LOCUS       NM_153547               1935 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus guanine nucleotide binding protein nucleolar 3 (Gnl3),
            transcript variant 1, mRNA.
ACCESSION   NM_153547
VERSION     NM_153547.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Lin,T., Lin,T.C., McGrail,D.J., Bhupal,P.K., Ku,Y.H., Zhang,W.,
            Meng,L., Lin,S.Y., Peng,G. and Tsai,R.Y.L.
  TITLE     Nucleostemin reveals a dichotomous nature of genome maintenance in
            mammary tumor progression
  JOURNAL   Oncogene 38 (20), 3919-3931 (2019)
   PUBMED   30692636
  REMARK    GeneRIF: Nucleostemin role in the mammary tumor progression.
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Katano,M., Ema,M., Nakachi,Y., Mizuno,Y., Hirasaki,M., Suzuki,A.,
            Ueda,A., Nishimoto,M., Takahashi,S., Okazaki,Y. and Okuda,A.
  TITLE     Forced expression of Nanog or Esrrb preserves the ESC status in the
            absence of nucleostemin expression
  JOURNAL   Stem Cells 33 (4), 1089-1101 (2015)
   PUBMED   25522312
  REMARK    GeneRIF: Nucleostemin expression participates in the preservation
            of the viability and integrity of embryonic stem cells.
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Lin,T., Ibrahim,W., Peng,C.Y., Finegold,M.J. and Tsai,R.Y.
  TITLE     A novel role of nucleostemin in maintaining the genome integrity of
            dividing hepatocytes during mouse liver development and
            regeneration
  JOURNAL   Hepatology 58 (6), 2176-2187 (2013)
   PUBMED   23813570
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Yamashita,M., Nitta,E., Nagamatsu,G., Ikushima,Y.M., Hosokawa,K.,
            Arai,F. and Suda,T.
  TITLE     Nucleostemin is indispensable for the maintenance and genetic
            stability of hematopoietic stem cells
  JOURNAL   Biochem Biophys Res Commun 441 (1), 196-201 (2013)
   PUBMED   24140061
  REMARK    GeneRIF: nucleostemin protects hematopoietic stem cells (HSCs) from
            DNA damage accumulation and is required for the maintenance of
            HSCs.
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Meng,L., Yasumoto,H. and Tsai,R.Y.
  TITLE     Multiple controls regulate nucleostemin partitioning between
            nucleolus and nucleoplasm
  JOURNAL   J Cell Sci 119 (Pt 24), 5124-5136 (2006)
   PUBMED   17158916
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Zhu,Q., Yasumoto,H. and Tsai,R.Y.
  TITLE     Nucleostemin delays cellular senescence and negatively regulates
            TRF1 protein stability
  JOURNAL   Mol Cell Biol 26 (24), 9279-9290 (2006)
   PUBMED   17000763
  REMARK    GeneRIF: Has roles in establishing early embryogenesis and delaying
            cellular senescence of embryonic fibroblasts.
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Beekman,C., Nichane,M., De Clercq,S., Maetens,M., Floss,T.,
            Wurst,W., Bellefroid,E. and Marine,J.C.
  TITLE     Evolutionarily conserved role of nucleostemin: controlling
            proliferation of stem/progenitor cells during early vertebrate
            development
  JOURNAL   Mol Cell Biol 26 (24), 9291-9301 (2006)
   PUBMED   17000755
  REMARK    GeneRIF: Nucleostemin has a unique ability, derived from an
            ancestral function, to control the proliferation rate of
            stem/progenitor cells in vivo independently of p53.
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Politz,J.C., Polena,I., Trask,I., Bazett-Jones,D.P. and Pederson,T.
  TITLE     A nonribosomal landscape in the nucleolus revealed by the stem cell
            protein nucleostemin
  JOURNAL   Mol Biol Cell 16 (7), 3401-3410 (2005)
   PUBMED   15857956
  REMARK    GeneRIF: analysis of nucleolar localization of stem cell protein
            nucleostemin
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Tsai,R.Y. and McKay,R.D.
  TITLE     A nucleolar mechanism controlling cell proliferation in stem cells
            and cancer cells
  JOURNAL   Genes Dev 16 (23), 2991-3003 (2002)
   PUBMED   12464630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ071960.1, CJ089318.1, AK077523.1 and AA041888.1.
            
            On Sep 28, 2013 this sequence version replaced NM_153547.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY181025.1, AK077523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                CJ071960.1         4-68
            66-70               CJ089318.1         29-33
            71-1860             AK077523.1         2-1791
            1861-1935           AA041888.1         432-506
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..1935
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="guanine nucleotide binding protein nucleolar 3"
                     /db_xref="GeneID:30877"
                     /db_xref="MGI:MGI:1353651"
     exon            1..203
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1807
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="nucleostemin; nucleolar GTP-binding protein 3;
                     guanine nucleotide binding protein-like 3 (nucleolar)"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 3"
                     /protein_id="NP_705775.2"
                     /db_xref="CCDS:CCDS26905.1"
                     /db_xref="GeneID:30877"
                     /db_xref="MGI:MGI:1353651"
                     /translation="MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKP
                     RKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEVSPGDEQSN
                     VETREESDEPKRKKAKAGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQIE
                     EAVIQSGSKKLILVLNKSDLVPKENLENWLNYLNKELPTVVFKASTNLKNRKTFKIKK
                     KKVVPFQSKICCGKEALWKLLGDFQQSCGKDIQVGVIGFPNVGKSSVINSLKQEWICN
                     VGISMGLTRSMQIVPLDKQITIIDSPCLIISPCNSPTALALRSPASIEELRPLEAASA
                     ILSQADNEQVVLKYTVPEYKDSLHFFTKLAQRRGLHQKGGSPNVESAAKLVWSEWTGA
                     SLGYYCHPPASWNHSLHFNENIAAVMKKGFNLEELEKNNAHSIQVLKGPHLTNRILFR
                     SSGLTNGILDEKDIVEESPRQTEDKQDADDQENGSGERNAEISDVAPVEETRELSPEQ
                     STAGKPSDGSSALDRASQEDETYDFTTDYI"
     exon            204..262
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            263..400
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            401..511
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            512..592
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            593..725
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            726..835
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            836..956
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1044
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1219
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1362
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1499
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1657
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1724
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1926
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="major polyA site"
ORIGIN      
        1 tggccgccag gcgagcccgg ctcggcgcga cagtgtatgt gtgtgcgcgc gcactcggcc
       61 cggccccgac acactttccg gcaggtcctg gagcgcgtga cgttgaaccg cagttccagt
      121 tcgcacgtgg cgcccgagaa gtcgtggtga tcccgagacc tcctctgctc ctgaagcgtc
      181 cgcggccagg atgaagaggc ctaagttaaa gaaagcgagt aaacgtatga cctgccataa
      241 gcgatataaa attcaaaaaa aggtccgaga acatcatcga aaattaagga aggaagctaa
      301 aaaacggggt cacaagaagc ctaggaagga cccaggtgtt ccaaatagtg ctccctttaa
      361 agaggctctt cttcgtgaag ctgaactaag gaaacagcag cttgaagaac taaaacagca
      421 gcagaaactt gataggcaaa aagagcaaga aaggaaaaga aaacttgaag ttagccctgg
      481 tgatgagcag tctaatgtgg aaactaggga ggaatctgac gagcccaaaa gaaagaaagc
      541 caaagcaggc aaacagaatc caaagaagtt acattgccag gaacttaaaa aggtgattga
      601 agcctcagac attgtgttag aagttttgga tgccagagat cctcttggtt gcaggtgtcc
      661 tcagatagaa gaagctgtta tccagagtgg gagtaagaag ctgatacttg tattaaataa
      721 gtctgatcta gtaccaaagg agaatttgga gaactggcta aattatttga ataaagaatt
      781 gccaaccgtg gtgttcaaag cctcaacaaa cttaaagaac agaaagacat tcaagataaa
      841 aaagaagaaa gttgttccat tccaaagcaa aatctgctgt ggcaaggaag ccctttggaa
      901 gcttcttgga gattttcagc agtcctgtgg aaaggatatt caagttggag tgattggttt
      961 cccaaatgtg gggaaaagca gtgtcattaa tagcttaaaa caagaatgga tttgcaatgt
     1021 tgggatttcc atgggactta caaggagcat gcagattgtc cctttagaca agcagatcac
     1081 aatcatagac agtccatgcc taattatctc accttgtaac tcccccactg cacttgccct
     1141 tcggagtcca gcaagcattg aggaactaag accgctggag gctgccagtg ccattctgtc
     1201 tcaggctgat aatgaacagg tggtgttaaa atatactgtc cctgagtata aggattctct
     1261 gcattttttt actaaacttg ctcaaagaag aggtctgcac caaaaaggtg gaagcccaaa
     1321 tgtggaaagt gctgctaagc tggtgtggtc tgagtggaca ggtgcctcat taggttacta
     1381 ttgccatccc cctgcatcct ggaatcattc tctgcatttt aatgagaata ttgcagcagt
     1441 catgaagaag ggctttaatc tagaagaact agaaaagaat aatgcacaca gcatacaagt
     1501 cctcaagggc cctcatttaa ctaatagaat cctttttcgg tcttcgggcc tgacaaatgg
     1561 aatactagac gagaaggaca tagtcgaaga atcaccaaga cagacagaag acaaacagga
     1621 tgctgacgat caagaaaatg gtagtggtga aagaaatgca gagatctcag atgtggcccc
     1681 tgtagaagag accagggagc tgtcacctga gcaatcaaca gcaggtaagc catctgacgg
     1741 gtcgtctgcc ttggatagag cgagtcaaga ggatgaaacc tatgacttca ccacagatta
     1801 tatataaccg ccacacacta acgtgctctc tgtacgctgt gtagtttagt gtatgatata
     1861 aactgtacat cttgtaaata tgtatcatgt tataaattca aaataaaata caagtatttg
     1921 cttgcaaaaa aaaaa
//
