LOCUS       NM_001417538            1980 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glucosamine-phosphate N-acetyltransferase 1 (Gnpnat1),
            transcript variant 1, mRNA.
ACCESSION   NM_001417538
VERSION     NM_001417538.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Boehmelt,G., Wakeham,A., Elia,A., Sasaki,T., Plyte,S., Potter,J.,
            Yang,Y., Tsang,E., Ruland,J., Iscove,N.N., Dennis,J.W. and Mak,T.W.
  TITLE     Decreased UDP-GlcNAc levels abrogate proliferation control in
            EMeg32-deficient cells
  JOURNAL   EMBO J 19 (19), 5092-5104 (2000)
   PUBMED   11013212
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Boehmelt,G., Fialka,I., Brothers,G., McGinley,M.D., Patterson,S.D.,
            Mo,R., Hui,C.C., Chung,S., Huber,L.A., Mak,T.W. and Iscove,N.N.
  TITLE     Cloning and characterization of the murine glucosamine-6-phosphate
            acetyltransferase EMeg32. Differential expression and intracellular
            membrane association
  JOURNAL   J Biol Chem 275 (17), 12821-12832 (2000)
   PUBMED   10777580
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Inohara,N., Ekhterae,D., Garcia,I., Carrio,R., Merino,J., Merry,A.,
            Chen,S. and Nunez,G.
  TITLE     Mtd, a novel Bcl-2 family member activates apoptosis in the absence
            of heterodimerization with Bcl-2 and Bcl-XL
  JOURNAL   J Biol Chem 273 (15), 8705-8710 (1998)
   PUBMED   9535847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025535.14.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY720339.1, SRR17253011.1306461.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CT025535.14        54520-54577         c
            59-226              CT025535.14        50353-50520         c
            227-289             CT025535.14        49166-49228         c
            290-355             CT025535.14        47785-47850         c
            356-483             CT025535.14        47328-47455         c
            484-545             CT025535.14        46709-46770         c
            546-1980            CT025535.14        42824-44258         c
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.92 cM"
     gene            1..1980
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /note="glucosamine-phosphate N-acetyltransferase 1"
                     /db_xref="GeneID:54342"
                     /db_xref="MGI:MGI:1858963"
     exon            1..58
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            59..226
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..693
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /EC_number="2.3.1.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucosamine 6-phosphate N-acetyltransferase;
                     phosphoglucosamine acetylase; phosphoglucosamine
                     transacetylase; glucosamine-6-phosphate acetyltransferase;
                     glucosamine-phosphate N-acetyltransferase 1;
                     glucosamine-6-phosphate acetyltransferase;
                     glucosamine-phosphate N-acetyltransferase"
                     /codon_start=1
                     /product="glucosamine 6-phosphate N-acetyltransferase
                     isoform 1"
                     /protein_id="NP_001404467.1"
                     /db_xref="GeneID:54342"
                     /db_xref="MGI:MGI:1858963"
                     /translation="MKPDETPMFDPSLLKEVDWSQNTAIFSPAISPTHPGEGLVLRPL
                     CTADLNKGFFKVLGQLTETGVVSPEQFMRLRPHSVLTDDFKGVDHLVLTVESFEHMKK
                     SGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLL
                     STLTLLSKKLNCYKITLECLPQNVGFYKKFDYTVSEENYMCRRFLK"
     exon            227..289
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            290..355
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            356..483
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            484..545
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            546..1980
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /note="hexamer: ATTAAA"
     polyA_site      1581
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /note="major polyA site"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /note="hexamer: ATTAAA"
     polyA_site      1927
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
     regulatory      1948..1953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="Gnpnat1"
                     /gene_synonym="EMeg32; Gpnat1; Gsnpat"
ORIGIN      
        1 gctttgaccc gcagggagac tgacgcgccg ggactggagc gtggtccgct ccagtgcgac
       61 tttactggaa agatgaaacc cgatgaaact cccatgtttg acccaagttt gctcaaagaa
      121 gtggactgga gtcagaatac agctatattt tctccagcca tttctccaac gcatcctgga
      181 gaaggcttgg ttttgaggcc tctctgtact gcagacttaa ataaaggttt ttttaaggta
      241 ttgggtcagc tgacagagac tggcgtcgtc agcccggaac agttcatgag gttacgtccc
      301 cattctgtac taacagacga ctttaaaggt gtggaccacc tagtgctgac cgttgaatct
      361 tttgagcata tgaagaagtc tggagattac tacgttacag ttgtggaaga tgtgacccta
      421 ggacaaattg tggctacagc aactctgata atagaacata aatttatcca ttcatgtgct
      481 aagagaggga gagtagaaga tgtcgtcgtt agtgacgagt gcagagggaa gcaactcggc
      541 aaactgttat tatcaactct tactttgcta agcaagaaat tgaactgtta caagatcacc
      601 cttgaatgtc taccacaaaa tgttggtttc tacaaaaagt ttgactatac agtatctgaa
      661 gaaaattaca tgtgtcggag gttcctaaag taaaaaccac catcaagagg ttaatgctac
      721 aaagcttaaa taactgtttt agagttcatt tttgttgctg cagcccagtg agctccctaa
      781 ctactagact gaagtacact gtggtgtgcc agtgtgtagt aacctgggag gatgctggga
      841 atacaaataa aggggaggat ttttaaccaa aggaatatat tttcaacttg aatcttttct
      901 tgcattgtat ttttctaaag tttgtcttca tttcttggta gtcaagtgta tgggtagtaa
      961 acatgtctgc tctatgctgc tcatttttaa atatatgtat atacatatat attgaataag
     1021 ggtgtttctt accataaaat tatttttgtc tcatacatct aaatagactt aaggtgcacc
     1081 atttctcatt ggacacttct gttatcatga ccaccagata catatttgtt gttgatccta
     1141 accctgcagt ctttttaaag caacaaaaga aaaatgggac aaggtacaac agcttaaata
     1201 acgatttact aagtgtaaag ttttgtgcag atactgtacc acctgccacc tgtcacatgg
     1261 tattagaatt atccagggtc cttttcattt gtcaatgagc agctcccaga gctgctaccc
     1321 tggtttccgt accattgaca tttgaagcct ttgagtcaca aaaaaatgtt cagtacttcc
     1381 taaatttagt atagctttaa aatgatggta gcttttctat ttaatgtgat tataatggta
     1441 ctattattct gatccctgtc ctttctgttt tatttaaatg atttttaaaa tagaatcaga
     1501 tactttatta atagtggttc taatcttttg cattccatgt tattacatta aacttgttta
     1561 tatgaatagt ctttcatgtt agaatcttgt cttgtgtttt tcttttttgt tgagacaggg
     1621 tgcccaggat atcctggaac ccctcacaca tgttctaaga actggtattc caggcatgta
     1681 ccaccatgat cagcttcagt ctattaggtt aagacctggc tcttaatacc ctaggtttaa
     1741 gtatctttgt acttcaattg gactttggat tttcctgcag tcattaggtt tgtctttgat
     1801 tttcagagtt ctttagttct gtaaccatga cacagcttca ttaggtttta tctatgttaa
     1861 aaaaagcctt ttccccaaag taaaatttag cactttattt tttaacatta aactctttgg
     1921 taagacagtc tgtgatgtta gtatttcaat aaaacccatg gagttgtgtt ttctcttaaa
//
