LOCUS       NM_001347389            8096 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus golgin A3 (Golga3), transcript variant 1, mRNA.
ACCESSION   NM_001347389 XM_006534960
VERSION     NM_001347389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8096)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8096)
  AUTHORS   Xu,C., Zhu,M., Zhao,S., Zhang,X., Wang,Y. and Liu,M.
  TITLE     Mutation of S461, in the GOLGA3 phosphorylation site, does not
            affect mouse spermatogenesis
  JOURNAL   PeerJ 11, e15133 (2023)
   PUBMED   37090114
  REMARK    GeneRIF: Mutation of S461, in the GOLGA3 phosphorylation site, does
            not affect mouse spermatogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8096)
  AUTHORS   Schimenti,J.C. and Handel,M.A.
  TITLE     Unpackaging the genetics of mammalian fertility: strategies to
            identify the 'reproductive genome'
  JOURNAL   Biol Reprod 99 (6), 1119-1128 (2018)
   PUBMED   29878059
  REMARK    Review article
REFERENCE   4  (bases 1 to 8096)
  AUTHORS   Bentson,L.F., Agbor,V.A., Agbor,L.N., Lopez,A.C., Nfonsam,L.E.,
            Bornstein,S.S., Handel,M.A. and Linder,C.C.
  TITLE     New point mutation in Golga3 causes multiple defects in
            spermatogenesis
  JOURNAL   Andrology 1 (3), 440-450 (2013)
   PUBMED   23495255
  REMARK    GeneRIF: Golga3(repro27) mice lack GOLGA3 protein and thus provide
            an in vivo tool to aid in deciphering the role of GOLGA3 in Golgi
            complex positioning, cargo trafficking and apoptosis signalling in
            male germ cells
REFERENCE   5  (bases 1 to 8096)
  AUTHORS   Williams,D., Hicks,S.W., Machamer,C.E. and Pessin,J.E.
  TITLE     Golgin-160 is required for the Golgi membrane sorting of the
            insulin-responsive glucose transporter GLUT4 in adipocytes
  JOURNAL   Mol Biol Cell 17 (12), 5346-5355 (2006)
   PUBMED   17050738
  REMARK    GeneRIF: These data demonstrate that golgin-160 plays an important
            role in directing insulin-regulated trafficking proteins toward the
            insulin-responsive compartment in adipocytes.
REFERENCE   6  (bases 1 to 8096)
  AUTHORS   Kim,D.W., Sacher,M., Scarpa,A., Quinn,A.M. and Ferro-Novick,S.
  TITLE     High-copy suppressor analysis reveals a physical interaction
            between Sec34p and Sec35p, a protein implicated in vesicle docking
  JOURNAL   Mol Biol Cell 10 (10), 3317-3329 (1999)
   PUBMED   10512869
REFERENCE   7  (bases 1 to 8096)
  AUTHORS   Matsukuma,S., Kondo,M., Yoshihara,M., Matsuda,M., Utakoji,T. and
            Sutou,S.
  TITLE     Mea2/Golga3 gene is disrupted in a line of transgenic mice with a
            reciprocal translocation between Chromosomes 5 and 19 and is
            responsible for a defective spermatogenesis in homozygotes
  JOURNAL   Mamm Genome 10 (1), 1-5 (1999)
   PUBMED   9892724
REFERENCE   8  (bases 1 to 8096)
  AUTHORS   Kondo,M. and Sutou,S.
  TITLE     Cloning and molecular characterization of cDNA encoding a mouse
            male-enhanced antigen-2 (Mea-2): a putative family of the Golgi
            autoantigen
  JOURNAL   DNA Seq 7 (2), 71-82 (1997)
   PUBMED   9063644
REFERENCE   9  (bases 1 to 8096)
  AUTHORS   Yang,J., Galipeau,J., Kozak,C.A., Furie,B.C. and Furie,B.
  TITLE     Mouse P-selectin glycoprotein ligand-1: molecular cloning,
            chromosomal localization, and expression of a functional P-selectin
            receptor
  JOURNAL   Blood 87 (10), 4176-4186 (1996)
   PUBMED   8639776
REFERENCE   10 (bases 1 to 8096)
  AUTHORS   Su,H., Kozak,C.A., Veerhuis,R., Lau,Y.F. and Wiberg,U.
  TITLE     Isolation of a phylogenetically conserved and testis-specific gene
            using a monoclonal antibody against the serological H-Y antigen
  JOURNAL   J Reprod Immunol 21 (3), 275-291 (1992)
   PUBMED   1522559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118260.7.
            
            On Mar 28, 2018 this sequence version replaced NM_001347389.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.6034.1,
                                           SRR9219381.252821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC118260.7         48014-48079
            67-377              AC118260.7         52760-53070
            378-647             AC118260.7         55495-55764
            648-760             AC118260.7         56943-57055
            761-1407            AC118260.7         58498-59144
            1408-1519           AC118260.7         59820-59931
            1520-1826           AC118260.7         60763-61069
            1827-2029           AC118260.7         64064-64266
            2030-2167           AC118260.7         64776-64913
            2168-2329           AC118260.7         72988-73149
            2330-2698           AC118260.7         73726-74094
            2699-2776           AC118260.7         74877-74954
            2777-3040           AC118260.7         75937-76200
            3041-3135           AC118260.7         76934-77028
            3136-3352           AC118260.7         78713-78929
            3353-3496           AC118260.7         79597-79740
            3497-3694           AC118260.7         80932-81129
            3695-3811           AC118260.7         83388-83504
            3812-3951           AC118260.7         87991-88130
            3952-4084           AC118260.7         88968-89100
            4085-4207           AC118260.7         89251-89373
            4208-4369           AC118260.7         91939-92100
            4370-4533           AC118260.7         92781-92944
            4534-8096           AC118260.7         94065-97627
FEATURES             Location/Qualifiers
     source          1..8096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.36 cM"
     gene            1..8096
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /note="golgin A3"
                     /db_xref="GeneID:269682"
                     /db_xref="MGI:MGI:96958"
     exon            1..66
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            67..377
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..4705
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     golgin subfamily A member 3; golgin-160; male-enhanced
                     antigen 2; golgi autoantigen, golgin subfamily a, 3"
                     /codon_start=1
                     /product="golgin subfamily A member 3 isoform 1"
                     /protein_id="NP_001334318.1"
                     /db_xref="CCDS:CCDS84928.1"
                     /db_xref="GeneID:269682"
                     /db_xref="MGI:MGI:96958"
                     /translation="MDGASAKQDGLWESKSSSDVSSCPEASLEIVGSLARLPDQQDTA
                     QDASVEVNRGFKEEGSPDRSSQVAICQNGQIPDLQLSLDPTTSPVGPDASTGVDGFHD
                     NLRNSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTASSLPLEKEEQVRLQARKRLEE
                     QLMQYRVKRHRERSSQPATKMKLFSTLDPELMLNPENLPRASTVAVTKEYSFLRTSVP
                     RGPKVGSLGLLAHSKEKKNSKSSKIRSLADYRTEDPSDSGGLGSTADAVGSSLKQSRS
                     STSVVSEVSPSSETDNRVESASMTGDSVSEADGNESDSSSHSSLSARGACGVLGNVGM
                     PGTAYMVDGQEISAEALGQFPSIKDVLQAAAAQHQDQNQEANGEVRSRRDSICSSVSM
                     ESSLAEPQDELLQILKDKRRLEGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVE
                     HSHSSQQKQDSLSSEVDTLKQSCWDLERAMTDLQSMLEAKNASLASSNNDLQVAEEQY
                     QRLMAKVEDMQRNILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLQASQAEITS
                     LQHARQWYQQQLTLAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQ
                     HRSIKEKERIAVQLQSIEADMLDQEAAFVQIREAKTMVEEDLQRRLEEFEGEREQLQK
                     VADAAASLEQQLEQVKLTLFQRDQQLAALQQEHLDVIKQLTSTQEALQAKGQSLDDLH
                     TRYDELQARLEELQREADSREDAIHFLQNEKIVLEVALQSAKSDKEELDRGARRLEED
                     TEETSGLLEQLRQDLAVKSNQVEHLQQETATLRKQMQKVKEQFVQQKVMVEAYRRDAT
                     SKDQLINELKATKKRLDSEMKELRQELIKLQGEKKTVEVEHSRLQKDMSLVHQQMAEL
                     EGHLQSVQKERDEMEIHLQSLKFDKEQMIALTEANETLKKQIEELQQEAKKAITEQKQ
                     KMKRLGSDLSSAQKEMKTKHKAYENAVSILSRRLQEALASKEATDAELNQLRAQSTGG
                     SSDPVLHEKIRALEVELQNVGQSKILLEKELQEVITMTSQELEESREKVLELEDELQE
                     SRGFRRKIKRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLV
                     QLNLQVQAVLQRKEEEDRQMKQLVQALQVSLEKEKMEVNSLKEQMAAARIEAGHNRRH
                     FKAATLELSEVKKELQAKEHLVQTLQAEVDELQIQDGKHSQEIAQFQTELAEARTQLQ
                     LLQKKLDEQMSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEQQGKKELEGTQQT
                     LQTIKSELEMVQEDLSETQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKKK
                     EPKGESNSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNNCLQQLKQEMDS
                     LQRQMEEHTITVHESLSSWAQVEAAPAEHAHPRGDTKLHNQNSVPRDGLGQ"
     exon            378..647
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            648..760
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1407
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1519
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1826
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2029
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2167
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2329
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2698
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2776
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..3040
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3135
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3352
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3496
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3694
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3811
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..3951
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            3952..4084
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            4085..4207
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            4208..4369
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4533
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     exon            4534..8096
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4781
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /note="major polyA site"
     regulatory      8077..8082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
                     /note="hexamer: AATAAA"
     polyA_site      8096
                     /gene="Golga3"
                     /gene_synonym="5330413L04; 5430416E01Rik; G1-499-14;
                     Mea-2; Mea2; Mea2/Golga3; repro27"
ORIGIN      
        1 accctgttgc gccccgcccc ttgcacagcc acgtcctacc ggagccgcag ggttgggccg
       61 gaaccggaat catggttgct tggtttgact tcaagccatt tatgagacat taaacctgaa
      121 aatggaaaac agagtaagat cctccttaga agctctgagc tgttgctaat ggcaaaaaac
      181 aaacttaatc cagagttact tgtagctcct cagagtcttc ttagtctggg ctgccctgac
      241 catggatgga gcatcagcca aacaggatgg cctctgggaa agcaagtcca gcagtgatgt
      301 ttcatcttgc cctgaagcct cgctggagat tgtgggctct ctggcccgac tgcctgatca
      361 acaggataca gctcaggatg ccagtgttga ggtaaacaga ggttttaagg aagaaggaag
      421 cccagataga tccagccagg tggccatctg tcagaatggg cagatcccag accttcagtt
      481 gtcccttgat cccacaacaa gcccagtggg acctgatgcc tctacaggtg tggatggttt
      541 ccatgacaac ctaaggaact ctcagggaac tagtgctgag ggcagtgtta gaaaagaagc
      601 tttgcagtcc ctcagactca gtcttcccat gcaagaaacg caactgtgct ccactgcatc
      661 ttcattgcct ttggaaaagg aggagcaggt tcgactgcag gcccggaagc gcctggaaga
      721 gcagctgatg cagtaccgag ttaagcgcca tcgggaaagg tccagtcaac ctgcaactaa
      781 aatgaaactt tttagtacac ttgatcctga gctcatgtta aatccagaaa atttgccaag
      841 ggccagtact gtagctgtga caaaagaata ttccttcctg cgtaccagtg ttcctcgagg
      901 gcccaaggta ggcagcttag ggctgctggc acattctaaa gagaaaaaga actccaaatc
      961 aagcaagatt cggtctctgg ctgactatag aactgaagat ccaagtgact ctggtggcct
     1021 tggttctact gctgatgctg ttggaagttc cctgaaacaa agtagaagta gcacttcagt
     1081 tgtgtctgag gttagcccat catctgagac tgataaccgt gtagagagtg cctccatgac
     1141 tggggatagt gtgtcagagg ctgatggaaa tgagagtgac agttcctcac acagcagcct
     1201 ctctgcccga ggggcctgtg gtgtcctggg gaacgtgggc atgccaggaa cagcttacat
     1261 ggttgatggc caggagattt ctgctgaggc cctgggccag tttccttcaa ttaaagacgt
     1321 actacaggct gcagcagccc agcaccaaga tcagaaccag gaagccaacg gagaggtgcg
     1381 gagccgtaga gacagcatct gcagcagtgt gtccatggag agctccttgg ctgaaccaca
     1441 ggatgaattg ttgcagattc ttaaagataa aaggaggctt gaaggacagg tggaggcttt
     1501 gtcattagaa gccagtcagg cacttcaaga gaaggctgag ctacaggccc agcttgctgc
     1561 cctgagcaca aggctacagg cacaggtgga acacagccac agcagccagc agaagcaaga
     1621 ctcccttagt tctgaagtgg acactttgaa gcagtcttgc tgggatctag agcgggccat
     1681 gactgacctg cagagcatgc tagaagctaa aaatgccagc ctggcatcct caaacaatga
     1741 cctacaagtg gcagaggagc agtatcagag actgatggcc aaagtggagg acatgcagag
     1801 aaacatcctc agcaaggaca acacagtgca tgacctgcgg cagcagatga cagcgctaca
     1861 gagccagctc cagcaagtac agctggagcg cacaaccctg accagcaaac tacaagcatc
     1921 acaggctgag atcacgtctc tgcagcatgc ccggcaatgg taccaacagc agcttacttt
     1981 ggcccaggag gccagggtca ggctgcaagg agagatggcc catatccagg ttggacaaat
     2041 gacccaggca ggccttttgg agcacctgaa gcttgagaat gtgtccctat cgcatcagct
     2101 gacagaaact cagcatcgat ccatcaagga gaaagagcgc atagctgttc agctccagag
     2161 cattgaggct gacatgttag atcaggaggc agcatttgta cagattcggg aggcgaagac
     2221 aatggtggag gaggacctcc aaaggaggct ggaagaattt gaaggtgaac gggagcagtt
     2281 acagaaagtg gcagatgcag cagcatccct ggagcaacag ttggaacagg tgaagctgac
     2341 attgttccag cgagatcagc agcttgcagc acttcagcag gagcacctag atgtgataaa
     2401 gcagcttacg tcgacgcagg aggctctgca ggccaaaggg cagtctcttg atgacctgca
     2461 tacacgttac gatgagctac aagcaaggct ggaggagctg cagagagagg ccgactccag
     2521 ggaggatgca attcacttct tgcagaatga gaagattgtc ttggaagtgg ctctacaatc
     2581 ggccaagagt gacaaggagg aacttgacag aggagcacgg cgtttggaag aagatactga
     2641 ggagacatca ggacttttgg aacaattgag acaagatttg gctgtcaagt ccaaccaggt
     2701 ggagcacttg cagcaggaga cagccacgtt gagaaaacag atgcagaaag taaaggagca
     2761 gtttgttcag caaaaggtga tggtagaggc ataccggcga gatgctactt ccaaagatca
     2821 actcatcaat gaactgaaag ccaccaaaaa acggctggac tctgagatga aggaactgag
     2881 gcaagagcta atcaagctgc agggagagaa gaagactgtg gaagtagagc actcacgact
     2941 gcagaaggac atgtccctgg ttcaccagca gatggcagag cttgaggggc atcttcagtc
     3001 agtgcagaaa gaacgagatg aaatggagat tcacctgcag tctttgaagt ttgacaaaga
     3061 gcagatgata gcccttaccg aggccaatga gacactgaag aaacaaatag aagagctgca
     3121 acaagaggcc aagaaggcca tcacagaaca gaagcagaag atgaagaggc tgggctcaga
     3181 tctgtccagc gcccagaagg agatgaagac taagcacaaa gcttatgaga atgctgtgag
     3241 cattctcagc cgtcgcctgc aggaggctct ggcttctaag gaggctacag atgcagagct
     3301 gaaccagctc agagctcaga gcacaggtgg cagcagtgac cctgtcctac atgagaagat
     3361 tcgtgctctg gaggtggaac tgcagaatgt tggccaaagc aagatactac tggagaagga
     3421 gttacaggag gtgatcacaa tgactagcca ggagctggaa gagtcccggg agaaggtgct
     3481 ggagctagaa gatgagcttc aagaatccag aggcttcaga aggaagataa aacgtcttga
     3541 agagtcaaat aagaaactag ctctggagtt agagcatgag cgagggaagc tcactggcct
     3601 tggacaatct aatgcagcgc tgcgggagca caacagcatt ctggagactg cactagccaa
     3661 gagggaagct gacctggtac agctgaatct gcaggtgcag gcagttttac agcgcaaaga
     3721 ggaggaggat cgccagatga agcaacttgt ccaagcctta caagtctcac tagagaaaga
     3781 aaagatggaa gtgaacagcc tgaaggaaca gatggctgct gccaggatag aagctgggca
     3841 caaccgccgc cactttaagg cagctacttt ggagctgagt gaggtgaaga aagaattgca
     3901 ggccaaagaa cacctggtac agacattgca ggccgaggtg gatgagctcc agattcagga
     3961 tggaaagcat tctcaagaaa tagcacaatt ccagactgag ctggcagaag ctagaaccca
     4021 gctccagctc ctacagaaga agctagatga gcagatgagc cagcaaccga cagggagcca
     4081 agagatggaa gatctcaaat gggaattgga tcagaaagaa cgagagattc agtccctgaa
     4141 gcagcagctt gacttgacag agcaacaggg caagaaagaa ctggagggga cacagcagac
     4201 acttcagacc atcaagtctg agttggaaat ggtacaagaa gatctgtctg agacgcagaa
     4261 ggataagttt atgcttcaag ccaaagtgtc tgaactgaag aacaacatga agactctgct
     4321 gcagcagaac caacagctca agctggatct ccgccgcggt gcagccaaga agaaagagcc
     4381 aaaaggtgag tccaactcat ccagtcctgc aacacccatc aagataccag attgccctgt
     4441 cccagcctca ttgctagagg agctgctgag gcccccaccc gctgtgagca aggaacccct
     4501 caagaatctc aacaactgtt tgcagcagct caagcaggaa atggacagtc tccagcgcca
     4561 gatggaggag cataccatca ctgtgcatga gtccctgtcc tcgtgggctc aggtggaagc
     4621 tgccccagca gagcatgccc atccccgggg agacacaaaa ctgcataatc aaaacagtgt
     4681 tcccagagac gggctgggcc aatgaccact gttgtcctca tcacacaagt atttgtgact
     4741 gttgaaggaa ttctcttgtc aatattattt atttgatcga atgctctggt ggctttcttt
     4801 tttccttttt taagaaagga catttaaatt tccctttact ttttatcaag gattaaaata
     4861 acagaaaaaa actgggaggt aatggtacat acttttaatc ccagcaccca ggaggcagat
     4921 gcaggcatga tctctgtgag tttgaggcca gcctggtcta cagatcaata gtttcagaac
     4981 agccagggct acaaagaaag actctgtcat aaataaataa ataaatggga tgaggcaagg
     5041 attaaaagca tagtcatttt aaaccacatc tagcttttcc catgaaatga ccaaatcctg
     5101 aaaacatcag agtttggact gctggtgaaa tctgagtctg tctgtctgaa cagtcacttg
     5161 cagaaggagg gaagcttgca tgtggctgta gacacacaca agacctttac tttccttcat
     5221 aaatgagttt ttatttacac cttttgcttt ttatttaatt tgcttttcaa actgttctac
     5281 ctaaatagga tgtatatata aatattgaaa gtcttttgaa aacatatacc tatattattt
     5341 aaggacctaa ttgtctttct gatttccttt ttgaaaattt gctattggga aacagtatat
     5401 atgtagcttt agcgatatca gtttaaaaat gtattttaag aaatataact tattttctat
     5461 gcatcctaaa accaaatact cttggcacag aaagagttga ttagttgtag tctttttatt
     5521 tctgaggtct tttctgccag catttccatg aattaatatc actgacctct cagccttctg
     5581 tggttttact cactttggct tacgaacagg cagggccagt cgtcaggcct tgcagttaac
     5641 aggggacgaa aggacctcca aggtctcctc atactcacct cacctaacat ttggagaaca
     5701 ctggtggagg aaaagagcag gagaggaggc cgccttggtc cttgtgggtt aagggctgca
     5761 tacaccgtgt cccagagatg gtgtttatga aacactgtga atgtctttct gtctggtcgt
     5821 caggaactac catggacctc tgttgagtat ttgtggcaca agaagtcaag agtaatacct
     5881 gaaaggaggt gggcaacttt ggtcttctga gacagggtca agagacaaaa gccttattta
     5941 aagtcagcac taagtgtgtg atttattgct gtctgcttcc caaatcataa taatgcttta
     6001 tatactgact aattaggaga gttgaggtct ttaatctttg tgaatgcttg tgaagagaat
     6061 ttaaaataaa gtggcttttt tgactcgtga ctgtaatccc agcacttgta ggtagagtca
     6121 ggaagaggat cagttcagga ctggttttca gctacacggc gagtttgagg caagactgtg
     6181 ttacatgaaa ccatgactta aaaagacaga caagctggaa caacaacaaa aaagatgtga
     6241 aatattgtta gaagggaaag agagaaaggc ctgaagaagg aatctctaag cagcagtgat
     6301 cagctagttg gtgtctttta gtgggtttct tgtctatttt gtggataatc ggtttggaat
     6361 ttttaatctg tgttctctta caatatccta ttagaaggtt agctgatgtg gttaaagtag
     6421 aactatccac agtgatgtct ggtgtttgaa aaatattctt tagcaagtat tggaacttta
     6481 agatgtgtat atcatttgta cagggtttat ctttaaaaaa aactttatta taattatacc
     6541 cttttaatct ctaagttaga aattagaaaa ggacggtaat ttgcattctt atttattttg
     6601 tatttttaat gacaaaacca agaaatagca cttggtttgg acttagttct gcaacagagc
     6661 tagattctcc tatgtgaaga gatcttcaag tgagttgtgt tgattgtgtt gtctgggaaa
     6721 gaatgagtta attctgaact cattcaagtg aaggttggtt tcatgtctta acccatttct
     6781 tcagttgctt tgctgtttca tgtgcacgga cacccacaga aacggcacct cttctaaact
     6841 ttatagtctg ccttgtgggc ccttggctag gttcctcttg gctccatgaa gggcctggca
     6901 tgtcttggct tcttgctctg tctctttttg tgaaccagtg tgtcttttct cacatttgcg
     6961 gttcagagga ctctcagatt ggagctggag ttctcttagg gttctttaag tcaccttgaa
     7021 gttgagtttt caagtttcct tgtttgtttg tttgtttgtt tgttttggct ttttccctcc
     7081 taagaggaat ctaagggatt ctattttact tcacctcctt gagcttattc ttgagtgaat
     7141 atagcttgat tactgttgcc tctgcagccg aaactgggaa ttttaggttt gctcatgagc
     7201 gagcgcaggc aggtctggag gattgctttt tcaggcaggc tcacaccatt gtgcgccgtt
     7261 tgtgcgtata tcatacatgc tgcatcgtgc cctagactgg acaccttggc ttgcatgatt
     7321 tgtactacca gttggttttc ttacgtttaa aaaaattacc acgaaatttc tatcattgtt
     7381 tttctggtag acgtccgatt gatcccatga ttttagattt ttacaccatt gtagcaggca
     7441 atgattttga gaagatgtaa ggctgacttt acatggactt tgggtacagg gagaaggacc
     7501 tgctgtctaa gaaggtggtc ttagtgtata aatcagaaag cttggtgaaa ttcttctctg
     7561 tttcaaaaca aactttacca gtatgtgaat actgtaaaag ccatagtctt ataggtcatt
     7621 atgatacata ttttaataca ttttgaaata aaaattggca ggtaaagatt ttggatttaa
     7681 aagggaccat catatttgaa aagaaaacct cctggagcct tggagggccc cagtgataag
     7741 aataatactg tggtatgaga tatcccgagt ctcatcctaa catgctcagt agttgggcat
     7801 tctagcccag tctaccctgt agtggtcata ggttctgcca agatctctgg gtccatgtcc
     7861 agtttggagg gtccaacatt tcagtgcttt ttgagtttct catttttata aaaagttatc
     7921 tcataaggga gtcagtcttc acgttggggc tttcccaggg aaactgtcat cactggtaac
     7981 aaactgtaac tttaaagggc atgttgttgc tgttattgtt ttgccttttt ttttttttta
     8041 atataagtgt gcttgggaac tccttacatt ttatgcaata aactattttt ggtaaa
//
