LOCUS       NM_010323               2482 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus gonadotropin releasing hormone receptor (Gnrhr),
            transcript variant 1, mRNA.
ACCESSION   NM_010323
VERSION     NM_010323.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Banik,J., Moreira,A.R.S., Lim,J., Tomlinson,S., Hardy,L.L.,
            Lagasse,A., Haney,A., Crimmins,M.R., Boehm,U., Odle,A.K.,
            MacNicol,M.C., Childs,G.V. and MacNicol,A.M.
  TITLE     The Musashi RNA binding proteins direct the translational
            activation of key pituitary mRNAs
  JOURNAL   Sci Rep 14 (1), 5918 (2024)
   PUBMED   38467682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2482)
  AUTHORS   Farkas,I., Skrapits,K., Sarvari,M., Gocz,B., Takacs,S., Rumpler,E.
            and Hrabovszky,E.
  TITLE     Functional GnRH receptor signaling regulates striatal cholinergic
            neurons in neonatal but not in adult mice
  JOURNAL   Front Endocrinol (Lausanne) 15, 1353151 (2024)
   PUBMED   38348415
  REMARK    GeneRIF: Functional GnRH receptor signaling regulates striatal
            cholinergic neurons in neonatal but not in adult mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2482)
  AUTHORS   Mohammadzadeh,P., Roueinfar,M. and Amberg,G.C.
  TITLE     AXL receptor tyrosine kinase modulates gonadotropin-releasing
            hormone receptor signaling
  JOURNAL   Cell Commun Signal 21 (1), 284 (2023)
   PUBMED   37828510
  REMARK    GeneRIF: AXL receptor tyrosine kinase modulates
            gonadotropin-releasing hormone receptor signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2482)
  AUTHORS   Moreira,A.R.S., Lim,J., Urbaniak,A., Banik,J., Bronson,K.,
            Lagasse,A., Hardy,L., Haney,A., Allensworth,M., Miles,T.K.,
            Gies,A., Byrum,S.D., Wilczynska,A., Boehm,U., Kharas,M.,
            Lengner,C., MacNicol,M.C., Childs,G.V., MacNicol,A.M. and Odle,A.K.
  TITLE     Musashi Exerts Control of Gonadotrope Target mRNA Translation
            During the Mouse Estrous Cycle
  JOURNAL   Endocrinology 164 (9) (2023)
   PUBMED   37477898
REFERENCE   5  (bases 1 to 2482)
  AUTHORS   Gotz,V., Qiao,S., Das,D., Wartenberg,P., Wyatt,A., Wahl,V.,
            Gamayun,I., Alasmi,S., Fecher-Trost,C., Meyer,M.R., Rad,R.,
            Kaltenbacher,T., Kattler,K., Lipp,P., Becherer,U., Mollard,P.,
            Candlish,M. and Boehm,U.
  TITLE     Ovulation is triggered by a cyclical modulation of gonadotropes
            into a hyperexcitable state
  JOURNAL   Cell Rep 42 (6), 112543 (2023)
   PUBMED   37224016
REFERENCE   6  (bases 1 to 2482)
  AUTHORS   Arora,K.K., Sakai,A. and Catt,K.J.
  TITLE     Effects of second intracellular loop mutations on signal
            transduction and internalization of the gonadotropin-releasing
            hormone receptor
  JOURNAL   J Biol Chem 270 (39), 22820-22826 (1995)
   PUBMED   7559413
REFERENCE   7  (bases 1 to 2482)
  AUTHORS   Montgomery,G.W., Penty,J.M., Lord,E.A., Brooks,J. and McNeilly,A.S.
  TITLE     The gonadotrophin-releasing hormone receptor maps to sheep
            chromosome 6 outside of the region of the FecB locus
  JOURNAL   Mamm Genome 6 (6), 436-438 (1995)
   PUBMED   7647469
REFERENCE   8  (bases 1 to 2482)
  AUTHORS   Kaiser,U.B., Zhao,D., Cardona,G.R. and Chin,W.W.
  TITLE     Isolation and characterization of cDNAs encoding the rat pituitary
            gonadotropin-releasing hormone receptor
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1645-1652 (1992)
   PUBMED   1339279
REFERENCE   9  (bases 1 to 2482)
  AUTHORS   Reinhart,J., Mertz,L.M. and Catt,K.J.
  TITLE     Molecular cloning and expression of cDNA encoding the murine
            gonadotropin-releasing hormone receptor
  JOURNAL   J Biol Chem 267 (30), 21281-21284 (1992)
   PUBMED   1328228
REFERENCE   10 (bases 1 to 2482)
  AUTHORS   Tsutsumi,M., Zhou,W., Millar,R.P., Mellon,P.L., Roberts,J.L.,
            Flanagan,C.A., Dong,K., Gillo,B. and Sealfon,S.C.
  TITLE     Cloning and functional expression of a mouse gonadotropin-releasing
            hormone receptor
  JOURNAL   Mol Endocrinol 6 (7), 1163-1169 (1992)
   PUBMED   1324422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107634.8 and L01119.1.
            
            On Jul 17, 2015 this sequence version replaced NM_010323.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L01119.1, M93108.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC107634.8         195899-195929       c
            32-1242             L01119.1           1-1211
            1243-2482           AC107634.8         178782-180021       c
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..2482
                     /gene="Gnrhr"
                     /note="gonadotropin releasing hormone receptor"
                     /db_xref="GeneID:14715"
                     /db_xref="MGI:MGI:95790"
     exon            1..598
                     /gene="Gnrhr"
                     /inference="alignment:Splign:2.1.0"
     exon            599..815
                     /gene="Gnrhr"
                     /inference="alignment:Splign:2.1.0"
     exon            816..2482
                     /gene="Gnrhr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgcttcgc gttcagttat gataaaacat cagaagtaac agggactcca ctcttgaagc
       61 ctgtccttgg agaaatatgg ctaacaatgc atctcttgag caggacccaa atcactgctc
      121 ggccatcaac aacagcatcc ccttgataca gggcaagctc ccgactctaa ccgtatctgg
      181 aaagatccga gtgaccgtga ctttcttcct tttcctactc tctactgcct tcaatgcttc
      241 cttcttgttg aagctgcaga agtggactca gaagaggaag aaaggaaaaa agctctcaag
      301 gatgaaggtg cttttaaagc atttgacctt agccaacctg ctggagactc tgatcgtcat
      361 gccactggat gggatgtgga atattactgt tcagtggtat gctggggagt tcctctgcaa
      421 agttctcagc tatctgaagc tcttctctat gtatgcccca gctttcatga tggtggtgat
      481 tagcctggac cgctccctgg ccatcactca gccccttgct gtacaaagca acagcaagct
      541 tgaacagtct atgatcagcc tggcctggat tctcagcatt gtctttgcag gaccacagtt
      601 atatatcttc aggatgatct acctagcaga cggctctggg cccacagtct tctcgcaatg
      661 tgtgacccac tgcagctttc cacagtggtg gcatcaggcc ttctacaact ttttcacctt
      721 cggctgcctc ttcatcatcc ccctcctcat catgctaatc tgcaatgcca aaatcatctt
      781 tgctctcacg cgagtccttc atcaagaccc acgcaaacta cagctgaatc agtccaagaa
      841 taatatccca agagctcggc tgagaacgct aaagatgaca gtcgcattcg ctacctcctt
      901 tgtcgtctgc tggactccct actatgtcct aggcatttgg tactggtttg atccagaaat
      961 gttgaacagg gtgtcagagc cagtgaatca ctttttcttt ctctttgctt tcctaaaccc
     1021 gtgcttcgac ccactcatat atgggtattt ctctttgtag ttgggagact acacaagaac
     1081 tcagatagaa ataaggtaac taattgcacc aattgagaat aaactcaaag cttttgacac
     1141 acttatatac aaggcagggt ttaaggttag attatcaacc ttgtttttgt acagagtttg
     1201 ttgttagagc ttcagaagac cttcaaaaac aaaaacaaaa aacaaaaaaa cccgaaatgt
     1261 gtccttactc ataagcttct aaactaacct cagccttgtc ggatattttg ctgtatatga
     1321 tttaggattc tttacttcct ccttagatca taatatataa atacttaaaa tgactacgtc
     1381 ctaaggtaaa cagtaccaaa aacaaaggct gggaaaacac aacatattca taacatcagc
     1441 acagtttggg gaattttttt tttttctcaa agggggctca gcatcaataa cagtctggct
     1501 ctatcctaac acctacaggt catcagcaaa aacagatgct atcccaagac ctaaagccca
     1561 gagacagaag tatcactgtc cataggttag caggaaaaac aggttgatgt tgtcccaaca
     1621 cctaaggcac agagacggta gaatcagtca ctgtccacag gtcaggagcg atgacaggct
     1681 gatgctatca cagcctagag cgcatacaga gcagaattac tgtccagaag tcaattctta
     1741 accgcaatga ttaaagcact tagttttctc ttttacttta aaagcttttt tgattctgat
     1801 tcagcaacaa atcccaccag cctggcaaga ttatttacat gataatacaa atcagtccca
     1861 tttacatgct acagattgtg acacatccct acatagtgga ggaatttaaa gggatagata
     1921 ttttccccca tagactgtta gactattcct tagaatattt catactgtac agtatatagg
     1981 gtttatgtta gctgacagtc atgagtagtg ttttaatata attaagaaaa tgcagatagg
     2041 agttatcttg taagaataat atacaatcca ctttaacaac atggtggaac ttttgtctat
     2101 caccttaacc tacggaatca ttttccacaa ataaataagg aaagttaatt taaaaaaaaa
     2161 catcaagcaa atatacaaac agaaagagga ggtttgatgt attaagggaa ctcaaggcag
     2221 gagagcatag aatttcccct acacagacca aatacaatag cagagaatat tagagaggag
     2281 cgaagtaaaa ctctacgtgt gaaaaaaaca actaccgctg aaaaagaacg cagtcctgaa
     2341 aagtatgtct gcagagtatc acgtgctttg ttcaactcgt gaaaaacggg aggaggtgaa
     2401 aattagacta caacacccac tcactcggga aagtatgtga actcacattc aataattact
     2461 aatagacatt gatgtgaact ac
//
