LOCUS       NM_010317               3200 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), gamma
            4 (Gng4), transcript variant 1, mRNA.
ACCESSION   NM_010317
VERSION     NM_010317.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Yim,Y.Y., McDonald,W.H., Betke,K.M., Kaya,A., Hyde,K., Erreger,K.,
            Gilsbach,R., Hein,L. and Hamm,H.E.
  TITLE     Specificities of Gbetagamma subunits for the SNARE complex before
            and after stimulation of alpha2a-adrenergic receptors
  JOURNAL   Sci Signal 14 (714), eabc4970 (2021)
   PUBMED   34932372
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Dasgupta,K., Chung,J.U., Asam,K. and Jeong,J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev Biol 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Ragancokova,D., Rocca,E., Oonk,A.M., Schulz,H., Rohde,E.,
            Bednarsch,J., Feenstra,I., Pennings,R.J., Wende,H. and Garratt,A.N.
  TITLE     TSHZ1-dependent gene regulation is essential for olfactory bulb
            development and olfaction
  JOURNAL   J Clin Invest 124 (3), 1214-1227 (2014)
   PUBMED   24487590
  REMARK    Erratum:[J Clin Invest. 2022 Aug 15;132(16):e163087. doi:
            10.1172/JCI163087.. PMID: 35968788]
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Hwang,E.M., Kim,E., Yarishkin,O., Woo,D.H., Han,K.S., Park,N.,
            Bae,Y., Woo,J., Kim,D., Park,M., Lee,C.J. and Park,J.Y.
  TITLE     A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates
            passive conductance in astrocytes
  JOURNAL   Nat Commun 5, 3227 (2014)
   PUBMED   24496152
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Martin,N., Jaubert,J., Glaser,P., Szatanik,M. and Guenet,J.L.
  TITLE     Genetic and physical delineation of the region overlapping the
            progressive motor neuropathy (pmn) locus on mouse chromosome 13
  JOURNAL   Genomics 75 (1-3), 9-16 (2001)
   PUBMED   11472062
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Kalyanaraman,S., Copeland,N.G., Gilbert,D.G., Jenkins,N.A. and
            Gautam,N.
  TITLE     Structure and chromosomal localization of mouse G protein subunit
            gamma 4 gene
  JOURNAL   Genomics 49 (1), 147-151 (1998)
   PUBMED   9570961
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Kalyanaraman,S., Kalyanaraman,V. and Gautam,N.
  TITLE     A brain-specific G protein gamma subunit
  JOURNAL   Biochem Biophys Res Commun 216 (1), 126-132 (1995)
   PUBMED   7488078
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Kleuss,C., Scherubl,H., Hescheler,J., Schultz,G. and Wittig,B.
  TITLE     Selectivity in signal transduction determined by gamma subunits of
            heterotrimeric G proteins
  JOURNAL   Science 259 (5096), 832-834 (1993)
   PUBMED   8094261
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Gautam,N., Northup,J., Tamir,H. and Simon,M.I.
  TITLE     G protein diversity is increased by associations with a variety of
            gamma subunits
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7973-7977 (1990)
   PUBMED   2122451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC171200.1 and BC016506.1.
            
            On Dec 10, 2014 this sequence version replaced NM_010317.2.
            
            Summary: This gene encodes the gamma subunit of the heterotrimeric
            G-proteins that are comprised of alpha, beta and gamma subunits.
            Upon activation by G protein-coupled receptors, the beta-gamma
            heterodimer dissociates from the alpha subunit to activate
            downstream signaling events. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016506.1, AK148452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC171200.1         80143-80374
            233-3200            BC016506.1         1-2968
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.29 cM"
     gene            1..3200
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 4"
                     /db_xref="GeneID:14706"
                     /db_xref="MGI:MGI:102703"
     exon            1..337
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /inference="alignment:Splign:2.1.0"
     exon            338..441
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /inference="alignment:Splign:2.1.0"
     exon            442..551
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..680
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /note="guanine nucleotide-binding protein G(I)/G(S)/G(O)
                     subunit gamma-4; heterotrimeric guanine nucleotide-binding
                     protein 3c"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-4 precursor"
                     /protein_id="NP_034447.1"
                     /db_xref="CCDS:CCDS36598.1"
                     /db_xref="GeneID:14706"
                     /db_xref="MGI:MGI:102703"
                     /translation="MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAASDLLAY
                     CEAHVREDPLIIPVPASENPFREKKFFCTIL"
     exon            552..3200
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3172..3177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /note="hexamer: AATAAA"
     polyA_site      3200
                     /gene="Gng4"
                     /gene_synonym="Hg3c"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgggag gagacctgct gcgaaggagt gggtgcggcc agcgtggcgc agcaggcgag
       61 ggttgggggg tcaccgtctt gcacccagtg ggcccactgc gcagacccga ggtcccgctt
      121 gcgggtggct ttgctgtggc ttgtgctccg tgccgcgccc ccttttctcc ccagacgcgc
      181 agggtcttct gtggtccggg accccgcggg tggcgacgcg gggcgcgctt tcactgagcc
      241 cggggcgagc gatgccgctt ggcctggcca accccgtcga gcgccgcgcc ggggacccag
      301 cccgcgtctg agcagcgccg gctgcgcgcc ggctgcggag aaccccacag caggaccctg
      361 agtcagcttc tcttccaaca gccaacttct gctgctgcag tgtcccctga ctggacctgc
      421 ccctgtacca cctctcagca gggagtgcag gaatgaagga aggcatgtct aataacagca
      481 ccaccagcat ctcccaggcc aggaaagccg tggagcagct gaagatggaa gcctgcatgg
      541 acagggtgaa ggtctcccag gctgcctcag acctcctggc ctactgtgaa gcccacgtgc
      601 gggaggaccc cctcatcatc ccagtgcctg cctcagaaaa ccccttccgg gagaagaagt
      661 tcttctgcac catcctctaa cacccatggc gatgaagcgg gccctttcct gctgtaacag
      721 ttctgagtag agaccatgca tgctcccatg tagaggcaca cctcccacaa caccccatct
      781 ctgtccaacc aatcatgatc tgggctcatc ttgttttatc atatttcctt catagcactg
      841 tttcctcttc cttttttttt tcttttttct tatttccatc cacagagaaa acagacattt
      901 ttatagccaa aaaacaaatg tgccatataa aagtgtagac ttaaaggtct acagttttta
      961 aacattccca accataaata tatccagtta ataaatttca gtgggtaatt cattgaaatc
     1021 aaaaccatgc acaagtgtct cccatgcgca gtaattcaat cgcagatgag agcttgtcag
     1081 ccagacacag gtgagggtgg ggtctctttc gcctctggca tctctatcat aggagccttc
     1141 aggggccata tggctaggtc ctgtaaatga ctaatatctc tatctgttta tcactgaaca
     1201 ttccaacgct gatgcttctg agaatacatt tgtggtgtag acgctggagc agccttgact
     1261 gtagatactc accagacagc cccactgggc catcttctca atccaaatgc cccgttctcc
     1321 ctgtttgctc cctccttggt gtttctagta aggcaagaag tctgacaaca ctgggtcctc
     1381 tggagtctcg gcacagttat ccctgaaagt gatgccacca atgcaactcg ctgatctaag
     1441 gatttatggg cgtcaacata tttaacctaa caataagtac tccaagtata ggtctagttt
     1501 tagagaggga atatcccagg catagagaaa tgacatttgc tgaaaactgc agatagaaag
     1561 taagcacacc aagacgtcca tgtgtgggta gtctatccct aaaaccctcc ctgaagctct
     1621 gaactgtgga cacctgtggc aagcgtgcag cttcacaaac agtcctaact gcacgcttgg
     1681 aatgaagcaa acacattttc acactaactg gatgtacacc tctctcccac cttggccaag
     1741 agaagtgtca caagcctaag ttatggcagt ttgtaataga tgatatgtag gtgccccaag
     1801 atcagatagc agtaagcctt gagattttcc atgacaaggc tgttggcccc atctaaggca
     1861 cccccatacc ctcccaatgg aggcggtaac cacagttgct gagggctctg tgagaacatt
     1921 tgttgtgtag atatttgaga actacccctc ctctggatct caacgaggct tgctgtgtgc
     1981 tgctgggcaa gccgttgtgt gccaagctgt tcaaaccggc aaactgcaga cagttaatta
     2041 ctcctcttgc ttttctgcca gggcaggaaa ccaagcaaag ctcgcattat ccttgaaagc
     2101 caacatgtgc tggatgacag cctataatgc tgtggagagt atatgatttc acagacacca
     2161 tggttctgag acgaggagtg caaaatggcc tccaaggagg tgactatcat ttttagatgg
     2221 gtttgtgcct tgctaccctc tcttgcagct ttggtggaag ctgttcttag tttcactact
     2281 gggcacgaga tgagaggcta agactctggt tttgttgggc tgtaagaaga tctctttatt
     2341 ctgtggctca tgttggcatc atcaaccgac agagtagacc atagtccaca aaagtcaaga
     2401 agtggggcag caccagcagt agcaaaatca ggtcaagaga acagtgtgct ttaatctcct
     2461 accaaactgt ctctgctttc ctgcctctcc ttcccacaca tcttccttac attctcctgt
     2521 ggatgccgtg tccactagta actgtcctgg gaagattccc ctccctcacc cccacccctg
     2581 ccactctacc acttggaccc attgagcttt ctgacttatt cctgaatttc tgttaattct
     2641 cagagtcttg tgatcaacct tgtaaactca ttattccaca aagtctcctc atttggatgt
     2701 gaatattttg tgaggagaca actctgccag agtgtgtact caacagaaat gtgtacatat
     2761 catcagaaga aatgcactag agtgttagag aagtactgct tacagtaacc atagccagaa
     2821 ggagcccctt acacccatgc caaaggaata aacagatgag ggtaatttgt gcagtggatt
     2881 ctcagctctg tccacagctt ggtgtgaatc ttgctggctt gagggactaa gagcaggcaa
     2941 gtccaagcta cagttccatt tccatacagc acaggcctgg caggccaacc caagcagatt
     3001 aaaggaggga cagtagctat tattctcaaa ggggccacag agaggggaca caaaaggctt
     3061 ctggaatgtt ctgtctctgg atctagctgt aggtcatcct gatgtgttta gtttgtgcaa
     3121 gttctccaac tgtccacttt tgggtgcttt tctgtatgtg tgttatactt caataaaaca
     3181 tcaggctttg tgattaccaa
//
