LOCUS       NM_010318                535 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus G protein subunit gamma 5 (Gng5), mRNA.
ACCESSION   NM_010318 XM_001000288
VERSION     NM_010318.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 535)
  AUTHORS   Li,C., Yang,Y., Luo,S., Qiu,W., Wang,X. and Ge,W.
  TITLE     GNG5 is a novel regulator of Abeta42 production in Alzheimer's
            disease
  JOURNAL   Cell Death Dis 15 (11), 815 (2024)
   PUBMED   39528445
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 535)
  AUTHORS   Yuan,Z., Ren,R. and Xu,Z.
  TITLE     G protein subunit gamma 5 promotes the proliferation, metastasis
            and glycolysis of breast cancer cells through the Wnt/beta-catenin
            pathway
  JOURNAL   Anticancer Drugs 33 (10), 1004-1011 (2022)
   PUBMED   36255067
  REMARK    GeneRIF: G protein subunit gamma 5 promotes the proliferation,
            metastasis and glycolysis of breast cancer cells through the
            Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 535)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 535)
  AUTHORS   Moon,A.M., Stauffer,A.M., Schwindinger,W.F., Sheridan,K.,
            Firment,A. and Robishaw,J.D.
  TITLE     Disruption of G-protein gamma5 subtype causes embryonic lethality
            in mice
  JOURNAL   PLoS One 9 (3), e90970 (2014)
   PUBMED   24599258
  REMARK    GeneRIF: Targeted disruption of the mouse Gng5 gene encoding the
            gamma5 subtype produces embryonic lethality associated with severe
            head and heart defects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 535)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   6  (bases 1 to 535)
  AUTHORS   Aoyama,C., Sugimoto,H., Ando,H., Yamashita,S., Horibata,Y.,
            Sugimoto,S. and Satou,M.
  TITLE     The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have
            lysophospholipase D activity
  JOURNAL   Biochem J 440 (2), 241-250 (2011)
   PUBMED   21812758
REFERENCE   7  (bases 1 to 535)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 535)
  AUTHORS   Schuller,U., Lamp,E.C. and Schilling,K.
  TITLE     Developmental expression of heterotrimeric G-proteins in the murine
            cerebellar cortex
  JOURNAL   Histochem Cell Biol 116 (2), 149-159 (2001)
   PUBMED   11685543
REFERENCE   9  (bases 1 to 535)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY132164.1 and AK146065.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001000288.1, NM_010318.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK791703.1, CJ044800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY132164.1         1-79
            80-535              AK146065.1         3-458
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.54 cM"
     gene            1..535
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /note="G protein subunit gamma 5"
                     /db_xref="GeneID:14707"
                     /db_xref="MGI:MGI:109164"
     exon            1..185
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..311
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 5 subunit"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-5"
                     /protein_id="NP_034448.2"
                     /db_xref="CCDS:CCDS17903.1"
                     /db_xref="GeneID:14707"
                     /db_xref="MGI:MGI:109164"
                     /translation="MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQ
                     HDPLLTGVSSSTNPFRPQKVCSFL"
     exon            186..325
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /inference="alignment:Splign:2.1.0"
     exon            326..535
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng5"
                     /gene_synonym="G(y)5"
                     /note="putative"
ORIGIN      
        1 acagccccgg aaacttcgac gaagttcgga gccccgcccc cgccgtcccg cgacctgccg
       61 ccccctgccc ggactgacga gtcggcccgg ctgtcccgag cgccatgtcg ggttcttcta
      121 gcgtcgccgc catgaagaag gtggtccagc agctccggct ggaggccggg ctcaaccgcg
      181 tgaaggtttc ccaggcagct gcagacttga aacagttctg tctgcagaat gctcaacatg
      241 accctctgct gactggagtg tcttcaagta cgaatccctt cagaccccag aaagtctgct
      301 cctttttgta gtcatctatc ttgaggtttc tcaaaccact tttcatgaac cagtgaatat
      361 tcaagagaac taaatttgaa gtctgtacaa aagcttctct ttaacacgtg ccataataca
      421 ctatcttctg ctcgtcagtc cttaacatct acctctctga atttcatgga tttctgtctc
      481 acaaggttta actattttat atacactggc tgtagcatac aataaagcat catac
//
