LOCUS       NP_075610                 69 aa            linear   ROD 28-APR-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
            [Mus musculus].
ACCESSION   NP_075610
VERSION     NP_075610.1
DBSOURCE    REFSEQ: accession NM_023121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 69)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (residues 1 to 69)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 69)
  AUTHORS   Ibanez,K.R., McFarland,K.N., Phillips,J., Allen,M., Lessard,C.B.,
            Zobel,L., De La Cruz,E.G., Shah,S., Vo,Q., Wang,X., Quicksall,Z.,
            Ryu,D., Funk,C., Ertekin-Taner,N., Prokop,S., Golde,T.E. and
            Chakrabarty,P.
  TITLE     Deletion of Abi3/Gngt2 influences age-progressive amyloid beta and
            tau pathologies in distinctive ways
  JOURNAL   Alzheimers Res Ther 14 (1), 104 (2022)
   PUBMED   35897046
  REMARK    GeneRIF: Deletion of Abi3/Gngt2 influences age-progressive amyloid
            beta and tau pathologies in distinctive ways.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 69)
  AUTHORS   Rodgers,H.M., Huffman,V.J., Voronina,V.A., Lewandoski,M. and
            Mathers,P.H.
  TITLE     The role of the Rx homeobox gene in retinal progenitor
            proliferation and cell fate specification
  JOURNAL   Mech Dev 151, 18-29 (2018)
   PUBMED   29665410
REFERENCE   5  (residues 1 to 69)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   6  (residues 1 to 69)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   7  (residues 1 to 69)
  AUTHORS   Downes,G.B., Gilbert,D.J., Copeland,N.G., Gautam,N. and
            Jenkins,N.A.
  TITLE     Chromosomal mapping of five mouse G protein gamma subunits
  JOURNAL   Genomics 57 (1), 173-176 (1999)
   PUBMED   10191100
REFERENCE   8  (residues 1 to 69)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
REFERENCE   9  (residues 1 to 69)
  AUTHORS   Rich,K.A., Zhan,Y. and Blanks,J.C.
  TITLE     Migration and synaptogenesis of cone photoreceptors in the
            developing mouse retina
  JOURNAL   J Comp Neurol 388 (1), 47-63 (1997)
   PUBMED   9364238
REFERENCE   10 (residues 1 to 69)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY117112.1, AL593858.20, BF470980.1 and BE994683.1.
            
            Transcript Variant: This variant (1) lacks an internal segment in
            the 5' UTR, compared to variant 3. Variants 1, 2, 3 and 4 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY117112.1, ERR3363660.2624719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..69
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     Protein         1..69
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-T2"
                     /note="heterotrimeric guanine nucleotide-binding protein
                     3i; guanine nucleotide binding protein (G protein), gamma
                     transducing polypeptide 2; G-gamma-8; g gamma-C"
                     /calculated_mol_wt=7671
     mat_peptide     1..66
                     /product="Guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-T2. /id=PRO_0000012647"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61017.2)"
                     /calculated_mol_wt=7503
     Region          8..69
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(8,11,15,18,22,27,29,32..33,36..37,40,49..50,60)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Site            66
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61017.2)"
     CDS             1..69
                     /gene="Gngt2"
                     /gene_synonym="Hg3i"
                     /coded_by="NM_023121.2:223..432"
                     /db_xref="CCDS:CCDS25284.1"
                     /db_xref="GeneID:14710"
                     /db_xref="MGI:MGI:893584"
ORIGIN      
        1 maqdlsekel lrmeveqlkk evknprdlis ktgkeikdyv eaqagtdpll kgipedknpf
       61 kekgtcvls
//
