LOCUS       NM_198110               4877 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus guanine nucleotide binding protein nucleolar 3 like
            (Gnl3l), transcript variant 1, mRNA.
ACCESSION   NM_198110 XM_909646
VERSION     NM_198110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4877)
  AUTHORS   Wei,C., Kesner,B., Yin,H. and Lee,J.T.
  TITLE     Imprinted X chromosome inactivation at the gamete-to-embryo
            transition
  JOURNAL   Mol Cell 84 (8), 1442-1459 (2024)
   PUBMED   38458200
REFERENCE   2  (bases 1 to 4877)
  AUTHORS   Cai,Q., Chen,S., Zhu,Y. and Li,Z.
  TITLE     Knockdown of GNL3L Alleviates the Progression of COPD Through
            Inhibiting the ATM/p53 Pathway
  JOURNAL   Int J Chron Obstruct Pulmon Dis 18, 2645-2659 (2023)
   PUBMED   38022822
  REMARK    GeneRIF: Knockdown of GNL3L Alleviates the Progression of COPD
            Through Inhibiting the ATM/p53 Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4877)
  AUTHORS   Zhu,Q., Meng,L., Hsu,J.K., Lin,T., Teishima,J. and Tsai,R.Y.
  TITLE     GNL3L stabilizes the TRF1 complex and promotes mitotic transition
  JOURNAL   J Cell Biol 185 (5), 827-839 (2009)
   PUBMED   19487455
  REMARK    GeneRIF: GNL3L mediates the mitotic increase of TRF1 protein and
            promotes the metaphase-to-anaphase transition.
REFERENCE   4  (bases 1 to 4877)
  AUTHORS   Yasumoto,H., Meng,L., Lin,T., Zhu,Q. and Tsai,R.Y.
  TITLE     GNL3L inhibits activity of estrogen-related receptor gamma by
            competing for coactivator binding
  JOURNAL   J Cell Sci 120 (Pt 15), 2532-2543 (2007)
   PUBMED   17623774
  REMARK    GeneRIF: work reveals a novel mechanism that negatively regulates
            the transcriptional function of ERRgamma (estrogen-related
            receptor)by GNL3L through coactivator competition.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB644039.1, BC057033.1 and BY640210.1.
            
            On Dec 12, 2009 this sequence version replaced NM_198110.1.
            
            Transcript Variant: This variant (2)represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079653.1, SRR1660821.124217.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BB644039.1         1-74
            75-4127             BC057033.1         1-4053
            4128-4869           BC057033.1         4055-4796
            4870-4877           BY640210.1         415-422
FEATURES             Location/Qualifiers
     source          1..4877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..4877
                     /gene="Gnl3l"
                     /note="guanine nucleotide binding protein nucleolar 3
                     like"
                     /db_xref="GeneID:237107"
                     /db_xref="MGI:MGI:2448557"
     exon            1..122
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            123..191
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1906
                     /gene="Gnl3l"
                     /note="guanine nucleotide binding protein-like 3
                     (nucleolar)-like"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 3-like
                     protein"
                     /protein_id="NP_932778.1"
                     /db_xref="CCDS:CCDS41174.1"
                     /db_xref="GeneID:237107"
                     /db_xref="MGI:MGI:2448557"
                     /translation="MMKIRHKNKKPGKGSKGCKKPARQNGKKVTSRPSSAPQIVHGND
                     HASREAELKKKRVEEMREKQQVAREQERQRHRTMESYCQDVLKRQQEFEQKEEVLQEL
                     NMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEETVLRAEGNKK
                     LVLVLNKIDLVPKEIVEKWLEYLLNELPTVAFKASTQHHQVKNLTRCKVPVDQASESL
                     LKSRACFGAENLMRVLGNYCRLGEVRGHIRVGVVGLPNVGKSSLINSLKRSRACSVGA
                     VPGVTKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCIHVQKLADPVTPVETILQ
                     RCNLEEISSYYGVSGFQTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLADWVSGKIS
                     FYTLPPPTHTLPTHLSAEIVKEMTEVFDIEDTEHANEDTMECLAVGESDELLGDMDPQ
                     EMEVRWLHSPLVKIADAIENRSTVYKIGNLTGYCTKPNRNQMGWPKRNVDHHCPQNNR
                     VVEVSSVDRRPMLQRILETDPLQQGQALASALKNKKKLQKRSDKIATKLSDSMMSMLD
                     LSGNSDDCAGD"
     exon            192..232
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            233..340
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            341..457
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            458..541
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            542..677
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            678..784
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            785..929
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1017
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1192
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1335
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1472
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1600
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1823
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..4877
                     /gene="Gnl3l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnl3l"
                     /note="hexamer: AATAAA"
     polyA_site      4869
                     /gene="Gnl3l"
                     /note="major polyA site"
ORIGIN      
        1 aaattaggcg gagcaaagag ctgggctggg atccggaagt ctgggcggag cctagctgcg
       61 cactcctgga ctggcgacgt tgtgcttcta acagctctcc gaggtccctg ccggaagtgt
      121 aggaagaagc agacagattt gaacatctct gtttccagct tctctgatca tcatgatgaa
      181 gattagacac aaaaacaaaa aaccaggtaa aggttccaaa ggctgtaaga agcctgcaag
      241 gcaaaatggg aagaaagtaa cctccagacc atcatctgct ccccagattg ttcatggcaa
      301 tgaccatgcc agtcgcgagg ccgaattaaa gaagaaaagg gtcgaggaga tgagggagaa
      361 gcagcaagtt gcccgggagc aagagagaca gagacacagg accatggaga gctattgtca
      421 ggatgtcctg aaacgtcagc aggaatttga acaaaaggag gaagttttgc aggaattaaa
      481 catgtttcct cagttggatg atgaggccac aaggaaggcc tattacaagg aattccggaa
      541 ggtggtagag tactctgatg tgattctgga agtcctagat gccagagacc cattgggctg
      601 ccgctgtttc cagatggagg agactgtcct tcgtgcagaa ggcaacaaga agctggtctt
      661 ggtcttaaat aagatagatc tcgttcccaa ggagattgtg gaaaagtggc tggaatacct
      721 tctcaatgaa ctgccaactg tggctttcaa ggccagcacc cagcatcatc aggtcaaaaa
      781 cttgactcgt tgtaaagttc cagtggacca ggcctctgag tcgcttttga aaagcagagc
      841 ctgctttgga gccgaaaatc tcatgagggt cctggggaac tattgtcgcc tgggggaagt
      901 gcgtggccac attcgtgtgg gtgttgtagg ccttcccaat gtggggaaga gcagtctgat
      961 caatagcctg aagcgcagcc gtgcttgtag tgtgggagct gttcctggtg tcacaaaatt
     1021 catgcaggag gtctacctag acaagtttat caggcttctg gatgcaccag gcattgtccc
     1081 aggacccaat tcagaggtgg gcaccatcct gcgtaattgc atccatgtgc agaagctggc
     1141 agaccctgtg accccggtgg agaccatcct tcagcgctgc aacctggagg agatttccag
     1201 ctactatggt gtatctggat tccagacgac tgagcacttt ctgactgcag tggcccatcg
     1261 cttgggaaag aagaagaagg gaggtgtata tagtcaggaa caggctgcca aagctgtgct
     1321 ggctgactgg gtgagtggga agatcagctt ctatacacta ccaccgccca ctcacactct
     1381 gcccacccat ctcagtgctg agattgttaa ggagatgact gaggtctttg atatagaaga
     1441 tactgagcac gccaatgaag acaccatgga atgcttagct gtgggagaat ccgatgagct
     1501 gttgggtgac atggacccac aagaaatgga ggtcaggtgg ctccattctc cactggtgaa
     1561 aatagcagat gctattgaaa atagaagcac cgtgtataag attggaaatc tcactgggta
     1621 ttgtaccaaa ccaaaccgta atcagatggg gtggcctaaa cgcaatgtgg accaccattg
     1681 cccccaaaat aaccgtgtag tagaggtcag ttctgtggac cgccgcccga tgttgcagag
     1741 gatcctggag acagacccac ttcagcaagg ccaggctctg gcatctgcct tgaagaataa
     1801 gaaaaaattg cagaagcgtt cagataaaat cgccactaag ttgtctgact ccatgatgtc
     1861 catgcttgac ctctctggca actccgatga ctgtgcaggt gactgagcag ctgaccttcc
     1921 ccctcatact gcaagtactg cttcccgtgc gatgggagag tccagatgcc tttccattct
     1981 ccctgatgta cttaatagga gaacacctcc atgtcatgta tcttctgctg ccgtgccctc
     2041 cattcttatc aaaggtctgg agctgccaaa ccctactacc ctctacttaa tccttcctgt
     2101 ctttgaaaat gaccttgtgt ttgttttgtg gtgccaggga ttgaacataa taggttctca
     2161 caaatgttag acaaccattc tattaccaag ctgtagtatt accatcatta ccatccatca
     2221 ttatcattgg ggagtctgct tactcaacct cccaagtact gggattacag gcttttgcca
     2281 ccattcccag ctcccactgt gttttctaag gtaaataaaa tcagcagact cttggcatgg
     2341 tggcaacata tctataaccc tgacacttgg gagactggag ctaggaggac tgtaagttat
     2401 gggccagcct gaactatctg gcaagaccct ttctcaacaa aacagcccaa aacaaataag
     2461 cagagtccag ctgggcatac acctttaatc ctagcactct ggaggcagag gcagatgaat
     2521 ctcgtgagtt tcaggccagc ctggtctacc gagcaagttc caggatagcc agggctgcat
     2581 agagaaactc cgtctcgaaa agtgaacaat aaaacaacaa aaagaatttg taattattta
     2641 aaaagcaaat aagcagagtc caagtgctga caatgtacct tggactctaa attcctgtgt
     2701 cgtaccctgt gagttaggct gataagggtt aaccttttgg acaggtaaat gtcctaaagg
     2761 ctagactgct gagaaacctg gtagcagtgg cgggggaggt ggcggttgtc cctggatggg
     2821 tgatcctttt catttttatc accctacaag atctcagtgc caaggctctt gcctgtgtat
     2881 tttccaaatc aatagctagc tcctcatctg ggtagtgtag gagtagagaa ggatagtgtg
     2941 agtctcctgt ctctggaagt gtctggggat agtgtagagg atgacgattc tagaaagggt
     3001 atacctatca tagtaagttg gaaagccatt ggctgcagga tgttcaggaa atgtagaccg
     3061 tacctgtttt ctggacggtt aggggctgag cacaaactac taaacaatga gaaacagtta
     3121 ccacctttaa ctttcactat atccgtatca ggaaggggta aggctcagaa agccgacaga
     3181 atgtgctcat gtcaacagta agtggtggtg tgctagatgt caaacttgag tctaatttaa
     3241 accttatgct agccttttgg tttgcattat tttgcctttt caacaagggc acaccactct
     3301 ggtattttct gttgtcatat atttaaaata tattttctct actctgtttt ttatttttat
     3361 ttatttattt attttttggg tttttcgaga cagggtttct ctgtatagtc ttggctgtcc
     3421 tggaactcac tttgtagacc aggctggcct cgaactcaga aatccgccta cctctgcctc
     3481 ccaagtgctg ggattaaagg cgtgcgccac caccgcccgg ctctgttttt taaaaaatgg
     3541 tagtatttat tgaaaaacta tgctttctaa gtctctttaa atgatgtcca acttaattca
     3601 ctgatctcat cttaagtttt gctagacaat aatatattag aaataaaagt atctagattc
     3661 ttgggaacat aatcatgtca aaataaaata gaactaaaac caggtgggtg gctcacacca
     3721 gtgctccaag cactaagaat gctgaagcag gaagatgtct gaagctgagt ccagcctggg
     3781 ctgcagagta agaggcagtc tcagggcgaa acaaaataat gtgggacttt agatattcta
     3841 actctaatgt atctcaaggt tgggggtagc atgcgcacgc acgcacagag agagagtttc
     3901 ccccatataa cccagtgtgg tcctgaactt tttaggcccc ccccccatta gctttccaag
     3961 tgctgggatt gcaggtgttt gctttcatgc ctggatattt ctttgttctt aaaacaattt
     4021 cttgggtctt tactctcccc ttaaaaatca tttttataca ataaatctca tccttcatgg
     4081 ttctatggtt ctgtaagttt agacaccttt tttttttttt tttttttccg agacagggtt
     4141 tctctgtgta atcctggctg tcctggaact caccaggctg gcctcgaact cagaaatccg
     4201 cctgcctctg cctcccaagt gctgggatta aaggcgtgcg ccaccacgcc cggttattta
     4261 gacacctttt aacaggggtg gcctgccatc ataatcaaga taagagaatt ttgtggcatt
     4321 tccccaaact tattgtgtcc tcttgtagta tagtcctgcc cccatcctca aatcctagca
     4381 ggcacagacc tctttcctgt tccttaatat aagtgtcgta agtcacacgg gggcttattt
     4441 tatggcatta agcttttagc tttttccttt tagatcttac attgaagtta gatgcagttg
     4501 tataagctcg gataaatgga taaagccgag taatcattaa tacaggacag aagagttcta
     4561 ttagcctctc ctttaccatt cctggtaatt tatagtcaaa ccttgttctc tccctgacag
     4621 tcacggactt gtgctttcac tttatggctt gtcttttgaa aagagttgta agtggaattt
     4681 aatagtatgt aacttttgag attaatgtgt tataaattat agacttgaga tccatatcac
     4741 tggatgtatc aatagtttga tttctgtttc atatgctatt gtgtggatgt cttattgctt
     4801 attcaaccct aagttggatt acattcttta cagttgagga ggaagttata aataaagctg
     4861 ctaaaaatcc ttgtgtg
//
