LOCUS       NM_030035              11025 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus golgin B1 (Golgb1), mRNA.
ACCESSION   NM_030035 XM_001001861 XM_001481060
VERSION     NM_030035.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11025)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11025)
  AUTHORS   Yamaguchi,H., Meyer,M.D., He,L. and Komatsu,Y.
  TITLE     Disruption of Trip11 in cranial neural crest cells is associated
            with increased ER and Golgi stress contributing to skull defects in
            mice
  JOURNAL   Dev Dyn 251 (7), 1209-1222 (2022)
   PUBMED   35147267
REFERENCE   3  (bases 1 to 11025)
  AUTHORS   Alfano,D., Altomonte,A., Cortes,C., Bilio,M., Kelly,R.G. and
            Baldini,A.
  TITLE     Tbx1 regulates extracellular matrix-cell interactions in the second
            heart field
  JOURNAL   Hum Mol Genet 28 (14), 2295-2308 (2019)
   PUBMED   31180501
REFERENCE   4  (bases 1 to 11025)
  AUTHORS   McGee,L.J., Jiang,A.L. and Lan,Y.
  TITLE     Golga5 is dispensable for mouse embryonic development and postnatal
            survival
  JOURNAL   Genesis 55 (7) (2017)
   PUBMED   28509431
REFERENCE   5  (bases 1 to 11025)
  AUTHORS   Wang,G., Li,R., Yang,Y., Cai,L., Ding,S., Xu,T., Han,M. and Wu,X.
  TITLE     Disruption of the Golgi protein Otg1 gene causes defective hormone
            secretion and aberrant glucose homeostasis in mice
  JOURNAL   Cell Biosci 6, 41 (2016)
   PUBMED   27293546
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11025)
  AUTHORS   Zhang,B., Zheng,C., Zhu,M., Tao,J., Vasievich,M.P., Baines,A.,
            Kim,J., Schekman,R., Kaufman,R.J. and Ginsburg,D.
  TITLE     Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
            accumulation of alpha1-antitrypsin
  JOURNAL   Blood 118 (12), 3384-3391 (2011)
   PUBMED   21795745
REFERENCE   7  (bases 1 to 11025)
  AUTHORS   Miyata,T., Ono,Y., Okamoto,M., Masaoka,M., Sakakibara,A.,
            Kawaguchi,A., Hashimoto,M. and Ogawa,M.
  TITLE     Migration, early axonogenesis, and Reelin-dependent layer-forming
            behavior of early/posterior-born Purkinje cells in the developing
            mouse lateral cerebellum
  JOURNAL   Neural Dev 5, 23 (2010)
   PUBMED   20809939
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 11025)
  AUTHORS   Kurth,I., Pamminger,T., Hennings,J.C., Soehendra,D., Huebner,A.K.,
            Rotthier,A., Baets,J., Senderek,J., Topaloglu,H., Farrell,S.A.,
            Nurnberg,G., Nurnberg,P., De Jonghe,P., Gal,A., Kaether,C.,
            Timmerman,V. and Hubner,C.A.
  TITLE     Mutations in FAM134B, encoding a newly identified Golgi protein,
            cause severe sensory and autonomic neuropathy
  JOURNAL   Nat Genet 41 (11), 1179-1181 (2009)
   PUBMED   19838196
REFERENCE   9  (bases 1 to 11025)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 11025)
  AUTHORS   Diella,F., Levi,G. and Callahan,R.
  TITLE     Characterization of the INT6 mammary tumor gene product
  JOURNAL   DNA Cell Biol 16 (7), 839-847 (1997)
   PUBMED   9260927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154763.2.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_001001861.2, XM_001481060.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC154763.2         18753-18930
            179-273             AC154763.2         19876-19970
            274-438             AC154763.2         20981-21145
            439-588             AC154763.2         21299-21448
            589-711             AC154763.2         23114-23236
            712-837             AC154763.2         25109-25234
            838-960             AC154763.2         27058-27180
            961-1074            AC154763.2         28573-28686
            1075-1477           AC154763.2         32247-32649
            1478-1593           AC154763.2         34200-34315
            1594-1708           AC154763.2         38295-38409
            1709-1782           AC154763.2         41564-41637
            1783-6911           AC154763.2         45614-50742
            6912-8799           AC154763.2         51651-53538
            8800-8978           AC154763.2         58375-58553
            8979-9141           AC154763.2         59478-59640
            9142-9279           AC154763.2         59831-59968
            9280-9423           AC154763.2         61997-62140
            9424-9521           AC154763.2         62378-62475
            9522-9656           AC154763.2         62998-63132
            9657-9762           AC154763.2         65301-65406
            9763-11025          AC154763.2         65565-66827
FEATURES             Location/Qualifiers
     source          1..11025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.19 cM"
     gene            1..11025
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /note="golgin B1"
                     /db_xref="GeneID:224139"
                     /db_xref="MGI:MGI:1099447"
     exon            1..178
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            179..273
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..9897
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /note="giantin; golgi autoantigen, golgin subfamily b,
                     macrogolgin 1"
                     /codon_start=1
                     /product="golgin subfamily B member 1"
                     /protein_id="NP_084311.1"
                     /db_xref="CCDS:CCDS49844.1"
                     /db_xref="GeneID:224139"
                     /db_xref="MGI:MGI:1099447"
                     /translation="MLSRLSGLANNVLHELSGDYTDWNLMASSDADSSQETAMESNNR
                     IMESTQEDALHRLAEAEKLVVELKDIISQKDVQLQQKDEALQEEKKAAENKIKKIKLH
                     AKAKIMSLNKHMEEIKTQGGAALPPEAQAEELSKHNKSSTEEEMEIEKIKHELQEKEK
                     LISSLQAQLDQSEQASQLDKSSAEMEDFVLMKQQLQEKEELISTLQTQLSQTQAEQAA
                     QLSSMQQVVREKDARFETQVRLHEDELLQLVTQSDVETEMQQKLRVMQRKLEEHEEAL
                     LGRAQVVDLLQKELTSAEQRNQVLSQQLQLLEAEHNTLKNTMETERQESKTLMEKVEL
                     EVAERKLSFHNLQEEMHQLQGQLERAGQAQADLETQYSALQQRHKTEMEEKTACILSL
                     QKNEQELQSACAALKEENSKLLQEKHDQAAESAQAMRQLEDQLQQKSKEISQFVNKPN
                     LQKNETASQTSLPDVNNEGDQAVMEETVASLQKRVVELENEKGALLLSSGELEELKAE
                     NEKLSSRITLLEAQNRAGEADGTVCEVSTAGTTLLNRSDSSPEENGQAVLENTFSQKH
                     KELSVLLVEMKEAQEEIAFLKSQLQGKRPEGDYEVLDRREVQLMESEGPPSVTAGDVL
                     CAPSDESSGPAAEEEQAGMKDRHRASEAGPLNDAGMELSSPKLDGVDKSLAVSHVCQC
                     HQGELERLKTQVLELETSLHTAEETYKRNLSEKVKEISSLTQLSEEVKESAEEARSTL
                     AAVTEERDQLLYQVKELDVLAELRARVQELESSLAEAEKQRGLDYESQRAQHNLLTEQ
                     IHSLSIEAKSKDVKIEALQRELDGVQLQFCEQGTQMKTLQSQLEAKEREVREGTERLR
                     DISQEMEGLSQALSQKELEIAKMDQLLLEKQKDVETLQQTIQEKDQQVTELSFSMTEK
                     MVQLNEEKFSLGVEIKTLKEQLNLLSRTEEATKEQVEESGAGSSLKLGHDESGQEGLQ
                     QELELLRKESEQRKRKLQAALINRKELLQKVSQLEEELAKVREDSRKEIPFGENERRK
                     LEEDRENRDDPEEWGTSKWREVEASLKQTISEKEVELEGIRRDLKEKTAAEEELQAVV
                     QRMTRDLQSKTKQIDLLQEEVTENQATIQKLVTGTMDAGNGGSAAPVKETAASSPPGA
                     GGEEHWKPELEGRILDLEKDKTQLQKKLQEALIARKAILKKAQEKEKQLKEELREQKD
                     AYHHLQGQFHEQNKEKENIADQLRQLQCQARESIDRQLPGTGQQEPGPPAPSLEGISL
                     EDTEPASESDLHAAQPSPPGETAALQATVSVAQIQAQLKEMEVEKEELELKVSSIASE
                     LAKKSEEVLLLQDQINEQGLEIQNLKAASVEAQAHTELLKQELESSQLKVAGLEHLKT
                     LQPELDALHKHMGQKEEEVNYLYGQLSEKEQTLTTVQTEMVEQERLIKALHTQLEMQA
                     KEHEERLKQAQVEICELKKKPTELEEETNAKQQLQRKLQAALISRKEALKENKSLQEQ
                     LSSARDAVERLTKSLADVESQVSVQNQEKDAVLGKLTILQEERDKLIAEMDRFLLENQ
                     SLSGSCESLKLALGGLTEDKEKLMEELESVRSSKMAESTEWQEKHKELQKEYEVLLQS
                     YENVSNEAERIQHVVESVRQEKQELYAKLRSTESDKREREKQLQDAEQEMEEMKEKMR
                     KFAKSKQQKILELEEENDRLRAEAQPVGGTGESMEALLSSNSSLKEELEKITLEHKTL
                     SKEFEALMAEKDALSEETRNLKLQVEAQVLKQASLEATEKSDEPKDVIEEVTQAVVGK
                     SQERDALSDSAKLEDSEAILMGDGAKPGVSETFSSHDDIKNYLQQLDQLKGRIAELEM
                     EKQKDRELSQALENEKNALLTQISAKDSELKLLEEEVTKRTTLNQQIQEELCRVTKLK
                     ETAEEEKDDLEERLMNQLAELNGSIGNYYQDVTDAQIKNEQLESEMRNLQRCVSELEE
                     EKQQLVKEKTKVESEIRKEYMEKIQGAQKGPANKSHAKELQELLREKQQEVKQLQKDC
                     IRYLERISALEKTVKALEFVHTESQKDLDVTKGNLAQAVEHRKKAQAELSSFKILLDD
                     TQSEAARVLADNLKLKKELQSNKESIKSQIKQKDEDLLRRLEQAEEKHRKEKKNMQEK
                     LDALHREKAHVEETLAEIQVSLTRKDQEMKELQGSLDSTLAQLAAFTKSMSSLQDDRD
                     RVIDEAKKWERRFGDAIQTKEEEVRLKEENCIALKDQLRQMAIHMEELKITVSRLEHD
                     KEIWESKAQTELQHHQKAYDKLQEENKELTSQLEDARQLYHDSKNELTKLESELKSLK
                     DQTTDLNNSLEKCKEHENNLEGIIKQQEADIQNCKFSCEQLETDLAASRELTSRLHDE
                     INAKEQKIISLLSGKEEAIQLAVEELHQQHSKEIKELENLLSQEEEENVALEEENKRA
                     LEKTNQLTEALEAIKKESFEQKAQLDSFVKSMSSLQDDRDRIVSDYRQLEERHLSAIL
                     EKDQLIQDAAAENNKLKEEMRGLRSHMDDLNSENAKLDAELVQYRRDLNEVIAIKDSQ
                     QKQLLDAQLQQNKELRNECTKLEERLKGLEAEKQSLQMSSDALQKEKQGLSKEIKNLQ
                     TQLTALQEEGTLGVYHAQLKAKEEELQRLNMALSSSQKRTADLEEELVCVQKEATRKV
                     SEIEDQLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLTVTKENKDLMA
                     QIQAFGRSMSSLQDSRDHATEELGDLKKKYDASLKELAQLKEWQDSSREGDVLSQAAF
                     PLSTSENVLSRLEKLNQQLTSKDEQLLHLSSELESSHNQVQSISKAMTSLQNERDRLW
                     SELEKFRKSEEGKQRAAAPSAASSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQ
                     MSQEMTELRPLKAQLQESQDQTKALQVMEEELRQENLSWQHELRQLRMEKNSWELHER
                     RMKEQFLMAISDKDQQLGHLQSLLRELRSSSQAQILSTQYQRQASPETSASLDGSQKL
                     VYETELLRTQLNDSLKEIHQKELRIQQLNSKFSQLLEEKNVLSTQLSDASQSLRENQH
                     HYSNLFNHCAILEKEVQKLQAGPLNTDVAPGAPQEKNGMHRKSEPETTGEEQPSFSEV
                     QQQLCNTKQDLRELKKLLEEERDQRLTAENALSLAKEQIRRLEHSEWESARTPIMGAC
                     GSQEQALLIDLPGHSCRRTRSGAGWKRVLRSLCHSRTRVPLLAAIYFLMIHVLLVLCF
                     TGHL"
     exon            274..438
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            439..588
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            589..711
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            712..837
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            838..960
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1074
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1477
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1593
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1708
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1782
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..6911
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            6912..8799
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            8800..8978
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            8979..9141
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9142..9279
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9280..9423
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9424..9521
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9522..9656
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9657..9762
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     exon            9763..11025
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11000..11005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /note="hexamer: AATAAA"
     polyA_site      11021
                     /gene="Golgb1"
                     /gene_synonym="4930428L02Rik; 628101; 6330407A06Rik;
                     C130074L01Rik; F730017E11Rik; Gm6840; mKIAA4151"
                     /note="major polyA site"
ORIGIN      
        1 catgtttgta caccaagtgc atgcagtgcc cgaagaggtc agaagagggc atcagatccc
       61 ctaggcctgg agctacagac agttgtgagc atccacatgg tttctgagaa gtgaattctg
      121 ggccctctgg aagagcgact ggcgttctta acctctgacc aactctgaag accccactag
      181 atgctgagcc gattatcggg gttagcaaat aatgttttgc atgaattatc aggagattac
      241 actgactgga atttgatggc ttcctcagac gctgactcat cccaggaaac tgccatggaa
      301 tcgaataata gaataatgga atccacgcaa gaggatgctc tgcaccgcct ggctgaggca
      361 gagaagttag tggtggagct gaaggatatt attagtcaga aggatgttca actccagcag
      421 aaggacgaag ctctgcagga ggaaaaaaaa gctgctgaaa acaaaattaa aaaaataaaa
      481 ctccatgcaa aggccaagat catgtccttg aacaaacaca tggaagaaat aaagacacaa
      541 ggaggggctg ctctgcctcc agaagcccag gcagaggagc tctccaagca taataagagt
      601 tcaacagaag aagagatgga aatagaaaaa ataaaacatg aactccagga aaaggagaaa
      661 ttaattagta gtttgcaagc ccagcttgac caatcagaac aagcctcgca gttggataag
      721 agttctgcag agatggaaga ctttgtcctg atgaagcagc agctccaaga aaaggaagaa
      781 ctcatcagca ctttgcaaac acagctcagc cagacacagg cagagcaagc tgcccagttg
      841 agttccatgc agcaggtggt ccgagagaaa gacgcccgct ttgaaacaca ggttcgtctc
      901 catgaagatg agctccttca gttagtaacc cagtcagatg tggaaacaga gatgcaacag
      961 aaattgaggg tgatgcagag gaagctggag gagcacgaag aagccttgct gggccgtgcc
     1021 caggttgtag acctgctgca gaaggagcta acgtctgcag agcagagaaa ccaggttctt
     1081 tcacagcagc tacagctgtt ggaggctgaa cataatactt taaagaatac catggaaaca
     1141 gaaagacagg agtccaagac cctgatggaa aaggtagaac tcgaagtggc agagagaaag
     1201 ttatccttcc ataaccttca agaagagatg catcagcttc agggacagct ggagcgagca
     1261 ggccaagccc aggctgacct ggagacacag tacagtgctc tccagcaaag acataagaca
     1321 gagatggagg agaagacggc ttgcattttg agtcttcaga agaacgagca agagctgcag
     1381 tctgcctgtg ctgctctgaa ggaggagaac tcgaagctgc ttcaggagaa gcacgaccag
     1441 gctgctgagt cagcccaggc catgcggcag ctggaagatc aactccagca aaaatctaaa
     1501 gaaattagcc aatttgtaaa taagccaaac ttgcaaaaaa atgaaacagc atctcagact
     1561 tctttaccag atgttaataa tgagggcgac caggcagtga tggaggagac tgtggcctct
     1621 ttacagaaga gagtggtaga gctagagaac gagaagggag ccttgctcct tagctctgga
     1681 gagctggagg agctgaaagc cgagaacgaa aaactctcct ctcggattac tcttttggaa
     1741 gctcagaata gagcagggga ggctgatggt acggtctgtg aggtcagcac ggctggtact
     1801 actctgctca acaggagtga ctcttctcct gaagaaaatg ggcaggctgt tctagagaac
     1861 acattttctc agaaacataa agagctatca gttttattag tggaaatgaa agaagcccag
     1921 gaggaaattg catttctcaa gtcacagctg cagggcaaga ggcccgaggg ggactatgag
     1981 gtcctcgacc gtagagaagt gcagctgatg gagagtgaag gaccgccctc agttacagca
     2041 ggagatgtcc tctgtgcacc cagtgatgag agcagcggcc cagcagctga agaggaacag
     2101 gcaggcatga aagatcggca tcgagcatct gaggcaggac ctctaaatga tgctggaatg
     2161 gaactgagct ccccgaagct ggatggcgtg gacaaatccc tcgcagtgtc ccatgtctgt
     2221 cagtgtcacc agggcgaact ggaaaggctg aaaactcaag ttttggagct tgagacaagc
     2281 cttcatacag cagaggaaac ttacaagaga aacttaagtg agaaagtgaa ggaaattagc
     2341 agcctaaccc agcttagcga agaggtcaaa gagagcgccg aggaagcccg cagcacgctc
     2401 gccgcagtga cggaagaaag agaccagctg ctttaccagg tgaaggagct tgatgtctta
     2461 gcagaactgc gggctcgggt ccaagaactg gaaagcagcc ttgcagaagc agaaaagcaa
     2521 agaggtctgg actatgaaag ccagagggct cagcacaacc tgctcacgga gcagatccat
     2581 agcctaagca tagaagccaa atctaaagat gtgaaaatcg aggctttaca gagagagctg
     2641 gatggtgtgc agctgcagtt ttgtgaacag ggaacccaga tgaaaaccct tcagagccag
     2701 ctagaggcaa aggagaggga agtgcgagag gggacagagc gtctgaggga catctcacag
     2761 gagatggaag gactgtcgca ggctctttct cagaaagaac tggagatagc caagatggac
     2821 caactcttgt tagagaaaca gaaagatgtg gagacactcc agcaaaccat ccaggagaag
     2881 gatcagcaag tgacagaact cagcttcagt atgacggaga aaatggttca gcttaacgaa
     2941 gagaaatttt ctcttggggt ggaaattaag actctgaagg agcagctcaa tttattgtcc
     3001 agaactgaag aagcaacaaa agagcaggta gaagagagtg gagctgggtc cagccttaaa
     3061 cttggtcacg atgagtcagg tcaagagggg cttcagcagg agctggagtt gctgcggaaa
     3121 gaaagtgagc agagaaagcg gaaactgcag gcagcgctga tcaacagaaa ggagctactg
     3181 cagaaagtca gccagctgga ggaggagcta gccaaggtga gagaggactc tcggaaagag
     3241 attcccttcg gggagaatga gaggagaaag ctggaggaag acagagagaa cagagatgac
     3301 ccagaagaat gggggacttc taagtggcga gaagtagaag cttccttaaa acagacaata
     3361 tctgaaaaag aagtggagct ggagggcata cggagggatt taaaagaaaa gacagcggca
     3421 gaggaagagt tacaggctgt ggtccagcgg atgactcggg acctgcagag taagacaaag
     3481 cagatagatt tgcttcaaga agaagtcact gaaaaccaag caactattca gaaattagtc
     3541 acaggaacca tggatgccgg gaatggaggc tcagcagcac ctgtaaaaga aacagcggcg
     3601 agcagcccac ccggtgcagg tggtgaggag cactggaagc cagagctgga gggaagaata
     3661 ctagaccttg aaaaagacaa gacacaactt caaaagaagc ttcaagaagc cttaattgcc
     3721 cgcaaggcga ttctgaaaaa ggcacaagag aaagagaaac agctaaagga agagctcagg
     3781 gagcagaagg acgcgtacca tcacctacag ggacagttcc atgagcagaa taaggagaag
     3841 gagaacattg cggaccagct aaggcaactc cagtgccaag caagggagtc catagacaga
     3901 cagctcccag gcactggcca gcaggaacct ggtcctcccg ctccaagttt agaaggcatt
     3961 tccctagaag acacagagcc tgcttcagaa tctgacttac acgcagctca gccttctcct
     4021 cccggagaga cagcagctct ccaggctact gtttctgttg cccagattca ggctcagttg
     4081 aaagaaatgg aggttgagaa ggaagagctg gaattgaaag ttagttctat agcaagtgag
     4141 ctggccaaaa agtcagaaga agtacttctc ttacaagacc agataaatga acagggttta
     4201 gaaatccaga atttgaaggc agcatccgtt gaagcccagg cccacacaga actgctgaag
     4261 caggagttgg aaagcagcca gttgaaagtt gctggcctgg aacatctgaa aacgttacag
     4321 cctgaactcg atgcactgca caagcacatg ggccagaagg aagaagaggt caactacctt
     4381 tatggacagc ttagtgagaa agagcagacc ctcaccacgg tccagacaga aatggtggag
     4441 caggagcgtt taatcaaggc tctgcacacc cagctggaaa tgcaagccaa ggagcatgaa
     4501 gagaggctaa agcaggccca ggtggaaatt tgtgagctga agaagaagcc aacagagctt
     4561 gaggaagaaa ctaatgcaaa gcaacagtta cagaggaaat tgcaggctgc gctcatctcc
     4621 cggaaggagg cactcaaaga aaacaagagc ctgcaagagc agttgtcctc agccagagat
     4681 gctgttgaac gcctgaccaa gtctctggca gatgtagaaa gccaggtttc tgtccagaat
     4741 caagagaaag atgcagtcct aggaaagtta accattcttc aggaagaaag agacaagctc
     4801 attgcagaaa tggacaggtt tttactggaa aaccagagcc tcagtggctc ttgcgaaagc
     4861 ctgaaactag ctctgggggg cctcacggaa gacaaggaaa agctgatgga ggagctggaa
     4921 tccgtgagaa gttctaagat ggcagagagc accgaatggc aagagaaaca caaggagctg
     4981 cagaaggagt acgaggttct tctgcagtcg tacgagaacg tgagcaacga agccgagagg
     5041 attcagcacg tggtggaaag tgtgcggcaa gagaagcaag agctgtacgc aaagttaagg
     5101 agcacagagt cggacaagag agagagagag aagcagctgc aggatgcaga gcaggaaatg
     5161 gaagagatga aagagaagat gcgaaagttt gcaaaatcta agcaacagaa gatccttgag
     5221 ctagaggaag aaaatgaccg gcttagagcg gaggcgcagc ctgtaggagg aaccggtgag
     5281 agcatggaag cacttctttc ttccaactcc agcttgaagg aggaactaga aaagatcaca
     5341 ttggagcata aaaccctttc taaggagttt gaggctttaa tggcggagaa ggacgctctg
     5401 agtgaagaga ctcgaaatct aaagcttcag gtagaagccc aagtactgaa acaagctagc
     5461 ctggaggcca ctgagaaatc tgatgagcca aaggatgtca ttgaagaggt aacacaagct
     5521 gtggtgggca agtctcaaga acgagatgct ctgagtgaca gtgccaagct tgaagattcg
     5581 gaagctattc tgatgggcga cggcgccaag ccgggtgtta gtgagacttt cagctcccac
     5641 gatgacatca agaactacct ccagcagctc gatcagctta aaggaagaat tgctgagtta
     5701 gagatggaga aacagaaaga cagggaactc agccaggctt tagaaaatga gaaaaatgcc
     5761 ctactgactc agatctctgc aaaggatagc gagctaaagc tcctggagga agaagtcacc
     5821 aaaagaacca cgctaaatca gcagatccaa gaagaactct gcagagttac caagctgaag
     5881 gagacggcag aagaggagaa agacgattta gaggagaggc tgatgaatca actggcagaa
     5941 cttaatggga gcatcgggaa ttattaccag gatgttacag atgcccaaat aaaaaacgag
     6001 caactagagt cggaaatgcg gaaccttcaa agatgtgtga gtgaattaga ggaagaaaag
     6061 cagcagctgg tcaaggaaaa aaccaaggtg gagtcagaaa tccgaaaaga gtacatggag
     6121 aagatccaag gtgcccagaa agggccggcc aataaaagcc atgcgaagga gctccaggag
     6181 ctgctgcggg aaaagcagca agaagtgaag caactgcaga aggactgcat ccggtacctc
     6241 gagaggatca gcgccctgga gaagaccgtc aaggccctcg agttcgttca caccgagtcc
     6301 cagaaggatt tggatgtgac caaaggaaat ctggcccagg cagttgaaca ccgcaagaag
     6361 gcacaagctg aattatctag cttcaagata ctgctcgatg acacccaaag cgaagctgcg
     6421 agagtgctag cggacaacct caaattgaaa aaggagcttc agtcaaacaa agaatccatc
     6481 aaaagccaga taaaacaaaa agatgaagac ctcttgcgaa gactggagca agcagaggag
     6541 aaacaccgga aagagaagaa gaacatgcaa gagaagctgg atgccttgca cagagagaag
     6601 gcccacgtgg aagaaacgct tgcagagatt caagtcagtc tgaccaggaa agaccaggag
     6661 atgaaggagc tgcagggaag cctggatagc accttggccc agcttgcagc cttcactaag
     6721 agcatgtcat ccctgcagga tgaccgggac agggtgatcg atgaagctaa gaaatgggag
     6781 cggaggtttg gcgatgccat tcaaaccaaa gaggaagagg tcagactcaa agaggagaac
     6841 tgcattgctc taaaggatca gctccgacag atggccatcc acatggagga attgaagatc
     6901 accgtctcca ggcttgaaca tgacaaggaa atctgggagt ccaaggccca gacggagctc
     6961 cagcatcacc agaaggctta tgataagctg caagaggaaa ataaagaact tacgtctcag
     7021 ttagaagacg ctcgccagct gtatcatgat tctaagaatg aattaactaa gttagaatca
     7081 gaacttaaga gtctcaaaga ccagacaact gacctaaata actctttaga aaaatgcaaa
     7141 gaacacgaaa acaacttgga agggatcata aagcagcaag aagctgatat ccaaaattgt
     7201 aagttcagtt gtgaacagct agagactgac ctagcggcct ccagagaact caccagtcgg
     7261 ctgcacgacg aaatcaatgc gaaggaacag aagatcataa gcctgctttc tggcaaagaa
     7321 gaggcgatcc aactagctgt tgaggaactg caccagcaac acagtaaaga gatcaaagaa
     7381 ctagaaaacc tgttgtccca ggaggaagag gagaatgtgg ccttagaaga ggaaaacaaa
     7441 agggcccttg agaaaaccaa tcagctcaca gaagcattgg aagccatcaa gaaggagagc
     7501 tttgagcaga aggctcagtt ggactccttt gtgaagtcta tgtcctctct ccaggatgac
     7561 cgggaccgca tcgtaagtga ctatcggcag ctggaagagc gacatctctc tgcaatcttg
     7621 gaaaaagacc agctcatcca agatgctgct gctgagaata ataaactgaa ggaggagatg
     7681 cgagggttgc gaagtcacat ggatgatctc aattctgaga atgccaagct ggatgcggag
     7741 ctggtccagt ataggcggga cctgaacgag gtgatagcca taaaggactc tcagcaaaag
     7801 cagctccttg atgctcagct acagcagaat aaagagctga gaaatgagtg tacaaagcta
     7861 gaggaaaggc tgaaagggtt agaagcagag aagcaaagcc tacaaatgtc ctccgatgcc
     7921 ctccagaagg agaaacaagg tttgtctaaa gagatcaaaa acttacagac acagttgacc
     7981 gccctgcagg aagaaggaac gctaggtgtc taccatgccc aactgaaagc aaaagaagaa
     8041 gagctccaga ggctaaatat ggctctctcc tcctcccaga agagaactgc agatctggaa
     8101 gaggagttag tttgtgtaca gaaggaagct accaggaagg taagtgaaat tgaagatcag
     8161 ctgaagaaag agctgaagca cctccatcac gacgcaggga taatgcgaaa cgagacagaa
     8221 acagccgaag agagggtggc agagctggcg agagacctgg ttgagatgga acagaagttg
     8281 cttacggtaa ccaaagagaa taaggatctt atggcgcaga ttcaggcctt tggaaggtca
     8341 atgagctcct tgcaggacag cagagatcat gccactgagg agcttggtga cctgaaaaag
     8401 aagtatgatg ccagtctcaa ggagctggcc cagctgaaag agtggcagga ctcaagcaga
     8461 gagggggacg ttctttccca ggctgccttt cccctgtcca cctctgagaa cgtcttgtcc
     8521 cgccttgaga aactgaacca gcagctcaca tccaaagacg agcagttgct tcacctatct
     8581 tcagaactag aaagttctca caaccaagtg cagtccatct ccaaagccat gaccagtcta
     8641 cagaatgaga gagatcgcct atggagtgag ctggagaaat tccggaagtc tgaggaaggg
     8701 aagcagaggg ctgcagcccc ttcagctgcc tccagcccag cagaagtaca gagcttgaaa
     8761 aaagccatgt cttcactcca gaatgacaga gatcgattgc tgaaggaact gaagaatctg
     8821 cagcagcagt acttacagat gagccaagag atgaccgagc tccgtccgct gaaggctcag
     8881 ctccaagaat ctcaagatca gacaaaggca ctacaggtga tggaggagga gctcaggcag
     8941 gaaaacctct cctggcaaca cgagctgcgt cagctcagga tggagaagaa ttcctgggag
     9001 ctgcatgaga ggaggatgaa ggaacagttc ctcatggcca tctcagataa agatcagcag
     9061 cttggtcatc tgcagagtct cctgagggag ctgaggtctt cttcccaggc tcagattctc
     9121 tccacacagt accagcgaca ggcatcccca gagacatcag cttccctcga tggatcacaa
     9181 aagctagttt atgagacaga acttctcagg actcagctca atgacagttt aaaggaaatt
     9241 catcaaaagg agctaagaat tcagcagcta aacagcaagt tctctcagct gctcgaggag
     9301 aagaacgtcc tctccaccca gctcagtgac gccagccaga gtctccgtga gaaccagcac
     9361 cactacagta acctcttcaa ccactgcgcc atcctggaga aggaggtgca gaagctgcag
     9421 gcggggccgc ttaatacaga tgttgctcct ggagcacccc aggaaaagaa tggaatgcac
     9481 cgaaagagtg aacctgagac cacaggagag gagcagccaa gcttctctga agtccagcag
     9541 cagctgtgca acactaaaca agatctgaga gagttaaaga agctgctgga agaagagcga
     9601 gaccaaaggc tgaccgctga gaatgcactc tccctggcca aggagcagat cagacggttg
     9661 gagcatagtg aatgggaatc ggcccggact cctatcatgg gtgcctgtgg ctctcaggag
     9721 caggcgctgc tgatagatct cccaggccat agctgtcgaa ggacccggag tggtgccgga
     9781 tggaagcggg tcctgcgttc actctgccat tctcgaaccc gagtgccact gctcgcagcc
     9841 atctacttcc taatgattca cgttttactg gttctgtgtt tcacgggtca cctataaact
     9901 tgttacttga ctgcaactct ggaacttgta attccttcat ctctagtgtc aggattgtcg
     9961 attccacagc agccttctca ctttagcccc tccacctctt cttggaaagt gcctgtgaaa
    10021 acagaggtgg ctgtgaggac aggcagagcc ttaaagcctg ccacatccgc tctccttaaa
    10081 cacttgtgct tggtctgagc agcttcccag atgtgctgtg ctcactgctc ttcagatgtt
    10141 gcagatccac atcctgtgtg gtcttgtagg atgctgaggg aggcctccca gccaggccaa
    10201 caagatggtt ccaataaaca cagtaatttg gaatccagta tcacttttct tggtaaccgg
    10261 ctttgtcttg tggcctgtat tttctcctgc ctcaggatga atacaaagtt gtgggcgtgt
    10321 gagcagtctt tggagactca ggtgggagct ggaaggctcc cagacttcag ttgttggatc
    10381 tcggggagga aggcattttc ttcctgcctg ttgcattgcc agcggaggga cggtttgttg
    10441 ctgtggatcg tcaggactgg accccattgc ttatgccttc agtcacatgt agactaagat
    10501 agtaagtggc cagtgccttt ccttgcatca aaaggcagga agaactgaca atggacagac
    10561 agcaaggttc gaattctata tttctggatg tgcctccata ggggtcctaa gactatccag
    10621 aggccagtgg ggccatgcca aggtgaactg gagtcagggc tgaataccac atcacaacta
    10681 gtctcaagaa ctactgagct gctgcaccag tgtgctggtc cttggttatt ctgtctccaa
    10741 cgccattgtc acccaccact gggcacaggg ctgaggcggt ggaaagaaaa ggcaaagcac
    10801 ctggatccag acctgagagc agtggccagg aatggatgga tcccaccgtg tcgatcctcc
    10861 cctttacgga catgatgtgc tcccttcctg ttctcacccc ctaaagaaga gtgaactgct
    10921 ggactcactc atcagccctt tgttctgtgg tgatgaaaat tttagtcaca acatcccaaa
    10981 accttaacta ctgtaaaata ataaaattat tttcagaata aggaa
//
