LOCUS       NM_001038015            1858 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus glucosamine-6-phosphate deaminase 2 (Gnpda2),
            transcript variant 1, mRNA.
ACCESSION   NM_001038015 XM_001052061 XM_001052062 XM_001052063
VERSION     NM_001038015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1858)
  AUTHORS   Arreola,R., Valderrama,B., Morante,M.L. and Horjales,E.
  TITLE     Two mammalian glucosamine-6-phosphate deaminases: a structural and
            genetic study
  JOURNAL   FEBS Lett 551 (1-3), 63-70 (2003)
   PUBMED   12965206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109186.7.
            
            On Dec 29, 2017 this sequence version replaced NM_001038015.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004084.1, AK141408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC109186.7         146958-147054       c
            98-260              AC109186.7         144411-144573       c
            261-362             AC109186.7         141215-141316       c
            363-545             AC109186.7         139724-139906       c
            546-730             AC109186.7         134258-134442       c
            731-905             AC109186.7         132728-132902       c
            906-1858            AC109186.7         129751-130703       c
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 37.13 cM"
     gene            1..1858
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /note="glucosamine-6-phosphate deaminase 2"
                     /db_xref="GeneID:67980"
                     /db_xref="MGI:MGI:1915230"
     exon            1..97
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     exon            98..260
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..967
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /EC_number="3.5.99.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glucosamine-6-phosphate isomerase 2; oscillin; GNPDA 2;
                     glcN6P deaminase 2"
                     /codon_start=1
                     /product="glucosamine-6-phosphate deaminase 2 isoform 1"
                     /protein_id="NP_001033104.1"
                     /db_xref="CCDS:CCDS19324.1"
                     /db_xref="GeneID:67980"
                     /db_xref="MGI:MGI:1915230"
                     /translation="MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGST
                     PLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPN
                     NAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK
                     TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAMEE
                     GVNHMWTVSAFQQHPRTIFVCDEDATLELRVKTVKYFKGLMHVHNKLVDPLYSMKEGN
                     "
     exon            261..362
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     exon            363..545
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     exon            546..730
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     exon            731..905
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1858
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /note="hexamer: AATAAA"
     polyA_site      1691
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /note="hexamer: AATAAA"
     polyA_site      1858
                     /gene="Gnpda2"
                     /gene_synonym="4921523I18Rik; 4933412A11Rik; Gnp2; GNPDA;
                     mKIAA4008; Sb52"
                     /note="major polyA site"
ORIGIN      
        1 caggcttcct cagtcctcac cggctggagt cgctggcggg ttgctgggtg tgttagctcc
       61 ggctcttcgg tcgttggatg aggctgtagg tccgccggtt tcaacctctt ggaccgagag
      121 ctgtgcatca cccataatga ggcttgtaat tcttgataac tatgacttgg ccagcgaatg
      181 ggcagccaag tacatctgca atcgtatcat aaaattcaaa cccggacagg acaggtactt
      241 ttccctgggc ttaccaacag ggagtacacc tttaggatgt tataaaaagc taatcgaata
      301 ccacaagagt ggaaaccttt catttaaata tgtgaagact tttaacatgg atgaatatgt
      361 cggacttcca agaaaccacc ctgaaagtta ccattcttat atgtggaata acttctttaa
      421 gcatatcgat atagatccga acaatgctca catcctcgat gggaacgctg cagatctgca
      481 ggcagagtgt gatgcatttg aggagaaaat caaagaagct ggaggaatag acctttttgt
      541 tggaggaata ggtccagatg gccatattgc tttcaatgaa ccaggatcca gtttagtatc
      601 aagaacgaga ttaaagacgc tagcaatgga caccattttg gcaaatgcta aatattttga
      661 tggagattta tcaaaagtgc caaccatggc tctgactgtt ggtgtgggga cagtgatgga
      721 tgctagggag gtgatgatcc tcataacagg tgcgcacaag gccttcgcgc tgtacaaagc
      781 catggaagaa ggagtcaatc acatgtggac ggtgtccgct ttccagcaac atccacgcac
      841 tatttttgta tgtgatgaag atgccactct agaattaaga gttaaaactg tgaaatactt
      901 taaaggttta atgcatgtgc acaataaact tgtggaccca ctctacagta tgaaagaagg
      961 gaactgaagg agacccagtt gtgctccgaa gaacctttcc atactgataa aatttcagct
     1021 tatgcaatat gataacaata tgtctcgaaa aacaaaaaca aaaaaaaatg acaacatgga
     1081 gaaataggaa gattcattta taaagaaaaa gaccacggtg tgttaaacat tccatattta
     1141 gaatatgtct gttttacact aggttctaga agtaattgga tcccaaagtt ctttggctat
     1201 tataaagtat agacactata tagctaccta taaacagtat agcagtgaaa tgtgtgcatt
     1261 ttaagagatc tgcactcttg ggtcttgtca gtggcataat ctctgacttg tttgaagaca
     1321 ctccaagcct ttccaatgtc atcctgctct cattacaaac cttcactttt ggaatggata
     1381 ttttttgtgc atcatacaca tgctttttgc ctgtagttgc cttagtcatc tttctgcagt
     1441 agcatctgga catcacaagt cctgctattc attaatcaag gaaatctgaa gagatgacag
     1501 tgccctaaag tagtttacat cctttcagaa agtatgtgta agtgcatgct tctatgcacc
     1561 ttcttatgta gtactttttt acagatatgc ttatttttat ttaatgaccg ggttaatgcc
     1621 cttcataagt atattggcaa ttatgagctt tatacctagc tacaaattaa ataaaatcct
     1681 tttgaaaaac attttctgat tattgttaaa ttttgtaaat catccttata tatgtctaaa
     1741 gagatattaa gtatgtacta aattactgta aacatttaaa ttgcaataac ttgcataatt
     1801 aagttgcaaa taaaaatatt gttttctatc tttaacacaa ataaagttta caataaaa
//
