LOCUS       NM_010321               1042 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus glycine N-methyltransferase (Gnmt), transcript variant
            1, mRNA.
ACCESSION   NM_010321
VERSION     NM_010321.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Kuo,K.L., Chiang,C.W., Chen,Y.A., Yu,C.C. and Lee,T.S.
  TITLE     Folic Acid Ameliorates Renal Injury in Experimental Obstructive
            Nephropathy: Role of Glycine N-Methyltransferase
  JOURNAL   Int J Mol Sci 24 (7), 6859 (2023)
   PUBMED   37047834
  REMARK    GeneRIF: Folic Acid Ameliorates Renal Injury in Experimental
            Obstructive Nephropathy: Role of Glycine N-Methyltransferase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Eudy,B.J., McDermott,C.E., Liu,X. and da Silva,R.P.
  TITLE     Targeted and untargeted metabolomics provide insight into the
            consequences of glycine-N-methyltransferase deficiency including
            the novel finding of defective immune function
  JOURNAL   Physiol Rep 8 (18), e14576 (2020)
   PUBMED   32951289
  REMARK    GeneRIF: Targeted and untargeted metabolomics provide insight into
            the consequences of glycine-N-methyltransferase deficiency
            including the novel finding of defective immune function.
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Huang,J.W., Chen,C.J., Yen,C.H., Chen,Y.A. and Liu,Y.P.
  TITLE     Loss of Glycine N-Methyltransferase Associates with
            Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice
  JOURNAL   Int J Mol Sci 20 (17), 4223 (2019)
   PUBMED   31470507
  REMARK    GeneRIF: Results suggest that glycine N-methyltransferase (GNMT)
            might be involved in insulin-induced angiopoietin-like protein 8
            (Angptl8) expression in high fat diet (HFD)-mediated metabolic
            syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Hughey,C.C., Trefts,E., Bracy,D.P., James,F.D., Donahue,E.P. and
            Wasserman,D.H.
  TITLE     Glycine N-methyltransferase deletion in mice diverts carbon flux
            from gluconeogenesis to pathways that utilize excess methionine
            cycle intermediates
  JOURNAL   J Biol Chem 293 (30), 11944-11954 (2018)
   PUBMED   29891549
  REMARK    GeneRIF: GNMT deletion promotes a metabolic shift whereby nutrients
            are channeled away from glucose formation toward pathways that
            utilize the elevated S-adenosylmethionine.
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Ferguson,D.A., Chiang,J.T., Richardson,J.A. and Graff,J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Pakhomova,S., Luka,Z., Grohmann,S., Wagner,C. and Newcomer,M.E.
  TITLE     Glycine N-methyltransferases: a comparison of the crystal
            structures and kinetic properties of recombinant human, mouse and
            rat enzymes
  JOURNAL   Proteins 57 (2), 331-337 (2004)
   PUBMED   15340920
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Wang,G., Zhang,J., Moskophidis,D. and Mivechi,N.F.
  TITLE     Targeted disruption of the heat shock transcription factor (hsf)-2
            gene results in increased embryonic lethality, neuronal defects,
            and reduced spermatogenesis
  JOURNAL   Genesis 36 (1), 48-61 (2003)
   PUBMED   12748967
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Lahbib-Mansais,Y., Leroux,S., Milan,D., Yerle,M., Robic,A.,
            Jiang,Z., Andre,C. and Gellin,J.
  TITLE     Comparative mapping between humans and pigs: localization of 58
            anchorage markers (TOASTs) by use of porcine somatic cell and
            radiation hybrid panels
  JOURNAL   Mamm Genome 11 (12), 1098-1106 (2000)
   PUBMED   11130978
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Aida,K., Tawata,M., Negishi,M. and Onaya,T.
  TITLE     Mouse glycine N-methyltransferase is sexually dimorphic and
            regulated by growth hormone
  JOURNAL   Horm Metab Res 29 (12), 646-649 (1997)
   PUBMED   9497905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D89664.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D89664.1, BC087960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1042
                     /gene="Gnmt"
                     /note="glycine N-methyltransferase"
                     /db_xref="GeneID:14711"
                     /db_xref="MGI:MGI:1202304"
     exon            1..220
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            221..348
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            349..459
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            460..602
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            603..724
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1032
                     /gene="Gnmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1012..1017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnmt"
                     /note="hexamer: AATACA"
     polyA_site      1032
                     /gene="Gnmt"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccggt caggatggtg gacagcgtgt accgtacccg ctccctgggg gtggcggccg
       61 aagggctccc ggaccagtat gcagatgggg aggccgcacg tgtgtggcag ctgtacatcg
      121 gggacacccg cagccgtacc gcagagtaca aggcgtggtt gcttgggctg ttgcgccagc
      181 acgggtgcca cagggtgctg gacgtagcct gtggcacagg agtggactcc atcatgctgg
      241 tggaagaggg cttcagcgtg atgagcgtgg acgccagcga caagatgctg aaatatgcgc
      301 ttaaggagcg ctggaaccgg aggaaagagc catcctttga caattgggtc attgaagaag
      361 ccaactggtt gacgctggac aaagatgtgc tttcaggaga tggctttgat gctgtcatct
      421 gccttgggaa cagttttgct cacttgccag actgcaaagg tgaccagagc gagcaccggc
      481 tggcactaaa gaacattgca agcatggtgc ggcccggggg cctgctggtg atcgaccacc
      541 gcaactacga ctatatcctc agcacaggct gtgcgccccc ggggaagaac atctactata
      601 agagtgacct gaccaaggac attacgacgt cagtactgac agtcaacaac aaagcccaca
      661 tggtaaccct ggactacaca gtgcaggtgc caggcactgg cagagatggc tctcctggct
      721 tcagtaagtt ccggctctct tactacccac actgtttggc gtctttcacg gagttggtgc
      781 gagcagcctt tgggggcagg tgccagcaca gcgtcctggg tgacttcaag ccctacaagc
      841 ctggccaggc ctacgttccc tgctacttca tccatgtgct caagaagaca gactgagttt
      901 ctccggctcc cagaagccca tgctcaggca atggccccta ccctaagacc atcccctaat
      961 gcagatattg catttgggtg cagatgtggg ggtcgggcaa acggagtaaa caatacagtc
     1021 tgcattctcc aaaaaaaaaa aa
//
