LOCUS       NM_010322               2984 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glyceronephosphate O-acyltransferase (Gnpat), mRNA.
ACCESSION   NM_010322
VERSION     NM_010322.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Dorninger,F., Kiss,A., Rothauer,P., Stiglbauer-Tscholakoff,A.,
            Kummer,S., Fallatah,W., Perera-Gonzalez,M., Hamza,O., Konig,T.,
            Bober,M.B., Cavalle-Garrido,T., Braverman,N.E., Forss-Petter,S.,
            Pifl,C., Bauer,J., Bittner,R.E., Helbich,T.H., Podesser,B.K.,
            Todt,H. and Berger,J.
  TITLE     Overlapping and Distinct Features of Cardiac Pathology in Inherited
            Human and Murine Ether Lipid Deficiency
  JOURNAL   Int J Mol Sci 24 (3), 1884 (2023)
   PUBMED   36768204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Fallatah,W., Cui,W., Di Pietro,E., Carter,G.T., Pounder,B.,
            Dorninger,F., Pifl,C., Moser,A.B., Berger,J. and Braverman,N.E.
  TITLE     A Pex7 Deficient Mouse Series Correlates Biochemical and
            Neurobehavioral Markers to Genotype Severity-Implications for the
            Disease Spectrum of Rhizomelic Chondrodysplasia Punctata Type 1
  JOURNAL   Front Cell Dev Biol 10, 886316 (2022)
   PUBMED   35898397
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Rishi,G., Secondes,E.S., Asplett,K., Wallace,D.F., Ostini,L.,
            Berger,J. and Subramaniam,V.N.
  TITLE     Dysregulated hepcidin response to dietary iron in male mice with
            reduced Gnpat expression
  JOURNAL   Biosci Rep 40 (8) (2020)
   PUBMED   32766721
  REMARK    GeneRIF: Dysregulated hepcidin response to dietary iron in male
            mice with reduced Gnpat expression.
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Alatibi,K.I., Wehbe,Z., Spiekerkoetter,U. and Tucci,S.
  TITLE     Sex-specific perturbation of complex lipids in response to
            medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase
            deficiency
  JOURNAL   FEBS J 287 (16), 3511-3525 (2020)
   PUBMED   31971349
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   An,P., Wang,J., Wang,H., Jiang,L., Wang,J., Min,J. and Wang,F.
  TITLE     Gnpat does not play an essential role in systemic iron homeostasis
            in murine model
  JOURNAL   J Cell Mol Med 24 (7), 4118-4126 (2020)
   PUBMED   32108988
  REMARK    GeneRIF: Gnpat does not play an essential role in systemic iron
            homeostasis in murine model.
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Hogenboom,S., Romeijn,G.J., Houten,S.M., Baes,M., Wanders,R.J. and
            Waterham,H.R.
  TITLE     Absence of functional peroxisomes does not lead to deficiency of
            enzymes involved in cholesterol biosynthesis
  JOURNAL   J Lipid Res 43 (1), 90-98 (2002)
   PUBMED   11792727
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Thai,T.P., Rodemer,C., Worsch,J., Hunziker,A., Gorgas,K. and
            Just,W.W.
  TITLE     Synthesis of plasmalogens in eye lens epithelial cells
  JOURNAL   FEBS Lett 456 (2), 263-268 (1999)
   PUBMED   10456321
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Ofman,R., Hogenhout,E.M. and Wanders,R.J.
  TITLE     Identification and characterization of the mouse cDNA encoding
            acyl-CoA:dihydroxyacetone phosphate acyltransferase
  JOURNAL   Biochim Biophys Acta 1439 (1), 89-94 (1999)
   PUBMED   10395968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI990299.1, BY775400.1, AK004771.1, AK004364.1 and BY469630.1.
            
            On Nov 14, 2007 this sequence version replaced NM_010322.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025972.1, AK004771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BI990299.1         1-5
            6-20                BY775400.1         2-16
            21-2897             AK004771.1         1-2877
            2898-2976           AK004364.1         1345-1423
            2977-2984           BY469630.1         458-465
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.81 cM"
     gene            1..2984
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /note="glyceronephosphate O-acyltransferase"
                     /db_xref="GeneID:14712"
                     /db_xref="MGI:MGI:1343460"
     exon            1..280
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            281..463
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            464..640
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            641..770
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            771..898
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            899..974
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1126
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1257
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1481
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1724
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1804
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1945
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2042
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2136
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2198
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2984
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /note="hexamer: AATAAA"
     polyA_site      2475
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /note="major polyA site"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /note="hexamer: AATAAA"
     polyA_site      2984
                     /gene="Gnpat"
                     /gene_synonym="D1Ertd819e; DHAPAT"
                     /note="major polyA site"
ORIGIN      
        1 gcggcttctg cgcgtgcgtc acggtccctg cgcggcctcg ggcctggtta agatggcggt
       61 gcccggggtc ccgtgcagtg gccgtacgga gtgccactgt cctgggcaga cgggagccgc
      121 cccgtgcgaa agaaccgccc ccagcggctg cactacagcc gtgtagcaga ccagcccagg
      181 ccccgccagg gacggcagcc gcgccatgga cgttcctagc tcctccagct cccgattctc
      241 ggtcggctcg gccagcccta gcagtgtgct cctctatgcg aaagacctca aaaagtggga
      301 tgagtttgaa gatctgttag aggagaggag acacatcagt gacttcaaat ttgcaatgaa
      361 gtgctacacc ccgcccttgt atagggggat cactccctgc aagccagggg acatcaagtc
      421 cattgtcctc agttctgaag agatcaacta tgtcattaag cagctttcta gggagtcgct
      481 gacaggtgtg gatgtcctcc gagaggaagc cagtgagatc ctcgaggaga tgagccacaa
      541 actgcgcata ggagccattc ggttctttgc ctttgttctg agcaaaatct ttaaacagat
      601 cttctcaaag gtgtgtgtga atgaagaagg cattcaaaag ctacaacgcg ctgtccagga
      661 gcaccctgtg gtcctgctgc ccagtcaccg cagctacatt gacttcctca tgctgtcctt
      721 cattctctac agctatgacc tgcctgtgcc agtgatcgca gcaggaatgg acttcctggg
      781 aatgagagtg gtcagtgagc tgctcaggat gtctggggcc ttcttcatgc gacgcacttt
      841 tggaggaaat aaactctact gggccgtatt ctctgaatat gtgaagacca tgctgcggtg
      901 tggttatgct cctgttgaat ttttcctcga agggacgagg agccgagctg ccaagaccct
      961 gactcctaag tttggtctcc tgaatattgt gatggaacca ttttttaaaa gagaagtctt
     1021 cgatacctac tttgtcccaa ttagcatcag ttatgataaa atattggaag agagtcttta
     1081 tgcatatgag atcctcggag ttcctaagcc gaaggagtcc accactggat tgttgaaagc
     1141 tagacggatt ctctctgaga actttggaag catccatgtg tacttcggag accctgtatc
     1201 actgcgttct ctagctgcag ggcggctcaa tcggaacacg tataacttgg tgccaagatg
     1261 catccctcag aagcagcctg aggacgtgca agcctttgtc actgaggtcg cctataagat
     1321 gcagcttctg cagattgaaa acctggctct gagcccatgg ctcctggtgg tcaccattct
     1381 acttcaaaac cagctatcca tggactttga cgccctggtg gagaagactc tgtggctgaa
     1441 gggcgtaacc caggtgttcg gcgggttcct gctttggcct gataacaaac ttcctgagga
     1501 agtggtccag tccagcatcc tcctgcactc taacctggcc agccttgtca aagaccaggt
     1561 ggttctgaaa atgaactctg gaagctcaca agtggtcaac gggcttgtgc ccgaacatat
     1621 cgccctcctc atgtgctctg cctacaggaa ccagctgctc aacatttttg cccgtccttc
     1681 cttagtcgcc ctggctttgc acatgacacc tgggctcagg aaagaggatg tcttcagttg
     1741 cttttccttc ctccgcaatg tgttttcaga tgagttcatc ttccttccag gaaacacact
     1801 cagggacttt gaggaaggct gttacttgct gtgtaaagct gaggctatgc agatggctgg
     1861 gaaggacatc atcctcacag acaaaggaac tgctgtgtta cagttcctca caagcctctt
     1921 taagcctttt gtggaatcat atcagttact ttgcagatac cttttgcatg aagaggacta
     1981 cttcggtgag aaggaatact tggttgcagc caggaagttc acccgtcagc ttctggatca
     2041 aggctcctct cagtgttacg atgcgctgtc ttctgaactg cagaaaaatg ccttagcagc
     2101 tttcgtgaga ctgggggtgg tggaaaagaa gaaggtagat agtaagtatg tgtattatgt
     2161 gaacgggcct gccacaagca agttagaaga aatgctcgga tgtaagaagc caataggaaa
     2221 accagccact gcaaaactat aacaataatg gagcagttgt agaaaacaca gttccatagt
     2281 gacagtcaca aaggacttac tctgccacaa atgggcactg agaggaagat gtgacgtctg
     2341 tctccttgag acctctgagc catgcttctg ccaggaggag gagagcatgg gagtgtcggt
     2401 gtgaccctcc caccgtgatg gctgctggcc ggcattcgtg gcactgtgtt gtcaaataaa
     2461 ggagtcttga aaacatttct tgggcagcag agctcaggcc cctccccgtt tactgccact
     2521 cagattccca cacctacccc actctcaggc tgacctccga ggtttagtac agcagcagca
     2581 ctgaccactt atctgtgcac tgaagaaggg acactggtgc gtgttcccac ccacagctcc
     2641 atgaggggcc caatcaaacc acagggcact aagaacactg tgtgttgggt gtgtataaaa
     2701 ccaaggacgt tcatgtctag attagctcaa gtctccagga cattttgttc tgcataagta
     2761 caccttccga acctgaaaag cagtccagct cactgttctc tgtcagtgtt ttcaataaac
     2821 tgttcttact aaacaaacaa aagctttaaa tctgacacac ttccatcata actattttgt
     2881 ataagggact caacctatat ctttttactt caattacgtt gtctcaacca agagcaaatt
     2941 tgacagaagt gtgtaataaa ttatttagtt tactttaaac ttta
//
