LOCUS       NM_010316               1699 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), gamma
            3 (Gng3), mRNA.
ACCESSION   NM_010316
VERSION     NM_010316.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Yim,Y.Y., McDonald,W.H., Betke,K.M., Kaya,A., Hyde,K., Erreger,K.,
            Gilsbach,R., Hein,L. and Hamm,H.E.
  TITLE     Specificities of Gbetagamma subunits for the SNARE complex before
            and after stimulation of alpha2a-adrenergic receptors
  JOURNAL   Sci Signal 14 (714), eabc4970 (2021)
   PUBMED   34932372
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Moon,A.M., Stauffer,A.M., Schwindinger,W.F., Sheridan,K.,
            Firment,A. and Robishaw,J.D.
  TITLE     Disruption of G-protein gamma5 subtype causes embryonic lethality
            in mice
  JOURNAL   PLoS One 9 (3), e90970 (2014)
   PUBMED   24599258
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Schwindinger,W.F., Mirshahi,U.L., Baylor,K.A., Sheridan,K.M.,
            Stauffer,A.M., Usefof,S., Stecker,M.M., Mirshahi,T. and
            Robishaw,J.D.
  TITLE     Synergistic roles for G-protein gamma3 and gamma7 subtypes in
            seizure susceptibility as revealed in double knock-out mice
  JOURNAL   J Biol Chem 287 (10), 7121-7133 (2012)
   PUBMED   22207761
  REMARK    GeneRIF: Synergistic roles for G-protein gamma3 and gamma7 subtypes
            in seizure susceptibility as revealed in double knock-out mice.
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Kalyanaraman,S., Kalyanaraman,V. and Gautam,N.
  TITLE     A brain-specific G protein gamma subunit
  JOURNAL   Biochem Biophys Res Commun 216 (1), 126-132 (1995)
   PUBMED   7488078
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Kleuss,C., Scherubl,H., Hescheler,J., Schultz,G. and Wittig,B.
  TITLE     Selectivity in signal transduction determined by gamma subunits of
            heterotrimeric G proteins
  JOURNAL   Science 259 (5096), 832-834 (1993)
   PUBMED   8094261
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Cali,J.J., Balcueva,E.A., Rybalkin,I. and Robishaw,J.D.
  TITLE     Selective tissue distribution of G protein gamma subunits,
            including a new form of the gamma subunits identified by cDNA
            cloning
  JOURNAL   J Biol Chem 267 (33), 24023-24027 (1992)
   PUBMED   1385432
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Gautam,N., Northup,J., Tamir,H. and Simon,M.I.
  TITLE     G protein diversity is increased by associations with a variety of
            gamma subunits
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7973-7977 (1990)
   PUBMED   2122451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290040.1, AK032646.1 and BE949484.1.
            
            On Jan 7, 2006 this sequence version replaced NM_010316.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032646.1, SRR1660815.461329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY290040.1         86-137
            53-1691             AK032646.1         1-1639
            1692-1699           BE949484.1         16-23               c
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.76 cM"
     gene            1..1699
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 3"
                     /db_xref="GeneID:14704"
                     /db_xref="MGI:MGI:102704"
     exon            1..256
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /inference="alignment:Splign:2.1.0"
     exon            257..356
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..485
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 3 subunit; heterotrimeric guanine nucleotide-binding
                     protein 3d"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-3"
                     /protein_id="NP_034446.1"
                     /db_xref="CCDS:CCDS29550.1"
                     /db_xref="GeneID:14704"
                     /db_xref="MGI:MGI:102704"
                     /translation="MKGETPVNSTMSIGQARKMVEQLKIEASLCRIKVSKAAADLMTY
                     CDAHACEDPLITPVPTSENPFREKKFFCALL"
     exon            357..1699
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      795..800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /note="hexamer: AATAAA"
     polyA_site      821
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /note="major polyA site"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
                     /note="hexamer: AATAAA"
     polyA_site      1699
                     /gene="Gng3"
                     /gene_synonym="Hg3d"
ORIGIN      
        1 agaatcagca gctccttcta gcatccttca tccttcaggt accagccatc tgggcagaac
       61 ttaagctgtg gagactgaga ccacccctcc aaggatctcg tctgagcatc tctagtgacc
      121 ttctctgcat taactgtcag tgctacggat atttttagct ccaagtcctg gcagggtggg
      181 gcacctatct gaggcagggt ttggtgcccc ctccccactg accctacatc cctggctgcc
      241 gctgctgtta cttcaggatg aaaggggaga cccccgttaa cagcactatg agtattggtc
      301 aagcacgcaa gatggtggaa cagcttaaga ttgaggccag cttgtgccgg ataaaggtgt
      361 ccaaggcagc agcagacctg atgacatact gtgatgccca cgcttgtgag gaccccctca
      421 tcactcctgt gcccacttcc gagaacccct tccgggagaa gaagttcttc tgtgcgctcc
      481 tctgaagagc ggtggacctc ctctgaactc atcgccccct cccagacccg cccttagatt
      541 ggaaattgta gtagatcact tctacccgca tttacccgga gattatttga agcacaaggc
      601 cctccttacc catgtctacc ccatctcctc accctttcag gctaactcca agcaccttct
      661 actctatcta taaagggacc ccgctaaact gccaaaatcc tgcctgtttc cctcggtgat
      721 ccatccgttc aggcaatgga gagggggatg cccgggtgct cacctggagc tatgaaaggt
      781 aaaggcattt gaagaataaa gtcattcaga gcctcagagg acaacgtctg tgttagcgtt
      841 cttgggaaag aggatcctta atcgatacac ttgccatatc cagggaacag ggccagtcga
      901 gcccgttaga cattgtaagg attggagatc gcaaagtata aggtgcccga gcgcccccag
      961 tggggggttg ttaaaacgag cgctcagaag ccgcggagca ttcacacgag cgcgcaacgt
     1021 aagcggcgag aaccacacaa gggcgagcag ggtgggtttc cgcaggccca gggacagcag
     1081 ccccgggggg aggtggcccg agaggccgtg gggcgggaca gggcgactcg gcgcggcagc
     1141 caatgcccaa gatggcggct gcctgttcgt acccgcatgg aggcacgcgc cgagggtgct
     1201 cttaaaatgg cggtccccag cgttcccaat agggaacgat cccttatgcg atcctctggt
     1261 cttaaaatgg ctgcccctgc cctctcaaag tcagagtcag gttctctgtc ccatagaatc
     1321 tggaactaga catgctttgg agaccaatca cggggagtgg ggatggggag acacctaaag
     1381 cagtcatggg ttcttaagtt cagtgtggtg accaacactc cggaggtgtt ggacacacac
     1441 agaggcagat ggatctctga gttccaagcc agccacgacg acacacaata cacaatgaaa
     1501 tcctgactta aaacaaccag tcactaggac tgggacccaa gaagcccaga gtgagttttg
     1561 cataagaatc tcgcctgagt agaggttccc tttgaggtgt atgtaataac acaaatgtgt
     1621 taaacaggcc atcttggagc accctgttcc ttggtctctg tgggatctaa ataagtaata
     1681 aatttgtttt cttgttgaa
//
