcgcggggca caggagggac tatgggaaac
      661 gggatgtgct cccgaaagca gaagcggatc ttccagacgc tgctgcttct cacggtggtc
      721 ttcggcttcc tctatggcgc gatgctctac ttggaactgc agacgcagct gcgcaaagct
      781 gaggcagtgg cgctcaagta ccagcagcac caggactctc tctctgccca gttgcaagtt
      841 gtatatgaac acagatcaag attagagaaa tctttgcaaa aagaaaggct tgaacacaag
      901 aaagcaaagg aagatttcct tgtttataag ttagaagcac aagaaacact taacaaagga
      961 aggcaagatt ccaatagcag atatagtgca ttgaatgtcc aacatcagat gctgaaaagt
     1021 cagcatgagg agctgaggaa gcagcacagt gacctggaag aggaacaccg gaagcaaggg
     1081 gaagacttca gtagaacgtt caatgaccac aagcagagat acctgcagct tcagcaagaa
     1141 aaggaacaag aactttctaa gctaaaagaa actgtatata atttgagaga agagaataga
     1201 caactaagaa aagcacacca agacattcac acacagcttc aagacgtcaa gcaacagcat
     1261 aagaatttac tctccgagca tgaacagctt gtagtgactt tggaagacca caagagtgca
     1321 ctggctgctg cgcagactca agttgcagaa tataaacaac tgaaagatac actgaacagg
     1381 attccaagct ttcgaaatcc tgacccagtc gagcagcaaa atgtcacctt tccccatggg
     1441 actcaccctc ctcaaggtta caacggaaga gagaagctga caggagagct ccaagaggtg
     1501 cagccgaatc acgaagcagg gcctagaaga atggaagaga aacctctgtc ttccatgcag
     1561 aaggatgcag gattccaggc tctagaagag cagaatcaag tggaacccag agagccagag
     1621 gagcgtcaag tggaagagga acacaggaag gcactggagg aggaggagat ggagcaggtg
     1681 gggcaggcgg agcatctgga ggaagaacac gacccatcac cagaggagca ggatcgagac
     1741 tggcgggatc agcagggaca gaatgcagcc caccttctgg atggccaccc tcaagctgag
     1801 gtggagcatt cgaccaaggc agctacaaac ttccaatccc catatgagga acagttggaa
     1861 cagcagaggc tggcagcgag gagagatgag gaagcccagc ggctgagaga acatcaggaa
     1921 gccttgcacc aacagaggct ccatgggcag ttgctaagac aacagcagca gcaacagttc
     1981 ctggccagag agatggctca gcagaagcag gtagcccatg aagatggcca gcagcagcac
     2041 caggagcagc taaggcagca agctcattac aatgctgtgg agaatgacat cgcacaggga
     2101 gtcgaggacc agggaatccc cgaagaagag ggaggtgcct atgacagaga taaccagcgc
     2161 caagatgaag ctgaaggaga cccaggcaac agacaggaac ttcgtgaacc aggacaccaa
     2221 gaaggcgacc ctgaagttga agcagatagg gcagctgtgg aggatataaa cccagcagat
     2281 gaccccaaca atcaaggcga agatgaattt gaggaagccg agcaagtgag agaagaaaat
     2341 ttgccagagg aaagtgaaga gcaaaaacaa agcgaagcaa agcaagggaa tgtagaaatg
     2401 gatgagcact tggtgatggc agggaatcca gaccagcagg aggataatgt tgatgagcag
     2461 tatcaggacg aaggagagga agaggttcag gaagatctga ctgaagagaa aaaacgggaa
     2521 atggagcata atgttgaaga gacatatggt gaacatcctg atgataagaa taatgatggt
     2581 gaagaacaag gagttcacaa cagggcgcat cctaaaggaa gacaggagca ttatgaggag
     2641 gaggaagatg aagaagacgg ggctgctgtt gctgagaaat cacatcgcag agctgaaatg
     2701 taactggact cagtttctag actgtgctca gccaacgatt tttttctcaa gctgctctaa
     2761 aacaaatccc gcctactgaa ttctagagta tttaattaca tacagaagta agggtttaga
     2821 cttttttaac ttttttatta gaaatgctat acatttatat gaatatattt tgatacctta
     2881 ggtgagaact tcttttatag tcgagttata catggacaag aagaaaagca gtaagacttg
     2941 ccttcaggtc tgaatctcat ttcccagcga tggtgggaag atgtgcttgg ctttggtgca
     3001 tgtctcagct cagtaccatt ttgttttctg gcttccgggt agtctactat ttatctcaga
     3061 taaaatgcaa gatatagaaa aaaaaaggtg tatggaaaaa caatatgcaa acatcagggg
     3121 aatggctggt gtcctcgtgg ctgttcttgc aggttcttgt atacagctct gaaagaatgt
     3181 cactactgca gagtgttggc aaatgagagc catctgtaca gttgaaaatc aattggaaag
     3241 cccgtgtgtc tgtgtcggtg tgtgtgcgtg cgtgtcagga caaagttttt tttcaaactt
     3301 tcaggtcact ttgaataata cgtagcaatt cttaaaatca cagctatctt gcttgagagg
     3361 aatcacgtat gaaagttgga taatattaat acccctatga aagtctcaag gactctgtct
     3421 tgtcagagag gccaaaggag ctgacacact tagaaataga tgcagtatgt tcagtgatgc
     3481 ttcctgggtg aactccccgt ctccccatcg gttatctgct tgctcgtcag tctccacttg
     3541 ctccagcata ttttcctctc ttaagctctg tgccttgatg tggaaccatt tggttcacag
     3601 ttatggatag gaaagcatgc gaagctacag tttaatagga ttatttttca gactatatga
     3661 taaaataact atagcactag gataggcacc cctcccttag cggctttact atttacccag
     3721 aattgacctg cctttgccta tgtatgaggc attctaatgg ctatcaagaa taatgcatcc
     3781 tttaaaagaa aactcaaact gaaaggtttt ccctgaaatg agcacatatt ttagtttaca
     3841 tcatcaatat tgttaaatac attgaactgg gccaccgtta atctgtgtgt ggtactttca
     3901 aaataataaa gcaaatttca ttttctgtta ttatcatatg agtgtaattt tagtttctaa
     3961 taaccacaat catgtatggt tttgattttc ccagctgagc aattgtgtat gtatgcatag
     4021 gaaatgttcc gctcaaattt agtttggatt tccagtaaca ataaatcaaa tctcatcttt
     4081 atgtataaaa gccccatatg taatgtaaaa tgtattatat tgtacataaa tactcagaat
     4141 acaattattt tggtaaatta gtttgtattt ttaatgtccc tttgcagtat ttaattattt
     4201 gaaacacatt gaaacttggg taataatcaa taaacttata aaaagttaag gataagtctt
     4261 ttaaagcata taatttctta gtgctttgtt atctatggtt tttctttata ggacaatata
     4321 aattaatgaa ttattaaatg cctttcccaa actgctttat ttttctttct ttttctgctt
     4381 taattgacac ttgaattctc atcatcaaac ttctttgaaa gaagaagcta ataatttcca
     4441 ttatctttaa gggctagaaa taagaaattg aactagaaag gtatgtaaaa catgagtgtc
     4501 atatccacaa ttcatatgta aatctggcca ttaaagcaac aatcacaaac c
//
