LOCUS       NM_008145                487 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus gonadotropin releasing hormone 1 (Gnrh1), transcript
            variant 1, mRNA.
ACCESSION   NM_008145
VERSION     NM_008145.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Amato,E. Jr., Taroc,E.Z.M. and Forni,P.E.
  TITLE     Illuminating the terminal nerve: Uncovering the link between GnRH-1
            neuron and olfactory development
  JOURNAL   J Comp Neurol 532 (3), e25599 (2024)
   PUBMED   38488687
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Jaime,J., DeFazio,R.A. and Moenter,S.M.
  TITLE     Development and prenatal exposure to androgens alter potassium
            currents in gonadotropin-releasing hormone neurons from female mice
  JOURNAL   J Neuroendocrinol 36 (3), e13373 (2024)
   PUBMED   38403894
  REMARK    GeneRIF: Development and prenatal exposure to androgens alter
            potassium currents in gonadotropin-releasing hormone neurons from
            female mice.
REFERENCE   3  (bases 1 to 487)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 487)
  AUTHORS   Sisk-Hackworth,L., Brown,J., Sau,L., Levine,A.A., Tam,L.Y.I.,
            Ramesh,A., Shah,R.S., Kelley-Thackray,E.T., Wang,S., Nguyen,A.,
            Kelley,S.T. and Thackray,V.G.
  TITLE     Genetic hypogonadal mouse model reveals niche-specific influence of
            reproductive axis and sex on intestinal microbial communities
  JOURNAL   Biol Sex Differ 14 (1), 79 (2023)
   PUBMED   37932822
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 487)
  AUTHORS   Sharova,V., Ignatiuk,V., Izvolskaia,M. and Zakharova,L.
  TITLE     Disruption of Intranasal GnRH Neuronal Migration Route into the
            Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo
            Rodent Models
  JOURNAL   Int J Mol Sci 24 (21), 15983 (2023)
   PUBMED   37958965
  REMARK    GeneRIF: Disruption of Intranasal GnRH Neuronal Migration Route
            into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo
            and In Vivo Rodent Models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 487)
  AUTHORS   Silverman,A.J., Roberts,J.L., Dong,K.W., Miller,G.M. and
            Gibson,M.J.
  TITLE     Intrahypothalamic injection of a cell line secreting
            gonadotropin-releasing hormone results in cellular differentiation
            and reversal of hypogonadism in mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10668-10672 (1992)
   PUBMED   1438263
REFERENCE   7  (bases 1 to 487)
  AUTHORS   Livne,I., Silverman,A.J. and Gibson,M.J.
  TITLE     Reversal of reproductive deficiency in the hpg male mouse by
            neonatal androgenization
  JOURNAL   Biol Reprod 47 (4), 561-567 (1992)
   PUBMED   1391342
REFERENCE   8  (bases 1 to 487)
  AUTHORS   Scott,I.S., Bennett,M.K., Porter-Goff,A.E., Harrison,C.J.,
            Cox,B.S., Grocock,C.A., O'Shaughnessy,P.J., Clayton,R.N.,
            Craven,R., Furr,B.J. et al.
  TITLE     Effects of the gonadotrophin-releasing hormone agonist 'Zoladex'
            upon pituitary and gonadal function in hypogonadal (hpg) male mice:
            a comparison with normal male and testicular feminized (tfm) mice
  JOURNAL   J Mol Endocrinol 8 (3), 249-258 (1992)
   PUBMED   1385960
REFERENCE   9  (bases 1 to 487)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 487)
  AUTHORS   Cattanach,B.M., Iddon,C.A., Charlton,H.M., Chiappa,S.A. and Fink,G.
  TITLE     Gonadotrophin-releasing hormone deficiency in a mutant mouse with
            hypogonadism
  JOURNAL   Nature 269 (5626), 338-340 (1977)
   PUBMED   198666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093020.6.
            
            On Feb 6, 2023 this sequence version replaced NM_008145.3.
            
            Summary: This gene encodes hypophysiotropic peptides belonging to
            the family of gonadotropin-releasing hormones that stimulate the
            release of gonadotropins and suppress secretion of prolactin from
            the pituitary gland. The encoded protein is proteolytically
            processed to generate two biologically active mature peptides. A
            deletional mutation encompassing the distal half of this gene in
            mice resulting in the loss of the encoded protein leads to
            hypogonadism and infertility. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ059442.1, AK139480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC093020.6         132331-132388
            59-200              AC093020.6         133402-133543
            201-296             AC093020.6         134866-134961
            297-487             AC093020.6         136313-136503
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.66 cM"
     gene            1..487
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /note="gonadotropin releasing hormone 1"
                     /db_xref="GeneID:14714"
                     /db_xref="MGI:MGI:95789"
     exon            1..58
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /inference="alignment:Splign:2.1.0"
     exon            59..200
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..338
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; gonadotropin releasing hormone 2;
                     progonadoliberin I; luteinizing hormone-releasing hormone
                     I"
                     /codon_start=1
                     /product="progonadoliberin-1 isoform 1 preproprotein"
                     /protein_id="NP_032171.1"
                     /db_xref="CCDS:CCDS27231.1"
                     /db_xref="GeneID:14714"
                     /db_xref="MGI:MGI:95789"
                     /translation="MILKLMAGILLLTVCLEGCSSQHWSYGLRPGGKRNTEHLVESFQ
                     EMGKEVDQMAEPQHFECTVHWPRSPLRDLRGALESLIEEEARQKKM"
     exon            201..296
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /inference="alignment:Splign:2.1.0"
     exon            297..487
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      463..468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /note="hexamer: AATAAA"
     polyA_site      487
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /note="major polyA site"
ORIGIN      
        1 gaagtactca acctaccaac ggaagctcga gatccctttg actttcacat ccaaacagag
       61 tggacatgat cctcaaactg atggccggca ttctactgct gactgtgtgt ttggaaggct
      121 gctccagcca gcactggtcc tatgggttgc gccctggggg aaagagaaac actgaacact
      181 tggttgagtc tttccaagag atgggcaagg aggtggatca aatggcagaa ccccagcact
      241 tcgaatgtac tgtccactgg ccccgttcac ccctcaggga tctgcgagga gctctggaaa
      301 gtctgattga agaggaagcc aggcagaaga agatgtagat gcactggccc aggtggatcc
      361 acaacacccg agtataacat tgaccctgag gcttgtgacc tgttaatggc tctgtaattg
      421 tgtaagcttg agcgttttta tacccagcag cgtagatttc ataataaagt agtttgttgt
      481 ggatcaa
//
