LOCUS       NM_023121                571 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), gamma
            transducing activity polypeptide 2 (Gngt2), transcript variant 1,
            mRNA.
ACCESSION   NM_023121
VERSION     NM_023121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 571)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 571)
  AUTHORS   Ibanez,K.R., McFarland,K.N., Phillips,J., Allen,M., Lessard,C.B.,
            Zobel,L., De La Cruz,E.G., Shah,S., Vo,Q., Wang,X., Quicksall,Z.,
            Ryu,D., Funk,C., Ertekin-Taner,N., Prokop,S., Golde,T.E. and
            Chakrabarty,P.
  TITLE     Deletion of Abi3/Gngt2 influences age-progressive amyloid beta and
            tau pathologies in distinctive ways
  JOURNAL   Alzheimers Res Ther 14 (1), 104 (2022)
   PUBMED   35897046
  REMARK    GeneRIF: Deletion of Abi3/Gngt2 influences age-progressive amyloid
            beta and tau pathologies in distinctive ways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 571)
  AUTHORS   Rodgers,H.M., Huffman,V.J., Voronina,V.A., Lewandoski,M. and
            Mathers,P.H.
  TITLE     The role of the Rx homeobox gene in retinal progenitor
            proliferation and cell fate specification
  JOURNAL   Mech Dev 151, 18-29 (2018)
   PUBMED   29665410
REFERENCE   5  (bases 1 to 571)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   6  (bases 1 to 571)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   7  (bases 1 to 571)
  AUTHORS   Downes,G.B., Gilbert,D.J., Copeland,N.G., Gautam,N. and
            Jenkins,N.A.
  TITLE     Chromosomal mapping of five mouse G protein gamma subunits
  JOURNAL   Genomics 57 (1), 173-176 (1999)
   PUBMED   10191100
REFERENCE   8  (bases 1 to 571)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
REFERENCE   9  (bases 1 to 571)
  AUTHORS   Rich,K.A., Zhan,Y. and Blanks,J.C.
  TITLE     Migration and synaptogenesis of cone photoreceptors in the
            developing mouse retina
  JOURNAL   J Comp Neurol 388 (1), 47-63 (1997)
   PUBMED   9364238
REFERENCE   10 (bases 1 to 571)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY117112.1, AL593858.20, BF470980.1 and BE994683.1.
            
            On Aug 30, 2006 this sequence version replaced NM_023121.1.
            
            Transcript Variant: This variant (1) lacks an internal segment in
            the 5' UTR, compared to variant 3. Variants 1, 2, 3 and 4 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY117112.1, ERR3363660.2624719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY117112.1         1-52
            53-54               AL593858.20        134034-134035
            55-187              BY117112.1         55-187
            188-554             BF470980.1         17-383
            555-571             BE994683.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..571
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma transducing activity polypeptide 2"
                     /db_xref="GeneID:14710"
                     /db_xref="MGI:MGI:893584"
     exon            1..132
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /inference="alignment:Splign:2.1.0"
     exon            133..216
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /inference="alignment:Splign:2.1.0"
     exon            217..306
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..432
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /note="heterotrimeric guanine nucleotide-binding protein
                     3i; guanine nucleotide binding protein (G protein), gamma
                     transducing polypeptide 2; G-gamma-8; g gamma-C"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-T2"
                     /protein_id="NP_075610.1"
                     /db_xref="CCDS:CCDS25284.1"
                     /db_xref="GeneID:14710"
                     /db_xref="MGI:MGI:893584"
                     /translation="MAQDLSEKELLRMEVEQLKKEVKNPRDLISKTGKEIKDYVEAQA
                     GTDPLLKGIPEDKNPFKEKGTCVLS"
     exon            307..555
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /inference="alignment:Splign:2.1.0"
     regulatory      532..537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /note="hexamer: AATAAA"
     polyA_site      555
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /note="major polyA site"
ORIGIN      
        1 attccgggac aagaggaagt cagaccctgg gccctgggcc tgggcctctc tgtaccctgc
       61 tcaggagaag ggggaaacca ggggcctgtt gggggctcgg tctctcaatc tcaccaagca
      121 aaggaagcca agatttctca gctgatgagg cgctaggaag ttcaaacacc attgtgtctg
      181 ggtcctggac cggtgatctg gagagagctc taacagggca ggatggccca ggacctcagt
      241 gagaaggagc tgttgaggat ggaggtggag cagctgaaga aggaagtgaa gaacccacgt
      301 gatctgattt ccaagacagg aaaggaaatc aaggattatg tagaggccca agcagggaca
      361 gaccctcttc tcaaaggcat cccagaagac aagaatccct tcaaggagaa aggcacttgt
      421 gtgctaagct gatggcccac cctcaccacc atcaccctct ctgtccctcc tcagccacgc
      481 ccaagtgtac tgggatacct aaggaccaat gttttcttcc tcttagacac aaataaagat
      541 gctgagaaaa agcaaaaaaa aaaaaaaaaa a
//
