LOCUS       NM_010314                967 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), gamma
            transducing activity polypeptide 1 (Gngt1), mRNA.
ACCESSION   NM_010314
VERSION     NM_010314.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 967)
  AUTHORS   Wang,Y., Snell,A., Dyka,F.M., Colvin,E.R., Ildefonso,C., Ash,J.D.
            and Lobanova,E.S.
  TITLE     Overexpression of Nfe2l1 increases proteasome activity and delays
            vision loss in a preclinical model of human blindness
  JOURNAL   Sci Adv 9 (28), eadd5479 (2023)
   PUBMED   37450596
REFERENCE   2  (bases 1 to 967)
  AUTHORS   Kolesnikov,A.V., Lobysheva,E., Gnana-Prakasam,J.P., Kefalov,V.J.
            and Kisselev,O.G.
  TITLE     Regulation of rod photoreceptor function by farnesylated G-protein
            gamma-subunits
  JOURNAL   PLoS One 17 (8), e0272506 (2022)
   PUBMED   35939447
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 967)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 967)
  AUTHORS   Dexter,P.M., Lobanova,E.S., Finkelstein,S. and Arshavsky,V.Y.
  TITLE     Probing Proteostatic Stress in Degenerating Photoreceptors Using
            Two Complementary In Vivo Reporters of Proteasomal Activity
  JOURNAL   eNeuro 7 (1) (2020)
   PUBMED   31826915
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 967)
  AUTHORS   Chaya,T., Tsutsumi,R., Varner,L.R., Maeda,Y., Yoshida,S. and
            Furukawa,T.
  TITLE     Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation
            during light-dark adaptation
  JOURNAL   EMBO J 38 (23), e101409 (2019)
   PUBMED   31696965
REFERENCE   6  (bases 1 to 967)
  AUTHORS   Kassai,H., Aiba,A., Nakao,K., Nakamura,K., Katsuki,M., Xiong,W.H.,
            Yau,K.W., Imai,H., Shichida,Y., Satomi,Y., Takao,T., Okano,T. and
            Fukada,Y.
  TITLE     Farnesylation of retinal transducin underlies its translocation
            during light adaptation
  JOURNAL   Neuron 47 (4), 529-539 (2005)
   PUBMED   16102536
REFERENCE   7  (bases 1 to 967)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   8  (bases 1 to 967)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 967)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   10 (bases 1 to 967)
  AUTHORS   Gautam,N., Northup,J., Tamir,H. and Simon,M.I.
  TITLE     G protein diversity is increased by associations with a variety of
            gamma subunits
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7973-7977 (1990)
   PUBMED   2122451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022235.5 and AK020903.1.
            
            On Feb 5, 2019 this sequence version replaced NM_010314.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020903.1, CO429472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC022235.5         85713-85716
            5-967               AK020903.1         2-964
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     gene            1..967
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma transducing activity polypeptide 1"
                     /db_xref="GeneID:14699"
                     /db_xref="MGI:MGI:109165"
     exon            1..79
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /inference="alignment:Splign:2.1.0"
     exon            80..182
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..311
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 1 subunit; transducin gamma chain; heterotrimeric
                     guanine nucleotide-binding protein 3g1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(T) subunit
                     gamma-T1"
                     /protein_id="NP_034444.1"
                     /db_xref="CCDS:CCDS39418.1"
                     /db_xref="GeneID:14699"
                     /db_xref="MGI:MGI:109165"
                     /translation="MPVINIEDLTEKDKLKMEVDQLKKEVTLERMMVSKCCEEVRDYI
                     EERSGEDPLVKGIPEDKNPFKELKGGCVIS"
     exon            183..967
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      412..417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /note="hexamer: AATAAA"
     polyA_site      435
                     /gene="Gngt1"
                     /gene_synonym="G(y)1; Gng1; Hg3g1"
                     /note="major polyA site"
ORIGIN      
        1 gagcagtgtt cagagagctt gttcatgaga gctggttatc atagacaatt tgaaagaaac
       61 ccaaaaaaca gcttccctga cagaagatgc cagtgatcaa catcgaagac ctgacagaaa
      121 aggacaagtt gaagatggag gtagaccagc ttaagaagga agtgacactg gagagaatga
      181 tggtttccaa atgttgtgaa gaagtgagag attatattga agaaaggtct ggagaagacc
      241 ctctagtgaa ggggattcca gaagacaaaa accccttcaa ggaactcaaa ggaggctgtg
      301 tgatttcata ggcgggaagg cattttctta gaatatttag aattttaatg ataatgcaaa
      361 ctgttctcct atataattaa actgtgtatg ttgtttaaat tattaaattt taataaaaat
      421 aaagatgtaa taatatgtaa actcattttt tcatgaagta tttcacataa ggtttaacaa
      481 ggaattaggt gtaatatcga tgaaccctgc tttagaagca gtgtattcta aactgccttt
      541 gcagttttat attccttcat ttttctttca atattaatga tacttttcta gaactttttt
      601 ttgtttatct gttttttttg ttttttgttt gtttgttttt caagacagga tttctctgtg
      661 cagtcctagc tgtcctggaa atcactctgt agaccaggct ggcctcgaac tcagaaatcc
      721 acctgcctct gcctcccaag tgctggtatt aaaggcgtgc gccacaaccg ctcggcctct
      781 tctagaattt ttatagttaa acatatttta ttctcaattt tctcacaggc ctacaaagat
      841 tattgtttca atacgcggat aatttatttt agcaaaaaac tatgtatata tatactttat
      901 atgtactgta tattgtagta tattgtatac tacatattgc ctattatata taatatacat
      961 taattat
//
