LOCUS       NM_001004164            5343 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-acetylglucosamine-1-phosphate transferase, alpha and
            beta subunits (Gnptab), transcript variant 1, mRNA.
ACCESSION   NM_001004164 XM_483936
VERSION     NM_001004164.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5343)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5343)
  AUTHORS   Mareninova,O.A., Vegh,E.T., Shalbueva,N., Wightman,C.J.,
            Dillon,D.L., Malla,S., Xie,Y., Takahashi,T., Rakonczay,Z. Jr.,
            French,S.W., Gaisano,H.Y., Gorelick,F.S., Pandol,S.J.,
            Bensinger,S.J., Davidson,N.O., Dawson,D.W., Gukovsky,I. and
            Gukovskaya,A.S.
  TITLE     Dysregulation of mannose-6-phosphate-dependent cholesterol
            homeostasis in acinar cells mediates pancreatitis
  JOURNAL   J Clin Invest 131 (15) (2021)
   PUBMED   34128834
REFERENCE   3  (bases 1 to 5343)
  AUTHORS   Westermann,L.M., Baranowsky,A., Di Lorenzo,G., Danyukova,T.,
            Soul,J., Schwartz,J.M., Hendrickx,G., Amling,M., Rose-John,S.,
            Garbers,C., Schinke,T. and Pohl,S.
  TITLE     Transgenic inhibition of interleukin-6 trans-signaling does not
            prevent skeletal pathologies in mucolipidosis type II mice
  JOURNAL   Sci Rep 11 (1), 3556 (2021)
   PUBMED   33574442
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5343)
  AUTHORS   Westermann,L.M., Fleischhauer,L., Vogel,J., Jenei-Lanzl,Z.,
            Ludwig,N.F., Schau,L., Morellini,F., Baranowsky,A., Yorgan,T.A., Di
            Lorenzo,G., Schweizer,M., de Souza Pinheiro,B., Guarany,N.R.,
            Sperb-Ludwig,F., Visioli,F., Oliveira Silva,T., Soul,J.,
            Hendrickx,G., Wiegert,J.S., Schwartz,I.V.D., Clausen-Schaumann,H.,
            Zaucke,F., Schinke,T., Pohl,S. and Danyukova,T.
  TITLE     Imbalanced cellular metabolism compromises cartilage homeostasis
            and joint function in a mouse model of mucolipidosis type III gamma
  JOURNAL   Dis Model Mech 13 (11) (2020)
   PUBMED   33023972
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5343)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5343)
  AUTHORS   Vogel,P., Payne,B.J., Read,R., Lee,W.S., Gelfman,C.M. and
            Kornfeld,S.
  TITLE     Comparative pathology of murine mucolipidosis types II and IIIC
  JOURNAL   Vet Pathol 46 (2), 313-324 (2009)
   PUBMED   19261645
  REMARK    GeneRIF: Retinal degeneration with storage disease phenotype in
            most exocrine glands in Gnptab null mice
REFERENCE   7  (bases 1 to 5343)
  AUTHORS   Gelfman,C.M., Vogel,P., Issa,T.M., Turner,C.A., Lee,W.S.,
            Kornfeld,S. and Rice,D.S.
  TITLE     Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase
            exhibit growth retardation, retinal degeneration, and secretory
            cell lesions
  JOURNAL   Invest Ophthalmol Vis Sci 48 (11), 5221-5228 (2007)
   PUBMED   17962477
REFERENCE   8  (bases 1 to 5343)
  AUTHORS   Lee,W.S., Payne,B.J., Gelfman,C.M., Vogel,P. and Kornfeld,S.
  TITLE     Murine UDP-GlcNAc:lysosomal enzyme
            N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit
            retains substantial activity toward acid hydrolases
  JOURNAL   J Biol Chem 282 (37), 27198-27203 (2007)
   PUBMED   17652091
REFERENCE   9  (bases 1 to 5343)
  AUTHORS   Sperisen,P., Schmid,C.D., Bucher,P. and Zilian,O.
  TITLE     Stealth proteins: in silico identification of a novel protein
            family rendering bacterial pathogens invisible to host immune
            defense
  JOURNAL   PLoS Comput Biol 1 (6), e63 (2005)
   PUBMED   16299590
REFERENCE   10 (bases 1 to 5343)
  AUTHORS   Cordes,S.P. and Barsh,G.S.
  TITLE     The mouse segmentation gene kr encodes a novel basic domain-leucine
            zipper transcription factor
  JOURNAL   Cell 79 (6), 1025-1034 (1994)
   PUBMED   8001130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140867.1 and AK173132.1.
            
            On Jun 29, 2018 this sequence version replaced NM_001004164.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173132.1, SRR1660825.151253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AK140867.1         46-189
            145-5343            AK173132.1         1-5199
FEATURES             Location/Qualifiers
     source          1..5343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.86 cM"
     gene            1..5343
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /note="N-acetylglucosamine-1-phosphate transferase, alpha
                     and beta subunits"
                     /db_xref="GeneID:432486"
                     /db_xref="MGI:MGI:3643902"
     exon            1..268
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3859
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /EC_number="2.7.8.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetylglucosamine-1-phosphotransferase subunits
                     alpha/beta; stealth protein GNPTAB;
                     glcNAc-1-phosphotransferase subunits alpha/beta;
                     UDP-N-acetylglucosamine-1-phosphotransferase subunits
                     alpha/beta"
                     /codon_start=1
                     /product="N-acetylglucosamine-1-phosphotransferase
                     subunits alpha/beta isoform 1"
                     /protein_id="NP_001004164.2"
                     /db_xref="CCDS:CCDS24110.1"
                     /db_xref="GeneID:432486"
                     /db_xref="MGI:MGI:3643902"
                     /translation="MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEW
                     SRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREHMEE
                     EQRAMRETLGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPPLPANCTLKDLPTLYPS
                     FHAASDMFNVAKPKNPSTNVSVVVFDTTKDVEDAHAGPFKGGSKQMVWRAYLTTDKEA
                     PGLVLMQGLAFLSGFPPTFKETSQLKTKLPEKLSSKIKLLRLYSEASVALLKLNNPKG
                     FQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLR
                     SIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDIFQNLSHLPTFSSPAIESHI
                     HRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDG
                     YCDKACNNSACDWDGGDCSGNTAGNRFVAGGGGTGNIGAGQHWQFGGGINTISYCNQG
                     CANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGEYLSYF
                     SFANIARRGVEGTYSDNPIIRHASIANKWKTIHLIMHSGMNATTIYFNLTLQNANDEE
                     FKIQIAVEVDTREAPKLNSTTQKAYESLVSPVTPLPQADVPFEDVPKEKRFPKIRRHD
                     VNATGRFQEEVKIPRVNISLLPKEAQVRLSNLDLQLERGDITLKGYNLSKSALLRSFL
                     GNSLDTKIKPQARTDETKGNLEVPQENPSHRRPHGFAGEHRSERWTAPAETVTVKGRD
                     HALNPPPVLETNARLAQPTLGVTVSKENLSPLIVPPESHLPKEEESDRAEGNAVPVKE
                     LVPGRRLQQNYPGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSL
                     RYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQF
                     AFSYFYYLMSAVQPLNISQVFHEVDTDQSGVLSDREIRTLATRIHDLPLSLQDLTGLE
                     HMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKN
                     KYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDARTVKAV
                     LRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIIFTIF
                     SFFAEQIIALKRKIFPRRRIHKEASPDRIRV"
     exon            269..354
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            355..474
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            475..516
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            517..722
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            723..787
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            788..922
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1084
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1264
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1435
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1559
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1763
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2803
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3003
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3223
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3337
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3423
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3522
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3690
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3781
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..5343
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4751..4756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /note="hexamer: AGTAAA"
     polyA_site      4770
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /note="hexamer: CATAAA"
     polyA_site      5343
                     /gene="Gnptab"
                     /gene_synonym="EG432486"
                     /note="major polyA site"
ORIGIN      
        1 agcgggccgt cggtcgccgg agcgacaatg tgcggcagcc gggggctgtg agctaagcgc
       61 ggcggcgcgt ccgggggccc ctgaatggcg gctcgctgag gcggtggcgc ggcgcgggct
      121 cctcctggcg tggggtggcg gggccggggt gatgctgctt aagctcctgc agagacagac
      181 ctatacctgc ctatcccaca ggtatgggct ctacgtctgc ttcgtgggcg tcgttgtcac
      241 catcgtctcg gctttccagt tcggagaggt ggttctggaa tggagccgag atcagtacca
      301 tgttttgttt gattcctaca gagacaacat tgctgggaaa tcctttcaga atcggctctg
      361 tctgcccatg ccaatcgacg tggtttacac ctgggtgaat ggcactgacc ttgaactgct
      421 aaaggagcta cagcaggtcc gagagcacat ggaggaagag cagagagcca tgcgggaaac
      481 cctcgggaag aacacaaccg aaccgacaaa gaagagtgag aagcagctgg aatgtctgct
      541 gacgcactgc attaaggtgc ccatgcttgt tctggacccg cccctgccag ccaactgcac
      601 cctgaaggat ctgccaaccc tttatccatc tttccacgct gccagcgaca tgttcaatgt
      661 tgcgaaacca aaaaatccgt ctactaatgt ctccgttgtc gtttttgaca ctactaagga
      721 tgttgaagac gcccatgctg gaccgtttaa gggaggcagc aaacagatgg tttggagagc
      781 ctacttgaca acagacaaag aagcccctgg cttagtgctg atgcaaggct tggcgttcct
      841 gagtggattc ccaccgacct tcaaggagac gagtcaactg aagacaaagc tgccagaaaa
      901 gctttcctct aaaataaagc tgttgcggct gtactcggag gccagtgtcg ctcttctgaa
      961 attgaataat cccaagggtt tccaagagct gaacaagcag accaagaaga acatgaccat
     1021 cgatgggaag gaactgacca tcagccctgc gtatctgctg tgggacctga gtgccatcag
     1081 ccagtccaag caggatgagg acgtgtctgc cagccgcttt gaggataatg aagagctgag
     1141 gtactcgctg cgatctatcg agagacacgc gccatgggta cggaatattt tcattgtcac
     1201 caacgggcag attccatcct ggctgaacct tgacaaccct cgagtgacca tagtgaccca
     1261 ccaggacatt ttccaaaatc tgagccactt gcctactttc agttcccctg ctattgaaag
     1321 tcacattcac cgcatcgaag ggctgtccca gaagtttatt tatctaaatg acgatgtcat
     1381 gttcggtaag gacgtctggc cggacgattt ttacagccac tccaaaggtc aaaaggttta
     1441 tttgacatgg cctgtgccaa actgtgcaga gggctgcccg ggctcctgga ttaaagacgg
     1501 ctattgtgat aaggcctgta ataactcagc ctgtgactgg gatggcggag actgctctgg
     1561 taatactgca gggaaccggt ttgttgcagg aggtgggggt accgggaata ttggagctgg
     1621 acagcactgg cagtttggtg gaggaataaa caccatctct tactgtaacc aaggatgtgc
     1681 aaactcctgg ctggctgaca agttctgtga ccaagcctgt aacgtcttat cctgcgggtt
     1741 tgatgctggt gactgtggac aagatcattt tcatgaattg tataaagtaa cacttctccc
     1801 aaaccagact cactatgttg tccccaaagg tgaatacctg tcttatttca gctttgcaaa
     1861 catagccaga agaggagttg aagggaccta cagcgacaac cccatcatcc gccacgcgtc
     1921 cattgcaaac aagtggaaaa ccatacacct gataatgcac agtgggatga acgcaaccac
     1981 gatctatttt aacctcactc ttcaaaacgc caacgacgaa gagttcaaga tccagatagc
     2041 agtagaggtg gacacgaggg aggcgcccaa actgaattct acaacccaga aggcctatga
     2101 aagtttggtt agcccagtga cacctcttcc tcaggctgac gtcccttttg aagatgtccc
     2161 caaagagaaa cgcttcccca agatcaggag acatgatgta aatgcaacag ggagattcca
     2221 agaggaggtg aaaatccccc gggtaaatat ttcactcctt cccaaagagg cccaggtgag
     2281 gctgagcaac ttggatttgc aactagaacg tggagacatc actctgaaag gatataactt
     2341 gtccaagtca gccctgctaa ggtctttcct ggggaattca ctagatacta aaataaaacc
     2401 tcaagctagg accgatgaaa caaaaggcaa cctggaggtc ccacaggaaa acccttctca
     2461 cagacgtcca catggctttg ctggtgaaca cagatcagag agatggactg ccccagcaga
     2521 gacagtgacc gtgaaaggcc gtgaccacgc tttgaatcca cccccggtgt tggagaccaa
     2581 tgcaagattg gcccagccta cactaggcgt gactgtgtcc aaagagaacc tttcaccgct
     2641 gatcgttccc ccagaaagcc acttgccaaa agaagaggag agtgacaggg cagaaggcaa
     2701 tgctgtacct gtaaaggagt tagtgcctgg cagacggttg cagcagaatt atccaggctt
     2761 tttgccctgg gagaaaaaaa agtatttcca agaccttctt gatgaggaag agtcattgaa
     2821 gacccagttg gcgtacttta cagacagcaa acataccggg aggcaactaa aagatacatt
     2881 tgcagactcc ctccgatacg tcaataaaat tctcaacagc aagtttggat tcacatccag
     2941 gaaagtccct gcacacatgc cgcacatgat tgacaggatc gttatgcaag aactccaaga
     3001 tatgttccct gaagaatttg acaagacttc atttcacaag gtgcgtcact ctgaggacat
     3061 gcagtttgcc ttctcctact tttattacct catgagtgca gttcagcccc tcaatatttc
     3121 ccaagtcttt catgaagtag acacagacca atctggtgtc ttgtctgata gggaaatccg
     3181 aacactggcc acgagaattc acgacctacc tttaagcttg caggatttga caggtttgga
     3241 acacatgtta ataaattgct caaaaatgct ccccgctaat atcactcaac tcaacaacat
     3301 cccaccgact caggaagcat actacgaccc caacctgcct ccggtcacta agagtcttgt
     3361 caccaactgt aagccagtaa ctgacaagat ccacaaagcc tataaagaca agaacaaata
     3421 caggtttgaa atcatgggag aggaagaaat cgctttcaag atgatacgaa ccaatgtttc
     3481 tcatgtggtt ggccagttgg atgacatcag aaaaaacccc aggaagttcg tttgtctgaa
     3541 tgacaacatt gaccacaacc ataaagatgc ccggacagtg aaggctgtcc tcagggactt
     3601 ctatgagtcc atgtttccca taccttccca gtttgagctg ccaagagagt atcggaaccg
     3661 ctttctgcac atgcatgagc tccaagaatg gcgggcatat cgagacaagc tgaagttttg
     3721 gacccactgc gtactagcaa cgttgattat atttactata ttctcatttt ttgctgaaca
     3781 gataattgct ctgaagcgaa agatatttcc caggaggagg atacacaaag aagctagtcc
     3841 agaccgaatc agggtgtaga agatcttcat ttgaaagtca cctacctcag catctgtgaa
     3901 catctccctc ctcgacacca cagcggagtc cctgtgatgt ggcacagagg cagcctcgtg
     3961 gggagaaggg acatcgtgca gaccgggttc ttctgcaatg ggaagagagc ccactgacct
     4021 ggaattattc agcacactaa gaacctgtgt caatagcttg tacagcttgt acttttaaag
     4081 gatttgccga aggacctgtc ggcttgttga caaaccctcc ctgacaagct gctggtttct
     4141 tcccccagtt actgcagact gagaaaccag tccatcttga aagcaagtgc ggaggggccc
     4201 cagtctttgc attccaaagc tttccagcat aatttctggc ttgtctcctc ctttgatcca
     4261 tttcccattt ttttttaaaa aacaataagt ggctactaag ttagtcattc tcacttctca
     4321 aaataacaaa tcaggatgtc aaaacatttg tatagatctt atttaaataa tatagaacga
     4381 ttacttcttt agcctatcta aattattgat ttttattaac agtcaagtgg tcttgaatcg
     4441 ctaacaacta ctgaagagct cgagattgac gttgaaagtg ctttgagctt gtttaactca
     4501 ttccccaaga atactgtgac ctcgtgtgcg ggcctgattg cgaagggcta gtgtcacgta
     4561 gcagtgctgc tcaccggatg taattatgtc gtggaaatgt acatacaaac aaaagtgcct
     4621 cacttcagaa atgagtagtg ctgatggcac cagcgagtga tggtgtccat ttggaaaccc
     4681 atgatacctt ccaatgccca ccctgcttac tttatacaga gcaggggtta accaacttct
     4741 gtcaaagaac agtaaagaac ttgagataca tccatctttg tcaaatagtc ttccttgcta
     4801 acatttatta ttgttggtgt tttgggaggt ttattttatt ttattgcttt gttatttttc
     4861 aagacgggga ttctctgtgt agctctggct gtttggtaat tcactctaaa gaccaggctg
     4921 gccttgaact tagagattca cctgcctctg cttcctgaat gctaggacat gtgcccacac
     4981 tgcctaccca cccccctttt ggggggggtg agcaactcaa taaaaagatg aaaacctgct
     5041 ttagtttgca gctatacaaa agcagcaggc ctcagccaga cttgaccccc ggggccattg
     5101 ttggcccacg ggagaatcat ttttgacgtg ggtaagcaaa ccctgatatt ggtcatgctg
     5161 tgttatgtca ttatgtggtg gttttgaatt ctggaagata tcttcagtca tgatctcagt
     5221 agtattcctc caaaatggca cacattttcg taataagaac ttgaaatgta aatattgtgt
     5281 ttgtgctgta aattttgtgt atttcaaaaa ctgaagtctc ataaaaaaac acacttattg
     5341 aaa
//
