LOCUS       NM_010313               2249 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus guanine nucleotide binding protein (G protein), beta 5
            (Gnb5), transcript variant 1, mRNA.
ACCESSION   NM_010313
VERSION     NM_010313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Zhang,J., Pandey,M., Awe,A., Lue,N., Kittock,C., Fikse,E.,
            Degner,K., Staples,J., Mokhasi,N., Chen,W., Yang,Y., Adikaram,P.,
            Jacob,N., Greenfest-Allen,E., Thomas,R., Bomeny,L., Zhang,Y.,
            Petros,T.J., Wang,X., Li,Y. and Simonds,W.F.
  TITLE     The association of GNB5 with Alzheimer disease revealed by genomic
            analysis restricted to variants impacting gene function
  JOURNAL   Am J Hum Genet 111 (3), 473-486 (2024)
   PUBMED   38354736
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2249)
  AUTHORS   Bustos,F.J., Pandian,S., Haensgen,H., Zhao,J.P., Strouf,H.,
            Heidenreich,M., Swiech,L., Deverman,B.E., Gradinaru,V., Zhang,F.
            and Constantine-Paton,M.
  TITLE     Removal of a partial genomic duplication restores synaptic
            transmission and behavior in the MyosinVA mutant mouse Flailer
  JOURNAL   BMC Biol 21 (1), 232 (2023)
   PUBMED   37957716
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2249)
  AUTHORS   Pandey,M., Zhang,J.H., Adikaram,P.R., Kittock,C., Lue,N., Awe,A.,
            Degner,K., Jacob,N., Staples,J., Thomas,R., Kohnen,A.B.,
            Ganesan,S., Kabat,J., Chen,C.K. and Simonds,W.F.
  TITLE     Specific regulation of mechanical nociception by Gbeta5 involves
            GABA-B receptors
  JOURNAL   JCI Insight 8 (13), e134685 (2023)
   PUBMED   37219953
  REMARK    GeneRIF: Specific regulation of mechanical nociception by Gbeta5
            involves GABA-B receptors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2249)
  AUTHORS   Yim,Y.Y., McDonald,W.H., Betke,K.M., Kaya,A., Hyde,K., Erreger,K.,
            Gilsbach,R., Hein,L. and Hamm,H.E.
  TITLE     Specificities of Gbetagamma subunits for the SNARE complex before
            and after stimulation of alpha2a-adrenergic receptors
  JOURNAL   Sci Signal 14 (714), eabc4970 (2021)
   PUBMED   34932372
REFERENCE   6  (bases 1 to 2249)
  AUTHORS   Saito,H., Mimmack,M., Kishimoto,J., Keverne,E.B. and Emson,P.C.
  TITLE     Expression of olfactory receptors, G-proteins and AxCAMs during the
            development and maturation of olfactory sensory neurons in the
            mouse
  JOURNAL   Brain Res Dev Brain Res 110 (1), 69-81 (1998)
   PUBMED   9733924
REFERENCE   7  (bases 1 to 2249)
  AUTHORS   Zhang,S., Coso,O.A., Lee,C., Gutkind,J.S. and Simonds,W.F.
  TITLE     Selective activation of effector pathways by brain-specific G
            protein beta5
  JOURNAL   J Biol Chem 271 (52), 33575-33579 (1996)
   PUBMED   8969224
REFERENCE   8  (bases 1 to 2249)
  AUTHORS   Watson,A.J., Aragay,A.M., Slepak,V.Z. and Simon,M.I.
  TITLE     A novel form of the G protein beta subunit Gbeta5 is specifically
            expressed in the vertebrate retina
  JOURNAL   J Biol Chem 271 (45), 28154-28160 (1996)
   PUBMED   8910430
REFERENCE   9  (bases 1 to 2249)
  AUTHORS   Williams,C.J., Schultz,R.M. and Kopf,G.S.
  TITLE     G protein gene expression during mouse oocyte growth and
            maturation, and preimplantation embryo development
  JOURNAL   Mol Reprod Dev 44 (3), 315-323 (1996)
   PUBMED   8858601
REFERENCE   10 (bases 1 to 2249)
  AUTHORS   Watson,A.J., Katz,A. and Simon,M.I.
  TITLE     A fifth member of the mammalian G-protein beta-subunit family.
            Expression in brain and activation of the beta 2 isotype of
            phospholipase C
  JOURNAL   J Biol Chem 269 (35), 22150-22156 (1994)
   PUBMED   8071339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK621143.1, U69145.1, BX513135.1, AI323394.1 and BY607717.1.
            
            On Oct 2, 2012 this sequence version replaced NM_010313.1.
            
            Transcript Variant: This variant (1; also known as Long, Beta-5L,
            Gbeta5L) encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.84704.1, BC016135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               CK621143.1         1-102
            103-1290            U69145.1           1-1188
            1291-1699           BX513135.1         123-531
            1700-2204           AI323394.1         6-510               c
            2205-2249           BY607717.1         355-399
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.3 cM"
     gene            1..2249
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /note="guanine nucleotide binding protein (G protein),
                     beta 5"
                     /db_xref="GeneID:14697"
                     /db_xref="MGI:MGI:101848"
     exon            1..86
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            87..228
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1290
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /note="isoform 1 is encoded by transcript variant 1; hug;
                     flail; flailer; guanine nucleotide-binding protein subunit
                     beta-5; transducin beta chain 5; guanine nucleotide
                     binding protein, beta 5; heterotrimeric guanine
                     nucleotide-binding protein 2e"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-5 isoform 1"
                     /protein_id="NP_034443.1"
                     /db_xref="CCDS:CCDS40692.1"
                     /db_xref="GeneID:14697"
                     /db_xref="MGI:MGI:101848"
                     /translation="MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLNYCSTCAEIMA
                     TDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLK
                     GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGC
                     AIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT
                     CALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA
                     FETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFS
                     LSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLR
                     VWA"
     exon            229..340
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            341..477
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            478..519
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            520..596
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            597..729
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            730..873
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            874..965
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1014
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1111
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1278
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2249
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /note="hexamer: AATAAT"
     polyA_site      2204
                     /gene="Gnb5"
                     /gene_synonym="flr; Gbeta5; GBS; Hg2e"
                     /note="major polyA site"
ORIGIN      
        1 ggtgaccaat ggctcaaatc ttcacaccac cgcagtaacc tccctcgttt ctggccagcc
       61 accccaggtg ttcattgctc tgtaagcctc atctcagcca agatgtgcga tcagaccttc
      121 ctggttaatg tgttcggctc atgtgacaaa tgcttcaaac aaagggccct aagacccgtt
      181 ttcaagaaat ctcaacaact caactactgc tccacgtgtg cagagatcat ggcaaccgat
      241 gggctgcacg agaacgagac gctggcgtcg ctgaagagcg aggccgagag cctcaagggc
      301 aagctagagg aggagcgggc aaagctgcat gacgtggagc tacaccaggt ggccgagcgg
      361 gtggaggccc tgggccagtt tgtcatgaag accagaagga ccctcaaagg ccacgggaac
      421 aaagtcctgt gcatggattg gtgcaaagac aagcggagaa tcgtgagctc ctcacaggat
      481 gggaaggtga ttgtctggga ttccttcact acgaacaagg agcacgcggt caccatgcct
      541 tgcacctggg tgatggcgtg tgcttacgcg ccatcgggat gcgccattgc ttgtggtggt
      601 ctggataata agtgctctgt gtatccactg acattcgaca agaacgagaa catggccgcc
      661 aagaagaagt ctgttgctat gcacaccaac tacctgtctg cctgcagctt caccaactct
      721 gacatgcaga ttctgacagc cagcggggat ggcacctgcg ccctgtggga tgtggaaagt
      781 ggacagctgt tacagagctt ccatgggcac ggggctgacg tcctctgctt ggacctggcc
      841 ccctcggaaa caggaaacac cttcgtgtct gggggttgtg acaagaaggc catggtgtgg
      901 gacatgcgct ctggccagtg cgtgcaagcc tttgaaactc atgaatcgga tgtcaacagt
      961 gttcggtact accccagtgg ggatgctttt gcttcggggt cggatgatgc cacgtgtcgc
     1021 ctctatgacc tgagggcaga tagagaggtc gccatctact ccaaggagag catcatattt
     1081 ggcgcctcga gtgtggactt ctccctcagt ggtcgcctgc tttttgctgg gtacaatgac
     1141 tataccatca atgtctggga tgttctcaag ggctcccggg tctccatcct gtttggacat
     1201 gaaaaccgcg tcagcactct gcgagtgtct cctgatggga cagcattctg ctcgggatca
     1261 tgggatcaca ccctaagagt ttgggcataa tcttctgaca gcgttcaaga atgtgtgtcc
     1321 tctcgtgtag atatgacttc tccatgagcc cagggcttcc cacaggttag cttatgggag
     1381 caacctcaca gctcggcact cactcacccc gtccagtgtc tccatgaaat ctgccccctc
     1441 cctggaaaca ctcggatagg ccgtggcact tcaactggac cttcaagccc ttctgtcatc
     1501 tcaaaaactc tgctaagttc tgtctgtttt tgaaattatt ccagccaatg gaatttcaca
     1561 tttatcagca tttaaaatgt ccctcgttgt ttccttggat ctagtctgtc ttcagagcac
     1621 tttaaactgt accttttctt ggcgtggact gtggcttcta gaaccatcct tgggatgtgc
     1681 cggttatgtg gactgtaaga aagaatgttc actggtctgt aatagaagga aattctattt
     1741 ccagatgtaa ctacacagaa ccacttttta aaactgtttt taggtaaaat tatctttttt
     1801 caacctgttc agttgtcttt tttaagataa tgtttggttt tgttttgggg gatgagggtc
     1861 tgggggagtc tttagaaatg aaacggacac atgcagaaaa cagaaaaaaa aaactgtata
     1921 attcacttgt gatcgatggc agtctaggct gagcatcccc gacacttgag ggcaaaacag
     1981 gttgccattc ctagcacaaa tactgcagag agcaaacaga accttctggc atgggaagac
     2041 aggccactaa actgatttaa aagcctgcta gtagtgttat cagaaatgcc taagataaac
     2101 tgtgtgttgt ccctataaat tatattcgaa tgtcctgcac agcagttgta ctgacacaga
     2161 ctggtgggca ggccatgaat aataataatg tctttgttat ccaaggggta tcttgtcttt
     2221 atttgaatca taaattcctt ctagatgcg
//
