LOCUS       NM_010315               3826 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), gamma
            2 (Gng2), transcript variant 1, mRNA.
ACCESSION   NM_010315
VERSION     NM_010315.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Luo,V.M., Shen,C., Worme,S., Bhagrath,A., Simo-Cheyou,E.,
            Findlay,S., Hebert,S., Wai Lam Poon,W., Aryanpour,Z., Zhang,T.,
            Zahedi,R.P., Boulais,J., Buchwald,Z.S., Borchers,C.H., Cote,J.F.,
            Kleinman,C.L., Mandl,J.N. and Orthwein,A.
  TITLE     The Deubiquitylase Otub1 Regulates the Chemotactic Response of
            Splenic B Cells by Modulating the Stability of the gamma-Subunit
            Gng2
  JOURNAL   Mol Cell Biol 44 (1), 1-16 (2024)
   PUBMED   38270191
  REMARK    GeneRIF: The Deubiquitylase Otub1 Regulates the Chemotactic
            Response of Splenic B Cells by Modulating the Stability of the
            gamma-Subunit Gng2.
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Yim,Y.Y., McDonald,W.H., Betke,K.M., Kaya,A., Hyde,K., Erreger,K.,
            Gilsbach,R., Hein,L. and Hamm,H.E.
  TITLE     Specificities of Gbetagamma subunits for the SNARE complex before
            and after stimulation of alpha2a-adrenergic receptors
  JOURNAL   Sci Signal 14 (714), eabc4970 (2021)
   PUBMED   34932372
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Gan,S., Shi,W. and Tang,J.
  TITLE     miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are
            involved in the pathogenesis of abdominal aortic aneurysm in mice
  JOURNAL   Gen Physiol Biophys 40 (1), 1-16 (2021)
   PUBMED   33655887
  REMARK    GeneRIF: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7
            are involved in the pathogenesis of abdominal aortic aneurysm in
            mice.
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Wang,W., Touhara,K.K., Weir,K., Bean,B.P. and MacKinnon,R.
  TITLE     Cooperative regulation by G proteins and Na(+) of neuronal GIRK2
            K(+) channels
  JOURNAL   Elife 5, e15751 (2016)
   PUBMED   27074662
  REMARK    GeneRIF: It was concluded that GIRK2, through its dual
            responsiveness to G protein beta-gamma and Na+, mediates a form of
            neuronal inhibition that is amplifiable in the setting of excess
            electrical activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Cali,J.J., Balcueva,E.A., Rybalkin,I. and Robishaw,J.D.
  TITLE     Selective tissue distribution of G protein gamma subunits,
            including a new form of the gamma subunits identified by cDNA
            cloning
  JOURNAL   J Biol Chem 267 (33), 24023-24027 (1992)
   PUBMED   1385432
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Characterization of the cDNA and genomic sequence of a G protein
            gamma subunit (gamma 5)
  JOURNAL   Mol Cell Biol 12 (4), 1585-1591 (1992)
   PUBMED   1549114
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Gautam,N., Northup,J., Tamir,H. and Simon,M.I.
  TITLE     G protein diversity is increased by associations with a variety of
            gamma subunits
  JOURNAL   Proc Natl Acad Sci U S A 87 (20), 7973-7977 (1990)
   PUBMED   2122451
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Gautam,N., Baetscher,M., Aebersold,R. and Simon,M.I.
  TITLE     A G protein gamma subunit shares homology with ras proteins
  JOURNAL   Science 244 (4907), 971-974 (1989)
   PUBMED   2499046
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Hurley,J.B., Fong,H.K., Teplow,D.B., Dreyer,W.J. and Simon,M.I.
  TITLE     Isolation and characterization of a cDNA clone for the gamma
            subunit of bovine retinal transducin
  JOURNAL   Proc Natl Acad Sci U S A 81 (22), 6948-6952 (1984)
   PUBMED   6438626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY245532.1, AK158697.1, AK160396.1 and AC130831.4.
            
            On Jan 6, 2006 this sequence version replaced NM_010315.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-6 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158697.1, SRR1660817.116339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BY245532.1         2-146
            146-1468            AK158697.1         147-1469
            1469-1573           AK160396.1         1199-1303
            1574-3826           AC130831.4         69878-72130         c
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.17 cM"
     gene            1..3826
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 2"
                     /db_xref="GeneID:14702"
                     /db_xref="MGI:MGI:102705"
     exon            1..292
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..333
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..449
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..578
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /EC_number="3.1.26.4"
                     /note="g gamma-I; heterotrimeric guanine
                     nucleotide-binding protein 3f1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2"
                     /protein_id="NP_034445.1"
                     /db_xref="CCDS:CCDS26840.1"
                     /db_xref="GeneID:14702"
                     /db_xref="MGI:MGI:102705"
                     /translation="MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAH
                     AKEDPLLTPVPASENPFREKKFFCAIL"
     exon            450..3826
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /note="hexamer: AATAAA"
     polyA_site      914
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /note="major polyA site"
     regulatory      3804..3809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /note="hexamer: AATAAA"
     polyA_site      3826
                     /gene="Gng2"
                     /gene_synonym="Hg3f1"
                     /note="major polyA site"
ORIGIN      
        1 gatgagctgc ttcctgtagg aatgaggatt gaagacaaag ctgggtgggg actcaggctt
       61 gggcttcagg ggctgctata cagacagaca cacgacgcct ctcggtgggc aactcctact
      121 acggctgggc tgggctgggc agggcttcgc tgcgctgggc tgggctgact gggctgggct
      181 gggctgggct gggctgggct gggctgggct tgggctgggc gggccgacct caccacccat
      241 ctgctccgcc aggggaagct gctctctaac caagcctccg gagccaagca agtcagatct
      301 gccagggagc gtcaggcctt gaacactgac cagagtctct gaagacccca tccaacgctc
      361 caatggccag caacaacacc gccagcatag cacaagccag gaagctggta gaacagctga
      421 agatggaagc caacatcgac aggataaagg tgtccaaggc agctgctgac ttgatggcct
      481 actgtgaggc acatgccaag gaagaccctc tgctgacccc agtcccagcc tcagaaaacc
      541 cctttcggga gaagaagttc ttctgcgcca tcctttaagt ctctgagagg aggctgaaga
      601 gtgttggggc tcctgggaca tacatgtaga gttcctagca aagtgggcgc ctttctcgtc
      661 cacagcattt aaagagagga aggagaacca tcctggacac tccgggctgt gcatgtttaa
      721 agaaatgtcc ccttatgaga atgaaagctg attccgtgtc ccaactttag agatctgacc
      781 ctgcagaccg gcctggagga gggaaatgta taaaaaatga gaatggtaat cacttctttt
      841 ctgctgtccc tctaagacat ttctgcttca tatttataaa caaaataaac attaaagccg
      901 gtgtcctgag ctgagatatg gctgacattc tggtaatgag aattgtcttt caaataccct
      961 ctgataagct gtcgccccat gtagccacaa tccagtttaa tggtttccac gtttagtctt
     1021 ttgtgccttt ttcttttcct tccctttctt ctcttttaga gggctgagag gataagactg
     1081 ggtttgtgtg ttagtctcaa ctccaagcag gaatgaaccc tgagatgttt agaaaagtgt
     1141 tccccatggg atttcttcat gagaataaca agaaaataga aagaaataca tacatgtaca
     1201 cacacacaca tgcacgcaca cacacacacc acacaattcc ggctctctgt gttctcttac
     1261 cactattctt aatatttgta tatgacagtt ttgattctac gagttaaagt gaaccacgtg
     1321 ttgtgactgg tgcttccata tctgtgatag tttgtgagta ctattgcatg aacatgtccc
     1381 tacatcgcat ccattcagaa gtttcgttgt tcagctgtaa agctaagaag agaagtgaga
     1441 gaaaaagagg ccagggagga aaaaaaaaat cctctgtatt ttgaaaattg ggatcacttc
     1501 agcgccttag ccatgcctga aatacctcct agtgaactgt ggtagaagta tctcttgaca
     1561 ggtttcccca gtccgcagca tttggactta cccaggatcc agggcagcac agttcccccc
     1621 acgcccccaa ctggagacca ggcagggatc cacgatgact tggaaaagca ctgtcagaat
     1681 agcatctcgt tcccacgtcc caggaacagt cgaaagcata tgtaaaagaa catgttccat
     1741 gttcatagct agacaaccat ggccctcttt agctcaagca tcagaagaaa taaagccaca
     1801 gctctaaggg aggtagccag cctcagaatg ctcgtttgag agacaaagtc cctgaattgt
     1861 gctccgacca acccttgcag ttggctctcc ttccagctca ttcccccaaa atttcaaagc
     1921 attccctgct ttgccctcca ccccgttcgt cagagcctca ccactctatt tacagcttcc
     1981 tttggctaga gctctcctcc cacagtaaga cattgagagt gagttttttt tttcatgaca
     2041 gttgtctcct ccatcagtaa cagaaggcct cggctgcctt cagacatttt gtcatctacc
     2101 cagtcaaaga gagcctctta cgattctttt tgttttcaga tcctaaaaga ccactaaatc
     2161 caagtaaaat ttcttttctc ctcttaccat tctcttcctc atggtttaaa agttggtggt
     2221 acttttaaag gaaagagaag ggaaaaagac ttcctatggc aaggacacat tttacaaata
     2281 gatggtaaga tatttctctt aactctttta tgggctttca gctaaaggag ttaactatgt
     2341 ccaattaaag ttcagacctg gggtgggaga gaagagggta ccggaatgat tattaatgta
     2401 caaatgcaat tctgtagccg aaaacttctg ttccggcaga aacttctgtc ctcaggagtt
     2461 tgttatagtt tgcgggacgc tcatgaagat ttaatggtag aaacaaaaca aaacagacaa
     2521 aaagaaccac tgtcagtctt tagagaactg cactgtaatt caattatcaa tactgaggga
     2581 tcagctgaaa gtatcacaca ttcaaagtga gctgacatga atctgtgttc acgtgtcaac
     2641 agctgtgact ggggcactct gtgctggttg ggggtggggt actcgaggag gattctggac
     2701 ttctgtgtaa attgagatct ctgaagcaat tccagtggaa acacaatctt tagggcgccc
     2761 cttatacagg cctaacaatt aaaaattcag aatttgcaaa tgacttgtga gcatgcttat
     2821 agaataaaaa ggcaggaaac tcaatcctct tccacataga aatttcagga aaacatcttt
     2881 tttacaattt catatccttc agtatggagc tatagctgga atcagatttg acttcttgat
     2941 gtttgtattt attaaaggga aaaaggtttg tttacttgga tctccaaaga gcttaattct
     3001 tttcaacgtg aaccatcatt gtcaccagca taattttacc ttagggtaac taataggaaa
     3061 cttcagttta actgtttaag gccctcattt ctatatacct gtataacaat tacaatctgc
     3121 catggaatta ataattaatg tcatacttat aatgcagtgt ctattaaaat acctgaacca
     3181 tttttaataa tcaactccga ttttaaatgt ttttacattc gaaggtaaaa tataatttaa
     3241 atcattggat ttaagaagac gtatcatact ttttcccata tccttgtatt cacacggtga
     3301 gttttgagaa aatcaagctg gtgaccttta gtgtgttttt ttatgttttt ttccccttgg
     3361 tgtttatttc tagctgctcc tgcaaatggc gaattatatg tatattactg tctcacagcc
     3421 caacaattgt acaattgttc agagcttaac acttttcctg tataagatct gtggaatgtg
     3481 tctttaaaga ggggaaaaca gaaaatgggg ggtcttgtgt tttggtgggg tttttccttt
     3541 ttgggttttt ttgtttggtt gtttagttgg gtttttttgt tttgtgttgg ttttttgttt
     3601 tttcaagaca gggtcttact atgtggctct ggctgtcctg gaacttgttc tgtagaccag
     3661 gctggcctcg aactcagaga ttcccctgtc tctgactcga gaataaaggc atgagccacc
     3721 acacccagct tagaaatgtt aaagcaggaa aacctgaatg tgatgtgcgc atctttaccc
     3781 cacatgaacg gtgtatttgt tttaataaat ggaattttca gattca
//
