LOCUS       NM_001199004            2847 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus golgin A5 (Golga5), transcript variant 1, mRNA.
ACCESSION   NM_001199004
VERSION     NM_001199004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2847)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2847)
  AUTHORS   McGee,L.J., Jiang,A.L. and Lan,Y.
  TITLE     Golga5 is dispensable for mouse embryonic development and postnatal
            survival
  JOURNAL   Genesis 55 (7) (2017)
   PUBMED   28509431
  REMARK    GeneRIF: Golga5 is not required for mouse embryonic development,
            postnatal survival, or fertility.
REFERENCE   3  (bases 1 to 2847)
  AUTHORS   Jiang,Q., Wang,L., Guan,Y., Xu,H., Niu,Y., Han,L., Wei,Y.P.,
            Lin,L., Chu,J., Wang,Q., Yang,Y., Pei,L., Wang,J.Z. and Tian,Q.
  TITLE     Golgin-84-associated Golgi fragmentation triggers tau
            hyperphosphorylation by activation of cyclin-dependent kinase-5 and
            extracellular signal-regulated kinase
  JOURNAL   Neurobiol Aging 35 (6), 1352-1363 (2014)
   PUBMED   24368089
  REMARK    GeneRIF: Its deficit is associated with Golgi fragmentation that
            induces tau hyperphosphorylation.
REFERENCE   4  (bases 1 to 2847)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2847)
  AUTHORS   Mulder,J., Aguado,T., Keimpema,E., Barabas,K., Ballester
            Rosado,C.J., Nguyen,L., Monory,K., Marsicano,G., Di Marzo,V.,
            Hurd,Y.L., Guillemot,F., Mackie,K., Lutz,B., Guzman,M., Lu,H.C.,
            Galve-Roperh,I. and Harkany,T.
  TITLE     Endocannabinoid signaling controls pyramidal cell specification and
            long-range axon patterning
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8760-8765 (2008)
   PUBMED   18562289
REFERENCE   6  (bases 1 to 2847)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 2847)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2847)
  AUTHORS   Zimmer,Y., Milo-Landesman,D., Svetlanov,A. and Efrat,S.
  TITLE     Genes induced by growth arrest in a pancreatic beta cell line:
            identification by analysis of cDNA arrays
  JOURNAL   FEBS Lett 457 (1), 65-70 (1999)
   PUBMED   10486565
REFERENCE   9  (bases 1 to 2847)
  AUTHORS   Bascom,R.A., Srinivasan,S. and Nussbaum,R.L.
  TITLE     Identification and characterization of golgin-84, a novel Golgi
            integral membrane protein with a cytoplasmic coiled-coil domain
  JOURNAL   J Biol Chem 274 (5), 2953-2962 (1999)
   PUBMED   9915833
  REMARK    Erratum:[J Biol Chem 1999 Apr 30;274(18):12950]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138455.1 and BC086782.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016784.1, AK138455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1193              AK138455.1         2-1194
            1194-2847           BC086782.1         1036-2689
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.51 cM"
     gene            1..2847
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /note="golgin A5"
                     /db_xref="GeneID:27277"
                     /db_xref="MGI:MGI:1351475"
     exon            1..230
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            231..798
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2450
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /note="golgin-84; protein Sumiko; golgi autoantigen golgin
                     subfamily a5; golgi autoantigen, golgin subfamily a, 5"
                     /codon_start=1
                     /product="golgin subfamily A member 5"
                     /protein_id="NP_001185933.1"
                     /db_xref="CCDS:CCDS36526.1"
                     /db_xref="GeneID:27277"
                     /db_xref="MGI:MGI:1351475"
                     /translation="MSWFADLAGRAEDLLNRVDQGAATALRKENTSNIFYSKNTDYPE
                     LQQQNTDSNYQTGQKANYISSAADNIRHQKATILAGTANVKVGSRTVGDATHPTEHAS
                     APRPSSQFVRRKKSEPDDELLFDFLNSSQKEPTGRVEVKKEKGRAPVSPSSPSGVSSV
                     NTSVTTTKAMGGNAGSQSPGVNSSDSVPEVHKEPSEESTAPSATSEEHSSTPSDGSSR
                     SQELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARVRVEKWNVDNSKSDR
                     ITRELRAQVDDLTEAVAAKDSQLAVLKVRLQEADQVLSSRTEALEALRSEKSRIMQDH
                     KEGSSLQNQALQTLQERLHEADATLKREQESYKQMQSEFAARLNKMEVDRQNLAEAVT
                     LAERKYSEEKKKVDELQQQVKLHRASLESAKQELVDYKQKATRILQSKEKLINSLKEG
                     SSFEGLESSTASSMELEELRHEKEMQKEEIQKLMGQMHQLRSELQDMEAQQVSEAESA
                     REQLQDLQDQIAKQRTSKQELETELERMKQEFRYMEEDLHRTKNTLQSRIKDREEEIQ
                     KLRNQLTNKTLSNSSQSELESRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQV
                     HSASSGPNSGSAINMSGVDSGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFS
                     IRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYSPEMHHDQPYGK"
     exon            799..1026
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1246
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1370
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1574
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1745
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1874
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1973
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2199
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2305
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2369
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2830
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /note="hexamer: ATTAAA"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /note="hexamer: AATAAA"
     polyA_site      2813
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
     polyA_site      2830
                     /gene="Golga5"
                     /gene_synonym="Ret-II"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgctag ggccccgcgg ccgccggcgc cgccgcctga gtgacctgct aggcggccgg
       61 cggcgctcag cttccggcca ctcaggcagc tcgttggcca ctctgttttg aggtcctcgc
      121 cgcccttcca cgtctcccgg aagagctagc cggcaggtcc gggagcagcg ggctgctgtg
      181 gcggcccggg cgggcgacga ggccgcggtg ctgccgctcg gcgtcctcag gttcatcagt
      241 aggattgctt tgctaccatc atgtcttggt ttgctgatct tgctggaagg gctgaagatc
      301 ttttaaaccg agtggatcag ggggctgcaa cagctctcag aaaggagaat accagcaaca
      361 tcttttatag caaaaatact gactatcctg aacttcagca gcaaaacaca gattcaaatt
      421 accagaccgg acagaaagct aactatattt cctcagctgc tgataacatc cgacatcaga
      481 aagccacgat cctagctggc acagcgaacg tgaaagtcgg atccaggaca gtcggggatg
      541 ccacccatcc caccgagcat gcgtctgccc ctaggccttc atcccagttt gttcggagga
      601 aaaaatcaga gcctgatgat gagctgctat ttgattttct taacagttcc caaaaagagc
      661 ccactgggag agtggaagtc aagaaagaga agggcagagc tcctgtctct ccaagttctc
      721 cgtcaggtgt cagttctgtc aacaccagtg taaccaccac caaggccatg ggaggaaacg
      781 ctgggagcca aagtcctgga gtgaacagtt cggattctgt gcctgaagtt cataaggaac
      841 cctcagagga gagcacggcc ccaagtgcca ccagcgagga gcacagctct acacctagtg
      901 acggtagcag caggtcgcag gagctgtcca atctccgact ggagaatcag ttgctcagga
      961 atgaagtcca gtctttaaat caggaaatgg cctcattact ccagagatcc aaagaaactc
     1021 aagaagaatt aaataaggca agagtaagag ttgaaaaatg gaatgttgac aattcaaaga
     1081 gcgatcgcat aactcgagaa ctgcgagcgc aagtagatga cctcaccgaa gcagtggccg
     1141 caaaggactc ccagctggct gtcctcaaag tgcgactgca ggaggctgac caggtgctaa
     1201 gttcccgcac agaagcacta gaagccttaa ggagtgaaaa gtcacgaata atgcaggatc
     1261 acaaggaagg tagtagccta cagaatcaag ctctgcaaac tcttcaagag aggctgcatg
     1321 aagctgatgc cactctaaag agagagcaag agagctacaa acaaatgcag agtgagtttg
     1381 ctgcacgcct taacaaaatg gaagtggacc gtcagaactt ggcagaagca gttactctgg
     1441 cagaaagaaa gtactccgag gagaagaaga aggttgatga actccagcag caagtcaagc
     1501 tacacagggc aagcttggag tcggctaagc aggagttagt tgactacaag cagaaagcta
     1561 cacggatact ccaatctaaa gaaaaactga tcaacagctt aaaggaaggc tcaagctttg
     1621 aaggcctaga gagcagcacg gctagcagca tggaattgga agaacttcgg catgagaagg
     1681 agatgcagaa ggaggagatc cagaagctga tgggccagat gcatcagctg aggtctgagc
     1741 tacaggacat ggaggctcag caggttagtg aagctgaatc agcaagagaa caattacaag
     1801 atctgcaaga ccagatagct aagcagagga catctaagca agagctggag acggagctgg
     1861 aacgaatgaa gcaggaattc cgctacatgg aggaggatct gcatagaaca aagaacacac
     1921 tgcaaagcag gattaaagat agggaggaag aaattcaaaa actgaggaat cagcttacca
     1981 acaaaacttt aagcaacagc agccagtcag agctagaaag ccggctccat cagctaacgg
     2041 aaacactcat ccagaaacag accatgctgg agagcctcag cacagaaaag aactccctgg
     2101 tcttccagct ggagcgcctt gagcagcagg tgcattctgc ctcctcgggg cccaacagtg
     2161 gatctgccat taacatgtct ggagtcgaca gtggtgaagg gacacgcctg cgaaatgttc
     2221 ctgttctttt taatgacacc gaaactaatc tggcaggaat gtatgggaag gttcgaaaag
     2281 ctgctagctc cattgaccaa tttagtattc gcctgggaat ttttctcaga agatacccca
     2341 tagcacgagt gtttgtaatc atctacatgg ctttgctgca cctctgggtc atgatcgtac
     2401 tgctgactta ctcaccagaa atgcaccatg accaaccgta cggcaagtga acagagccac
     2461 tggttcccat gagtgcctgc cattgtccag agctgggatc tgcagaaaga tcagcactaa
     2521 gactgctagg aaccgtgcac aagatggttt cttcatggag agcttttaat cttttaactt
     2581 atttctctgg tgtctgactc tcccctattc ccataagagt ctctaaatgc agacagtaat
     2641 ttgacaaatt aagctcaact ttttctgagt tcagttccct agatatgtat agagaaagag
     2701 aaaaggcgat ttgggggtgt tcacctctgt acagaccttt ctatatttta ggtgacactg
     2761 attatgggtt ataatcaggg aaactaattg tatttaggga ttaaaaataa aaagatttct
     2821 tttttaataa aaaaaaaaaa aaaaaaa
//
