LOCUS       NM_001410161            7678 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus golgin A4 (Golga4), transcript variant 2, mRNA.
ACCESSION   NM_001410161 XM_006512189
VERSION     NM_001410161.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7678)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7678)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7678)
  AUTHORS   Guo,S., Chunyu,Lv., Ouyang,S., Wang,X., Liao,A. and Yuan,S.
  TITLE     GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis
            and male fertility in mice
  JOURNAL   Biochem Biophys Res Commun 529 (3), 642-646 (2020)
   PUBMED   32736686
  REMARK    GeneRIF: GOLGA4, A Golgi matrix protein, is dispensable for
            spermatogenesis and male fertility in mice.
REFERENCE   4  (bases 1 to 7678)
  AUTHORS   Lieu,Z.Z., Lock,J.G., Hammond,L.A., La Gruta,N.L., Stow,J.L. and
            Gleeson,P.A.
  TITLE     A trans-Golgi network golgin is required for the regulated
            secretion of TNF in activated macrophages in vivo
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3351-3356 (2008)
   PUBMED   18308930
  REMARK    GeneRIF: golgin-245 is a key regulator of TNF secretion; LPS
            activation of macrophages results in increased Golgi carriers for
            export, up-regulating the transport pathway for TNF export.
REFERENCE   5  (bases 1 to 7678)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 7678)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7678)
  AUTHORS   Cowan,D.A., Gay,D., Bieler,B.M., Zhao,H., Yoshino,A., Davis,J.G.,
            Tomayko,M.M., Murali,R., Greene,M.I. and Marks,M.S.
  TITLE     Characterization of mouse tGolgin-1 (golgin-245/trans-golgi
            p230/256 kD golgin) and its upregulation during oligodendrocyte
            development
  JOURNAL   DNA Cell Biol 21 (7), 505-517 (2002)
   PUBMED   12162805
  REMARK    GeneRIF: Characterization of mouse tGolgin-1
            (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation
            during oligodendrocyte development.
REFERENCE   8  (bases 1 to 7678)
  AUTHORS   Gay,D., Lavi,E., Zhao,H., Mumin,A. and Bhandoola,A.
  TITLE     OlP-1, a novel protein that distinguishes early oligodendrocyte
            precursors
  JOURNAL   J Neurosci Res 50 (4), 591-604 (1997)
   PUBMED   9404721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173340.1 and CT486004.9.
            
            On Jul 28, 2022 this sequence version replaced XM_006512189.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.9895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC173340.1         124265-124551
            288-377             AC173340.1         132174-132263
            378-476             AC173340.1         137080-137178
            477-542             AC173340.1         140512-140577
            543-854             AC173340.1         145004-145315
            855-902             AC173340.1         148268-148315
            903-959             AC173340.1         150538-150594
            960-1058            AC173340.1         152601-152699
            1059-1191           AC173340.1         153336-153468
            1192-1376           AC173340.1         154753-154937
            1377-1460           AC173340.1         155236-155319
            1461-1608           AC173340.1         156871-157018
            1609-1787           AC173340.1         166617-166795
            1788-1919           AC173340.1         169826-169957
            1920-2075           AC173340.1         171429-171584
            2076-6286           AC173340.1         173567-177777
            6287-6408           AC173340.1         178296-178417
            6409-6539           AC173340.1         178736-178866
            6540-6650           AC173340.1         183551-183661
            6651-6671           AC173340.1         184953-184973
            6672-6740           AC173340.1         185175-185243
            6741-6816           AC173340.1         186958-187033
            6817-6920           AC173340.1         190912-191015
            6921-7007           CT486004.9         139306-139392       c
            7008-7678           CT486004.9         134015-134685       c
FEATURES             Location/Qualifiers
     source          1..7678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 70.23 cM"
     gene            1..7678
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /note="golgin A4"
                     /db_xref="GeneID:54214"
                     /db_xref="MGI:MGI:1859646"
     exon            1..287
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..7031
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     golgin-245; golgin subfamily A member 4; tGolgin-1; golgi
                     autoantigen, golgin subfamily a, 4"
                     /codon_start=1
                     /product="golgin subfamily A member 4 isoform 2"
                     /protein_id="NP_001397090.1"
                     /db_xref="GeneID:54214"
                     /db_xref="MGI:MGI:1859646"
                     /translation="MFKKLKQKISEEQQQLQQALAPAQASSSSSTPTRTRSRTSSFTD
                     QLDDVTPNRELLAGMVAEPAFLSEYTIFALDSSKQPKTQTGSVNASTQATKSPDGVSK
                     DESSPSQSGDTQTFAQKLQLRVPSMESLFRSPIKESLFRSSKEPLVRTSSRESLNQLD
                     LDCSAAAFDPPSDMESEAEDAPWNSDGLSREQLLQRLRRMERSLSSYRGKYSELVTAF
                     QTLQREKKKLQGILSQSQDKSLRRISELREELQMDQQAKKHLQDEFDACLEEKDQYIS
                     VLQTQVSLLKQRLQNGPMNVDAPKPLPPGELQAEVHGDTEKMEGVGEPVGGGTSAKTL
                     EMLQQRVKRQENLLQRCKETIGSHKEQCALLLSEKEALQEQLDERLQELEKMKELHMA
                     EKTKLITQLRDAKNLIEQLEQDKGMVITETKRQMLETLELKEDEIAQLRSHIKQMTTQ
                     GEELREQKEKSERAAFEELEKALSTAQKTEDAQRRMKMEMDEQMKAVERASEEERLRL
                     QHELSRVRQEAASMAKKNSEEQVAALQKLHAEELASKEQELSRRLEARERELQEQMRI
                     ALEKSRSEYLKLTQEKEQQESLALEELELQKKAILTESENKLQELGQEAEAYRTRILE
                     LETSLEKSLQESKTQSEHLAVHLEAEKNKHNKELTALAEQHRTEVEGLQQQQDSLWTE
                     RLQSLSQQHQAAVEELREKYQQEKDALLKEKESLFQAHIQDMNEKTLEKLDKKQMELE
                     SVSSELSEALRARDQLAEELSVLRGDADKMKQALEAELEEQRRHHQREVGSISEQQEL
                     TVRRAEKALKDELSRLGALLDERDEHLRERQARVQDLEAHLQKSAGELQQALAKLDLL
                     HSEQSAAREQAGAYEEQLAQMQQKVLDLETEKSLLTKQVVEMETHKKHVCEELDAQRA
                     QVQQLERQRSELEEKVRSLAQLQDSQLKNSTVEKEQARQSLMEKENIILQMREEQAKE
                     IEILKQTLSSKEESISILHEEYETKFKNQEKRMEKIKQKAKEMQETKKKLLDQEAKLK
                     KELENTVLELSQKEKQFNAQILEMAQANSAGISDTVSRLEENQRQQIESLTGAHQRKL
                     DDVIEAWEKKLSQQAAELRDKHAEQMEEKEQGLGELRQKVRIVQSEKEELTKEVARLK
                     EAVSGQDVALAGLQGQLEQKSAVIVSLSERESQLQSQVEKLEADLGCSLSEKLSLQEE
                     LAELKLLADKSQLRVSELTGQVQAAEKELQSCKSLHELSKKSLEDKSLNLKSLLEELA
                     SQLDSRCERTKALLEAKTNELVCTSRDKADAILARLSQCQRHTATVGEALLRRMGQVS
                     ELEAQLTQLTEEQRTLKSSFQQVTNQLEEKEKQIKTMKADIEGLLTEKEALQQEGGQQ
                     RQAASEKESCITQLKKELAENINAVTLLREELSEKKSEIASLSKQLSDLGAQLESSIS
                     PSDKAEAISALSKQHEEQELQLQAQLQELSLKVDALSKEKMSALEQVDHWSNKFSEWK
                     KKAQSRLAQHQSTIKDLQAQLDVKATDAREKEEQICLLKEDLDRQNKKFECLKGEMEV
                     RKSKMEKKECDLETALKTQTARVVELEDCVTQRKKEVESLNETLKNYNQQRDTEHSGL
                     VQRLQHLEELGEEKDNKVREAEETVLRLREHVSSLEAELGTVKKELEHVNSSVKSRDG
                     ELKALEDKLELESAAKVELKRKAEQKIAAIRKQLLSQMEEKTQRYAKDTENRLSELSA
                     QLKEREKQVHSLEDKLKNLESSPHPEVPAVSRSMQSVAASPEQEAPDSQDCTHKACKE
                     RLCMLQRRLSEKEKLLRRLEQGEGEARPSQPEAQHRALSGKLDCTRARQLEDHVLIGC
                     LPEELEEKMKCSLIVSQPMGEETGNNTGVKQNWASVVDSVQKTLQEKELTCQALEQRV
                     KELESDLVRERGAHRLEVEKLTLKYEKSQSSQQEMDGENKCVEVLEDRPEENSQSHEI
                     QSNVGTVDGLRSDLESKLTGAERDKQKLSKEVARLQKELRALRREHQQELDILKRECE
                     QEAEEKLKQEQEDLELKHTSTLKQLMREFNTQLAQKEQELERTVQETIDKAQEVEAEL
                     LESHQEETQQLHRKIAEKEDDLRRTARRYEEILDAREEEMTGKVTDLQTQLEELQKKY
                     QQRLEQEESTKDSVTILELQTQLAQKTTLISDSKLKEQELREQVHNLEDRLKRYEKNA
                     CAATVGTPYKGGNLYHTEVSLFGEPTEFEYLRKVMFEYMMGRETKTMAKVITTVLKFP
                     DDQAQKILEREDARLMSWLRTSS"
     exon            288..377
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..476
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..542
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..854
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..902
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..959
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1058
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1191
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1376
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1460
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1608
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1787
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1919
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2075
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..6286
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6287..6408
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6409..6539
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6540..6650
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6651..6671
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6672..6740
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6741..6816
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6817..6920
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            6921..7007
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            7008..7678
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7659..7664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /note="hexamer: AATAAA"
     polyA_site      7678
                     /gene="Golga4"
                     /gene_synonym="Olp-1"
                     /note="major polyA site"
ORIGIN      
        1 acctgctgcc gttgtcgccg ccgccgccgc cgctgacggg gctggatggg gggccgaggc
       61 cagccagggg cacccagaaa gaagagacgc ggcggcggcg acgccgacac ccgcacgacg
      121 agcgccccga ggtgcccgcc agctccacag gaaggcggcg aggcccgggc ccggccgccc
      181 cgcgggtaga gacgctgccg gcccctcgcc gcgccatgtt caagaagctg aagcagaaga
      241 tcagcgagga gcagcagcag ctgcagcagg cgttagcccc tgctcaggct tcctccagct
      301 cttcaacacc aacaaggaca agaagcagga catcttcatt tacagaccag cttgatgacg
      361 tgacacccaa cagagagcta ctagccggga tggtagcaga gcctgccttt ctctctgaat
      421 acactatctt tgctttggat tcctccaaac agcccaaaac acagactggc agtgtgaatg
      481 catcaactca agcaacaaaa tctccagatg gtgtcagtaa agatgagtcg tccccctctc
      541 agtcgggtga cacacagact tttgcgcaga agctccagct ccgagtacct tccatggagt
      601 ctctgtttcg aagtcccata aaggaatccc tgtttcggtc ttctaaagag cctttggtcc
      661 ggacgtcctc cagagagtcc ttgaaccagc ttgacctgga ctgttctgct gcggcctttg
      721 accccccttc tgatatggag agcgaggctg aagacgcacc atggaactca gacggtctca
      781 gcagagagca gctgcttcag cggctgcgca gaatggagcg aagcctaagt agctacagag
      841 ggaagtactc cgagctcgtc acagcgtttc agactcttca gagagagaag aaaaagcttc
      901 aaggtatatt gagtcagagt caagataaat cacttcggag aatttcagaa ttaagagagg
      961 agctgcaaat ggaccagcaa gcaaagaaac atcttcagga cgagtttgat gcatgtttgg
     1021 aggagaaaga tcagtatatc agtgttctcc agactcaggt ttctcttcta aagcagcgat
     1081 tacagaatgg cccaatgaat gttgatgctc ccaaacccct ccctcccggg gagctccagg
     1141 cagaagtgca cggtgacacg gagaagatgg agggcgtcgg ggaaccagtg ggaggtggga
     1201 cttccgctaa aaccctggaa atgctccagc aaagagtgaa acgtcaggag aatctgcttc
     1261 agcgctgtaa ggagacaatt gggtcccaca aggagcagtg cgcactgctg ctgagtgaga
     1321 aggaggcact gcaggagcag ttggatgaaa ggctgcagga gctggaaaag atgaaggagc
     1381 ttcatatggc tgagaagact aaacttatca ctcagttgcg tgatgcaaag aacttaattg
     1441 aacagcttga acaagataag gggatggtaa taaccgagac gaagcggcaa atgcttgaga
     1501 ccctggaact gaaagaagat gaaattgctc agcttcgtag tcatatcaaa cagatgacta
     1561 cccagggaga ggaactgcgg gaacagaaag aaaagtctga aagagctgct tttgaggaac
     1621 ttgaaaaagc cttgagtaca gcccaaaaaa ctgaagatgc acagagaaga atgaagatgg
     1681 agatggatga acagatgaag gctgttgaga gagcgagcga ggaggagcgc ctccgccttc
     1741 agcatgagct gagtcgggtg aggcaggagg ctgccagcat ggcaaagaag aactcagaag
     1801 aacaagttgc tgcactccag aagctgcatg cagaggagct cgccagcaaa gagcaggagc
     1861 tgagcaggag gcttgaggcc cgggaaaggg agctgcagga gcagatgaga atagctctcg
     1921 aaaagagtcg atcagaatat ttgaagctca cccaagaaaa agagcagcaa gaatccttgg
     1981 ctttagaaga gttagagctg cagaaaaaag ccatccttac agagagtgaa aataaactcc
     2041 aggaacttgg gcaagaagca gaggcttacc gaaccagaat tcttgaattg gaaacctctt
     2101 tggaaaaaag tttacaagaa agcaaaacac agtcagagca tctggctgtt catctggaag
     2161 ctgagaagaa taagcacaat aaagaactca cagccctggc tgagcagcat aggacagaag
     2221 tggagggcct ccagcagcag caggacagcc tgtggactga gagactccaa agcctctctc
     2281 agcagcatca ggctgctgtg gaggagctca gagagaagta tcagcaagag aaagatgcac
     2341 tactgaagga gaaggagagt ctcttccagg cccacataca agacatgaat gaaaagacct
     2401 tggagaagct tgacaagaag caaatggaac tggaatctgt ctcttctgag ctgtcagaag
     2461 cactgagagc tcgggaccag cttgcagagg agctttctgt cctaagaggt gatgcagata
     2521 aaatgaaaca ggctttagag gccgagctgg aggagcagcg gcgtcaccac cagcgtgagg
     2581 ttggcagcat cagtgagcaa caagaactaa ccgtccgcag agctgagaag gcactgaaag
     2641 atgagctcag tcggctgggg gctctgctgg acgagaggga cgagcacctg agagagcggc
     2701 aggcccgggt gcaggacctg gaagctcatc ttcagaagtc tgccggggag ctccagcagg
     2761 ccttggccaa actagatctc ttgcactctg agcagagcgc cgcacgcgag caggcaggtg
     2821 cgtatgagga gcagctggcc caaatgcagc aaaaggtgtt agacctggaa acagagaaga
     2881 gccttcttac caagcaggta gtggagatgg aaacacacaa aaagcatgtg tgtgaggaat
     2941 tagatgctca gagagctcaa gtgcagcagc tggagagaca gaggagtgag ctggaggaga
     3001 aggtcaggtc gctagcccag ctccaggact cacagctcaa gaacagtact gtggagaagg
     3061 agcaggctcg gcaaagcctg atggaaaagg aaaacatcat cttacagatg cgagaggagc
     3121 aggccaagga aatcgagatc ctcaaacaga cattgtcttc taaagaagag agcattagta
     3181 ttttgcatga agaatatgaa accaaattta aaaatcagga aaaaagaatg gaaaaaatta
     3241 agcagaaagc aaaagaaatg caagaaacaa agaaaaagtt gttggatcag gaagccaaac
     3301 ttaaaaaaga gcttgaaaat actgtcctag agcttagtca gaaagagaag cagttcaatg
     3361 cgcagatcct ggaaatggca caggctaact cagctggaat cagcgacacg gtgtcgagac
     3421 tggaggagaa ccagaggcag cagatagaaa gcctgaccgg ggctcatcag cgaaaacttg
     3481 atgatgtcat agaggcctgg gaaaagaagc tgagtcagca agctgcagag ctccgggaca
     3541 agcatgcaga gcagatggag gagaaggagc aggggctggg agagctgagg cagaaggtcc
     3601 gcatagtcca gtctgaaaaa gaggagctga ctaaggaggt ggcgcgattg aaagaggcgg
     3661 tcagtgggca ggacgtggca ctagctggcc tgcagggaca gctggagcag aagtctgctg
     3721 tcatcgtttc cctttcggag cgtgaatctc agctgcagtc acaagtggaa aagctggaag
     3781 ctgatttggg ttgttctctg agtgaaaagc tttcccttca agaagagctg gctgagctga
     3841 aactgctggc agacaagagt cagctgaggg tctccgagct gacgggccag gtgcaggctg
     3901 cggagaagga gctccagagc tgtaagtctc tgcatgagct cagcaagaag agcctggagg
     3961 acaagagctt gaacctcaaa agcttgcttg aggagctagc atctcagcta gacagtcgct
     4021 gtgagagaac caaagctctg ttagaagcca agacgaacga actagtgtgc accagccgtg
     4081 acaaagccga cgctattctc gctaggctgt cccaatgcca gcgccacaca gccacagttg
     4141 gggaggcgct gctcaggaga atgggccagg tttctgagtt agaagcacaa cttacacagc
     4201 tgacagagga gcagcgcaca ctaaagagct cttttcagca ggttaccaat cagctggaag
     4261 agaaagagaa gcagattaag accatgaagg ctgacattga aggtcttctc acagaaaaag
     4321 aagccttaca gcaagaagga ggccagcagc ggcaggcggc ctctgagaag gagtcctgca
     4381 tcacacagct gaagaaggag ttagcggaga acatcaatgc cgtcacacta ctgagagaag
     4441 agctgtcgga gaagaagtct gagattgcca gtcttagcaa gcagttaagt gatctcggtg
     4501 ctcagctgga gagcagcatc agcccgagtg acaaggccga agccatctct gccctgagca
     4561 agcagcacga ggaacaagag ctgcagctgc aagctcagct tcaggagctg tctctgaaag
     4621 tcgatgctct gagtaaagag aaaatgtctg cccttgagca ggtggatcat tggtccaaca
     4681 agttctcaga gtggaagaaa aaagcacagt ccagacttgc ccagcaccaa agcactatta
     4741 aagacttgca ggcacagcta gacgtaaaag ccacggacgc tcgtgagaag gaggagcaga
     4801 tatgtttact gaaggaagac cttgatcggc agaataaaaa gtttgaatgt ttaaaaggcg
     4861 agatggaagt caggaagagc aagatggaga aaaaggagtg tgacttagag actgcgttaa
     4921 agactcagac agcaagggtc gttgaattag aagactgcgt tactcagagg aaaaaagaag
     4981 ttgagtccct aaatgaaaca cttaagaatt acaaccagca gagggacact gagcacagtg
     5041 ggctggttca gagacttcag cacttggaag agttgggaga agagaaagac aacaaggtta
     5101 gggaggctga agagaccgtc ctgagactac gagagcacgt gtcctcgctg gaagctgaac
     5161 ttggaactgt gaagaaggaa ctagaacatg taaattcaag tgtgaaaagc agagatgggg
     5221 agctgaaagc tttagaagac aaacttgagt tagaaagtgc tgcaaaagtg gagctgaaga
     5281 ggaaggccga gcagaagatc gctgccatca ggaagcagct cttgtctcag atggaagaga
     5341 aaacccagcg gtatgcgaag gacacagaga accgactgag tgagctgagt gcacaattaa
     5401 aagaaagaga aaagcaagtt cacagcctag aagacaaact taaaaacctg gagagttctc
     5461 cacacccaga agtgccagcg gtgtccagat ctatgcaaag tgtggcagcg tctcccgagc
     5521 aagaggctcc agattcccag gactgcacac acaaggcctg taaagaaaga ctctgcatgc
     5581 tgcaaagacg tttaagtgaa aaagagaagc tgctgcgcag gctggagcag ggcgaaggcg
     5641 aggcgaggcc atcgcagcct gaggctcagc acagggcgct ctctggaaag ttagactgca
     5701 ctagagccag gcagcttgaa gatcacgttt tgataggatg tcttccagaa gaactcgaag
     5761 aaaagatgaa atgttcctta attgtgtctc agcccatggg agaagaaact ggtaacaaca
     5821 caggggtgaa gcagaattgg gcaagtgtgg ttgacagtgt tcagaaaacc ctccaggaaa
     5881 aggagctcac ttgccaggcc ctagagcaaa gggtgaaaga actggagtcg gacttagtaa
     5941 gagagagggg cgcccataga cttgaagtgg aaaagttgac cttaaaatat gaaaaatcgc
     6001 aatcttccca gcaagaaatg gatggggaaa ataaatgtgt agaagtgttg gaagacaggc
     6061 ctgaggaaaa ctcccaatcc catgagatcc agtcaaacgt ggggaccgtg gacggcctgc
     6121 gcagcgacct ggagtccaag ttgacaggag cggagcggga caagcagaag ctgagcaagg
     6181 aggtggcgag gctgcagaag gagctgcgag ctctgcggag ggagcaccag caggagctgg
     6241 acatcctgaa gagggagtgc gagcaggagg ccgaggaaaa gctcaaacag gagcaagagg
     6301 atcttgagtt gaagcacacg tccacactga agcagctgat gcgggagttt aacacacaac
     6361 tggcacagaa ggagcaggag ctggaaagaa ctgtccagga gaccattgat aaggcccaag
     6421 aggtggaagc cgaacttctg gaaagccacc aagaagagac acagcagttg catagaaaga
     6481 tcgcggagaa agaggatgat ctgagaagga cagccaggag atacgaggag atactcgatg
     6541 cccgtgaaga agaaatgact ggcaaagtga cggacctgca gacccagctc gaggagctcc
     6601 agaagaaata ccagcagagg ctggagcagg aggagagcac caaggacagt gtaacaattt
     6661 tggagctaca gacacaacta gcgcagaaga ccactctgat cagcgactcc aagctgaagg
     6721 agcaggagtt gagagaacag gtccataatt tagaagaccg tttgaaaaga tatgaaaaga
     6781 atgcatgtgc agcaactgtg gggacacctt acaaaggtgg caatttgtac cacactgagg
     6841 tctcactctt cggagaacct accgagtttg agtatttgcg aaaagtgatg tttgaatata
     6901 tgatgggtcg cgagactaag accatggcca aagttataac cactgtcctg aaattccctg
     6961 atgatcaggc tcagaaaatt ttggaaagag aagatgctcg tctgatgtca tggctccgaa
     7021 cctcatcttg aagaaatgga gagagtgagg ctgggcagcc gctgcctggg aagctgtcca
     7081 cctgtggggc ttttagagaa tggcgctgtc attacaggcc attggtgtag cttgaaggca
     7141 gatgctactc tggcctcaga tacattgctg tggaagcagg cgcttttggt ggggagatgg
     7201 tggtgggttt gtcctttttt attcagtttt ttcttgggaa gttttctgtg gtttaaaggc
     7261 tgttctgact ggccccacct ggcttggctc ttcagtgtct ttttcttgtg ttctccctct
     7321 ctttaaagaa ctgtccatct tccttattta ttttagggtg gtttcttttt cttcctaaag
     7381 acttgtgcaa tatattttga ggtgaaactt agtgaatttt tttctgataa attagagatt
     7441 ttaattgact gtttcacaga ttgatttttt gaatatttgc taaagcctag ttctttatgc
     7501 tatgataagt cccaaatggc agtacctcat gtttacctag cttttggact tatattattt
     7561 ttcagaggaa aaaatactac tgtaaattgt aaatagtaca taatcctatt gtctgcagct
     7621 ctgtgactgt tggccatgtc atctcagagg atcagataaa taaagtttat ttcctata
//
